Lactoferrin gene expression is estrogen responsive in human and rhesus monkey endometrium.

abstract：:A rapid fluorescence in-situ hybridization (FISH) technique was used for direct chromosomal analysis on germ cells from an infertile male with large-headed spermatozoa. The interphase chromosomes were fluorescently-labelled using an extremely bright cyanine dye during a 5-15 min FISH procedure. Germ cells were analyse...

journal_title：Molecular human reproduction

authors： Yurov YB,Saias MJ,Vorsanova SG,Erny R,Soloviev IV,Sharonin VO,Guichaoua MR,Luciani JM

更新日期：1996-09-01 00:00:00

abstract：:We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases of globozoospermia were associated with DNA alterations, suggesting that DPY19L2-dependent globozoospermia may be associated with poor DNA quality. However the origins of such defects have no...

journal_title：Molecular human reproduction

authors： Yassine S,Escoffier J,Martinez G,Coutton C,Karaouzène T,Zouari R,Ravanat JL,Metzler-Guillemain C,Lee HC,Fissore R,Hennebicq S,Ray PF,Arnoult C

更新日期：2015-02-01 00:00:00

abstract：:Inhibin production has been demonstrated in malignant epithelial ovarian tumours, but secretion of inhibins by benign cystadenoma has not yet been reported. The present study evaluated the concentrations of inhibin A and inhibin B and the relationship with oestradiol and nitric oxide metabolites in fluid collected fro...

journal_title：Molecular human reproduction

authors： Reis FM,Faletti A,Luisi S,Bifulco G,Cauci S,Quadrifoglio F,Dor J,Petraglia F

更新日期：2000-12-01 00:00:00

abstract：:The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptid...

journal_title：Molecular human reproduction

authors： Bauskin AR,Franken DR,Eberspaecher U,Donner P

更新日期：1999-06-01 00:00:00

abstract：:Imprinted genes are characterized by expression of only one of the two alleles according to its inheritance from the mother or the father. This mono-allelic expression must arise from primary differential epigenetic modification of the parental alleles of the imprinted gene in the spermatozoon and the oocyte. Most of ...

journal_title：Molecular human reproduction

authors： Salpekar A,Huntriss J,Bolton V,Monk M

更新日期：2001-09-01 00:00:00

abstract：STUDY QUESTION:Do human adult Leydig cells (ALCs) within hyperplastic micronodules display characteristics of foetal LCs (FLCs)? SUMMARY ANSWER:The gene expression profiles of FLCs and all ALC subgroups were clearly different, but there were no significant differences in expressed genes between the normally clustered ...

journal_title：Molecular human reproduction

authors： Lottrup G,Belling K,Leffers H,Nielsen JE,Dalgaard MD,Juul A,Skakkebæk NE,Brunak S,Rajpert-De Meyts E

更新日期：2017-05-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) deletions are present in both human oocytes and embryos. It has been found that these tissues contain a mtDNA mutation which is present in high amounts in patients with Kearns-Sayre syndrome (KSS) and progressive external ophthalmoplegia. In the present study, the frequency of this KSS deleti...

journal_title：Molecular human reproduction

authors： Brenner CA,Wolny YM,Barritt JA,Matt DW,Munné S,Cohen J

更新日期：1998-09-01 00:00:00

abstract：:It is widely assumed that, after ovulation, the human endometrium undergoes specific changes and becomes receptive to the implantation of embryo during the mid-secretory phase. When implantation does not take place, further changes occur which eventually result in the shedding of human endometrium. The present study w...

journal_title：Molecular human reproduction

authors： von Wolff M,Thaler CJ,Strowitzki T,Broome J,Stolz W,Tabibzadeh S

更新日期：2000-07-01 00:00:00

abstract：:Human endometrial stromal cells (ESC) can produce a variety of chemokines, especially after inflammatory stimulation. Interferon-gamma-inducible protein-10 (IP-10) is a potent chemoattractant for lymphocytes, and belongs to the family of non-ELR CXC chemokines. The expression of IP-10 in ESC after stimulation with int...

journal_title：Molecular human reproduction

authors： Kai K,Nasu K,Nakamura S,Fukuda J,Nishida M,Miyakawa I

更新日期：2002-02-01 00:00:00

abstract：:In male mice heterozygous for a null apolipoprotein B (apoB), allele infertility was noticed. These data led us to investigate a possible role of APOB gene polymorphism and male infertility in humans. In this case-control study, we searched for an association between the insertion/deletion (I/D) polymorphism of the AP...

