Methylation status in the intragenic differentially methylated region of the IGF2 locus in Bos taurus indicus oocytes with different developmental competencies.

abstract：:Virtually all testicular germ cell tumours originate from a common precursor, the carcinoma in situ (CIS) cell. The precise nature of the molecular mechanisms leading to CIS remains largely unknown. We performed the first systematic analysis of gene expression in testis with CIS compared to normal testis by the differ...

journal_title：Molecular human reproduction

authors： Hoei-Hansen CE,Nielsen JE,Almstrup K,Hansen MA,Skakkebaek NE,Rajpert-DeMeyts E,Leffers H

更新日期：2004-06-01 00:00:00

abstract：:No phenotypic effect is observed in most inversion heterozygotes. However, reproductive risks may occur in the form of infertility, spontaneous abortions or chromosomally unbalanced children as a consequence of meiotic recombination between inverted and non-inverted chromosomes. An odd number of crossovers within the ...

journal_title：Molecular human reproduction

authors： Chantot-Bastaraud S,Ravel C,Berthaut I,McElreavey K,Bouchard P,Mandelbaum J,Siffroi JP

更新日期：2007-01-01 00:00:00

abstract：:A rapid fluorescence in-situ hybridization (FISH) technique was used for direct chromosomal analysis on germ cells from an infertile male with large-headed spermatozoa. The interphase chromosomes were fluorescently-labelled using an extremely bright cyanine dye during a 5-15 min FISH procedure. Germ cells were analyse...

journal_title：Molecular human reproduction

authors： Yurov YB,Saias MJ,Vorsanova SG,Erny R,Soloviev IV,Sharonin VO,Guichaoua MR,Luciani JM

更新日期：1996-09-01 00:00:00

abstract：:To mimic post-ovulatory ageing, we have extended the in vitro maturation (IVM) phase to 48 h and examined effects on (i) developmental potential, (ii) expression of a panel of developmentally important genes and (iii) gene-specific epigenetic marks. Results were compared with the 24 h IVM protocol (control) usually em...

journal_title：Molecular human reproduction

authors： Heinzmann J,Mattern F,Aldag P,Bernal-Ulloa SM,Schneider T,Haaf T,Niemann H

更新日期：2015-10-01 00:00:00

abstract：STUDY QUESTION:Can RNA sequencing of human cumulus cells (CC) reveal molecular pathways involved in the physiology of reproductive aging? STUDY FINDING:Senescent but not young CC activate gene pathways associated with hypoxia and oxidative stress. WHAT IS KNOWN ALREADY:Shifts in socioeconomic norms are resulting in l...

journal_title：Molecular human reproduction

authors： Molinari E,Bar H,Pyle AM,Patrizio P

更新日期：2016-08-01 00:00:00

abstract：:Oligozoospermia (low sperm count) is a common semen deficiency. However, to date, few genetic defects have been identified to cause this condition. Moreover, even fewer molecular genetic diagnostic tests are available for patients with oligozoospermia in the andrology clinic. Based on animal and gene expression studie...

journal_title：Molecular human reproduction

authors： Yatsenko AN,Georgiadis AP,Murthy LJ,Lamb DJ,Matzuk MM

更新日期：2013-06-01 00:00:00

abstract：:Premature loss of ovarian activity before 40 years of age is known as primary ovarian insufficiency (POI) and occurs in ∼1% of women. A more subtle decline in ovarian activity, known as premature ovarian ageing (POA), occurs in ∼10% of women. Despite the high prevalence of POA, very little is known regarding its genet...

journal_title：Molecular human reproduction

authors： Subramanian GN,Lavin M,Homer HA

更新日期：2020-12-18 00:00:00

abstract：STUDY QUESTION:Are there novel hyaladherins in human sperm? SUMMARY ANSWER:Zona pellucida-binding protein 2 (ZPBP2), containing a Link-like hyaluronic acid (HA)-binding domain, and several other proteins containing BX7B motifs, such as ADAM32 and Midkine, may be novel hyaladherins with HA-binding properties. WHAT IS ...

journal_title：Molecular human reproduction

authors： Torabi F,Bogle OA,Estanyol JM,Oliva R,Miller D

更新日期：2017-12-01 00:00:00

abstract：:Charcot-Marie-Tooth (CMT) disease is the 'common' name for a range of hereditary peripheral neuropathies. CMT1 is the most common form and is transmitted in an autosomal dominant manner. CMT1A maps to chromosome 17p11.2 and is caused, in the majority of cases, by a 1.5 Mb DNA duplication, that includes the peripheral ...

journal_title：Molecular human reproduction

authors： De Vos A,Sermon K,De Rijcke M,Goossens V,Henderix P,Van Ranst N,Platteau P,Lissens W,Devroey P,Van Steirteghem A,Liebaers I

更新日期：2003-07-01 00:00:00

abstract：:The aim of the present study was to investigate the potential role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS)-induced preterm delivery. Intraperitoneal injection of LPS in the presence or absence of previous TLR4 blockade was performed to establish a murine model of preterm delivery. The incidences of ...

