Abstract：
:There are few studies that examine prevalence, quantity, and cellular proclivity of latent human herpesvirus 6 (HHV-6) in healthy populations. We examined 69 tonsils with paired blood specimens from children without evidence of acute infection. By polymerase chain reaction (PCR), HHV-6 was detected at low levels in 100% of tonsils and 39% of blood samples (n = 27), suggesting that prevalence of latent HHV-6 infection is high in children and may be underestimated by PCR analysis of blood. Although HHV-6A and HHV-6B were detected, HHV-6B predominated, being found in 97% of samples (n = 67). Tonsil sections from 7 cases were examined by in situ hybridization using 2 HHV-6 probes and immunohistochemical analysis. Using both in situ hybridization and immunohistochemical analysis, all tissues revealed marked HHV-6-specific staining in the squamous epithelium of the tonsillar crypts and rare positive lymphocytes. We conclude that HHV-6 is present universally in tonsils of children, and tonsillar epithelium may be an important viral reservoir in latent infection.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Roush KS,Domiati-Saad RK,Margraf LR,Krisher K,Scheuermann RH,Rogers BB,Dawson DBdoi
10.1309/Y2HH-B1CK-0F5L-U7B8subject
Has Abstractpub_date
2001-11-01 00:00:00pages
648-54issue
5eissn
0002-9173issn
1943-7722journal_volume
116pub_type
杂志文章abstract：:Three stillborn fetuses are reported in which an abdominal wall defect was associated with defects in the urogenital and anal region. Autopsy of these fetuses provided clues indicative of how and where the embryonic development went wrong. The malformation involved a disturbance of the cell deposition process, occurri...
journal_title：American journal of clinical pathology
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journal_title：American journal of clinical pathology
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journal_title：American journal of clinical pathology
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journal_title：American journal of clinical pathology
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journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/78.1.127
更新日期：1982-07-01 00:00:00
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journal_title：American journal of clinical pathology
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更新日期：1989-09-01 00:00:00
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journal_title：American journal of clinical pathology
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更新日期：1993-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1981-02-01 00:00:00
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更新日期：2019-05-03 00:00:00
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journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/aqz207
更新日期：2020-04-15 00:00:00
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journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/88.4.520
更新日期：1987-10-01 00:00:00
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journal_title：American journal of clinical pathology
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更新日期：2005-06-01 00:00:00
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journal_title：American journal of clinical pathology
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更新日期：1985-04-01 00:00:00
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journal_title：American journal of clinical pathology
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doi：10.1309/AJCPWE2HBFCGDIDS
更新日期：2015-06-01 00:00:00
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journal_title：American journal of clinical pathology
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doi：
更新日期：1975-06-01 00:00:00
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journal_title：American journal of clinical pathology
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更新日期：1975-08-01 00:00:00
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journal_title：American journal of clinical pathology
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journal_title：American journal of clinical pathology
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journal_title：American journal of clinical pathology
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更新日期：1986-07-01 00:00:00
abstract：OBJECTIVES:Although diffuse alveolar damage, a subtype of acute lung injury (ALI), is the most common microscopic pattern in coronavirus disease 2019 (COVID-19), other pathologic patterns have been described. The aim of the study was to review autopsies from COVID-19 decedents to evaluate the spectrum of pathology and ...
journal_title：American journal of clinical pathology
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更新日期：2020-11-04 00:00:00
