The genotype of the NK cell receptor, KIR2DL4, influences INFgamma secretion by decidual natural killer cells.

abstract：:Ovaries surgically removed for fertility preservation from a total of 24 women served as a source of human small antral follicles, including the follicular fluid (FF) and the corresponding granulosa cells (GC). The FF was used to evaluate the intrafollicular concentrations of anti-Müllerian hormone (AMH), inhibin-B, e...

journal_title：Molecular human reproduction

authors： Eilsø Nielsen M,Rasmussen IA,Fukuda M,Westergaard LG,Yding Andersen C

更新日期：2010-09-01 00:00:00

abstract：:We compared latent TGF-ss binding protein-1 (LTBP-1) and fibrillin-1 (FBN-1) expression in leiomyomata and myometrium, correlated with leiomyomata size. We studied in vivo and in vitro effects of ovarian steroids using matched leiomyomata and myometrium samples from both phases of the menstrual cycle. Leiomyomata were...

journal_title：Molecular human reproduction

authors： Zhao Y,Wen Y,Polan ML,Qiao J,Chen BH

更新日期：2007-05-01 00:00:00

abstract：:The pool of primordial follicles in humans is laid down during embryonic development and follicles can remain dormant for prolonged intervals, often decades, until individual follicles resume growth. The mechanisms that induce growth and maturation of primordial follicles are poorly understood but follicles once activ...

journal_title：Molecular human reproduction

authors： Markholt S,Grøndahl ML,Ernst EH,Andersen CY,Ernst E,Lykke-Hartmann K

更新日期：2012-02-01 00:00:00

abstract：STUDY HYPOTHESIS:In women with preterm premature rupture of the membranes (PPROM), increased oxidative stress may accelerate premature cellular senescence, senescence-associated inflammation and proteolysis, which may predispose them to rupture. STUDY FINDING:We demonstrate mechanistic differences between preterm birt...

journal_title：Molecular human reproduction

authors： Dutta EH,Behnia F,Boldogh I,Saade GR,Taylor BD,Kacerovský M,Menon R

更新日期：2016-02-01 00:00:00

abstract：:Patients with rare overgrowth disorders, such as Beck-Wiedemann syndrome and Simpson-Golabi-Behmel syndrome, are predisposed to embryonal tumours, including Wilms' tumour of the kidney. Therefore, these disorders offer a link between hyperplastic growth and cancer. Genetic lesions at chromosome 11p15 have been associa...

journal_title：Molecular human reproduction

authors： Ward A

更新日期：1997-02-01 00:00:00

abstract：:Patients with endometriosis are characterized by the ability of the endometrium to implant and by the peritoneal response to the tissue; angiogenic factors may play a significant role in the aetiology of endometriosis supporting the implantation of ectopic endometrial cells. Vascular endothelial growth factor (VEGF) i...

journal_title：Molecular human reproduction

authors： Fasciani A,D'Ambrogio G,Bocci G,Monti M,Genazzani AR,Artini PG

更新日期：2000-01-01 00:00:00

abstract：:Success rate in human pregnancies is believed to be very low and sex-specific mechanisms may operate in prenatal loss. Assuming a sex-differential in prenatal loss exists, we examined genetic markers in biologically plausible targets in the HLA complex, other immune system-related and iron-regulatory genes in 388 heal...

journal_title：Molecular human reproduction

authors： Ucisik-Akkaya E,Davis CF,Do TN,Morrison BA,Stemmer SM,Amadio WJ,Dorak MT

更新日期：2010-10-01 00:00:00

abstract：:In early gestation, the human placental renin-angiotensin system (RAS) is upregulated and plays a role in placental development. Among other functions, signalling through the angiotensin II type 1 receptor (AT1R) initiates proliferation. Many microRNAs (miRNAs) targeting placental RAS mRNAs are downregulated at this t...

journal_title：Molecular human reproduction

authors： Arthurs AL,Lumbers ER,Pringle KG

更新日期：2019-04-01 00:00:00

abstract：:Follicular development and ovulation are major processes in the reproductive system. Understanding their complexity is important to female fertility treatments and the control of reproductive processes. Wnt signaling pathway components were shown to be involved in reproduction in animal models. The secreted frizzled-r...

journal_title：Molecular human reproduction

authors： Maman E,Yung Y,Cohen B,Konopnicki S,Dal Canto M,Fadini R,Kanety H,Kedem A,Dor J,Hourvitz A

更新日期：2011-07-01 00:00:00

abstract：:During pregnancy, a cervical connective tissue remodelling takes place, clinically recognized as softening, effacement and dilatation. The role of oestrogens and their receptors (ER) in this process is not clear. ERalpha is a ligand-activated transcription factor involved in many physiological processes. The identific...

