Abnormal cell cycle regulation in malignancy.

abstract：Objectives:Approximately 15% of breast cancers show equivocal human epidermal growth factor receptor 2 (HER2) results on HER2 immunohistochemistry (IHC) and are reflexed for fluorescence in situ hybridization (FISH). However, some cases remain equivocal. In this study, we evaluated these double-equivocal cases by using...

journal_title：American journal of clinical pathology

authors： Hou Y,Nitta H,Li Z

更新日期：2017-01-01 00:00:00

abstract：:We reviewed the cytologic features of 20 adrenal cortical carcinomas (ACCs; 9 primary and 11 metastatic) from 19 patients and highlighted diagnostic pitfalls. The mean size of primary ACCs was 11.9 cm, and that of metastatic ACCs was 3.0 cm. The metastatic sites were liver, lung, lymph node, soft tissue, and bone. Pri...

journal_title：American journal of clinical pathology

authors： Ren R,Guo M,Sneige N,Moran CA,Gong Y

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. METHODS:From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, includin...

journal_title：American journal of clinical pathology

authors： Frank R,Li S,Ahmad NA,Sepulveda AR,Jhala NC

更新日期：2014-09-01 00:00:00

abstract：:Because T-regulatory cells (Tregs) can harmfully impair HIV-specific responses or beneficially limit immune activation, we compared the number of Tregs in lymph nodes from 48 HIV+ patients and 106 HIV- subjects. By using a microscope counting grid, we found that the mean ± SD number of Tregs in lymph nodes was 3 times...

journal_title：American journal of clinical pathology

authors： Arce J,Levin M,Xie Q,Albanese J,Ratech H

更新日期：2011-07-01 00:00:00

abstract：:Several monoclonal antibodies (MoAbs) are now available for immunophenotyping non-Hodgkin's lymphomas (NHLs) in paraffin-embedded tissue sections. To determine the reliability of these reagents in predicting the genotype, 44 cases of NHL were studied with the alkaline phosphatase-anti-alkaline phosphatase technique wi...

journal_title：American journal of clinical pathology

authors： Elghetany MT,Kurec AS,Schuehler K,Forbes BA,Duggan DB,Davey FR

更新日期：1991-04-01 00:00:00

abstract：:The authors report a case of metastatic prostate cancer masquerading as a primary lung tumor. Histologically, the lung tumor displayed eosinophilic crystalloids in the malignant glands typical of those previously described in prostatic adenocarcinoma. Review of histologic material from 30 additional patients with meta...

journal_title：American journal of clinical pathology

authors： Molberg KH,Mikhail A,Vuitch F

更新日期：1994-03-01 00:00:00

abstract：:Urine myoglobin concentrations are measured clinically to assess rhabdomyolysis and the related risk of renal damage. We studied urine myoglobin concentrations in vitro to explore the factors affecting stability. Myoglobin was very unstable in urine specimens, especially below pH 6.5, and its immunoreactivity deterior...

journal_title：American journal of clinical pathology

authors： Chen-Levy Z,Wener MH,Toivola B,Daum P,Reyes M,Fine JS

更新日期：2005-03-01 00:00:00

abstract：:A markedly prolonged activated partial thromboplastin time (APTT) was observed in a 61-year-old woman with bruising and a decreasing hematocrit. Coagulation laboratory evaluation was sought to determine the cause of the prolonged APTT and bleeding. Evaluation demonstrated that, rather than identifying a coagulopathy, ...

journal_title：American journal of clinical pathology

authors： Humphries JE,Acker MN,Schnell DE,Knarr JW

更新日期：1993-08-01 00:00:00

abstract：:Hairy cell populations of greater than 90 purity were prepared from six samples obtained from four patients with leukemic reticuloendotheliosis (LRE). These then were analyzed for surface immunoglobulin (SIg) and antigens specified by a panel of monoclonal antibodies. The hairy cells from all patients displayed SIg an...

journal_title：American journal of clinical pathology

authors： Janckila AJ,Stelzer GT,Wallace JH,Yam LT

更新日期：1983-04-01 00:00:00

abstract：:This practice parameter, developed by the Practice Parameters and Outcomes Measurement Committee of the American Society of Clinical Pathologists (ASCP), is a guideline for the development of reasonable stat lists. Stat testing lists vary according to practice setting. Furthermore, although stat lists exist, extenuati...

