Internal carbohydrate complexity of the oligosaccharide chains of recombinant human follicle stimulating hormone (Puregon, Org 32489): a comparison with Metrodin and Metrodin-HP.

abstract：:The androgen receptor (AR) gene is located on the X chromosome and contains a polymorphic CAG tract. CAG repeat expansions in the AR have been associated with male infertility and the neuromuscular disease, spinal bulbar muscular atrophy (SBMA). Based on Mendelian inheritance patterns, moderate CAG expansions in infer...

journal_title：Molecular human reproduction

authors： Cram DS,Song B,McLachlan RI,Trounson AO

更新日期：2000-09-01 00:00:00

abstract：:Maturation (M-phase) promoting factor (MPF) plays a pivotal role in oocytes during their maturation. This review concentrates on its function at three important time-points. First, its activation during meiotic progression from prophase I arrest at germinal vesicle breakdown. Second, its role during the transition fro...

journal_title：Molecular human reproduction

authors： Jones KT

更新日期：2004-01-01 00:00:00

abstract：:Recombinant human ZP3 (rhuZP3) generated by Chinese hamster ovary cells transfected with a plasmid containing human ZP3 cDNA was used to study the acrosome reaction (AR) and intracellular calcium fluxes in capacitated human spermatozoa. Conditioned medium containing rhuZP3 significantly induced the AR (P < or = 0.005)...

journal_title：Molecular human reproduction

authors： Brewis IA,Clayton R,Barratt CL,Hornby DP,Moore HD

更新日期：1996-08-01 00:00:00

abstract：:Follicular prostaglandin concentrations increase following the gonadotrophin surge in domestic animals and rodents approximately 10 h before follicle rupture, suggesting a unifying role for prostaglandins in the timing of ovulation. However, little is known about prostaglandin production by the primate ovulatory folli...

journal_title：Molecular human reproduction

authors： Duffy DM,Stouffer RL

更新日期：2001-08-01 00:00:00

abstract：:This study assesses the role of progesterone receptor membrane component 1 (PGRMC1) in actions of progesterone (P4) on human myometrium during pregnancy and labour. Myometrial tissues were obtained from non-pregnant patients during hysterectomy or pregnant women undergoing C-section at term and preterm, before and dur...

journal_title：Molecular human reproduction

authors： Wu W,Shi SQ,Huang HJ,Balducci J,Garfield RE

更新日期：2011-04-01 00:00:00

abstract：:The spindle assembly checkpoint modulates the timing of anaphase initiation in response to the improper alignment of chromosomes at the metaphase plate. If defects are detected, a signal is transduced to halt further progression of the cell cycle until correct bipolar attachment to the spindle is achieved. The mitotic...

journal_title：Molecular human reproduction

authors： Steuerwald N,Cohen J,Herrera RJ,Sandalinas M,Brenner CA

更新日期：2001-01-01 00:00:00

abstract：:We have entered a new era of genomics in biomedical research with the availability of genome-wide sequences and expression data, resulting in the identification of a huge number of novel reproductive genes. The challenge we are facing today is how to determine the function of those novel and known genes and their role...

journal_title：Molecular human reproduction

authors： Lee T,Shah C,Xu EY

更新日期：2007-11-01 00:00:00

abstract：Study Question:Can endometrial mesenchymal stromal cells (E-MSCs) differentiate into endothelial cells in an in vitro co-culture system with human umbilical vein endothelial cells (HUVECs)? Summary Answer:E-MSCs can acquire endothelial markers and function in a direct co-culture system with HUVECs. What is Known Alre...

journal_title：Molecular human reproduction

authors： Canosa S,Moggio A,Brossa A,Pittatore G,Marchino GL,Leoncini S,Benedetto C,Revelli A,Bussolati B

更新日期：2017-03-01 00:00:00

abstract：:Charcot-Marie-Tooth (CMT) disease is the 'common' name for a range of hereditary peripheral neuropathies. CMT1 is the most common form and is transmitted in an autosomal dominant manner. CMT1A maps to chromosome 17p11.2 and is caused, in the majority of cases, by a 1.5 Mb DNA duplication, that includes the peripheral ...

journal_title：Molecular human reproduction

authors： De Vos A,Sermon K,De Rijcke M,Goossens V,Henderix P,Van Ranst N,Platteau P,Lissens W,Devroey P,Van Steirteghem A,Liebaers I

更新日期：2003-07-01 00:00:00

abstract：:The endometrium plays a key role in reproduction, and this function is tightly regulated by endogenous and xenobiotic steroids. Sulphation, catalysed by members of the sulphotransferase (SULT) enzyme family, is a major deactivating mechanism for steroid hormones and we have investigated the expression and regulation i...

