Quantitative measurement of transcript levels throughout human preimplantation development: analysis of hypoxanthine phosphoribosyl transferase.

abstract：:Granzyme B (graB) plays a pivotal role in cytotoxic lymphocyte granule-mediated apoptosis through cleavage of intracellular proteins in target cells. Proteinase inhibitor-9 (PI-9) is a potent inhibitor of graB and is highly expressed in cytotoxic lymphocytes. Here, we show by immunohistochemistry that PI-9 is also abu...

journal_title：Molecular human reproduction

authors： Hirst CE,Buzza MS,Sutton VR,Trapani JA,Loveland KL,Bird PI

更新日期：2001-12-01 00:00:00

abstract：:The aim of the present study was to investigate the potential role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS)-induced preterm delivery. Intraperitoneal injection of LPS in the presence or absence of previous TLR4 blockade was performed to establish a murine model of preterm delivery. The incidences of ...

journal_title：Molecular human reproduction

authors： Li L,Kang J,Lei W

更新日期：2010-04-01 00:00:00

abstract：:We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases of globozoospermia were associated with DNA alterations, suggesting that DPY19L2-dependent globozoospermia may be associated with poor DNA quality. However the origins of such defects have no...

journal_title：Molecular human reproduction

authors： Yassine S,Escoffier J,Martinez G,Coutton C,Karaouzène T,Zouari R,Ravanat JL,Metzler-Guillemain C,Lee HC,Fissore R,Hennebicq S,Ray PF,Arnoult C

更新日期：2015-02-01 00:00:00

abstract：:Uterine contractions are tightly regulated by the electrical activity of myometrial smooth muscle cells (MSMCs). These cells require a depolarizing current to initiate Ca(2+) influx and induce contraction. Cationic leak channels, which permit a steady flow of cations into a cell, are known to cause membrane depolariza...

journal_title：Molecular human reproduction

authors： Reinl EL,Cabeza R,Gregory IA,Cahill AG,England SK

更新日期：2015-10-01 00:00:00

abstract：:Placental trophoblast cells are unique endocrine cells that play vital roles during the processes of embryonic implantation and placentation. However, research into the function of human trophoblast has been largely restrained mainly due to a lack of adequate cell models. A normal placenta-origin cytotrophoblast cell ...

journal_title：Molecular human reproduction

authors： Wang YL,Qiu W,Feng HC,Li YX,Zhuang LZ,Wang Z,Liu Y,Zhou JQ,Zhang DH,Tsao GS

更新日期：2006-07-01 00:00:00

abstract：:Microarray studies generating lists of genes with altered expression in placentas from pregnancies complicated with pre-eclampsia (PE) have so far been published in several different studies. Working under the assumption that altered gene expression in PE may be the result of altered expression of regulatory transcrip...

journal_title：Molecular human reproduction

authors： Vásárhelyi B,Cseh A,Kocsis I,Treszl A,Györffy B,Rigó J Jr

更新日期：2006-01-01 00:00:00

abstract：:Success rate in human pregnancies is believed to be very low and sex-specific mechanisms may operate in prenatal loss. Assuming a sex-differential in prenatal loss exists, we examined genetic markers in biologically plausible targets in the HLA complex, other immune system-related and iron-regulatory genes in 388 heal...

journal_title：Molecular human reproduction

authors： Ucisik-Akkaya E,Davis CF,Do TN,Morrison BA,Stemmer SM,Amadio WJ,Dorak MT

更新日期：2010-10-01 00:00:00

abstract：:In mammals, egg activation is initiated by multiple cytosolic Ca(2+) transients (Ca(2+) oscillations) that are triggered following delivery of a putative sperm factor from the fertilizing sperm. The identity of this 'sperm factor' thus holds much significance, not only as a vital component in creating a new life, but ...

journal_title：Molecular human reproduction

authors： Kashir J,Nomikos M,Swann K,Lai FA

更新日期：2015-05-01 00:00:00

abstract：:Preimplantation factor (PIF) is detected in the serum of women shortly after fertilization; its origin, however, has not been established. In this study, the embryonal origin of PIF was investigated and partial characterization of the factor was carried out. Culture media from viable human 2-8-cell stage embryos and m...

journal_title：Molecular human reproduction

authors： Roussev RG,Coulam CB,Kaider BD,Yarkoni M,Leavis PC,Barnea ER

更新日期：1996-11-01 00:00:00

abstract：:During folliculogenesis, the gonadotrophin (GTH)-dependent phase begins at the small antral follicle stage and ends with Graafian follicles. In this study, pregnant mare's serum GTH was used to induce GTH-dependent folliculogenesis in mice, following which the developmental events that follicles undergo, as well as th...

