Case-series investigation of intracranial neoplasms at a petrochemical research facility.

Abstract:

BACKGROUND:From 1970 through 1997, 17 intracranial neoplasms were identified among 6,800 employees of a petrochemical research facility. This investigation describes the case-series. METHODS:The intracranial neoplasms were identified by self reports and record linkages, and were confirmed by medical records and a pathology review. Standardized incidence ratios (SIRs) compare observed and expected numbers of cases according to certain work characteristics. RESULTS:Overall, there were 17 observed and 10.5 expected intracranial neoplasms, including 11/4.7 benign intracranial tumors and 6/5.9 brain cancers. All brain cancers occurred among male research scientists or technicians. Four had worked at some time on the same floor of one building (SIR=12.6, 95% CI=3.4-32.1), and several had worked on a research project with at least one other brain cancer case. The benign intracranial neoplasm cases did not have common building assignments or work activities. CONCLUSIONS:The occurrence pattern of brain cancers, but not that of benign tumors, suggests a possible occupational etiology.

journal_name

Am J Ind Med

authors

Delzell E,Beall C,Rodu B,Lees PS,Breysse PN,Cole P

doi

10.1002/(sici)1097-0274(199910)36:4<450::aid-ajim6

subject

Has Abstract

pub_date

1999-10-01 00:00:00

pages

450-8

issue

4

eissn

0271-3586

issn

1097-0274

pii

10.1002/(SICI)1097-0274(199910)36:4<450::AID-AJIM6

journal_volume

36

pub_type

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