journal_title：Molecular human reproduction

authors： Peterlin B,Zorn B,Volk M,Kunej T

更新日期：2006-12-01 00:00:00

abstract：:The major regulators of endometrial function are oestrogen and progesterone, which act through binding their nuclear receptors and by activating transcription of their target genes. Interactions between steroid receptors and transcription proteins, e.g. c-JUN/AP-1, can modulate steroid action at the transcriptional le...

journal_title：Molecular human reproduction

authors： Salmi A,Pakarinen P,Peltola AM,Rutanen EM

更新日期：1998-12-01 00:00:00

abstract：:Sperm experience intense and varied selection that dramatically impacts the evolution of sperm quality. Selection acts to ensure that sperm are fertilization-competent and able to overcome the many challenges experienced on their way towards eggs. However, simply being able to fertilize an egg is not enough to ensure ...

journal_title：Molecular human reproduction

authors： Fitzpatrick JL,Lüpold S

更新日期：2014-12-01 00:00:00

abstract：STUDY QUESTION:Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER:We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in ...

journal_title：Molecular human reproduction

authors： Martinez G,Hograindleur JP,Voisin S,Abi Nahed R,Abd El Aziz TM,Escoffier J,Bessonnat J,Fovet CM,De Waard M,Hennebicq S,Aucagne V,Ray PF,Schmitt E,Bulet P,Arnoult C

更新日期：2017-02-10 00:00:00

abstract：:In the implantation, trophoblasts penetrate maternal decidua by secreting proteases. It has been reported that cathepsins are highly expressed in the mouse villi, and play an important role in normal embryonal growth and decidualization. In this study, we evaluated cathepsins and their endogenous inhibitors, cystatins...

journal_title：Molecular human reproduction

authors： Nakanishi T,Ozaki Y,Blomgren K,Tateyama H,Sugiura-Ogasawara M,Suzumori K

更新日期：2005-05-01 00:00:00

abstract：:The human endometrium is a dynamic tissue, which undergoes extensive tissue remodelling during the menstrual cycle. Due to their involvement in such processes, several well-characterized matrix metalloproteinases (MMP) have previously been studied in the endometrium. MMP-26 is a newly described matrilysin. We studied ...

journal_title：Molecular human reproduction

authors： Pilka R,Whatling C,Domanski H,Hansson S,Eriksson P,Casslén B

更新日期：2003-05-01 00:00:00

abstract：:Follicular prostaglandin concentrations increase following the gonadotrophin surge in domestic animals and rodents approximately 10 h before follicle rupture, suggesting a unifying role for prostaglandins in the timing of ovulation. However, little is known about prostaglandin production by the primate ovulatory folli...

journal_title：Molecular human reproduction

authors： Duffy DM,Stouffer RL

更新日期：2001-08-01 00:00:00

abstract：:Using a dispersed human luteal cell culture model, progesterone synthesis following treatment by incremental doses of human chorionic gonadotrophin (HCG) and the stable prostaglandin F2alpha (PGF2alpha) analogue cloprostenol, alone or in combination, was related to corpora lutea (CL) mRNA transcript abundance coding f...

journal_title：Molecular human reproduction

authors： Ottander U,Leung CH,Olofsson JI

更新日期：1999-05-01 00:00:00

abstract：:Patients with endometriosis are characterized by the ability of the endometrium to implant and by the peritoneal response to the tissue; angiogenic factors may play a significant role in the aetiology of endometriosis supporting the implantation of ectopic endometrial cells. Vascular endothelial growth factor (VEGF) i...

journal_title：Molecular human reproduction

authors： Fasciani A,D'Ambrogio G,Bocci G,Monti M,Genazzani AR,Artini PG

更新日期：2000-01-01 00:00:00

abstract：:Folate deficiency has been linked to a wide range of pregnancy disorders. Most research about folate-deficiency has focused on the embryo itself, little attention has been paid to possible effects on the placenta. According to our results, the morphology of the placenta, endocrine function, and the expression of genes...

journal_title：Molecular human reproduction

authors： Yin X,Gao R,Geng Y,Chen X,Liu X,Mu X,Ding Y,Wang Y,He J

更新日期：2019-06-06 00:00:00

abstract：:Recombinant human ZP3 (rhuZP3) generated by Chinese hamster ovary cells transfected with a plasmid containing human ZP3 cDNA was used to study the acrosome reaction (AR) and intracellular calcium fluxes in capacitated human spermatozoa. Conditioned medium containing rhuZP3 significantly induced the AR (P < or = 0.005)...

journal_title：Molecular human reproduction

authors： Brewis IA,Clayton R,Barratt CL,Hornby DP,Moore HD

更新日期：1996-08-01 00:00:00

abstract：:Nuclear oligomerization domains (NODs) are cytosolic pattern recognition receptors (PRRs), present in epithelial cells, monocytes and dendritic cells. This study details their expression, regulation and role in human endometrium. Real-time PCR showed that NOD1 mRNA is constitutively expressed in endometrium. NOD2 is u...

