Abstract:
INTRODUCTION:Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tuberculosis (Tb). The contribution of inflammatory cytokines to the risk of silicosis and Tb in different populations has previously been reported. Since genetic background might be related to susceptibility to silicosis and Tb, the study of polymorphisms within IL-1α, IL-1β, and tumor necrosis factor protein-coding genes may contribute to elucidating the genetic basis of these diseases. METHODS:Single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction using restriction fragment length polymorphism or by Taqman methodology, in a sample of 102 silica-exposed patients from Brazil. RESULTS:No significant associations were observed between the SNPs studied and the severity of silicosis. However, significant associations were found between Tb and the C allele (odds ratio [OR] = 1.93, 95% confidence interval [CI], 1.01-3.73) and the CC genotype (OR = 2.34, 95% CI, 1.04-5.31) of IL1A -899C>T. The IL1B +3954C>T polymorphism also showed an association with Tb (T allele dominant model OR = 2.38, 95% CI, 1.04-5.41). CONCLUSION:These preliminary results demonstrate that the IL1A and IL1B gene variations may contribute to some extent to susceptibility to Tb, but not silicosis. However, additional studies are still needed to confirm these results.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Salum KCR,de Castro MCS,Moreira VB,Nani ASF,Kohlrausch FBdoi
10.1002/ajim.23066subject
Has Abstractpub_date
2020-01-01 00:00:00pages
74-84issue
1eissn
0271-3586issn
1097-0274journal_volume
63pub_type
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journal_title:American journal of industrial medicine
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更新日期:2004-11-01 00:00:00
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更新日期:2007-04-01 00:00:00
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更新日期:2015-12-01 00:00:00
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journal_title:American journal of industrial medicine
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