Association between the apolipoprotein B signal peptide gene insertion/deletion polymorphism and male infertility.

abstract：:In women with premature ovarian failure, fertility may be preserved by ovarian tissue culture in vitro. However, techniques for tissue culture and follicle maturation have remained suboptimal. Our aim was to characterize ovarian tissue degeneration in cultures and to establish a model for cell death research in cultur...

journal_title：Molecular human reproduction

authors： Otala M,Erkkilä K,Tuuri T,Sjöberg J,Suomalainen L,Suikkari AM,Pentikäinen V,Dunkel L

更新日期：2002-03-01 00:00:00

abstract：:We aimed to confirm the ovarian site of gonadotrophin surge-attenuating factor (GnSAF) production and produce granulosa/luteal cell-conditioned medium (G/LCM) containing GnSAF for purification studies. Blue dye affinity chromatography followed by pseudochromatofocusing of G/LCM yielded bioactive fractions at pH 5.74 a...

journal_title：Molecular human reproduction

authors： Fowler PA,Sorsa-Leslie T,Cash P,Dunbar B,Melvin W,Wilson Y,Mason HD,Harris W

更新日期：2002-09-01 00:00:00

abstract：:The clinical application of quantitative fluorescent polymerase chain reaction (QF-PCR) for rapid prenatal detection of chromosome aneuploidies has been limited in most studies to the detection of autosomal trisomies. Recently it has been shown that a newly identified highly polymorphic marker, termed X22, which maps ...

journal_title：Molecular human reproduction

authors： Cirigliano V,Ejarque M,Cañadas MP,Lloveras E,Plaja A,Perez MM,Fuster C,Egozcue J

更新日期：2001-10-01 00:00:00

abstract：STUDY QUESTION:Can enzymatically dispersed testicular cells from adult men reassemble into seminiferous cord-like structures in vitro? SUMMARY ANSWER:Adult human testicular somatic cells reassembled into testicular cord-like structures via dynamic interactions of Sertoli and peritubular cells. WHAT IS KNOWN ALREADY:I...

journal_title：Molecular human reproduction

authors： Mincheva M,Sandhowe-Klaverkamp R,Wistuba J,Redmann K,Stukenborg JB,Kliesch S,Schlatt S

更新日期：2018-02-01 00:00:00

abstract：:In the interest of classifying cases of male factor infertility, we have paid particular attention to the sugar ligand binding properties of the human sperm surface and the functional capacity of the acrosome for exocytosis--key parameters for assessing sperm fertilizing ability. Zona recognition and binding involve t...

journal_title：Molecular human reproduction

authors： Benoff S,Hurley IR,Mandel FS,Cooper GW,Hershlag A

更新日期：1997-10-01 00:00:00

abstract：:Glycoforms of recombinant human follicle stimulating hormone (rhFSH) (Org 32489, Puregon) were characterized using concanavalin A lectin affinity chromatography to reveal information about the internal carbohydrate complexity (extent of carbohydrate side-chain branching) of the preparations. The rhFSH glycoforms were ...

journal_title：Molecular human reproduction

authors： Harris SD,Anobile CJ,McLoughlin JD,Mitchell R,Lambert A,Robertson WR

更新日期：1996-10-01 00:00:00

abstract：:Sperm are motile cells. Thus, a significant component of the spermatogenic cycle is devoted to the formation of flagellum, a process that must be coordinated to insure proper construction. To document the temporal pattern of flagellar gene expression, we employed real-time PCR to assess changes in accumulation of a co...

journal_title：Molecular human reproduction

authors： Horowitz E,Zhang Z,Jones BH,Moss SB,Ho C,Wood JR,Wang X,Sammel MD,Strauss JF 3rd

更新日期：2005-04-01 00:00:00

abstract：:Several studies have demonstrated an association between polycystic ovary syndrome (PCOS) and the dinucleotide repeat microsatellite marker D19S884, which is located in intron 55 of the fibrillin-3 (FBN3) gene. Fibrillins, including FBN1 and 2, interact with latent transforming growth factor (TGF)-beta-binding protein...

journal_title：Molecular human reproduction

authors： Prodoehl MJ,Hatzirodos N,Irving-Rodgers HF,Zhao ZZ,Painter JN,Hickey TE,Gibson MA,Rainey WE,Carr BR,Mason HD,Norman RJ,Montgomery GW,Rodgers RJ

更新日期：2009-12-01 00:00:00

abstract：:Embryo implantation and subsequent decidualization, trophoblast invasion and formation of a functional placenta are crucial for establishment and maintenance of pregnancy. Interleukin-11 signalling has been shown to be obligatory for adequate decidualization and trophoblast invasion in mice. Defects in IL-11 signallin...

journal_title：Molecular human reproduction

authors： von Rango U,Alfer J,Kertschanska S,Kemp B,Müller-Newen G,Heinrich PC,Beier HM,Classen-Linke I