journal_title：Molecular human reproduction

authors： King AE,Horne AW,Hombach-Klonisch S,Mason JI,Critchley HO

更新日期：2009-05-01 00:00:00

abstract：:We have developed a competitive reverse transcription-polymerase chain reaction (RT-PCR) sensitive enough to detect and quantify as little as 2-fold differences in gene expression in individual oocytes and embryos throughout human preimplantation development. This RT-PCR assay can be tailored for the examination of an...

journal_title：Molecular human reproduction

authors： Taylor DM,Handyside AH,Ray PF,Dibb NJ,Winston RM,Ao A

更新日期：2001-02-01 00:00:00

abstract：:A number of placental cytokines participate in the feto-maternal defence mechanism. Monocyte chemotactic and activating factor (MCAF) is one of these chemokines. We investigated the pattern of placental MCAF production, the localization of MCAF-producing cells in the placenta, and alterations in its expression in chor...

journal_title：Molecular human reproduction

authors： Shimoya K,Matsuzaki N,Sawai K,Saji F,Murata Y,Yasumoto K,Su S,Mukaida N,Matsushima K

更新日期：1998-04-01 00:00:00

abstract：:Cystic fibrosis (CF) is usually considered a rare disease in the Indian population. Two studies have reported on the frequency of cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in Indian males with congenital absence of the vas deferens (CAVD), however, data on the spectrum of CFTR gene muta...

journal_title：Molecular human reproduction

authors： Sharma H,Mavuduru RS,Singh SK,Prasad R

更新日期：2014-09-01 00:00:00

abstract：:Idiopathic fetal growth restriction (FGR) is often associated with placental insufficiency. Previously, we isolated and characterized homeobox gene DLX4 from the placenta and provided evidence that DLX4 may regulate placental development. Here, we have investigated whether DLX4 expression levels were altered in idiopa...

journal_title：Molecular human reproduction

authors： Murthi P,Said JM,Doherty VL,Donath S,Nowell CJ,Brennecke SP,Kalionis B

更新日期：2006-12-01 00:00:00

abstract：:The human endometrium is a cyclically regenerating organ under the influence of ovarian steroid hormones. Disturbances in this highly coordinated regulation of endometrial proliferation and differentiation may result in infertility and diseases such as endometriosis and endometrial cancer. Environmental toxins belongi...

journal_title：Molecular human reproduction

authors： Willing C,Peich M,Danescu A,Kehlen A,Fowler PA,Hombach-Klonisch S

更新日期：2011-02-01 00:00:00

abstract：STUDY HYPOTHESIS:Does a preferential X chromosome inactivation (XCI) pattern exist in female human pluripotent stem cells (hPSCs) and does the pattern change during long-term culture or upon differentiation? STUDY FINDING:We identified two independent phenomena that lead to aberrant XCI patterns in female hPSC: a rapi...

journal_title：Molecular human reproduction

authors： Geens M,Seriola A,Barbé L,Santalo J,Veiga A,Dée K,Van Haute L,Sermon K,Spits C

更新日期：2016-04-01 00:00:00

abstract：:We report here the molecular cloning and characterization of human haspin cDNA and its genomic DNA construct. The haspin protein is a unique protein kinase, first isolated from mouse testis. Specifically expressed in mouse testicular germ cells, haspin is suggested to play a role in cell cycle arrest in haploid sperma...

journal_title：Molecular human reproduction

authors： Tanaka H,Iguchi N,Nakamura Y,Kohroki J,de Carvalho CE,Nishimune Y

更新日期：2001-03-01 00:00:00

abstract：:SUN domain proteins are integral proteins of the inner nuclear membrane and functions in linkage of the nuclear lamina to the cytoskeleton. Moreover, SUN domain proteins seem to mediate the tethering of the centrosome to the nuclear membrane, and they are involved in telomere attachment to the nuclear envelope in meio...

journal_title：Molecular human reproduction

authors： Frohnert C,Schweizer S,Hoyer-Fender S

更新日期：2011-04-01 00:00:00

abstract：:The expression of adhesion molecules and matrix proteins by human spermatozoa as well as their binding to and penetration of zona-free hamster eggs were investigated in 17 patients by means of flow cytometry. Both binding and penetration of hamster oocytes and expression of alpha- and beta-chains of beta 1, beta 3 and...

journal_title：Molecular human reproduction

authors： Henkel R,Schaller J,Glander HJ,Schill WB

更新日期：1996-05-01 00:00:00