Abstract:
:Chemically induced epidermal carcinogenesis is usually divided into two stages: initiation, which involves the conversion of some epidermal cells into latent neoplastic cells; and promotion, which results in tumors. The hallmark of chemical promoters is epidermal hyperplasia. The hyperplasia caused by a strong promoter, such as 12-O-tetradecanoylphorbol-13-acetate (TPA), differs morphologically from that caused by weak promoters, such as acetic acid and mezerin. The epidermal regeneration that follows abrasion results in a hyperplastic epidermis that resembles the effects of strong promoters. Repeated mechanical injuries are capable of enhancing papillomas and carcinomas in mouse skin initiated with 7,12-dimethylbenzanthracene (DMBA). Thus, a regenerative epidermal hyperplasia appears to be a precondition for tumor promotion. It is highly probable that many epidermal cells are initiated during the lifetime of man. In the work place, repeated mechanical injury could predispose to epidermal neoplasms.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Argyris TSdoi
10.1002/ajim.4700080412subject
Has Abstractpub_date
1985-01-01 00:00:00pages
329-37issue
4-5eissn
0271-3586issn
1097-0274journal_volume
8pub_type
杂志文章abstract::The objective of this study was to examine the endocrine profiles of a group of male workers chronically exposed to trichloroethylene (TCE) in an electronics factory. A total of 124 workers participated in a preliminary study, for which 85 satisfied the selection criteria and were recruited to take part in a more deta...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199709)32:3<217::aid-ajim6
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:We evaluated particulate matter in combined induced sputum (IS) and oxidation in exhaled breath condensate (EBC) to test whether underlying inflammatory changes are present in asymptomatic welders. METHODS:Thirty welders from the Israel Defense Forces exposed to aluminum/iron (Group 1) or to cadmium/chromiu...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20586
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Engineering or administrative methods are often insufficient or impractical to control exposure to chemicals in anatomy laboratories. This study explored the feasibility of wearing one or a combination of respirators and goggles used as personal protective equipment (PPE) to control exposure in one such labo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10180
更新日期:2003-03-01 00:00:00
abstract::Incinerator workers are exposed to many toxic compounds, most notably heavy metals. We evaluated medical and exposure monitoring data of an actively employed cohort of Philadelphia incinerator workers following an Agency for Toxic Substances and Disease Registry site survey and National Institute for Occupational Safe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700220309
更新日期:1992-01-01 00:00:00
abstract::We conducted a comparative study of pulmonary dysfunction among workers who were exposed to silica, asbestos, or coalmine dust. The results showed that all three groups of dust-exposed workers, even those without radiographic signs of pneumoconiosis, had decreased spirometric parameters and diffusing capacity (DLco) i...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199705)31:5<495::aid-ajim2
更新日期:1997-05-01 00:00:00
abstract::To study their socioeconomic and health status, 1,770 workers in the organized electronics industry in India were surveyed. Mean age of the workers employed in this industry was 32.5 +/- 6.01 years. The average per capita income/month was Rupees 333, indicating a higher socioeconomic status, compared with the status o...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230209
更新日期:1993-02-01 00:00:00
abstract::In view of the increasing incidence of diseases such as gastritis and ulcers in workers exposed to noise, we assessed whether noise does in fact affect gastric secretion. Then, considering the conflicting findings published on the effects of noise on gastric secretion, we also investigated whether the response was rel...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700260310
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND:The US military is a large, well-defined occupational cohort offering tremendous opportunities to study risk factors for important health outcomes. This article describes our nested case-control methods to evaluate risk factors for fatal motor vehicle crashes (MVC) within all Service branches in a 1991 Gulf ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20190
更新日期:2005-08-01 00:00:00
abstract::This study uses the National Mortality Followback Survey of 1986 to identify the top five Sentinel Health Events Occupational [SHE(O)s], the five leading causes of death, and to ascertain the primary occupations and industries associated with these. We found that, as expected, cardiovascular diseases were four of the ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700270205
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:This study updates information on mortality and cancer morbidity in a cohort of Norwegian talc workers. METHODS:Follow-up was extended with 24 years, covering 1953-2011. Comparisons were made with the general population and between subgroups within the cohort. RESULTS:Standardized mortality ratio for non-m...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22749
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Geographic analysis is now integral to public health surveillance, but has been underused for occupational injury/illness. METHODS:Mapping and spatial statistics are used to examine national county-level mean establishment Lost Workday Injury/Illness (LWDII) rates in the Occupational Safety and Health Admin...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20611
更新日期:2008-09-01 00:00:00
abstract::Certain refining processes were investigated to determine their influence on the dermal carcinogenic activity of petroleum-derived lubricating oil distillates. Specifically, the effects of solvent refining, hydroprocessing, a combination of both processes, and the blending of oils processed using each technique were e...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700050403
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Community Participatory Approach to Measuring Farmworker Pesticide Exposure, PACE3, used a longitudinal design to document pesticide biomarkers among farmworkers. This article presents an overview of PACE3 and provides a descriptive analysis of participant characteristics and one set of pesticide biomarkers,...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20703
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Potential confounding or effect modification by employment status is frequently overlooked in pregnancy outcome studies. METHODS:To characterize how employed and non-employed women differ, we compared demographics, behaviors, and reproductive histories by maternal employment status for 8,343 mothers of cont...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22700
更新日期:2017-04-01 00:00:00
abstract::Seven cases of fiberglass dermatitis among production operators in the electronics industry are reported. This was due to the repeated daily handling of printed circuit boards (PRCBs). The predominant complaint of the workers was itch of the lateral aspects of the fingers and finger webs. In six workers, unroofed vesi...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700210208
更新日期:1992-01-01 00:00:00
abstract::Data were collected on 228 consecutive back injuries in Boston's General Mail Facility and 228 non-injured controls drawn randomly from each case's work unit, matching on craft (clerk, mailhandler, maintenance), shift, and general supervisor. Data were collected on age, gender, duration of employment, 3 year history o...
