Oestrogen receptor (ER)-alpha and ER-beta isoforms in normal endometrial and endometriosis-derived stromal cells.

abstract：:Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency is the most common defect in fatty acid oxidation. The disease is inherited in an autosomal recessive fashion (carrier frequency around 1 in 70) and probably affects as many as 1 in 10000 new-borns. Affected children usually present within the two first years of li...

journal_title：Molecular human reproduction

authors： Sermon K,Henderix P,Lissens W,De Vos A,Vandervorst M,Vanderfaeillie A,Vamos E,Van Steirteghem A,Liebaers I

更新日期：2000-12-01 00:00:00

abstract：:This study assessed the participation of amphiregulin (AREG) and bone morphogenetic protein 15 (BMP15) during maturation of bovine cumulus-oocyte complexes (COCs) on cumulus cell function and their impact on subsequent embryo development. AREG treatment of COCs enhanced blastocyst formation and quality only when in th...

journal_title：Molecular human reproduction

authors： Sugimura S,Ritter LJ,Sutton-McDowall ML,Mottershead DG,Thompson JG,Gilchrist RB

更新日期：2014-06-01 00:00:00

abstract：:Human endometrium is the major organ that produces glycodelin A (GdA). The production of endometrial GdA causes a fluctuation of the peripheral glycodelin concentrations in women during the menstrual cycle and pregnancy. It has recently been reported that the rise of plasma concentrations of glycodelin is correlated w...

journal_title：Molecular human reproduction

authors： Tseng L,Zhu HH,Mazella J,Koistinen H,Seppälä M

更新日期：1999-04-01 00:00:00

abstract：:Early embryonic development is characterized by drastic changes in chromatin structure that affects the accessibility of the chromatin. In human, the chromosome reorganization and its involvement in the first linage segregation are poorly characterized due to the difficulties in obtaining human embryonic material and ...

journal_title：Molecular human reproduction

authors： Yang M,Tao X,Titus S,Zhao T,Scott RT,Seli E

更新日期：2020-09-01 00:00:00

abstract：:We have previously reported that endometrial expression of matrix metalloproteinase (MMP)-26 mRNA comes to a maximum in the early secretory phase. Since tissue inhibitor of metalloproteinase (TIMP)-4 is a potent inhibitor of MMP-26, the objective of this study was to identify the pattern of TIMP-4 mRNA expression in t...

journal_title：Molecular human reproduction

authors： Pilka R,Domanski H,Hansson S,Eriksson P,Casslén B

更新日期：2004-09-01 00:00:00

abstract：:Immunocytochemistry was used to localize endothelial (eNOS) and inducible (iNOS) nitric oxide synthase in human uterine tissues collected at various stages of the menstrual cycle, after exposure to exogenous progestagens, and in early pregnancy. Endothelial NOS-like immunoreactivity was detected in all specimens in en...

journal_title：Molecular human reproduction

authors： Telfer JF,Irvine GA,Kohnen G,Campbell S,Cameron IT

更新日期：1997-01-01 00:00:00

abstract：:In mature mammalian oocytes, cortical f-actin distribution is polarized, as evidenced by a prominent cap subtended by the metaphase II (MII) spindle. Formation of a polarized actin cap is a consequence of a complex actomyosin-driven contractile process that directs polar body extrusion. Human mature oocytes also displ...

journal_title：Molecular human reproduction

authors： Coticchio G,Guglielmo MC,Albertini DF,Dal Canto M,Mignini Renzini M,De Ponti E,Fadini R

更新日期：2014-03-01 00:00:00

abstract：STUDY QUESTION:Does a heterozygous mutation in AMHR2, identified in whole-exome sequencings (WES) of patients with primary ovarian insufficiency (POI), cause a defect in anti-Müllerian hormone (AMH) signaling? SUMMARY ANSWER:The I209N mutation at the adenosine triphosphate binding domain of AMHR2 exerts dominant negat...

journal_title：Molecular human reproduction

authors： Li L,Zhou X,Wang X,Wang J,Zhang W,Wang B,Cao Y,Kee K

更新日期：2016-09-01 00:00:00

abstract：:Natural killer (NK) cells are the predominant leukocyte in first trimester decidua and play a role in vascular remodelling through interferon gamma (IFNgamma) secretion. Membrane expression of the killer immunoglobulin-like receptor (KIR) KIR2DL4 on peripheral blood NK (pNK) cells is controlled by the 9A/10A transmemb...

journal_title：Molecular human reproduction

authors： Goodridge JP,Lathbury LJ,John E,Charles AK,Christiansen FT,Witt CS

更新日期：2009-08-01 00:00:00

abstract：:We aimed to confirm the ovarian site of gonadotrophin surge-attenuating factor (GnSAF) production and produce granulosa/luteal cell-conditioned medium (G/LCM) containing GnSAF for purification studies. Blue dye affinity chromatography followed by pseudochromatofocusing of G/LCM yielded bioactive fractions at pH 5.74 a...

