当前位置： SCI文献检索 > MOLECULAR HUMAN REPRODUCTION期刊下所有文献 > Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility.

Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility.

Abstract：

:Successful embryo implantation depends on the quality of the embryo, as well as on the receptivity of the endometrium. The aim of this study was to investigate the endometrial gene expression profile in women with unexplained infertility in comparison with fertile controls at the time of embryo implantation in order to find potential predictive markers of uterine receptivity and to identify the molecular mechanisms of infertility. High-density oligonucleotide gene arrays, comprising 44 000 gene targets, were used to define the endometrial gene expression profile in infertile (n = 4) and fertile (n = 5) women during the mid-secretory phase (day LH + 7). Microarray results were validated using real-time PCR. Analyses of expression data were carried out using non-parametric methods. Hierarchical clustering and principal component analysis showed a clear distinction in endometrial gene expression between infertile and fertile women. In total we identified 145 significantly (>3-fold change) up-regulated and 115 down-regulated genes in infertile women versus controls. Via Database for Annotation, Visualization and Integrated Discovery functional analysis we detected a substantial number of dysregulated genes in the endometria of infertile women, involved in cellular localization (21.1%) and transport (18.8%) and transporter activity (13.1%) and with major localization in extracellular regions (19.2%). Ingenuity Pathways Analysis of the gene list showed dysregulation of gene pathways involved in leukocyte extravasation signalling, lipid metabolism and detoxification in the endometria of infertile women. In conclusion, endometrial gene expression in women with unexplained infertility at the time of embryo implantation is markedly different from that in fertile women. These results provide new information on genes and pathways that may have functional significance as regards to endometrial receptivity and subsequent embryo implantation.

journal_name

Mol Hum Reprod

journal_title

Molecular human reproduction

authors

Altmäe S,Martínez-Conejero JA,Salumets A,Simón C,Horcajadas JA,Stavreus-Evers A

doi

10.1093/molehr/gap102

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

178-87

issue

3

eissn

1360-9947

issn

1460-2407

pii

gap102

journal_volume

16

pub_type

杂志文章

相关文献

MOLECULAR HUMAN REPRODUCTION文献大全
  • Genetic risk factors for endometriosis near estrogen receptor 1 and coexpression of genes in this region in endometrium.

    abstract：:The etiology and pathogenesis of endometriosis are complex with both genetic and environmental factors contributing to disease risk. Genome-wide association studies (GWAS) have identified multiple signals in the estrogen receptor 1 (ESR1) region associated with endometriosis and other reproductive traits and diseases....

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gaaa082

    authors： Marla S,Mortlock S,Houshdaran S,Fung J,McKinnon B,Holdsworth-Carson SJ,Girling JE,Rogers PAW,Giudice LC,Montgomery GW

    更新日期：2021-01-22 00:00:00

  • Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility.

    abstract：:The DAZL (DAZ-like) gene is suggested to be an ancestral gene of the DAZ (deleted in azoospermia) gene on the Y chromosome, which is a strong candidate for the azoospermic factor. Recently, it has been reported that the T54A (Thr54-->Ala) polymorphism in exon 3 of the DAZL gene is associated with spermatogenic failure...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gah202

    authors： Yang XJ,Shinka T,Nozawa S,Yan HT,Yoshiike M,Umeno M,Sato Y,Chen G,Iwamoto T,Nakahori Y

    更新日期：2005-07-01 00:00:00

  • Sodium leak channel, non-selective contributes to the leak current in human myometrial smooth muscle cells from pregnant women.

    abstract：:Uterine contractions are tightly regulated by the electrical activity of myometrial smooth muscle cells (MSMCs). These cells require a depolarizing current to initiate Ca(2+) influx and induce contraction. Cationic leak channels, which permit a steady flow of cations into a cell, are known to cause membrane depolariza...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gav038

    authors： Reinl EL,Cabeza R,Gregory IA,Cahill AG,England SK

    更新日期：2015-10-01 00:00:00

  • Different regulation of oestrogen receptors alpha and beta in the human cervix at term pregnancy.