journal_title：Molecular human reproduction

authors： Rubin GL,Harrold AJ,Mills JA,Falany CN,Coughtrie MW

更新日期：1999-11-01 00:00:00

abstract：:We have previously demonstrated that the reduced form of vitamin C (l-ascorbic acid, AA) is able to induce the production of both steroid and peptide hormones in human choriocarcinoma cells. Here, we attempted to investigate the role and underlying mechanism of the oxidized form of vitamin C, dehydroascorbic acid (DHA...

journal_title：Molecular human reproduction

authors： Wang Y,Tang C,Wu M,Pan Y,Ruan H,Chen L,Yao H,Zhu H,Wu X

更新日期：2014-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is relevant for normal pregnancy, and abnormalities in VEGF functions are associated with hypertensive disorders of pregnancy. Because there are few studies on how VEGF genetic polymorphisms affect susceptibility to pre-eclampsia (PE), and no studies on how they affect suscept...

journal_title：Molecular human reproduction

authors： Sandrim VC,Palei AC,Cavalli RC,Araújo FM,Ramos ES,Duarte G,Tanus-Santos JE

更新日期：2009-02-01 00:00:00

abstract：:The molecular mechanism of stress-associated reproductive dysfunction is complex and largely unknown. This study was designed to systematically analyze molecular effects of systemic in vivo blockade of α1-adrenergic receptors (α1-ADRs) on stress-induced disturbance of cAMP/cGMP signaling in testosterone-producing Leyd...

journal_title：Molecular human reproduction

authors： Stojkov NJ,Baburski AZ,Bjelic MM,Sokanovic SJ,Mihajlovic AI,Drljaca DM,Janjic MM,Kostic TS,Andric SA

更新日期：2014-01-01 00:00:00

abstract：:Stress-activated protein kinase/c-Jun kinase (SAPK/JNK) is thought to be necessary for preimplantation embryonic development (Maekawa et al., 2005). However, media increases SAPK/JNK phosphorylation and these levels negatively correlate with embryonic development (Wang et al., 2005). Culture-induced stress could confu...

journal_title：Molecular human reproduction

authors： Xie Y,Puscheck EE,Rappolee DA

更新日期：2006-04-01 00:00:00

abstract：:The pool of primordial follicles in humans is laid down during embryonic development and follicles can remain dormant for prolonged intervals, often decades, until individual follicles resume growth. The mechanisms that induce growth and maturation of primordial follicles are poorly understood but follicles once activ...

journal_title：Molecular human reproduction

authors： Markholt S,Grøndahl ML,Ernst EH,Andersen CY,Ernst E,Lykke-Hartmann K

更新日期：2012-02-01 00:00:00

abstract：:Previous studies have implicated receptor tyrosine kinases in progesterone-induced [Ca2+]i signalling, and consequent induction of the acrosome reaction, in human spermatozoa. We have investigated the effects of tyrosine kinase inhibition on [Ca2+]i responses in large numbers of individual human spermatozoa. Genistein...

journal_title：Molecular human reproduction

authors： Kirkman-Brown JC,Lefièvre L,Bray C,Stewart PM,Barratt CL,Publicover SJ

更新日期：2002-04-01 00:00:00

abstract：:Observational human data and several lines of animal experimental data indicate that maternal obesity impairs offspring health. Here, we comprehensively tested the model that maternal obesity causes defects in the next three generations of oocytes and embryos. We exposed female F0 mice to a high-fat/high-sugar (HF/HS)...

journal_title：Molecular human reproduction

authors： Andreas E,Reid M,Zhang W,Moley KH

更新日期：2019-11-30 00:00:00

abstract：:Matrix metalloproteinases (MMP), tissue inhibitors of metalloproteinases (TIMP), and MMP-TIMP interactions may contribute to the highly programmed process of embryo implantation. The loss of the delicate MMP-TIMP balance may lead to abnormal implantation. The role of TIMP-4 in mouse implantation has not been reported....

journal_title：Molecular human reproduction

authors： Zhang J,Zhao YG,Cao YJ,Sang QX,Duan EK

更新日期：2003-03-01 00:00:00

abstract：STUDY QUESTION:Could a more detailed evaluation of marmoset spermatogonial morphology, kinetics and niches using high-resolution light microscopy (HRLM) lead to new findings? SUMMARY ANSWER:Three subtypes of marmoset undifferentiated spermatogonia, which were not evenly distributed in terms of number and position alon...

journal_title：Molecular human reproduction

authors： Caldeira-Brant AL,Eras-Garcia L,Alves-Freitas D,Almeida FRCL,Chiarini-Garcia H

更新日期：2018-06-01 00:00:00

abstract：:Development of uterine glands (adenogenesis) in mammals typically begins during the early post-natal period and involves budding of nascent glands from the luminal epithelium and extensive cell proliferation in these structures as they grow into the surrounding stroma, elongate and mature. Uterine glands are essential...

