Pulmonary adenocarcinoma with epidermal growth factor receptor-mutations in asbestos exposed non-smokers: A case series.

Abstract:

BACKGROUND:Cigarette smoke and asbestos are recognized causes of lung carcinoma and together promote carcinogenesis. Adenocarcinoma is currently the most common cause of lung cancer in the USA and it has been linked to both smoking and asbestos exposure. Mutations in the epidermal growth factor gene receptor (EGFR) occur predominantly in non-smokers with adenocarcinoma. Methods Mutations in the EGFR gene were investigated using next-generation sequencing. RESULTS:We report the presence of EGFR exon point mutations in the pulmonary adenocarcinomas of three never-smokers occupationally exposed to asbestos. CONCLUSION:The role of asbestos as a possible cause of EGFR mutagenesis requires further investigation. Am. J. Ind. Med. 60:306-309, 2017. © 2017 Wiley Periodicals, Inc.

journal_name

Am J Ind Med

authors

Kradin RL,Iafrate J,Christiani DC

doi

10.1002/ajim.22691

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

306-309

issue

3

eissn

0271-3586

issn

1097-0274

journal_volume

60

pub_type

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