    abstract：:During pregnancy, a cervical connective tissue remodelling takes place, clinically recognized as softening, effacement and dilatation. The role of oestrogens and their receptors (ER) in this process is not clear. ERalpha is a ligand-activated transcription factor involved in many physiological processes. The identific...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/7.3.293

    authors： Wang H,Stjernholm Y,Ekman G,Eriksson H,Sahlin L

    更新日期：2001-03-01 00:00:00

  • The double-edged sword of the mammalian oocyte--advantages, drawbacks and approaches for basic and clinical analysis at the single cell level.

    abstract：:Oocytes are usually the largest cells in the body and as such offer unique opportunities for single-cell analysis. Unfortunately, these cells are also some of the rarest in the mammalian female, usually necessitating single-cell analysis. In cases of infertility in humans, determining the quality of the oocyte is ofte...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章,评审

    doi：10.1093/molehr/gav064

    authors： Brayboy LM,Wessel GM

    更新日期：2016-03-01 00:00:00

  • Apoptotic gene expression in potentially fertile and subfertile men.

    abstract：:Human sperm contain similar amounts of protamine-1 (P1) and protamine-2 (P2). Although an aberrant protamine ratio have been observed in subfertile men, functional evidence is provided by protamine knockout mice exhibiting male infertility. As sperm DNA integrity is known to be linked with DNA fragmentation and apopto...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gar011

    authors： Cavalcanti MC,Steilmann C,Failing K,Bergmann M,Kliesch S,Weidner W,Steger K

    更新日期：2011-07-01 00:00:00

  • Asthenoteratozoospermia in mice lacking testis expressed gene 18 (Tex18).

    abstract：:Testis expressed gene 18 (Tex18) is a small gene with one exon of 240 bp, which is specifically expressed in male germ cells. The gene encodes for a protein of 80 amino acids with unknown domain. To investigate the function of (Tex18) gene, we generated mice with targeted disruption of the (Tex18) gene by homologous r...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gal107

    authors： Jaroszynski L,Dev A,Li M,Meinhardt A,de Rooij DG,Mueller C,Böhm D,Wolf S,Adham IM,Wulf G,Engel W,Nayernia K

    更新日期：2007-03-01 00:00:00

  • Large scale validation of human N-myc downstream-regulated gene (NDRG)-1 expression in endometrium during the menstrual cycle.

    abstract：:A major challenge in the comprehension of the endometrial transformations leading to the completion of each menstrual cycle in humans is in the identification of specific molecular pathways underlying these monthly turnovers. Towards this goal we compared, by the differential display technique, the relative expression...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gag084

    authors： Malette B,Cherry E,Lagacé M,Bernard M,Gosselin D,Hugo P,Shazand K

    更新日期：2003-11-01 00:00:00

  • Involvement of protein kinases in platelet activating factor-induced acrosome reaction of human spermatozoa.

    abstract：:The involvement of protein kinases in platelet activating factor (PAF)-induced acrosome reaction of human spermatozoa was investigated using specific inhibitors of protein kinase A (PKA), protein kinase C (PKC) and protein tyrosine kinase (PTK). PAF (10(-9)-10(-11) M) treatment of spermatozoa enhanced the acrosome rea...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/2.6.401

    authors： Sengoku K,Tamate K,Takuma N,Takaoka Y,Yoshida T,Nishiwaki K,Ishikawa M

    更新日期：1996-06-01 00:00:00

  • Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium.

    abstract：:We have previously shown that the estrogen responsiveness of the human lactoferrin gene in a transient transfection system is mediated through an imperfect estrogen response element (ERE) and a steroidogenic factor 1 binding element (SFRE) 26 bp upstream from ERE. Reporter constructs containing SFRE and ERE respond to...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/8.1.58

    authors： Teng CT,Gladwell W,Beard C,Walmer D,Teng CS,Brenner R

    更新日期：2002-01-01 00:00:00

  • Effects of SAPK/JNK inhibitors on preimplantation mouse embryo development are influenced greatly by the amount of stress induced by the media.