journal_title：Molecular human reproduction

authors： Chen Y,Wang X,Yang C,Liu Q,Ran Z,Li X,He C

更新日期：2020-12-10 00:00:00

abstract：:Human pregnancy represents a situation of semiallograft to maternal host. Therefore, it has been reported that tolerance to the fetal allograft represents a mechanism for maintaining a pregnancy. CD4(+)CD25(bright) regulatory T cells are known to play an important role in the development and maintenance of tolerance i...

journal_title：Molecular human reproduction

authors： Sasaki Y,Sakai M,Miyazaki S,Higuma S,Shiozaki A,Saito S

更新日期：2004-05-01 00:00:00

abstract：:We have previously reported that endometrial expression of matrix metalloproteinase (MMP)-26 mRNA comes to a maximum in the early secretory phase. Since tissue inhibitor of metalloproteinase (TIMP)-4 is a potent inhibitor of MMP-26, the objective of this study was to identify the pattern of TIMP-4 mRNA expression in t...

journal_title：Molecular human reproduction

authors： Pilka R,Domanski H,Hansson S,Eriksson P,Casslén B

更新日期：2004-09-01 00:00:00

abstract：:We have investigated the possible roles of oncostatin M (OSM), which is a member of the interleukin-6 family of cytokines, in endometrial and endometriotic stromal cell growth. Endometrial and endometriotic stromal cells were collected from the uterus or ovarian chocolate cysts. We observed the expression of mRNA tran...

journal_title：Molecular human reproduction

authors： Ohata Y,Harada T,Fujii A,Yoshida S,Iwabe T,Terakawa N

更新日期：2001-07-01 00:00:00

abstract：:Charcot-Marie-Tooth (CMT) disease type 1A is an autosomal dominant peripheral neuropathy characterized by slow progressive distal muscle wasting and weakness, and decreased nerve conduction velocities. Most CMT1A cases (>98%) are caused by a duplication of a 1.5 Mb region on the short arm of chromosome 17 containing t...

journal_title：Molecular human reproduction

authors： De Vos A,Sermon K,Van de Velde H,Joris H,Vandervorst M,Lissens W,Mortier G,De Sutter P,Löfgren A,Van Broeckhoven C,Liebaers I,Van Steirteghem A

更新日期：1998-10-01 00:00:00

abstract：:An understanding of the relationship between nuclear morphology and DNA function is important in cytology and preimplantation diagnosis. In this study, direct polymerase chain reaction (PCR) amplification was used to diagnose the common delta F508 mutation of cystic fibrosis in 62 biopsied human embryo cells. The nucl...

journal_title：Molecular human reproduction

authors： Cui KH,Matthews CD

更新日期：1996-01-01 00:00:00

abstract：:The androgen receptor (AR) gene is located on the X chromosome and contains a polymorphic CAG tract. CAG repeat expansions in the AR have been associated with male infertility and the neuromuscular disease, spinal bulbar muscular atrophy (SBMA). Based on Mendelian inheritance patterns, moderate CAG expansions in infer...

journal_title：Molecular human reproduction

authors： Cram DS,Song B,McLachlan RI,Trounson AO

更新日期：2000-09-01 00:00:00

abstract：:Retrograde flow of menstrual blood cells during menstruation is considered as the dominant theory for the development of endometriosis. Moreover, current evidence suggests that endometrial-derived stem cells are key players in the pathogenesis of endometriosis. In particular, endometrial stromal stem cells have been s...

journal_title：Molecular human reproduction

authors： Nikoo S,Ebtekar M,Jeddi-Tehrani M,Shervin A,Bozorgmehr M,Vafaei S,Kazemnejad S,Zarnani AH

更新日期：2014-09-01 00:00:00

abstract：:The identification of polymorphisms in genes encoding proinflammatory cytokines that affect transcription or the secretion rate has opened new ways to understand the variation in responses to infection during pregnancy. In this study, human amniochorion carrying hyper-responsive alleles of tumour necrosis factor-alpha...

journal_title：Molecular human reproduction

authors： Hernandez-Guerrero C,Monzon-Bordonaba F,Jimenez-Zamudio L,Ahued-Ahued R,Arechavaleta-Velasco F,Strauss JF 3rd,Vadillo-Ortega F

更新日期：2003-10-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a genomic disorder mostly caused by deletions of 15q11-q13 region (70%). It has been suggested that the particular genomic architecture of 15q11-q13 region, characterized to be flanked by low copy repeats, could predispose it to Non-Allelic Homologous Recombination (NAHR). However, no st...

journal_title：Molecular human reproduction

authors： Molina O,Blanco J,Vidal F

更新日期：2010-05-01 00:00:00

abstract：:In recent years, the impact of sperm DNA damage on fertility has become an important issue. The different technologies developed to check sperm DNA fragmentation lead to the same conclusion: DNA damage negatively impacts upon reproductive processes. Oocyte DNA repair capacity is one of the cues to understanding embryo...