更新日期：2004-11-01 00:00:00

abstract：:Zinc dynamics are essential for oocyte meiotic maturation, egg activation, and preimplantation embryo development. During fertilisation and egg activation, the egg releases billions of zinc atoms (Zn2+) in an exocytotic event termed the 'zinc spark'. We hypothesised that this zinc transport and exocytosis is dependent...

journal_title：Molecular human reproduction

authors： Lee HC,Edmonds ME,Duncan FE,O'Halloran TV,Woodruff TK

更新日期：2020-04-24 00:00:00

abstract：:Advanced glycation end products (AGEs) affect the follicular microenvironment. The close relationship between AGEs, proinflammatory cytokine production and activation of the unfolded protein response (UPR), which involves activating transcription factor 4 (ATF4), is crucial for regulation of various cellular functions...

journal_title：Molecular human reproduction

authors： Takahashi N,Harada M,Azhary JMK,Kunitomi C,Nose E,Terao H,Koike H,Wada-Hiraike O,Hirata T,Hirota Y,Koga K,Fujii T,Osuga Y

更新日期：2019-11-30 00:00:00

abstract：:Polar body emission is a specialized cell division throughout the animal kingdom, serving to reduce chromosome ploidy while preserving the egg cytoplasm. Critical to polar body emission are the asymmetric positioning of the meiotic spindle prior to anaphase, with one pole attached to the oocyte cortex, and the simulta...

journal_title：Molecular human reproduction

authors： Leblanc J,Zhang X,McKee D,Wang ZB,Li R,Ma C,Sun QY,Liu XJ

更新日期：2011-05-01 00:00:00

abstract：:Binder of SPerm (BSP) proteins are a family of proteins expressed exclusively in the male reproductive tract (seminal vesicles or epididymis) of several mammalian species. They are known to promote capacitation, a sperm maturation step essential for fertilization. Our recent studies have shown that in human, the Binde...

journal_title：Molecular human reproduction

authors： Plante G,Thérien I,Lachance C,Leclerc P,Fan J,Manjunath P

更新日期：2014-05-01 00:00:00

abstract：:In recent years, advances in imaging probes, cutting-edge microscopy techniques and powerful bioinformatics image analysis have markedly expanded the imaging toolbox available to developmental biologists. Apart from traditional qualitative studies, embryonic development can now be investigated in vivo with improved sp...

journal_title：Molecular human reproduction

authors： Welling M,Ponti A,Pantazis P

更新日期：2016-03-01 00:00:00

abstract：:Endometriosis is a gynaecological disease with a certain genetic background, but the locations of possible genomic aberrations are still poorly clarified. Intercellular adhesion molecule-1 (ICAM-1), which is a surface glycoprotein that promotes adhesion in immunological and inflammatory reactions, seems to play a role...

journal_title：Molecular human reproduction

authors： Viganò P,Infantino M,Lattuada D,Lauletta R,Ponti E,Somigliana E,Vignali M,DiBlasio AM

更新日期：2003-01-01 00:00:00

abstract：:The Prader-Willi (PWS) and Angelman (AS) syndromes are two clinically distinct syndromes which result from lack of expression of imprinted genes within chromosome 15q11-q13. These two syndromes result from 15q11-q13 deletions, chromosome 15 uniparental disomy (UPD), imprinting centre mutations and, for AS, probable mu...

journal_title：Molecular human reproduction

authors： Glenn CC,Driscoll DJ,Yang TP,Nicholls RD

更新日期：1997-04-01 00:00:00

abstract：:The maternal aorta undergoes substantial functional and structural adaptation in pregnancy. Both aortic diameter and compliance are increased and studies of animal and human gestation indicate that these changes are initiated in early pregnancy and maintained until delivery. The mechanisms underlying aortic adaptation...

journal_title：Molecular human reproduction

authors： Kelly BA,Bond BC,Poston L

更新日期：2004-05-01 00:00:00

abstract：:Glutathione S-transferase M1 (GSTM1), one member of the GST family, is responsible for metabolism of xenobiotics and carcinogens. Myeloperoxidase (MPO) plays an important role in the oxidation and activation of carcinogens and nitric oxide. Allelic variants of GSTM1 and MPO gene polymorphisms might impair detoxificati...

journal_title：Molecular human reproduction

authors： Hsieh YY,Chang CC,Tsai FJ,Lin CC,Chen JM,Tsai CH

更新日期：2004-10-01 00:00:00

abstract：:The causes for recurrent spontaneous abortion (RSA) remain unknown in a large proportion of the cases. Human leukocyte antigen (HLA)-G and HLA-E are expressed on invasive trophoblast cells, and are supposed to confer to materno-fetal tolerance. A total of 14 different nucleotide sequences have been described for HLA-G...

journal_title：Molecular human reproduction

authors： Pfeiffer KA,Fimmers R,Engels G,van der Ven H,van der Ven K

更新日期：2001-04-01 00:00:00

abstract：:Several investigators have noted that hormone-dependent development of endometriosis implants lags behind that of simultaneously analysed eutopic endometrium. With the recent discovery of the oestrogen receptor-beta (ER-beta) isoform, the aim of this study was to investigate whether differences in the expression of ER...