    abstract：:Stress-activated protein kinase/c-Jun kinase (SAPK/JNK) is thought to be necessary for preimplantation embryonic development (Maekawa et al., 2005). However, media increases SAPK/JNK phosphorylation and these levels negatively correlate with embryonic development (Wang et al., 2005). Culture-induced stress could confu...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gal021

    authors： Xie Y,Puscheck EE,Rappolee DA

    更新日期：2006-04-01 00:00:00

  • MicroRNA mimics that target the placental renin-angiotensin system inhibit trophoblast proliferation.

    abstract：:In early gestation, the human placental renin-angiotensin system (RAS) is upregulated and plays a role in placental development. Among other functions, signalling through the angiotensin II type 1 receptor (AT1R) initiates proliferation. Many microRNAs (miRNAs) targeting placental RAS mRNAs are downregulated at this t...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gaz010

    authors： Arthurs AL,Lumbers ER,Pringle KG

    更新日期：2019-04-01 00:00:00

  • High concentrations of inhibin A and inhibin B in ovarian serous cystadenoma: relationship with oestradiol and nitric oxide metabolites.

    abstract：:Inhibin production has been demonstrated in malignant epithelial ovarian tumours, but secretion of inhibins by benign cystadenoma has not yet been reported. The present study evaluated the concentrations of inhibin A and inhibin B and the relationship with oestradiol and nitric oxide metabolites in fluid collected fro...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/6.12.1079

    authors： Reis FM,Faletti A,Luisi S,Bifulco G,Cauci S,Quadrifoglio F,Dor J,Petraglia F

    更新日期：2000-12-01 00:00:00

  • Expansion of human trophoblastic spheroids is promoted by decidualized endometrial stromal cells and enhanced by heparin-binding epidermal growth factor-like growth factor and interleukin-1 β.

    abstract：:Successful pregnancy in humans depends on deep invasion of the maternal decidua by extravillous trophoblast cells (EVTs), a process regulated by autocrine and paracrine signals in the decidual-trophoblast microenvironment. Here we examined whether trophoblast invasion is affected by decidual differentiation of endomet...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gar015

    authors： Gonzalez M,Neufeld J,Reimann K,Wittmann S,Samalecos A,Wolf A,Bamberger AM,Gellersen B

    更新日期：2011-07-01 00:00:00

  • Expression of endothelial and inducible nitric oxide synthase in non-pregnant and decidualized human endometrium.

    abstract：:Immunocytochemistry was used to localize endothelial (eNOS) and inducible (iNOS) nitric oxide synthase in human uterine tissues collected at various stages of the menstrual cycle, after exposure to exogenous progestagens, and in early pregnancy. Endothelial NOS-like immunoreactivity was detected in all specimens in en...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/3.1.69

    authors： Telfer JF,Irvine GA,Kohnen G,Campbell S,Cameron IT

    更新日期：1997-01-01 00:00:00

  • Isolation and gene expression analysis of single potential human spermatogonial stem cells.

    abstract：STUDY HYPOTHESIS:It is possible to isolate pure populations of single potential human spermatogonial stem cells without somatic contamination for down-stream applications, for example cell culture and gene expression analysis. STUDY FINDING:We isolated pure populations of single potential human spermatogonial stem cel...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gaw006

    authors： von Kopylow K,Schulze W,Salzbrunn A,Spiess AN

    更新日期：2016-04-01 00:00:00

  • Interleukin-1beta stimulates placental leucine aminopeptidase/oxytocinase expression in BeWo choriocarcinoma cells.

    abstract：:In addition to prostaglandins, inflammatory cytokines induce uterine contraction via oxytocin (OT). Placental leucine aminopeptidase (P-LAP), an oxytocinase that is identical to cystine aminopeptidase, destroys OT activity. Patients with spontaneous preterm delivery have higher concentrations of inflammatory cytokines...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gag015

    authors： Ikoma Y,Nomura S,Ito T,Katsumata Y,Nakata M,Iwanaga K,Okada M,Kikkawa F,Tamakoshi K,Nagasaka T,Tsujimoto M,Mizutani S

