Abstract:
:While blood lead concentration has been inversely associated with indicators of reproductive health in occupationally exposed male workers, the utility of lead concentration in semen as an indicator of lead exposure to the male reproductive system has not been fully explored. Blood and semen lead concentrations from 81 lead smelter workers were examined in relation to semen quality and endocrine function parameters. Mean blood and semen lead concentrations were 22.8 micrograms/dl (range 5-58) and 1.9 micrograms/dl (range 0.1-17.6), respectively. Total sperm count and concentration decreased with increasing blood lead concentration; p for trend was 0.003 and 0.009, respectively. Semen lead concentration was inversely related to total sperm count (p = 0.05), ejaculate volume (p = 0.001), and serum testosterone (p = 0.004), but not to sperm concentration. The association between semen lead concentration and total sperm count was eliminated when volume was included in the model. Blood lead concentration was more consistently associated with indicators of sperm production than was semen lead. In contrast, semen lead concentration was negatively associated with circulating testosterone concentrations. Our findings indicate that measurement of semen lead may not be a valuable adjunct to conventional blood lead monitoring for investigations of male reproductive system toxicity.
journal_name
Am J Ind Medjournal_title
American journal of industrial medicineauthors
Alexander BH,Checkoway H,Faustman EM,van Netten C,Muller CH,Ewers TGdoi
10.1002/(sici)1097-0274(199811)34:4<464::aid-ajim2subject
Has Abstractpub_date
1998-11-01 00:00:00pages
464-9issue
5eissn
0271-3586issn
1097-0274pii
10.1002/(SICI)1097-0274(199811)34:4<464::AID-AJIM2journal_volume
34pub_type
杂志文章abstract:BACKGROUND:Rates of occupational injury among immigrant workers are widely believed to be underestimated. The goal of this study was to enhance understanding of the burden of occupational injury and the work organization factors underlying injury among immigrant Latino residential construction workers. METHODS:Prospec...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22014
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:A medical surveillance program of benzene-exposed workers has to be established in such a way as to observe early signs of benzene-induced cytopenia, pancytopenia, or leukemia. This study evaluates the utility of routine medical survey applied to benzene-exposed workers by analyzing the hematological, immuno...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10296
更新日期:2003-11-01 00:00:00
abstract::Thirty-three U.S. Occupational Safety and Health Administration (OSHA) standards contain mandated medical service provisions. The German Berufsgenossenschaften Guidelines for Preventive Occupational Health Examinations currently comprise 38 guidelines, which contain mandated medical service provisions. Based on a prev...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199704)31:4<373::aid-ajim1
更新日期:1997-04-01 00:00:00
abstract::This study examined the association between exposure to occupational hazards and pregnancy outcomes using data from a case-control study conducted in 29 hospitals in Shanghai, China. The sample included 1,875 perinatal deaths and newborns with birth defects and the same number of controls. Information on mother's expo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700210312
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine the association between Dupuytren's contracture (DC), repetitive handwork (RHW), heavy handwork (HHW), and/or vibration exposure. METHODS:Frequency and intensity of the three types of handwork were collected and compared between DC patients and controls. Hours of wo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22736
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Exposure to silica dust is considered to be one of etiological factors of antineutrophil cytoplasmic antibodies (ANCA) -associated vasculitis (AAV). METHODS:Subjects exposed to silica dust in Central Bohemia and followed in the Department of Occupational Medicine, Charles University, were selected for study...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20327
更新日期:2006-07-01 00:00:00
abstract::The occupational histories of fathers were collected prospectively as part of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC), and were used to investigate the association of paternal job title with a baby's birth weight and gestational age. The analysis cohort consisted of 4,795 singleton live-born ba...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199706)31:6<738::aid-ajim1
更新日期:1997-06-01 00:00:00
abstract::The objective of this study was to examine the endocrine profiles of a group of male workers chronically exposed to trichloroethylene (TCE) in an electronics factory. A total of 124 workers participated in a preliminary study, for which 85 satisfied the selection criteria and were recruited to take part in a more deta...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199709)32:3<217::aid-ajim6
更新日期:1997-09-01 00:00:00
abstract::Pesticides may be transformed by chemical and biological processes or transported from the site of application by several processes including runoff, movement through the soil to ground water, volatilization, transport on soil particles, and wind erosion. Contamination of water by pesticide residues is a matter of con...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700180418
更新日期:1990-01-01 00:00:00
abstract::A one-year prospective survey was conducted to study the incidence of and potential risk factors for farm-related injuries in Eastern Ontario. One hundred and seventeen dairy and beef farms were surveyed using a personal interview. Information was collected on demographic characteristics of the farm owners, workers, a...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700210503
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:A variety of neurophysiological measures are useful in hospital settings for diagnostic and other clinical purposes. Previously, abnormal changes in various sensory evoked potentials (EPs), and heart rate variability (HRV) were observed in patients with acquired and fetal Minamata disease (MD; methylmercury ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.20471
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:Previous epidemiological studies investigating modification of organophosphate (OP) neurotoxicity by xenobiotic metabolizing enzymes (XMEs) polymorphisms have produced inconsistent results. METHODS:A cross-sectional study of 301 emerging farmers was conducted. Neurotoxicity testing included forward and back...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22790
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Previous studies of a cohort of rubber hydrochloride workers indicated an association between benzene exposure and excess mortality from leukemia and multiple myeloma. To determine whether risks remain elevated with increasing time since plant shutdown, we extended follow-up from 1981 through 1996. MATERIAL...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10138