journal_title：Molecular human reproduction

authors： Brandenberger AW,Lebovic DI,Tee MK,Ryan IP,Tseng JF,Jaffe RB,Taylor RN

更新日期：1999-07-01 00:00:00

abstract：:Charcot-Marie-Tooth (CMT) disease is the 'common' name for a range of hereditary peripheral neuropathies. CMT1 is the most common form and is transmitted in an autosomal dominant manner. CMT1A maps to chromosome 17p11.2 and is caused, in the majority of cases, by a 1.5 Mb DNA duplication, that includes the peripheral ...

journal_title：Molecular human reproduction

authors： De Vos A,Sermon K,De Rijcke M,Goossens V,Henderix P,Van Ranst N,Platteau P,Lissens W,Devroey P,Van Steirteghem A,Liebaers I

更新日期：2003-07-01 00:00:00

abstract：:In Europe up to one in four couples experience difficulty conceiving and in half of these cases the problem has been attributed to sub or infertility in the male partner. The development of assisted reproductive technologies (ART) such as in vitro fertilization and intra-cytoplasmic spermatozoa injection has allowed s...

journal_title：Molecular human reproduction

authors： Paul C,Melton DW,Saunders PT

更新日期：2008-01-01 00:00:00

abstract：:Mammalian sperm chromatin is highly condensed, so isolating DNA from such chromatin can be a formidable task. The procedures that produce high quality DNA from somatic cells fail to yield quality sperm DNA. In this study we have modified the previously used guanidinium method to make it simple and efficient in isolati...

journal_title：Molecular human reproduction

authors： Hossain AM,Rizk B,Behzadian A,Thorneycroft IH

更新日期：1997-11-01 00:00:00

abstract：:The two estrogen receptors, ERalpha and ERbeta, are likely to have roles in the pathophysiology of fibroid development. They have been detected in myometrial and leiomyoma (fibroid) tissue, but the cell types expressing ERalpha and ERbeta have not been determined. ERs have also been detected in human endothelial cells...

journal_title：Molecular human reproduction

authors： Gargett CE,Bucak K,Zaitseva M,Chu S,Taylor N,Fuller PJ,Rogers PA

更新日期：2002-08-01 00:00:00

abstract：STUDY QUESTION:Can RNA sequencing of human cumulus cells (CC) reveal molecular pathways involved in the physiology of reproductive aging? STUDY FINDING:Senescent but not young CC activate gene pathways associated with hypoxia and oxidative stress. WHAT IS KNOWN ALREADY:Shifts in socioeconomic norms are resulting in l...

journal_title：Molecular human reproduction

authors： Molinari E,Bar H,Pyle AM,Patrizio P

更新日期：2016-08-01 00:00:00

abstract：:FSH is a pituitary gonadotropin that along with LH plays a key role in the regulation of gonadal function. The gonadotropic hormones are composed of two subunits, the common alpha subunit and the hormone-specific beta subunit, which determines the binding to specific receptors and induction of biological response. Unl...

journal_title：Molecular human reproduction

authors： Lamminen T,Jokinen P,Jiang M,Pakarinen P,Simonsen H,Huhtaniemi I

更新日期：2005-08-01 00:00:00

abstract：:Folate deficiency has been linked to a wide range of pregnancy disorders. Most research about folate-deficiency has focused on the embryo itself, little attention has been paid to possible effects on the placenta. According to our results, the morphology of the placenta, endocrine function, and the expression of genes...

journal_title：Molecular human reproduction

authors： Yin X,Gao R,Geng Y,Chen X,Liu X,Mu X,Ding Y,Wang Y,He J

更新日期：2019-06-06 00:00:00

abstract：STUDY QUESTION:Could a more detailed evaluation of marmoset spermatogonial morphology, kinetics and niches using high-resolution light microscopy (HRLM) lead to new findings? SUMMARY ANSWER:Three subtypes of marmoset undifferentiated spermatogonia, which were not evenly distributed in terms of number and position alon...

journal_title：Molecular human reproduction

authors： Caldeira-Brant AL,Eras-Garcia L,Alves-Freitas D,Almeida FRCL,Chiarini-Garcia H

更新日期：2018-06-01 00:00:00

abstract：STUDY QUESTION:Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER:We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in ...

journal_title：Molecular human reproduction

authors： Martinez G,Hograindleur JP,Voisin S,Abi Nahed R,Abd El Aziz TM,Escoffier J,Bessonnat J,Fovet CM,De Waard M,Hennebicq S,Aucagne V,Ray PF,Schmitt E,Bulet P,Arnoult C

更新日期：2017-02-10 00:00:00

abstract：:We report here the molecular cloning and characterization of human haspin cDNA and its genomic DNA construct. The haspin protein is a unique protein kinase, first isolated from mouse testis. Specifically expressed in mouse testicular germ cells, haspin is suggested to play a role in cell cycle arrest in haploid sperma...

journal_title：Molecular human reproduction

authors： Tanaka H,Iguchi N,Nakamura Y,Kohroki J,de Carvalho CE,Nishimune Y

更新日期：2001-03-01 00:00:00