Abstract:
:Preimplantation development shifts from a maternal to embryonic programme rapidly after fertilization. Although the majority of oogenetic products are lost during the maternal to embryonic transition (MET), several do survive this interval to contribute directly to supporting preimplantation development. Embryonic genome activation (EGA) is characterized by the transient expression of several genes that are necessary for MET, and while EGA represents the first major wave of gene expression, a second mid-preimplantation wave of transcription that supports development to the blastocyst stage has been discovered. The application of genomic approaches has greatly assisted in the discovery of stage specific gene expression patterns and the challenge now is to largely define gene function and regulation during preimplantation development. The basic mechanisms controlling compaction, lineage specification and blastocyst formation are defined. The requirement for embryo culture has revealed plasticity in the developmental programme that may exceed the adaptive capacity of the embryo and has fostered important research directions aimed at alleviating culture-induced changes in embryonic programming. New levels of regulation are emerging and greater insight into the roles played by RNA-binding proteins and miRNAs is required. All of this research is relevant due to the necessity to produce healthy preimplantation embryos for embryo transfer, to ensure that assisted reproductive technologies are applied in the most efficient and safest way possible.
journal_name
Mol Hum Reprodjournal_title
Molecular human reproductionauthors
Bell CE,Calder MD,Watson AJdoi
10.1093/molehr/gan063subject
Has Abstractpub_date
2008-12-01 00:00:00pages
691-701issue
12eissn
1360-9947issn
1460-2407pii
gan063journal_volume
14pub_type
杂志文章abstract::Intense macrophage infiltration is observed during luteolysis in various animals including women; however, we still do not know how macrophage infiltration into the human corpus luteum (CL) during luteolysis is regulated. In this study, we examined the expression, localization and regulation of an important chemokine ...
journal_title:Molecular human reproduction
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pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Molecular human reproduction
pub_type: 杂志文章
doi:10.1093/molehr/gat005
更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/molehr/7.10.913
更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/molehr/gam069
更新日期:2007-11-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
doi:10.1093/molehr/gax028
更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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doi:10.1093/molehr/gax067
更新日期:2018-02-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
doi:10.1093/molehr/gah017
更新日期:2004-02-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
doi:10.1093/molehr/8.10.912
更新日期:2002-10-01 00:00:00
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更新日期:2001-02-01 00:00:00
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更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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更新日期:2017-09-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
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更新日期:2001-08-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
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更新日期:1998-07-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
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更新日期:2019-11-30 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
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更新日期:2008-02-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章,评审
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更新日期:2004-01-01 00:00:00
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更新日期:2014-04-01 00:00:00
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journal_title:Molecular human reproduction
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00