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:The Limulus amebocyte lysate (LAL) assay may underestimate endotoxins because only soluble endotoxins are determined. The solubility of endotoxins was, therefore, studied in two species of Gram-negative bacteria. METHODS:Cultures were grown in serum broth, cells were harvested by centrifugation and washed i...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20089
更新日期:2004-10-01 00:00:00
abstract::Occupational diseases are now being assessed at the cellular and molecular levels; this presents new opportunities for prevention and control [Calleman et al., 1978; Ong et al., 1987; Stejskal et al., 1989; Welch and Cullen, 1988; Garry et al., 1989]. The key to these opportunities is the ability to detect biological ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/ajim.4700200402
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:Noise exposure has long been an occupational health concern and has been an important area of focus of the Occupational Safety and Health Administration (OSHA) since its founding. Nevertheless, it remains unclear what effects OSHA's noise standards have had on employer efforts to reduce risks. Consequently...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23116
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Although increased attention has been focused on the relationship between occupational health and productivity, solid scientific data on this topic are sparse. The purpose of the present case study was to assess the relationship between productivity and work environment in a storage building. MATERIALS AND ...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.10119
更新日期:2002-10-01 00:00:00
abstract::Hearing loss is a significant and unfortunately common occupational malady. Over the past several decades both the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH) have initiated efforts to better understand and to limit the occurrence of occupa...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0274(200001)37:1<112::aid-ajim9
更新日期:2000-01-01 00:00:00
abstract::Several studies have shown that playing-related musculoskeletal disorders (PRMDs) present a significant health problem for musicians. To examine physiological, psychological, and behavioral risk factors of musicians' PRMDs, data for a case-control analysis were collected from classically-trained professional and unive...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199709)32:3<292::aid-ajim1
更新日期:1997-09-01 00:00:00
abstract:BACKGROUND:The roles of age, length of service and job in various work-related injury types are unknown and deserve investigations among female workers. This study assessed their roles in the occurrence of injury. METHODS:Three-year prospective study of all 22,952 permanently employed women at the French national rail...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22259
更新日期:2014-02-01 00:00:00
abstract::A microcomputer system for on-lone analysis of saccadic and smooth-pursuit tracking eye movements is described. Results from a longitudinal study of lead workers and matched controls reveal a consistent decrease in saccade accuracy in the lead workers compared to the controls. Saccade peak velocity and latency and smo...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700010112
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Around the globe, work has a heavy impact on health. To better advise policy makers, we assessed the global burden of disease and injury due to selected occupational hazards. This article presents an overview, and describes the methodology employed in the companion studies. METHODS:Using the World Health Or...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.20211
更新日期:2005-12-01 00:00:00
abstract::Epidemiological investigation involving historical cohorts requires reconstruction of individual cohort member exposures during the period of study. However, past approaches to exposure assessment by industrial hygienists were characterized by different professional expectations for air sampling, and different orienta...
journal_title:American journal of industrial medicine
pub_type: 历史文章,杂志文章
doi:10.1002/ajim.4700210114
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Use of worker's compensation (WC) as payer underestimates work-related (WR) injuries. We evaluated three methods to identify WR injuries: WC as payer, ICD-9-CM work-status codes E000.0/E000.1, and other ICD-9-CM external cause codes. METHODS:We identified injury-related emergency department visits from Nort...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22984
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Organic solvents are widely used, but conflicting reports exist concerning paternal exposure and adverse pregnancy outcomes. We conducted a meta-analysis to assess the risks of spontaneous abortions (SAs) and major malformations (MMs) after paternal exposure to organic solvents. METHODS:Medline, Toxline, Re...
journal_title:American journal of industrial medicine
pub_type: 杂志文章,meta分析
doi:10.1002/ajim.20102
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:There is growing evidence that exposure to organic solvents can play a role in the etiology of rheumatoid arthritis (RA). This prospective cohort study aimed to investigate the association between RA and toluene exposure. METHODS:The study cohort consisted of Korea Occupational Safety and Health Agency data...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.23226
更新日期:2021-01-29 00:00:00
abstract:BACKGROUND:Nickel (Ni) compounds have been classified as carcinogenic to humans. The aim of the study is to evaluate exposures to Ni at workplaces in Italy. METHODS:Data on Ni compounds were collected from an occupational exposure registry. Statistical analysis was carried out for exposure-related variables. The numbe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22914
更新日期:2018-12-01 00:00:00
abstract::This study assesses the causes of medical surveillance changes leading to specialist referral from one isocyanate-using company where 39 workers (about 20% of all employees) were referred to a hospital occupational clinic during a 5-year period for concerns regarding their surveillance respiratory questionnaire or spi...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/(sici)1097-0274(199901)35:1<87::aid-ajim12
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Potential confounding or effect modification by employment status is frequently overlooked in pregnancy outcome studies. METHODS:To characterize how employed and non-employed women differ, we compared demographics, behaviors, and reproductive histories by maternal employment status for 8,343 mothers of cont...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.22700
更新日期:2017-04-01 00:00:00
abstract::Incinerator workers are exposed to many toxic compounds, most notably heavy metals. We evaluated medical and exposure monitoring data of an actively employed cohort of Philadelphia incinerator workers following an Agency for Toxic Substances and Disease Registry site survey and National Institute for Occupational Safe...
journal_title:American journal of industrial medicine
pub_type: 杂志文章
doi:10.1002/ajim.4700220309
更新日期:1992-01-01 00:00:00