journal_title:American journal of industrial medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ajim.4700200406
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Workers in poultry processing and pork meatpacking have high rates of acute injuries and chronic disease among. The presence of zoonotic pathogens in these workplaces may interact with injury. METHODS:We investigated incidence of worker injuries, lacerations, and infections reported by 10 companies from 200...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22325
更新日期:2014-06-01 00:00:00
abstract::Measurement of specific organic compounds in exhaled breath has been used as an indicator of recent exposure to pollutants or as an indicator of the health of an individual. A typical application involves the collection of multiple breaths onto a sorbent cartridge or into an evacuated canister with the use of a relati...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700280110
更新日期:1995-07-01 00:00:00
abstract::Carpal tunnel syndrome (CTS) is the most commonly reported nerve entrapment syndrome. The prevalence of CTS among 652 active workers in jobs with specific hand force and repetitiveness characteristics was estimated. The prevalence of CTS ranged from 0.6% among workers in low force-low repetitive jobs to 5.6% among wor...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700110310
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The prerequisites necessary for attributing lung carcinoma to asbestos, represent a controversial issue. METHODS:Three parameters (occupational history, pleural plaques, and lung asbestos bodies) were investigated in 414 consecutive cases of lung carcinoma, examined at necropsy at the Hospital of Monfalcone...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199909)36:3<360::aid-ajim3
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Workers in the Agriculture, Forestry, and Fisheries (AgFF) sector experience exposures directly related to the work itself, as well as the physical environment in which the work occurs. Health outcomes vary from immediate to delayed, and from acute to chronic. METHODS:We reviewed existing literature on the ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.22170
更新日期:2013-08-01 00:00:00
abstract::Investigators must often rely on self-reported work history information collected with questionnaires. However, little is known about the agreement between self-reported estimates of exposure and records kept by companies. As part of a cross-sectional medical study of structural fumigation workers, self-reported work ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199710)32:4<364::aid-ajim7
更新日期:1997-10-01 00:00:00
abstract::Attitudes of occupational health care professionals toward smoking and their activity to address smoking issues were investigated by a questionnaire survey. Data were also collected on employees' exposure to environmental tobacco smoke and on smoking policies that existed in workplaces. Questionnaires were mailed to a...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199807)34:1<73::aid-ajim10
更新日期:1998-07-01 00:00:00
abstract:INTRODUCTION:Occupational health researchers can play a pivotal role in increasing our understanding of the role of physical and psychosocial working conditions in producing socioeconomic health disparities and trends of increasing socioeconomic health disparities, contributing to interventions to reduce such dispariti...
journal_title:American journal of industrial medicine
pub_type: 社论,评审
doi:10.1002/ajim.20766
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:In this study, we describe the methodology used for historical estimation of exposure to fluoride and to PAH in vertical stud Søderberg (VSS) potrooms at two Norwegian aluminum smelters. The assessment was performed in order to develop exposure data for epidemiological studies of cause-specific mortality and...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199902)35:2<164::aid-ajim8
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:The Denver International Airport construction project provided a rare opportunity to identify risk factors for injury on a large construction project for which 769 contractors were hired to complete 2,843 construction contracts. Workers' compensation claims and payroll data for individual contracts were reco...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199808)34:2<113::aid-ajim3
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:A variety of neurophysiological measures are useful in hospital settings for diagnostic and other clinical purposes. Previously, abnormal changes in various sensory evoked potentials (EPs), and heart rate variability (HRV) were observed in patients with acquired and fetal Minamata disease (MD; methylmercury ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.20471
更新日期:2007-10-01 00:00:00
abstract::A sensitive K-X-ray fluorescence (K-XRF) instrument was used to measure lead levels in the tibia and patella on a series of twelve subjects who had relatively well-documented histories of lead exposure and blood lead levels. For some subjects, K-XRF measurements were taken at multiple points in time, and before and af...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700200603
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tubercul...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23066
更新日期:2020-01-01 00:00:00
abstract::Animal studies suggest that mesothelioma is most effectively induced by fibers longer than 8 mu. However, studies of asbestos fibers recovered from human lungs in cases of mesothelioma indicate that, at least in large-scale samples, relatively few fibers meet this size criterion, perhaps implying that the animal data ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700110508
更新日期:1987-01-01 00:00:00