journal_title：Molecular human reproduction

authors： Fowler PA,Sorsa-Leslie T,Cash P,Dunbar B,Melvin W,Wilson Y,Mason HD,Harris W

更新日期：2002-09-01 00:00:00

abstract：:Patients with endometriosis are characterized by the ability of the endometrium to implant and by the peritoneal response to the tissue; angiogenic factors may play a significant role in the aetiology of endometriosis supporting the implantation of ectopic endometrial cells. Vascular endothelial growth factor (VEGF) i...

journal_title：Molecular human reproduction

authors： Fasciani A,D'Ambrogio G,Bocci G,Monti M,Genazzani AR,Artini PG

更新日期：2000-01-01 00:00:00

abstract：:Charcot-Marie-Tooth (CMT) disease is the 'common' name for a range of hereditary peripheral neuropathies. CMT1 is the most common form and is transmitted in an autosomal dominant manner. CMT1A maps to chromosome 17p11.2 and is caused, in the majority of cases, by a 1.5 Mb DNA duplication, that includes the peripheral ...

journal_title：Molecular human reproduction

authors： De Vos A,Sermon K,De Rijcke M,Goossens V,Henderix P,Van Ranst N,Platteau P,Lissens W,Devroey P,Van Steirteghem A,Liebaers I

更新日期：2003-07-01 00:00:00

abstract：:In Europe up to one in four couples experience difficulty conceiving and in half of these cases the problem has been attributed to sub or infertility in the male partner. The development of assisted reproductive technologies (ART) such as in vitro fertilization and intra-cytoplasmic spermatozoa injection has allowed s...

journal_title：Molecular human reproduction

authors： Paul C,Melton DW,Saunders PT

更新日期：2008-01-01 00:00:00

abstract：STUDY QUESTION:Does dynamin regulate human sperm acrosomal exocytosis? SUMMARY ANSWER:Our studies of dynamin localization and function have implicated this family of mechanoenzymes in the regulation of progesterone-induced acrosomal exocytosis in human spermatozoa. WHAT IS KNOWN ALREADY:Completion of an acrosome reac...

journal_title：Molecular human reproduction

authors： Zhou W,Anderson AL,Turner AP,De Iuliis GN,McCluskey A,McLaughlin EA,Nixon B

更新日期：2017-10-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are present in both human oocytes and embryos. It has been found that these tissues contain a mtDNA mutation which is present in high amounts in patients with Kearns-Sayre syndrome (KSS) and progressive external ophthalmoplegia. In the present study, the frequency of this KSS deleti...

journal_title：Molecular human reproduction

authors： Brenner CA,Wolny YM,Barritt JA,Matt DW,Munné S,Cohen J

更新日期：1998-09-01 00:00:00

abstract：:The endometrium plays a key role in reproduction, and this function is tightly regulated by endogenous and xenobiotic steroids. Sulphation, catalysed by members of the sulphotransferase (SULT) enzyme family, is a major deactivating mechanism for steroid hormones and we have investigated the expression and regulation i...

journal_title：Molecular human reproduction

authors： Rubin GL,Harrold AJ,Mills JA,Falany CN,Coughtrie MW

更新日期：1999-11-01 00:00:00

abstract：:Male and female preimplantation mammalian embryos differ not only in their chromosomal complement, but in their proteome and subsequent metabolome. This phenomenon is due to a finite period during preimplantation development when both X chromosomes are active, between embryonic genome activation and X chromosome inact...

journal_title：Molecular human reproduction

authors： Gardner DK,Larman MG,Thouas GA

更新日期：2010-08-01 00:00:00

abstract：:The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide maps of open chrom...

journal_title：Molecular human reproduction

authors： Browne JA,Yang R,Song L,Crawford GE,Leir SH,Harris A

更新日期：2014-12-01 00:00:00

abstract：:The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptid...

journal_title：Molecular human reproduction

authors： Bauskin AR,Franken DR,Eberspaecher U,Donner P

更新日期：1999-06-01 00:00:00

abstract：:Granzyme B (graB) plays a pivotal role in cytotoxic lymphocyte granule-mediated apoptosis through cleavage of intracellular proteins in target cells. Proteinase inhibitor-9 (PI-9) is a potent inhibitor of graB and is highly expressed in cytotoxic lymphocytes. Here, we show by immunohistochemistry that PI-9 is also abu...

journal_title：Molecular human reproduction

authors： Hirst CE,Buzza MS,Sutton VR,Trapani JA,Loveland KL,Bird PI

更新日期：2001-12-01 00:00:00

abstract：:In women with premature ovarian failure, fertility may be preserved by ovarian tissue culture in vitro. However, techniques for tissue culture and follicle maturation have remained suboptimal. Our aim was to characterize ovarian tissue degeneration in cultures and to establish a model for cell death research in cultur...