journal_title：Molecular human reproduction

authors： Wang H,Stjernholm Y,Ekman G,Eriksson H,Sahlin L

更新日期：2001-03-01 00:00:00

abstract：:Estrogen and selective estrogen receptor modulators (SERMs) differentially impact endometrial cell function, however, the biological basis of these differences is not established. Deregulated cell adhesion to the extracellular matrix, cell movement and invasion are related to endometrial disorders, such as endometrios...

journal_title：Molecular human reproduction

authors： Flamini MI,Sanchez AM,Goglia L,Tosi V,Genazzani AR,Simoncini T

更新日期：2009-10-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) plays a key role in the maintenance of human pregnancy and labour onset. PGE2 can elicit diverse actions within the uterus depending on the PGE2 receptors (EP1, EP2, EP3 and EP4) expressed. By signalling through different intracellular pathways the EP receptors may inhibit or promote smooth mus...

journal_title：Molecular human reproduction

authors： Astle S,Thornton S,Slater DM

更新日期：2005-04-01 00:00:00

abstract：:Endometriosis, the presence of ectopic endometrial tissue outside the uterine cavity, is a common disease affecting women during their reproductive years. The aim of this study was to identify the molecular mechanism of transcriptional regulation of inflammatory cyclooxygenase-2 (COX-2) gene during endometriosis by hy...

journal_title：Molecular human reproduction

authors： Kim KH,Kim HY,Kim HH,Lee KS,Cheong J

更新日期：2011-11-01 00:00:00

abstract：:Round spermatids contain high levels of extremely varied mRNAs that are synthesized either throughout early spermatogenesis or during spermiogenesis from the haploid genome. Concomitantly, with major changes in the chromatin organization, arrest of transcription occurs at midspermiogenesis. However, previous investiga...

journal_title：Molecular human reproduction

authors： Dadoune JP,Pawlak A,Alfonsi MF,Siffroi JP

更新日期：2005-02-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared with luteinized granulosa cells from women with a normal...

journal_title：Molecular human reproduction

authors： Jiang L,Huang H,Qian Y,Li Y,Chen X,Di N,Yang D

更新日期：2020-08-01 00:00:00

abstract：STUDY HYPOTHESIS:What factors in mouse oocytes are involved in the ageing-related decline in oocyte quality? STUDY FINDING:The maternal effect gene Mater is involved in ageing-related oocyte quality decline in mice. WHAT IS KNOWN ALREADY:Premature loss of centromere cohesion is a hallmark of ageing-related oocyte qua...

journal_title：Molecular human reproduction

authors： Lu YQ,He XC,Zheng P

更新日期：2016-04-01 00:00:00

abstract：:In humans, the most common chromosomal abnormality is aneuploidy. Because the majority of aneuploid conceptuses die during the early stages of embryonic development, an accurate estimate of the frequency of aneuploidy at conception can only be assessed by directly studying the gametes. The vast majority of aneuploidie...

journal_title：Molecular human reproduction

authors： Templado C,Uroz L,Estop A

更新日期：2013-10-01 00:00:00

abstract：:Successful embryo implantation depends on the quality of the embryo, as well as on the receptivity of the endometrium. The aim of this study was to investigate the endometrial gene expression profile in women with unexplained infertility in comparison with fertile controls at the time of embryo implantation in order t...

journal_title：Molecular human reproduction

authors： Altmäe S,Martínez-Conejero JA,Salumets A,Simón C,Horcajadas JA,Stavreus-Evers A

更新日期：2010-03-01 00:00:00

abstract：:The molecular mechanism of stress-associated reproductive dysfunction is complex and largely unknown. This study was designed to systematically analyze molecular effects of systemic in vivo blockade of α1-adrenergic receptors (α1-ADRs) on stress-induced disturbance of cAMP/cGMP signaling in testosterone-producing Leyd...

journal_title：Molecular human reproduction

authors： Stojkov NJ,Baburski AZ,Bjelic MM,Sokanovic SJ,Mihajlovic AI,Drljaca DM,Janjic MM,Kostic TS,Andric SA

更新日期：2014-01-01 00:00:00

abstract：:A molecule isolated from the peritoneal fluids of women undergoing laparoscopy for in-vitro fertilization techniques has been chemically characterized and identified as 1-palmitic-3-phosphorylcholine (lysophosphatidylcholine, LPC). This lipid is able, at physiological concentrations, to completely inhibit sperm motili...

journal_title：Molecular human reproduction

authors： Keller F,Togni G,Soldati G,Balmelli T,Medici G,Rose K,Balerna M

更新日期：1997-03-01 00:00:00

abstract：:Intense macrophage infiltration is observed during luteolysis in various animals including women; however, we still do not know how macrophage infiltration into the human corpus luteum (CL) during luteolysis is regulated. In this study, we examined the expression, localization and regulation of an important chemokine ...