journal_title：Molecular human reproduction

authors： El-Mouatassim S,Bilotto S,Russo GL,Tosti E,Menezo Y

更新日期：2007-08-01 00:00:00

abstract：:The requisite endpoint of mammalian oocyte maturation, whether in vivo or in vitro, is a metaphase II oocyte which is able to be fertilized and which can eventually support normal embryonic development. Oocytes which have been matured in vivo basically fulfill these criteria. On the other hand, a completely different ...

journal_title：Molecular human reproduction

authors： Fulka J Jr,First NL,Moor RM

更新日期：1998-01-01 00:00:00

abstract：:This study was initiated to determine the relationship between the fertilizing potential of spermatozoa and abnormalities in the compact packing of their chromatin which occurs in the final stage of male germ cell differentiation. Chromatin packing involves disulphide bridge covalent cross-linking. The degree of packi...

journal_title：Molecular human reproduction

authors： Filatov MV,Semenova EV,Vorob'eva OA,Leont'eva OA,Drobchenko EA

更新日期：1999-09-01 00:00:00

abstract：:This study was undertaken to evaluate the effects of gamma-aminobutyric acid (GABA) and GABAergic agonists and antagonists on sperm kinematic parameters and hyperactivation, evaluated by a computer-assisted semen analysis (CASA) system, and intracellular cAMP content in 22 normozoospermic semen samples. Because of the...

journal_title：Molecular human reproduction

authors： Calogero AE,Hall J,Fishel S,Green S,Hunter A,D'Agata R

更新日期：1996-10-01 00:00:00

abstract：:Inhibin production has been demonstrated in malignant epithelial ovarian tumours, but secretion of inhibins by benign cystadenoma has not yet been reported. The present study evaluated the concentrations of inhibin A and inhibin B and the relationship with oestradiol and nitric oxide metabolites in fluid collected fro...

journal_title：Molecular human reproduction

authors： Reis FM,Faletti A,Luisi S,Bifulco G,Cauci S,Quadrifoglio F,Dor J,Petraglia F

更新日期：2000-12-01 00:00:00

abstract：:Human endometrium is the major organ that produces glycodelin A (GdA). The production of endometrial GdA causes a fluctuation of the peripheral glycodelin concentrations in women during the menstrual cycle and pregnancy. It has recently been reported that the rise of plasma concentrations of glycodelin is correlated w...

journal_title：Molecular human reproduction

authors： Tseng L,Zhu HH,Mazella J,Koistinen H,Seppälä M

更新日期：1999-04-01 00:00:00

abstract：:In early gestation, the human placental renin-angiotensin system (RAS) is upregulated and plays a role in placental development. Among other functions, signalling through the angiotensin II type 1 receptor (AT1R) initiates proliferation. Many microRNAs (miRNAs) targeting placental RAS mRNAs are downregulated at this t...

journal_title：Molecular human reproduction

authors： Arthurs AL,Lumbers ER,Pringle KG

更新日期：2019-04-01 00:00:00

abstract：:Embryo implantation and subsequent decidualization, trophoblast invasion and formation of a functional placenta are crucial for establishment and maintenance of pregnancy. Interleukin-11 signalling has been shown to be obligatory for adequate decidualization and trophoblast invasion in mice. Defects in IL-11 signallin...

journal_title：Molecular human reproduction

authors： von Rango U,Alfer J,Kertschanska S,Kemp B,Müller-Newen G,Heinrich PC,Beier HM,Classen-Linke I

更新日期：2004-11-01 00:00:00

abstract：:Recent data demonstrated that CD4+CD25+ regulatory T (Treg) cells and an enzyme called indoleamine 2,3-dioxygenase (IDO) mediate maternal tolerance to the fetus. Interestingly, Treg cells express the CTLA-4 molecule on their surface, and B7 (CD80/86) ligation by CTLA-4 enhanced IDO activity of dendritic cells (DCs) an...

journal_title：Molecular human reproduction

authors： Miwa N,Hayakawa S,Miyazaki S,Myojo S,Sasaki Y,Sakai M,Takikawa O,Saito S

更新日期：2005-12-01 00:00:00

abstract：:In oocytes, cytoplasmic 3' polyadenylation regulates translational activation of dormant mRNA during meiotic maturation. Thus exogenous proteins are hardly expressed after injection of conventional RNA. To circumvent this, we synthesized a long polyadenylated (approximately 250 A) tail to encode RNA with an enhanced y...

journal_title：Molecular human reproduction

authors： Aida T,Oda S,Awaji T,Yoshida K,Miyazaki S

更新日期：2001-11-01 00:00:00

abstract：STUDY QUESTION:Can RNA sequencing of human cumulus cells (CC) reveal molecular pathways involved in the physiology of reproductive aging? STUDY FINDING:Senescent but not young CC activate gene pathways associated with hypoxia and oxidative stress. WHAT IS KNOWN ALREADY:Shifts in socioeconomic norms are resulting in l...

journal_title：Molecular human reproduction

authors： Molinari E,Bar H,Pyle AM,Patrizio P

更新日期：2016-08-01 00:00:00