Turning it on and off: M-phase promoting factor during meiotic maturation and fertilization.

Abstract:

:Maturation (M-phase) promoting factor (MPF) plays a pivotal role in oocytes during their maturation. This review concentrates on its function at three important time-points. First, its activation during meiotic progression from prophase I arrest at germinal vesicle breakdown. Second, its role during the transition from meiosis I to meiosis II, a defining feature of meiosis involving segregation of homologous chromosomes. Third, maintenance of its activity at metaphase II arrest and the necessity for its destruction during oocyte activation. An understanding of how oocytes switch it on and turn it off underpins much of the basic cell biology of oocyte maturation.

journal_name

Mol Hum Reprod

authors

Jones KT

doi

10.1093/molehr/gah009

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

1-5

issue

1

eissn

1360-9947

issn

1460-2407

journal_volume

10

pub_type

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