journal_title：American journal of clinical pathology

authors： Hilborne L,Lee H,Cathcart P

更新日期：1996-06-01 00:00:00

abstract：:Three cases of pulmonary squamous cell carcinoma (SCC) are described displaying a prominent microcystic pattern closely resembling microcystic adnexal carcinoma of the skin (MAC). The patients were 2 women and 1 man aged 72 to 83 years. Histologically, in addition to conventional SCC, all tumors showed striking microc...

journal_title：American journal of clinical pathology

authors： Weissferdt A,Moran CA

更新日期：2011-09-01 00:00:00

abstract：:A unilateral multicystic mass in the connective tissue adjacent to the vas deferens in a 46-year-old man is reported. Anatomically, it was distinct from the epididymis and vas and contained no sperm. The epithelial lining was simple, ciliated, and cuboidal to columnar. The cysts were surrounded by connective tissue co...

journal_title：American journal of clinical pathology

authors： Schned AR,Seremetis GM,Rous SN

更新日期：1994-04-01 00:00:00

abstract：:There are few studies that examine prevalence, quantity, and cellular proclivity of latent human herpesvirus 6 (HHV-6) in healthy populations. We examined 69 tonsils with paired blood specimens from children without evidence of acute infection. By polymerase chain reaction (PCR), HHV-6 was detected at low levels in 10...

journal_title：American journal of clinical pathology

authors： Roush KS,Domiati-Saad RK,Margraf LR,Krisher K,Scheuermann RH,Rogers BB,Dawson DB

更新日期：2001-11-01 00:00:00

abstract：:Cytokeratin (CK) expression was studied in 22 sinonasal inverted papillomas. Columnar (respiratory) epithelium in inverted papillomas abundantly expressed CK7, CK8, CK18, and CK19. Immunoreactivity for CK5/14 and CK17 was found in basal and parabasal/suprabasal cells. Transitional (cuboidal) and squamous epithelium in...

journal_title：American journal of clinical pathology

authors： Schwerer MJ,Kraft K,Baczako K,Maier H

更新日期：2001-05-01 00:00:00

abstract：:Factitious laboratory results often lead to unnecessary testing or treatment. This brief review of factitious biochemical results due to preexisting hematologic conditions focuses on the mechanisms underlying the factitious results and suggests ways to prevent them. An observant pathologist identifies these errors, in...

journal_title：American journal of clinical pathology

authors： Dalal BI,Brigden ML

更新日期：2009-02-01 00:00:00

abstract：:We evaluated a more efficient method of processing liquid-based cervical cytology specimens for human papillomavirus (HPV) DNA testing by Hybrid Capture II (HCII). Aliquots were made from 701 specimens in the following sequence: 4.0, 2.0, 1.0, 0.5, and 1.5 mL. The 4.0-mL aliquot was processed by the standard method (S...

journal_title：American journal of clinical pathology

authors： Castle PE,Garcia-Meijide M,Holladay EB,Chuke R,Payne J,Long A,Siefers H,Demuth F,Lorincz AT

更新日期：2005-02-01 00:00:00

abstract：:The authors report two cases of vernix caseosa peritonitis, an infrequent complication of cesarean section with distinctive histopathologic findings. Both patients underwent exploratory laparotomy for unexplained abdominal pain after cesarean section. Histopathologic evaluation of surgically removed tissue revealed an...

journal_title：American journal of clinical pathology

authors： George E,Leyser S,Zimmer HL,Simonowitz DA,Agress RL,Nordin DD

更新日期：1995-06-01 00:00:00

abstract：:An immunohistochemical study was conducted of 108 papillary carcinoma cases, including 48 cases with intratumoral heterotopic ossification (IHO). In 48 cases, papillary carcinoma with IHO was accompanied by nodular fibrosis. Cases of papillary carcinoma with IHO or nodular fibrosis showed higher incidences of lymph no...

journal_title：American journal of clinical pathology

authors： Takeda M,Mikami T,Numata Y,Okamoto M,Okayasu I

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVES:Many nonpathologists and some pathologists consider utilization review essential to laboratory quality improvement, but (1) confusion surrounding the definition of "appropriate" laboratory utilization, (2) the reliance on manual chart review, and (3) a lack of leadership have contributed to its unstandardize...

journal_title：American journal of clinical pathology

authors： Hauser RG,Shirts BH

更新日期：2014-06-01 00:00:00

abstract：:A 61-year-old man with acquired immunodeficiency syndrome (AIDS) sought care because of the onset of progressive dysphagia. He was found to have a perforated, fungating esophageal mass. The combined histologic and immunologic findings were diagnostic of Hodgkin's disease, nodular sclerosis type, lymphocyte-depleted va...

