Abstract:
:Cytogenetically, uterine leiomyomata are the best investigated human tumours. The most frequent clonal abnormalities are structural rearrangements involving 12q14-15 and deletions of part of the long arm of chromosome 7. The present study investigated a possible growth advantage conferred by these abnormalities, when compared with myomata having an apparently normal karyotype. A total of 155 myomata were included in the study. All samples were obtained after hysterectomy enabling karyotype analysis of all detectable tumours. Myomata with clonal chromosome abnormalities were significantly larger than those with a normal karyotype (6.8 +/- 5.3 versus 3.4 +/- 2.1 cm; P < 0.001). However, when differentiating between the two main aberrations, this was found to be true for the myomata with 12q14-15 changes affecting the high mobility group protein IC (HMGIC) gene (8.9 +/- 5.6 cm), but not for the group of tumours characterized by deletions of chromosome 7 (3.5 +/- 2.0 cm). The results are compatible with the hypothesis that myomata develop due to an unknown event, whereas the chromosomal abnormalities act as secondary changes, with those affecting the HMGIC gene increasing the growth potential of the corresponding tumours.
journal_name
Mol Hum Reprodjournal_title
Molecular human reproductionauthors
Hennig Y,Deichert U,Bonk U,Thode B,Bartnitzke S,Bullerdiek Jdoi
10.1093/molehr/5.12.1150subject
Has Abstractpub_date
1999-12-01 00:00:00pages
1150-4issue
12eissn
1360-9947issn
1460-2407journal_volume
5pub_type
杂志文章abstract::The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptid...
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更新日期:2014-09-01 00:00:00
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更新日期:2017-07-01 00:00:00
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更新日期:1997-08-01 00:00:00
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更新日期:2000-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1998-08-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
doi:10.1093/molehr/gah095
更新日期:2004-10-01 00:00:00
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