journal_title：Molecular human reproduction

authors： Cooke PS,Spencer TE,Bartol FF,Hayashi K

更新日期：2013-09-01 00:00:00

abstract：STUDY HYPOTHESIS:It is possible to isolate pure populations of single potential human spermatogonial stem cells without somatic contamination for down-stream applications, for example cell culture and gene expression analysis. STUDY FINDING:We isolated pure populations of single potential human spermatogonial stem cel...

journal_title：Molecular human reproduction

authors： von Kopylow K,Schulze W,Salzbrunn A,Spiess AN

更新日期：2016-04-01 00:00:00

abstract：:The human endometrium is a cyclically regenerating organ under the influence of ovarian steroid hormones. Disturbances in this highly coordinated regulation of endometrial proliferation and differentiation may result in infertility and diseases such as endometriosis and endometrial cancer. Environmental toxins belongi...

journal_title：Molecular human reproduction

authors： Willing C,Peich M,Danescu A,Kehlen A,Fowler PA,Hombach-Klonisch S

更新日期：2011-02-01 00:00:00

abstract：:In male mice heterozygous for a null apolipoprotein B (apoB), allele infertility was noticed. These data led us to investigate a possible role of APOB gene polymorphism and male infertility in humans. In this case-control study, we searched for an association between the insertion/deletion (I/D) polymorphism of the AP...

journal_title：Molecular human reproduction

authors： Peterlin B,Zorn B,Volk M,Kunej T

更新日期：2006-12-01 00:00:00

abstract：:Estrogen and selective estrogen receptor modulators (SERMs) differentially impact endometrial cell function, however, the biological basis of these differences is not established. Deregulated cell adhesion to the extracellular matrix, cell movement and invasion are related to endometrial disorders, such as endometrios...

journal_title：Molecular human reproduction

authors： Flamini MI,Sanchez AM,Goglia L,Tosi V,Genazzani AR,Simoncini T

更新日期：2009-10-01 00:00:00

abstract：:The maternal aorta undergoes substantial functional and structural adaptation in pregnancy. Both aortic diameter and compliance are increased and studies of animal and human gestation indicate that these changes are initiated in early pregnancy and maintained until delivery. The mechanisms underlying aortic adaptation...

journal_title：Molecular human reproduction

authors： Kelly BA,Bond BC,Poston L

更新日期：2004-05-01 00:00:00

abstract：:We aimed to confirm the ovarian site of gonadotrophin surge-attenuating factor (GnSAF) production and produce granulosa/luteal cell-conditioned medium (G/LCM) containing GnSAF for purification studies. Blue dye affinity chromatography followed by pseudochromatofocusing of G/LCM yielded bioactive fractions at pH 5.74 a...

journal_title：Molecular human reproduction

authors： Fowler PA,Sorsa-Leslie T,Cash P,Dunbar B,Melvin W,Wilson Y,Mason HD,Harris W

更新日期：2002-09-01 00:00:00

abstract：:G12 monoclonal antibody (mAb), one of a library of constructed mAb directed against human sperm proteins, was found by immunoperoxidase staining to label the post-acrosomal and neck regions of fixed human cauda epididymal and ejaculated spermatozoa. Epithelium and fluid of caput epididymis were strongly labelled while...

journal_title：Molecular human reproduction

authors： Lefèvre A,Martin Ruiz C,Chokomian S,Duquenne C,Finaz C

更新日期：1997-06-01 00:00:00

abstract：:Zinc dynamics are essential for oocyte meiotic maturation, egg activation, and preimplantation embryo development. During fertilisation and egg activation, the egg releases billions of zinc atoms (Zn2+) in an exocytotic event termed the 'zinc spark'. We hypothesised that this zinc transport and exocytosis is dependent...

journal_title：Molecular human reproduction

authors： Lee HC,Edmonds ME,Duncan FE,O'Halloran TV,Woodruff TK

更新日期：2020-04-24 00:00:00

abstract：:Testis expressed gene 18 (Tex18) is a small gene with one exon of 240 bp, which is specifically expressed in male germ cells. The gene encodes for a protein of 80 amino acids with unknown domain. To investigate the function of (Tex18) gene, we generated mice with targeted disruption of the (Tex18) gene by homologous r...

journal_title：Molecular human reproduction

authors： Jaroszynski L,Dev A,Li M,Meinhardt A,de Rooij DG,Mueller C,Böhm D,Wolf S,Adham IM,Wulf G,Engel W,Nayernia K

更新日期：2007-03-01 00:00:00

abstract：:E-cadherin (uvomorulin)-mediated cell interactions are essential for preimplantation development in mammals. We observed that E-cadherin is expressed at contact sites between blastomeres of 2-cell mouse embryos of non-blocking genotype (CBA x C57BL F1) explanted at 32 h post human chorionic gonadotrophin (HCG) and cul...

journal_title：Molecular human reproduction

authors： Neganova IE,Sekirina GG,Eichenlaub-Ritter U

更新日期：2000-05-01 00:00:00