Promotion of epidermal carcinogenesis by repeated damage to mouse skin.

Abstract:

:Chemically induced epidermal carcinogenesis is usually divided into two stages: initiation, which involves the conversion of some epidermal cells into latent neoplastic cells; and promotion, which results in tumors. The hallmark of chemical promoters is epidermal hyperplasia. The hyperplasia caused by a strong promoter, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), differs morphologically from that caused by weak promoters, such as acetic acid and mezerin. The epidermal regeneration that follows abrasion results in a hyperplastic epidermis that resembles the effects of strong promoters. Repeated mechanical injuries are capable of enhancing papillomas and carcinomas in mouse skin initiated with 7,12-dimethylbenzanthracene (DMBA). Thus, a regenerative epidermal hyperplasia appears to be a precondition for tumor promotion. It is highly probable that many epidermal cells are initiated during the lifetime of man. In the work place, repeated mechanical injury could predispose to epidermal neoplasms.

journal_name

Am J Ind Med

authors

Argyris TS

doi

10.1002/ajim.4700080412

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

329-37

issue

4-5

eissn

0271-3586

issn

1097-0274

journal_volume

8

pub_type

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