Abstract:
:Animal studies suggest that mesothelioma is most effectively induced by fibers longer than 8 mu. However, studies of asbestos fibers recovered from human lungs in cases of mesothelioma indicate that, at least in large-scale samples, relatively few fibers meet this size criterion, perhaps implying that the animal data do not apply to man. Since asbestos concentration in lung is known to be extremely inhomogeneous, it is also possible that long fibers may selectively accumulate in specific sites, such as under the pleura. To examine this possibility, we selected ten cases of mesothelioma that contained relatively large amounts of amosite asbestos and extracted fibers from an 0.5-cm-thick strip of subpleural tissue and an area 3-cm deep to the subpleural sample for upper and lower lobes. Amosite fibers were identified and sized by electron microscopic techniques. Fibers in the peripheral upper lobe were significantly longer, broader, and of higher aspect ratio than those in the central upper lobe. The lower lobe showed a reverse pattern, with longer fibers and broader fibers in the central sample. These data indicate that the two lobes behave differently in regard to fiber size, with selective accumulation of long fibers in the peripheral upper lobe, but not in the peripheral lower lobe. Whether these differences reflect differences in initial deposition of fibers within the lung, or, more likely, specific redistribution of fibers, is unclear, but in either case, accumulation of long fibers immediately under the upper lobe pleura may be important in the genesis of mesothelioma.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Churg A,Wiggs Bdoi
10.1002/ajim.4700110508subject
Has Abstractpub_date
1987-01-01 00:00:00pages
563-9issue
5eissn
0271-3586issn
1097-0274journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Existing research suggests that workplace injuries can have significant economic and social consequences for workers; but there are no quantitative studies on complete populations. METHODS:The British Columbia Linked Health Database (BCLHD) was used to examine 1994 injured workers who lost work time due to ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20503
更新日期:2007-09-01 00:00:00
abstract::Attention to psychosocial hazards in work environments should become an increasingly important component of occupational safety and health interventions. Research findings have linked a number of measurable psychosocial characteristics with negative psychological and physiological consequences. Some serious physical h...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199604)29:4<308::AID-AJIM6
更新日期:1996-04-01 00:00:00
abstract::Since 1988, the National Institute for Occupational Safety and Health (NIOSH) has notified workers who were subjects in occupational epidemiology studies of the study findings ("worker notification"). This paper describes seven notifications and the worker's reactions to them. The chemicals of interest in the studies ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270403
更新日期:1995-04-01 00:00:00
abstract:BACKGROUND:We sought to gain insight into workers' knowledge, beliefs, and attitudes on the subject of testing for genetic susceptibility to beryllium. METHODS:Five focus groups were held with 30 current and former beryllium workers and nine family members. Audio recordings were transcribed and assessed by hierarchica...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20962
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Multiple comorbidities have been reported among rescue/recovery workers responding to the 9/11/2001 WTC disaster. In this study, we developed an index that quantifies the cumulative physiological burden of comorbidities and predicts life expectancy in this cohort. METHODS:A machine learning approach (gradie...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22786
更新日期:2018-01-01 00:00:00
abstract::A death certificate mortality odds ratio study of seven cancer sites was conducted by using 1979-1984 data on Illinois deaths in white and black males. Cancer sites selected include stomach, pancreas, lung, prostate, bladder, brain, and non-Hodgkin's lymphomas. This surveillance study was undertaken to detect occupati...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.4700150609
更新日期:1989-01-01 00:00:00
abstract::Following a work refusal at a plant manufacturing ice cream novelties in Ontario, we were asked to document cases of cumulative trauma disorders (CTDs) and carpal tunnel syndrome (CTS) in this workplace. There were 17 employees with possible hand and wrist problems identified from Workers Compensation Board (WCB) Form...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700220312
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Production of asbestos-cement products in Brazil started in the 1940s, peaked in the 60-70s and is still an active industry. This study was designed to assess the non-malignant effects of asbestos exposure in the asbestos-cement industry in Brazil. METHODS:A group of 828 former asbestos-cement workers enrol...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1095
更新日期:2001-09-01 00:00:00
abstract:BACKGROUND:Metal fabrication workers experience high rates of traumatic occupational injuries. Machine operators in particular face high risks, often stemming from the absence or improper use of machine safeguarding or the failure to implement lockout procedures. METHODS:The National Machine Guarding Program (NMGP) wa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22514
更新日期:2015-11-01 00:00:00
abstract::The effects of aluminum on the pulmonary function of aluminum workers were investigated in this study. Serum aluminum levels and spirometry were measured in 55 male workers and 30 male controls. The mean serum aluminum level of workers (72.7 +/- 9.9 ng/ml) was significantly high compared to that of controls, indicatin...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199803)33:3<305::aid-ajim1
更新日期:1998-03-01 00:00:00
abstract::In 15 random autopsies, nickel (Ni) and chromium (Cr) were determined quantitatively by atomic absorption spectrometry (AAS) in human lung tissue to evaluate norm values. None of the deceased persons had had an occupational exposure to Cr or Ni or their compounds. In all, 22 tissue samples were taken from each lung at...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700120107
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Respirable crystalline silica (RCS) can potentially cause silicosis, lung cancer, and renal failure. The current study estimates the percentages of workers potentially overexposed to concentrations of RCS dust and silicosis proportional mortality rates (PMRs) by industry. METHODS:Occupational Safety and Hea...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23109
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:This study examines the hypothesis that acid mist or mixtures of acid mists and acid gases are associated with ulcerative lesions of the oral mucosa. METHODS:All 665 active male workers of a metal processing factory were the study population. Semi-quantitative measures of exposure were estimated from a job ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10343