journal_title：Molecular human reproduction

authors： Otala M,Erkkilä K,Tuuri T,Sjöberg J,Suomalainen L,Suikkari AM,Pentikäinen V,Dunkel L

更新日期：2002-03-01 00:00:00

abstract：:The expression of adhesion molecules and matrix proteins by human spermatozoa as well as their binding to and penetration of zona-free hamster eggs were investigated in 17 patients by means of flow cytometry. Both binding and penetration of hamster oocytes and expression of alpha- and beta-chains of beta 1, beta 3 and...

journal_title：Molecular human reproduction

authors： Henkel R,Schaller J,Glander HJ,Schill WB

更新日期：1996-05-01 00:00:00

abstract：:Genes containing the evolutionarily conserved homeodomain sequence encode a family of DNA-binding transcription factors whose functions are crucial for embryonic development in vertebrates, invertebrates and plants. We describe the detection and analysis of transcripts of homeobox-containing genes present in cDNA libr...

journal_title：Molecular human reproduction

authors： Adjaye J,Monk M

更新日期：2000-08-01 00:00:00

abstract：:Oocyte quality is one of the most important aspects of in vitro embryo development. Extensive epigenetic programming must occur during oocyte growth and maturation. A specific DNA methylation pattern of the imprinted genes must be established on differentially methylated regions (DMR). The insulin-like growth factor 2...

journal_title：Molecular human reproduction

authors： Fagundes NS,Michalczechen-Lacerda VA,Caixeta ES,Machado GM,Rodrigues FC,Melo EO,Dode MA,Franco MM

更新日期：2011-02-01 00:00:00

abstract：:Prostaglandin F2α (PGF2α) plays a critical role in the initiation and process of parturition. Since human labor has been described as an inflammatory event, we investigated the role of PGF2α in the inflammatory process using cultured human uterine smooth muscle cells (HUSMCs) isolated from term pregnant women as a mod...

journal_title：Molecular human reproduction

authors： Xu C,Liu W,You X,Leimert K,Popowycz K,Fang X,Wood SL,Slater DM,Sun Q,Gu H,Olson DM,Ni X

更新日期：2015-07-01 00:00:00

abstract：:Zinc dynamics are essential for oocyte meiotic maturation, egg activation, and preimplantation embryo development. During fertilisation and egg activation, the egg releases billions of zinc atoms (Zn2+) in an exocytotic event termed the 'zinc spark'. We hypothesised that this zinc transport and exocytosis is dependent...

journal_title：Molecular human reproduction

authors： Lee HC,Edmonds ME,Duncan FE,O'Halloran TV,Woodruff TK

更新日期：2020-04-24 00:00:00

abstract：:We report here the molecular cloning and characterization of a novel human actin capping protein alpha3 (cpalpha3) cDNA, an orthologue of the mouse male germ cell-specific cpalpha3, and the organization of the human cpalpha3 genomic structure. The entire coding region of the human cpalpha3 cDNA showed 82.1% similarity...

journal_title：Molecular human reproduction

authors： Miyagawa Y,Tanaka H,Iguchi N,Kitamura K,Nakamura Y,Takahashi T,Matsumiya K,Okuyama A,Nishimune Y

更新日期：2002-06-01 00:00:00

abstract：:During pregnancy, a cervical connective tissue remodelling takes place, clinically recognized as softening, effacement and dilatation. The role of oestrogens and their receptors (ER) in this process is not clear. ERalpha is a ligand-activated transcription factor involved in many physiological processes. The identific...

journal_title：Molecular human reproduction

authors： Wang H,Stjernholm Y,Ekman G,Eriksson H,Sahlin L

更新日期：2001-03-01 00:00:00

abstract：:It is well known that human embryonic stem cells (hESCs) frequently acquire recurrent chromosomal abnormalities, very reminiscent of those found in cancerous cells. Given the parallels between cancer and stem cell biology, we set out to investigate the occurrence of a common form of genome instability in tumors, namel...

journal_title：Molecular human reproduction

authors： Nguyen HT,Markouli C,Geens M,Barbé L,Sermon K,Spits C

更新日期：2014-10-01 00:00:00

abstract：:Analysis of small numbers of chromosomes using interphase fluorescent in-situ hybridization (FISH) probes has revealed that 50% of human preimplantation embryos contain abnormal cells. Detection of high levels of mosaicism with so few probes has led some researchers to extrapolate that a full analysis of all 23 pairs ...

journal_title：Molecular human reproduction

authors： Wells D,Delhanty JD

更新日期：2000-11-01 00:00:00