Abstract:
BACKGROUND:The oncogene product EGF-receptor (EGF-R), the tumor suppressor gene product p53, and anti-p53 antibodies are detectable in serum of certain cancer patients. Increased levels of some of these products were reported in lung cancer patients after occupational asbestos exposure, after exposure to polycyclic aromatic hydrocarbons or vinyl chloride. This molecular epidemiological study investigated the use of serum EGF-R, p53-protein, and anti-p53 antibodies as biomarkers for detection of effects of radon and its decay products. METHODS:Serum EGF-R, p53-protein, and anti-53 antibodies were measured using ELISA in former uranium miners of SDAG Wismut without lung disease (n=106) and miners with Schneeberg lung cancer (n=22). They were compared with healthy subjects (n=23), patients with lung cancer not due to ionizing radiation (n=88), and patients with non-malignant lung or pleural diseases (n=50). RESULTS:No significantly elevated or decreased serum values for p53 protein, EGF-R, or anti-p53 antibodies could be found. There was no correlation of these with Working Level Months (WLM). CONCLUSIONS:p53 protein, EGF-R, or anti-p53 antibodies in serum are not useful as biomarkers for detection of lung cancer related to ionizing radiation (i.e., Schneeberg lung cancer).
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Schneider J,Presek P,Braun A,Woitowitz HJdoi
10.1002/(sici)1097-0274(199912)36:6<602::aid-ajim2subject
Has Abstractpub_date
1999-12-01 00:00:00pages
602-9issue
6eissn
0271-3586issn
1097-0274pii
10.1002/(SICI)1097-0274(199912)36:6<602::AID-AJIM2journal_volume
36pub_type
杂志文章,多中心研究abstract::Using injury information from the 1986 Mine Safety and Health Administration database, and demographic information from a 1986 sample survey of the miner population, acute traumatic injury rates for male workers in underground bituminous coal mines were computed by age, current job experience, and total mine work expe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700230304
更新日期:1993-03-01 00:00:00
abstract::Assessing the health risks of complex mixtures of polynuclear aromatic hydrocarbons such as diesel fumes and asphalt or bitumen continues to be a major challenge for occupational and environmental health scientists. The special Asphalt issue of the American Journal of Industrial Medicine (Cancer Mortality Among Europe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10215
更新日期:2003-03-01 00:00:00
abstract::In it's worker health and safety training program, the California-Arizona Consortium aims to promote worker action to improve health and safety conditions. To assess action on worker-identified health and safety problems, 278 trainees were interviewed 3-8 months after training. Associations with three outcomes were an...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199612)30:6<730::AID-AJIM1
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Biomass cooking fuel is the main source of indoor air pollution in the majority of households in the developing world. Sri Lanka is an island of about 20 million population with urban, rural, and estate population of 14.6%, 80.0%, and 5.4%, respectively. This study describes biomass fuel use for cooking in S...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.21023
更新日期:2012-12-01 00:00:00
abstract::Studies describing respiratory health hazards for workers in swine production facilities have been published in the United States, Sweden, Canada, the Netherlands, and Denmark. Up to 50% of these workers experience bronchitis, organic dust toxic syndrome, hyper-reactive airways disease, chronic mucous membrane irritat...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199601)29:1<33::AID-AJIM5>
更新日期:1996-01-01 00:00:00
abstract::This paper describes the development of an evaluative outcome measure for patients with upper extremity musculoskeletal conditions. The goal is to produce a brief, self-administered measure of symptoms and functional status, with a focus on physical function, to be used by clinicians in daily practice and as a researc...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199606)29:6<602::AID-AJIM4
更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:Geographic analysis is now integral to public health surveillance, but has been underused for occupational injury/illness. METHODS:Mapping and spatial statistics are used to examine national county-level mean establishment Lost Workday Injury/Illness (LWDII) rates in the Occupational Safety and Health Admin...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20611
更新日期:2008-09-01 00:00:00
abstract::The aim of this study is to determine the validity of the ICD-9 for diagnostic classification of soft tissue disorders of the neck and upper limb, using routinely collected data at a large steel company. The documentation in the clinical chart served as the gold standard. First, the overall accuracy of identifying the...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0274(199602)29:2<171::AID-AJIM7
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Mineral dusts that contain crystalline silica have been associated directly or indirectly with the development of pneumoconiosis or silicosis, non-malignant respiratory diseases, lung cancer, and other diseases. The health impacts on workers with silica mixed dust exposure in tin mines and dose-response rela...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20248
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Small retail businesses experience high robbery and violent crime rates leading to injury and death. Workplace violence prevention programs (WVPP) based on Crime Prevention Through Environmental Design reduce this risk, but low small business participation limits their effectiveness. Recent dissemination mod...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22436
更新日期:2015-06-01 00:00:00
abstract::Combined data sources, including union administrative records and workers' compensation claims, were used to construct event histories for a dynamic cohort of union carpenters from Washington State during the period 1989-1992. Person-time at risk and the events of interest were stratified by age, sex, time in the unio...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199712)32:6<629::aid-ajim9
更新日期:1997-12-01 00:00:00
abstract::In an epidemiologic study of 6,359 oil shale workers, 1,664 (46.7%) of 3,566 survivors were investigated. No excess of skin disease (as reported in response to a questionnaire) was found in men exposed to oil or dust, whether compared to men who were not exposed to oil or dust or to coalminers. A low prevalence of sim...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700090503
更新日期:1986-01-01 00:00:00
abstract::A five-year total community study of lung cancer incidence by occupation revealed that 1) virtually all the cases occurred in smokers; 2) all major histologic types of lung cancer were strongly associated with smoking behavior; 3) in most high-risk occupations the significant elevations of risk were limited to one or ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700030409
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Standardized proportionate mortality ratio (SPMR) was found to be 2.2 (95% CI = 1.3-3.5) for esophageal cancer (EC) among workers exposed to refractory brick dust in a large iron-steel complex in China. METHODS:A nested case-control design within a cohort of industrial workers. One hundred and twenty-five E...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199903)35:3<272::aid-ajim7
更新日期:1999-03-01 00:00:00
abstract::To investigate the effects of styrene exposure on peripheral, central, and autonomic nervous system functions in man, we measured the distribution of nerve conduction velocities (DCV), short-latency somatosensory evoked potentials (SSEP), and variability in electrocardiographic R-R interval (CVRR) as well as conventio...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700200609
更新日期:1991-01-01 00:00:00
abstract::The Editorial Board of the American Journal of Industrial Medicine strongly supports the "Call for an International Ban on Asbestos". We concur with the Collegium Ramazzini that a ban is necessary, overdue and essential for public health. To eliminate the burden of disease and death that is caused worldwide by exposur...