journal_title：Molecular human reproduction

authors： Nio-Kobayashi J,Kudo M,Sakuragi N,Kimura S,Iwanaga T,Duncan WC

更新日期：2015-08-01 00:00:00

abstract：:Oxidative stress is a major aetiology in many pathologies, including that of male infertility. Recent evidence in somatic cells has linked oxidative stress to the induction of a novel cell death modality termed ferroptosis. However, the induction of this iron-regulated, caspase-independent cell death pathway has never...

journal_title：Molecular human reproduction

authors： Bromfield EG,Walters JLH,Cafe SL,Bernstein IR,Stanger SJ,Anderson AL,Aitken RJ,McLaughlin EA,Dun MD,Gadella BM,Nixon B

更新日期：2019-05-01 00:00:00

abstract：:Stromal cell-derived factor-1 (SDF-1 or CXCL12) is the physiologic ligand for the chemokine receptor CXCR4. CXCR4-mediated signalling regulates cell migration and apoptosis in certain haematopoietic and neuronal cells. Using gene profiling, we determined that CXCR4 is the only chemokine receptor for which mRNA express...

journal_title：Molecular human reproduction

authors： Jaleel MA,Tsai AC,Sarkar S,Freedman PV,Rubin LP

更新日期：2004-12-01 00:00:00

abstract：:The two estrogen receptors, ERalpha and ERbeta, are likely to have roles in the pathophysiology of fibroid development. They have been detected in myometrial and leiomyoma (fibroid) tissue, but the cell types expressing ERalpha and ERbeta have not been determined. ERs have also been detected in human endothelial cells...

journal_title：Molecular human reproduction

authors： Gargett CE,Bucak K,Zaitseva M,Chu S,Taylor N,Fuller PJ,Rogers PA

更新日期：2002-08-01 00:00:00

abstract：:Glycoforms of recombinant human follicle stimulating hormone (rhFSH) (Org 32489, Puregon) were characterized using concanavalin A lectin affinity chromatography to reveal information about the internal carbohydrate complexity (extent of carbohydrate side-chain branching) of the preparations. The rhFSH glycoforms were ...

journal_title：Molecular human reproduction

authors： Harris SD,Anobile CJ,McLoughlin JD,Mitchell R,Lambert A,Robertson WR

更新日期：1996-10-01 00:00:00

abstract：:A rapid fluorescence in-situ hybridization (FISH) technique was used for direct chromosomal analysis on germ cells from an infertile male with large-headed spermatozoa. The interphase chromosomes were fluorescently-labelled using an extremely bright cyanine dye during a 5-15 min FISH procedure. Germ cells were analyse...

journal_title：Molecular human reproduction

authors： Yurov YB,Saias MJ,Vorsanova SG,Erny R,Soloviev IV,Sharonin VO,Guichaoua MR,Luciani JM

更新日期：1996-09-01 00:00:00

abstract：:Inhibin production has been demonstrated in malignant epithelial ovarian tumours, but secretion of inhibins by benign cystadenoma has not yet been reported. The present study evaluated the concentrations of inhibin A and inhibin B and the relationship with oestradiol and nitric oxide metabolites in fluid collected fro...

journal_title：Molecular human reproduction

authors： Reis FM,Faletti A,Luisi S,Bifulco G,Cauci S,Quadrifoglio F,Dor J,Petraglia F

更新日期：2000-12-01 00:00:00

abstract：:Microarray studies generating lists of genes with altered expression in placentas from pregnancies complicated with pre-eclampsia (PE) have so far been published in several different studies. Working under the assumption that altered gene expression in PE may be the result of altered expression of regulatory transcrip...

journal_title：Molecular human reproduction

authors： Vásárhelyi B,Cseh A,Kocsis I,Treszl A,Györffy B,Rigó J Jr

更新日期：2006-01-01 00:00:00

abstract：:In recent years, the impact of sperm DNA damage on fertility has become an important issue. The different technologies developed to check sperm DNA fragmentation lead to the same conclusion: DNA damage negatively impacts upon reproductive processes. Oocyte DNA repair capacity is one of the cues to understanding embryo...

journal_title：Molecular human reproduction

authors： El-Mouatassim S,Bilotto S,Russo GL,Tosti E,Menezo Y

更新日期：2007-08-01 00:00:00

abstract：:Analysis of small numbers of chromosomes using interphase fluorescent in-situ hybridization (FISH) probes has revealed that 50% of human preimplantation embryos contain abnormal cells. Detection of high levels of mosaicism with so few probes has led some researchers to extrapolate that a full analysis of all 23 pairs ...

journal_title：Molecular human reproduction

authors： Wells D,Delhanty JD

更新日期：2000-11-01 00:00:00