journal_title：American journal of clinical pathology

authors： Gelb AB,Medeiros LJ,Chen YY,Weiss LM,Weidner N

更新日期：1997-11-01 00:00:00

abstract：:This is apparently the second report of a case of human meningoencephalitis caused by the nematode Micronema deletrix. The patient had severe granulomatous meningoencephalitis with numerous foci of hemorrhage and encephalomalacia. Numerous adult female and larval M. deletrix were in the brain. The organisms probably i...

journal_title：American journal of clinical pathology

authors： Shadduck JA,Ubelaker J,Telford VQ

更新日期：1979-10-01 00:00:00

abstract：:Determination of hemoglobin A1c (HbA1c) is one of the most important monitoring procedures for long-term control of diabetes mellitus. Several analytical methods have been developed for the measurement of glycohemoglobin (GHb). Those most frequently used are ion-exchange chromatography for HbA1c and affinity chromatog...

journal_title：American journal of clinical pathology

authors： Hamwi A,Schweiger CR,Veitl M,Schmid R

更新日期：1995-07-01 00:00:00

abstract：:A variant hemoglobin fraction may be an incidental finding during HbA(1c) analysis using the G8 Tosoh HPLC analyzer, but it is unclear if the retention times and fraction patterns can reliably predict the findings of a high-performance liquid chromatography (HPLC) β-thalassemia program (Bio Rad Variant II analyzer). W...

journal_title：American journal of clinical pathology

authors： Froom P,Henig C,Zalman L,Barak M

更新日期：2012-09-01 00:00:00

abstract：:Histologic diagnosis of a nonpalpable breast lesion requires the following: (1) mammographically directed excision of the suspect lesion, (2) recovery of the target lesion from the tissue specimen, and (3) demonstration of the lesion in histologic section. Recovery of lesional tissue is a function of localization with...

journal_title：American journal of clinical pathology

authors： Alberhasky MT

更新日期：1989-10-01 00:00:00

abstract：:Immunocytochemical assays for progesterone receptor (PR) using monoclonal antirabbit PR antibodies (PR-ICA) and for estrogen receptor (ER) (ER-ICA) were compared with radioligand binding (dextran-coated charcoal [DCC]) methods for receptor determination in patients with breast cancer. Immunocytochemical staining for P...

journal_title：American journal of clinical pathology

authors： Seymour L,Meyer K,Esser J,MacPhail AP,Behr A,Bezwoda WR

更新日期：1990-10-01 00:00:00

abstract：:Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly men were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+,...

journal_title：American journal of clinical pathology

authors： Hsi ED,Hoeltge G,Tubbs RR

更新日期：2000-06-01 00:00:00

abstract：:We present what, to our knowledge, is the first reported case of nephrogenic metaplasia of the ureter. Nephrogenic metaplasia involves the transitional epithelium of the urinary tract and results in the formation of epithelial tubules, which are histologically similar to renal tubules. Special stains demonstrated both...

journal_title：American journal of clinical pathology

authors： Lugo M,Petersen RO,Elfenbein IB,Stein BS,Duker NJ

更新日期：1983-07-01 00:00:00

abstract：:A number of reports have highlighted discrepancies between the DuPont aca and fibrometer-based methods for quantitating plasma fibrinogen levels. Although many authors have suggested that the presence of fibrin(ogen) degradation products are in some way responsible for the discrepancies, no direct test of this hypothe...

journal_title：American journal of clinical pathology

authors： Hoffman M,Greenberg CS

更新日期：1987-10-01 00:00:00

abstract：:Although Stat tests are one of the most important features of clinical laboratory performance, the indexed literature is devoid of significant discussion of the subject. The authors, undertook a study by querying hospital laboratories about their current practices and received 38 useable answers dealing with the types...

journal_title：American journal of clinical pathology

authors： Barnett RN,McIver DD,Gorton WL

更新日期：1978-05-01 00:00:00

abstract：:Cytology frequently has some role in preoperatively distinguishing pancreatic mucus-producing neoplasia (intraductal papillary mucinous neoplasms [IPMNs] and mucinous cystic neoplasms [MCNs]) from other pancreatic cysts. We evaluated all cytologic specimens at our institutions from resected pancreatic cystic lesions f...

journal_title：American journal of clinical pathology

authors： Stelow EB,Shami VM,Abbott TE,Kahaleh M,Adams RB,Bauer TW,Debol SM,Abraham JM,Mallery S,Policarpio-Nicolas ML

更新日期：2008-01-01 00:00:00