journal_title:American journal of industrial medicine
pub_type: 指南,杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract:BACKGROUND:Because of the rarity of peritoneal mesothelioma, occupational risks associated with it have seldom been studied, particularly among women. In this respect, death certificates databases may provide numbers large enough for analysis, although the International Classification of Diseases, 9th revision (ICD-9) ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199901)35:1<9::aid-ajim2>3
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:First-line health care providers are the primary access point for workers' benefits. However, little is known about their impact on quality of care and return-to-work. Our objective was to critically compare literature on the practices of first-line providers for workers with musculoskeletal injuries in Onta...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.22972
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The prerequisites necessary for attributing lung carcinoma to asbestos, represent a controversial issue. METHODS:Three parameters (occupational history, pleural plaques, and lung asbestos bodies) were investigated in 414 consecutive cases of lung carcinoma, examined at necropsy at the Hospital of Monfalcone...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199909)36:3<360::aid-ajim3
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:The aim of this study was to compile nationally representative statistics describing inpatient hospital care for patients with work-related injuries and illnesses covered under workers' compensation (WC) insurance in the United States. METHODS:Three years of data (1997-1999) from the Nationwide Inpatient Sa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10273
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND:Community Participatory Approach to Measuring Farmworker Pesticide Exposure, PACE3, used a longitudinal design to document pesticide biomarkers among farmworkers. This article presents an overview of PACE3 and provides a descriptive analysis of participant characteristics and one set of pesticide biomarkers,...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20703
更新日期:2009-07-01 00:00:00
abstract::In the past 10 years there has been growing awareness among occupational health professionals worldwide of the large burden of illness associated with musculoskeletal disorders of the neck and upper limbs. It has been suggested that these disorders are associated with highly repetitive work and are due, at least in pa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,meta分析
doi:10.1002/ajim.4700190111
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:The Limulus amebocyte lysate (LAL) assay may underestimate endotoxins because only soluble endotoxins are determined. The solubility of endotoxins was, therefore, studied in two species of Gram-negative bacteria. METHODS:Cultures were grown in serum broth, cells were harvested by centrifugation and washed i...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20089
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Exposure to chemicals in polluted soil was studied during the remediation of four polluted sites. They are sawmill areas contaminated with chlorophenols and polychlorinated dibenzo-p-dioxins and furanes (PCDD/F), wood impregnating plants contaminated with polycyclic aromatic hydrocarbons (PAH) from creosote ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.1031
更新日期:2001-04-01 00:00:00
abstract::Recent studies suggest that semiconductor workers have an increased incidence of work-related illness. Semiconductor manufacturing is a chemically intensive industry involving many potentially hazardous operations. As this industry moves into new geographic areas, health care professionals will be asked to evaluate me...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700110209
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Existing datasets often lack job exposure data. Standard Occupational Classification (SOC) codes can link work exposure data to health outcomes via a Job Exposure Matrix, but manually assigning SOC codes is laborious. We explored the utility of two SOC autocoding programs. METHODS:We entered industry and oc...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22928
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The Sheet Metal Occupational Health Institute Trust (SMOHIT) was formed in 1985 to examine the health hazards of the sheet metal industry in the U.S. and Canada through an asbestos disease screening program. A study of mortality patterns among screening program participants was undertaken. METHODS:A cohort ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20725
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:The extent that cigarette smoking may confound the relationship between diesel exhaust exposure and lung cancer was assessed in a retrospective cohort study of 55,395 U.S. railroad workers followed from 1959 to 1976. METHODS:The relative risk (RR) of lung cancer due to diesel exhaust was indirectly adjusted...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/1097-0274(200010)38:4<399::aid-ajim5>3.0.c
更新日期:2000-10-01 00:00:00
abstract:INTRODUCTION:Silicosis is a fibrotic lung disease resulting from the inhalation of crystalline silica and can be classified as simple or complicated according to the International Labour Organization criteria. Furthermore, individuals exposed to crystalline silica also have a higher risk for the development of tubercul...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23066
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:This study sought to identify impacts of compensation system characteristics on doctors in Québec and Ontario. METHODS:(i) Legal analysis; (ii) Qualitative methods applied to documentation and individual and group interviews with doctors (34) and other system participants (31); and (iii) Inter-jurisdictiona...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22651
更新日期:2016-12-01 00:00:00