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Endocrine profiles of male workers with exposure to trichloroethylene.

Abstract：

:The objective of this study was to examine the endocrine profiles of a group of male workers chronically exposed to trichloroethylene (TCE) in an electronics factory. A total of 124 workers participated in a preliminary study, for which 85 satisfied the selection criteria and were recruited to take part in a more detailed study. Each of the 85 workers had urine collected and analyzed for trichloroacetic acids (TCA) on the day blood was taken for analysis of serum testosterone (T), follicle-stimulating hormone (FSH), dehydroepiandrosterone sulphate (DHEAS), and sex-hormone binding globulin (SHBG). Environmental TCE exposures were conducted for 12 workers. The geometric mean concentration of environmental TCE was 29.6 ppm (range 9-131) and the mean urine TCA was 22.4 mg/g creatinine (range 0.8-136.4). The results showed that years of exposure to TCE were significantly correlated with DHEAS and negatively correlated with SHBG and T levels. Serum FSH, T, and SHBG levels showed a gradual decline with increasing years of exposure to TCE. This dose-response decrease indicated that there was a disruption of peripheral endocrine function. This disruption could be a result of TCE-induced liver malfunction. The most dramatic change was that the increase in DHEAS concentration was associated with years of exposure to TCE, rising from 255 to 717.8 ng/ml for < 3 to > or = 7 years exposure, respectively. This evidence suggests that chronic exposure to TCE may also affect adrenal function. These findings, however, must be confirmed by further investigations.

journal_name

Am J Ind Med

journal_title

American journal of industrial medicine

authors

Chia SE,Goh VH,Ong CN

doi

10.1002/(sici)1097-0274(199709)32:3<217::aid-ajim6

subject

Has Abstract

pub_date

1997-09-01 00:00:00

pages

217-22

issue

3

eissn

0271-3586

issn

1097-0274

pii

10.1002/(SICI)1097-0274(199709)32:3<217::AID-AJIM6

journal_volume

32

pub_type

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