    更新日期：2003-02-01 00:00:00

  • Successful reversal of ovarian hyperstimulation syndrome in a mouse model by rapamycin, an mTOR pathway inhibitor.

    abstract：:Ovarian hyperstimulation syndrome (OHSS) is a potentially life-threatening, iatrogenic complication of ovarian stimulation in assisted reproduction technology. This complex syndrome is characterised by enlarged ovaries with multiple corpora luteum, elevated sex steroid hormones in serum and increased capillary permeab...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gaz033

    authors： Liu W,Zhang C,Wang L,Huang X,Zhang J,He Y,Chen L,Li J

    更新日期：2019-08-01 00:00:00

  • Induction of superoxide dismutase by decidualization in human endometrial stromal cells.

    abstract：:The present study was undertaken to investigate the effect of decidualization on superoxide dismutase (SOD) expression in human endometrial stromal cells (ESC). To induce decidualization, isolated ESC were incubated with medroxyprogesterone acetate (MPA, 10(-6) mol/l) and oestradiol (10(-8) mol/l) for 23 days. Insulin...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/6.2.178

    authors： Sugino N,Kashida S,Takiguchi S,Nakamura Y,Kato H

    更新日期：2000-02-01 00:00:00

  • Pregnancy after preimplantation genetic diagnosis for Charcot-Marie-Tooth disease type 1A.

    abstract：:Charcot-Marie-Tooth (CMT) disease type 1A is an autosomal dominant peripheral neuropathy characterized by slow progressive distal muscle wasting and weakness, and decreased nerve conduction velocities. Most CMT1A cases (>98%) are caused by a duplication of a 1.5 Mb region on the short arm of chromosome 17 containing t...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/4.10.978

    authors： De Vos A,Sermon K,Van de Velde H,Joris H,Vandervorst M,Lissens W,Mortier G,De Sutter P,Löfgren A,Van Broeckhoven C,Liebaers I,Van Steirteghem A

    更新日期：1998-10-01 00:00:00

  • Glutathione S-transferase M1*null genotype but not myeloperoxidase promoter G-463A polymorphism is associated with higher susceptibility to endometriosis.

    abstract：:Glutathione S-transferase M1 (GSTM1), one member of the GST family, is responsible for metabolism of xenobiotics and carcinogens. Myeloperoxidase (MPO) plays an important role in the oxidation and activation of carcinogens and nitric oxide. Allelic variants of GSTM1 and MPO gene polymorphisms might impair detoxificati...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gah095

    authors： Hsieh YY,Chang CC,Tsai FJ,Lin CC,Chen JM,Tsai CH

    更新日期：2004-10-01 00:00:00

  • Recombinant expression and affinity purification of a novel epididymal human sperm-binding protein, BSPH1.

    abstract：:Mammalian sperm undergo a series of maturation steps before acquiring fertilization competence. Our previous work demonstrated the importance of binder of sperm (BSP) proteins in bovine sperm capacitation. Recent studies identified a BSP-homologous DNA sequence in the human genome (BSPH1) and mRNA expression in the ep...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gan077

    authors： Lefebvre J,Boileau G,Manjunath P

    更新日期：2009-02-01 00:00:00

  • A molecular evaluation of germ cell death induced by etoposide in pubertal rat testes.

    abstract：:Etoposide is widely used in the treatment of patients with testicular cancer. The mechanism underlying apoptosis induction in cancer cells has been studied in different cell types, but it is not known whether the same factors participate in viable germ cells undergoing programmed cell death. Since testicular cancer pr...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gap024

    authors： Ortiz RJ,Lizama C,Codelia VA,Moreno RD

    更新日期：2009-06-01 00:00:00

  • Chromosomal translocations affecting 12q14-15 but not deletions of the long arm of chromosome 7 associated with a growth advantage of uterine smooth muscle cells.