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:A beryllium materials manufacturer is conducting a limited pilot program that offers testing for HLA-DP beta 1E69 with genetic counseling through a third party to applicants for employment. An important consideration in this regard is the prevalence of this marker in the general population, and its consequen...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10072
更新日期:2002-06-01 00:00:00
abstract::Although OSHA promulgates standards for chemical exposures on the basis of workers' relative risk of acquiring chronic disease, it interprets the limits as absolute levels never to be exceeded. This poses a dilemma to the gathering of useful information which can be used to assess and reduce exposures, because employe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700060407
更新日期:1984-01-01 00:00:00
abstract::To study their socioeconomic and health status, 1,770 workers in the organized electronics industry in India were surveyed. Mean age of the workers employed in this industry was 32.5 +/- 6.01 years. The average per capita income/month was Rupees 333, indicating a higher socioeconomic status, compared with the status o...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230209
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Continuous increase in male incidence of malignant mesothelioma of the pleura (MMP) despite the drop of asbestos production since 1980 in Québec motivated this study aiming to assess when the rates of MMP will decline. METHODS:Age-standardized rates and trends were estimated over the 1984-2007 period by sex...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22442
更新日期:2015-05-01 00:00:00
abstract::Semen analysis has proven useful in the clinical diagnosis of infertility and is the most widely used method of monitoring the effects of occupational exposure on male fertility. Collection and analysis of semen samples in a field setting, however, require a highly motivated population and excellent technical resource...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700200209
更新日期:1991-01-01 00:00:00
abstract::Multiphasic health testing was provided to 744 rubber workers at a tire manufacturing plant. Sixty-two white males from this population had worked longest in the curing department. Personal exposure to respirable particulates was measured for curing press operators. Outcome on screening tests for curing workers was co...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700020208
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:Standardized proportionate mortality ratio (SPMR) was found to be 2.2 (95% CI = 1.3-3.5) for esophageal cancer (EC) among workers exposed to refractory brick dust in a large iron-steel complex in China. METHODS:A nested case-control design within a cohort of industrial workers. One hundred and twenty-five E...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199903)35:3<272::aid-ajim7
更新日期:1999-03-01 00:00:00
abstract::Currently available computerized hospital records from four hospitals in Southwest Oregon were utilized for occupational health surveillance by administering brief occupational questionnaires to hospitalized male patients. Patients with occupational exposure to the lumber and wood products industries showed statistica...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700040605
更新日期:1983-01-01 00:00:00
abstract::Substances referred to as formaldehyde releasers were identified on review of the literature. Information on product categories and typical concentrations for chemical products containing formaldehyde and formaldehyde releasers was obtained from the Danish Product Register Data Base (PROBAS). As of February 1992, 62,0...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700240505
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND:Work-related mortality is a relatively new concept which aims to widen occupational health and safety; to take into account not only recognized fatal occupational accidents and diseases but also other work-related deaths. Few countries in the world have a register for work-related diseases. METHODS:Estimate...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20411
更新日期:2007-01-01 00:00:00
abstract::The occupational injury experience of the U.S. and Australian construction industries for 1988-1991 was compared to identify similarities and differences in risk and to share information vital for planning strategies for prevention. There were 4,158 deaths in the U.S. and 264 in the Australian construction industries....
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199608)30:2<202::AID-AJIM1
更新日期:1996-08-01 00:00:00
abstract::To study genotoxic effects of exposure to low levels of benzene, single-strand breaks (SSB) in DNA of leukocytes and urinary levels of the oxidative DNA adduct 8-hydroxydeoxyguanosine (8OHdG) were determined in 33 men occupationally exposed to benzene from gasoline and in 33 controls. The average exposure to benzene o...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199609)30:3<317::AID-AJIM1
更新日期:1996-09-01 00:00:00
abstract:INTRODUCTION:Live-in formal caregivers spend consecutive days in patients' homes, raising questions about their ability to secure adequate sleep while on duty. Few studies have examined sleeping conditions and outcomes for this growing workforce. METHODS:We collected weeklong sleep logs and interview data from 32 Fili...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22647
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Field-portable instruments can offer expeditious analytical results to health professionals in field settings and in areas lacking laboratory infrastructure. This study further evaluated an electroanalytical field-portable instrument, which rapidly analyzes blood lead concentrations. METHODS:A portable anod...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20096
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND:Per a Congressional directive and funding, this study describes worker and workplace characteristics of emergency department (ED) patients who reported their injury/illness to their employer. The study also responds to Congress's request to enumerate injured/ill self-employed workers and workers with chronic...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22607
更新日期:2016-08-01 00:00:00
abstract::Exposure to mineral dust was studied among construction workers (N = 437) with the aid of a questionnaire and a chest X-ray examination of the lungs. The results of the questionnaire showed that 81% of the construction workers had been exposed to asbestos. Exposure had occurred in all of the occupational groups studie...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700210411
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Rates of musculoskeletal disorders in construction remain high. Few studies have described barriers and facilitators to the use of available ergonomic solutions. This paper describes these barriers and facilitators and their relationship to the level of adoption. METHODS:Three analysts rated 16 proposed erg...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22693
更新日期:2017-03-01 00:00:00