    abstract：:Cytogenetically, uterine leiomyomata are the best investigated human tumours. The most frequent clonal abnormalities are structural rearrangements involving 12q14-15 and deletions of part of the long arm of chromosome 7. The present study investigated a possible growth advantage conferred by these abnormalities, when ...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/5.12.1150

    authors： Hennig Y,Deichert U,Bonk U,Thode B,Bartnitzke S,Bullerdiek J

    更新日期：1999-12-01 00:00:00

  • Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.

    abstract：:We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases of globozoospermia were associated with DNA alterations, suggesting that DPY19L2-dependent globozoospermia may be associated with poor DNA quality. However the origins of such defects have no...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gau099

    authors： Yassine S,Escoffier J,Martinez G,Coutton C,Karaouzène T,Zouari R,Ravanat JL,Metzler-Guillemain C,Lee HC,Fissore R,Hennebicq S,Ray PF,Arnoult C

    更新日期：2015-02-01 00:00:00

  • Contributions of the actin cytoskeleton to the emergence of polarity during maturation in human oocytes.

    abstract：:In mature mammalian oocytes, cortical f-actin distribution is polarized, as evidenced by a prominent cap subtended by the metaphase II (MII) spindle. Formation of a polarized actin cap is a consequence of a complex actomyosin-driven contractile process that directs polar body extrusion. Human mature oocytes also displ...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gat085

    authors： Coticchio G,Guglielmo MC,Albertini DF,Dal Canto M,Mignini Renzini M,De Ponti E,Fadini R

    更新日期：2014-03-01 00:00:00

  • Reprogramming with defined factors: from induced pluripotency to induced transdifferentiation.

    abstract：:Ever since work on pluripotency induction was originally published, reporting the reprogramming of somatic cells to induced pluripotent stem cells (iPS cells) by the ectopic expression of the four transcription factors Oct4, Sox2, Klf4 and c-Myc, high expectations regarding their potential use for regenerative medicin...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章,评审

    doi：10.1093/molehr/gaq059

    authors： Masip M,Veiga A,Izpisúa Belmonte JC,Simón C

    更新日期：2010-11-01 00:00:00

  • Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence.

    abstract：STUDY QUESTION:Can RNA sequencing of human cumulus cells (CC) reveal molecular pathways involved in the physiology of reproductive aging? STUDY FINDING:Senescent but not young CC activate gene pathways associated with hypoxia and oxidative stress. WHAT IS KNOWN ALREADY:Shifts in socioeconomic norms are resulting in l...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gaw038

    authors： Molinari E,Bar H,Pyle AM,Patrizio P

    更新日期：2016-08-01 00:00:00

  • Sperm fucosyltransferase-5 mediates spermatozoa-oviductal epithelial cell interaction to protect human spermatozoa from oxidative damage.

    abstract：:Oxidative damage by reactive oxygen species (ROS) is a major cause of sperm dysfunction. Excessive ROS generation reduces fertilization and enhances DNA damage of spermatozoa. Interaction between spermatozoa and oviductal epithelial cells improves the fertilizing ability of and reduces chromatin damage in spermatozoa....

    journal_title：Molecular human reproduction

    pub_type： 杂志文章

    doi：10.1093/molehr/gav015

    authors： Huang VW,Lee CL,Lee YL,Lam KK,Ko JK,Yeung WS,Ho PC,Chiu PC

    更新日期：2015-06-01 00:00:00

  • Sex-related physiology of the preimplantation embryo.

    abstract：:Male and female preimplantation mammalian embryos differ not only in their chromosomal complement, but in their proteome and subsequent metabolome. This phenomenon is due to a finite period during preimplantation development when both X chromosomes are active, between embryonic genome activation and X chromosome inact...

    journal_title：Molecular human reproduction

    pub_type： 杂志文章,评审

    doi：10.1093/molehr/gaq042

    authors： Gardner DK,Larman MG,Thouas GA

    更新日期：2010-08-01 00:00:00