journal_title：Molecular human reproduction

authors： Li L,Kang J,Lei W

更新日期：2010-04-01 00:00:00

abstract：:Patients with rare overgrowth disorders, such as Beck-Wiedemann syndrome and Simpson-Golabi-Behmel syndrome, are predisposed to embryonal tumours, including Wilms' tumour of the kidney. Therefore, these disorders offer a link between hyperplastic growth and cancer. Genetic lesions at chromosome 11p15 have been associa...

journal_title：Molecular human reproduction

authors： Ward A

更新日期：1997-02-01 00:00:00

abstract：:Because of its distinctive ability to act as a mitogen, a mitogen and a morphogen, hepatocyte growth factor/scatter factor (HGF/SF) has all the characteristics of a molecule able to function in regulatory networks of motility, such as the spermatogenic epithelium, and this through binding of its receptor p190MET (C-ME...

journal_title：Molecular human reproduction

authors： Depuydt CE,Zalata A,de Potter CR,van Emmelo J,Comhaire FH

更新日期：1996-01-01 00:00:00

abstract：:In order to improve assisted fertilization in humans it is important to elucidate the mechanisms of control of growth and development in the early pre-embryo. Increasing evidence shows that growth factors are of importance for such control mechanisms. As platelet-derived growth factor (PDGF) has been shown to enhance ...

journal_title：Molecular human reproduction

authors： Osterlund C,Wramsby H,Pousette A

更新日期：1996-07-01 00:00:00

abstract：:Prostaglandins (PGs) are important factors in the physiology of human parturition and the control of uterine contractility. We have characterized the expression of 15 genes from all stages of the PG pathway in human pregnant and non-pregnant (NP) myometrium and in other uterine tissues at delivery, and the results sho...

journal_title：Molecular human reproduction

authors： Phillips RJ,Al-Zamil H,Hunt LP,Fortier MA,López Bernal A

更新日期：2011-01-01 00:00:00

abstract：:The influence of seminal plasma on the mRNA expression of cytokines in human endometrial epithelial and stromal cells and the cytokine production of spermatozoa were investigated in vitro. Seminal plasma and spermatozoa were collected from healthy volunteers and were screened by enzyme-linked immunosorbent assay for c...

journal_title：Molecular human reproduction

authors： Gutsche S,von Wolff M,Strowitzki T,Thaler CJ

更新日期：2003-12-01 00:00:00

abstract：STUDY QUESTION:Can a pre-in vitro maturation (pre-IVM) medium containing signaling molecules rather than chemical/pharmaceutical agents, sustain meiotic arrest and improve developmental competence of in vitro matured oocytes in CF1 outbred mice? SUMMARY ANSWER:A short 2 h period of pre-IVM prevents spontaneous meiotic...

journal_title：Molecular human reproduction

authors： Santiquet NW,Greene AF,Becker J,Barfield JP,Schoolcraft WB,Krisher RL

更新日期：2017-09-01 00:00:00

abstract：:The non-classical major histocompatibility complex molecule, human leukocyte antigen (HLA)-G, is thought to contribute to maternal immune tolerance and successful placentation during pregnancy. Genetic polymorphisms in HLA-G are known to influence expression levels as well as the relative expression of individual prot...

journal_title：Molecular human reproduction

authors： Loisel DA,Billstrand C,Murray K,Patterson K,Chaiworapongsa T,Romero R,Ober C

更新日期：2013-03-01 00:00:00

abstract：:In Europe up to one in four couples experience difficulty conceiving and in half of these cases the problem has been attributed to sub or infertility in the male partner. The development of assisted reproductive technologies (ART) such as in vitro fertilization and intra-cytoplasmic spermatozoa injection has allowed s...

journal_title：Molecular human reproduction

authors： Paul C,Melton DW,Saunders PT

更新日期：2008-01-01 00:00:00

abstract：:Several laboratories have independently isolated mitotically active germ cells, termed female germline stem cells or oogonial stem cells (OSCs), from adult mouse ovaries. However, a recent study using Ddx4-Cre;Rosa26 reporter mice concluded that such germ cells do not exist. Given the disparity in conclusions drawn in...

journal_title：Molecular human reproduction

authors： Park ES,Tilly JL

更新日期：2015-01-01 00:00:00

abstract：:PKDREJ is a testis-specific protein thought to be located on the sperm surface. Functional studies in the mouse revealed that loss of PKDREJ has effects on sperm transport and the ability to undergo an induced acrosome reaction. Thus, PKDREJ has been considered a potential target of post-copulatory sexual selection in...

journal_title：Molecular human reproduction

authors： Vicens A,Gómez Montoto L,Couso-Ferrer F,Sutton KA,Roldan ER

更新日期：2015-02-01 00:00:00

abstract：:Success rate in human pregnancies is believed to be very low and sex-specific mechanisms may operate in prenatal loss. Assuming a sex-differential in prenatal loss exists, we examined genetic markers in biologically plausible targets in the HLA complex, other immune system-related and iron-regulatory genes in 388 heal...

journal_title：Molecular human reproduction

authors： Ucisik-Akkaya E,Davis CF,Do TN,Morrison BA,Stemmer SM,Amadio WJ,Dorak MT

更新日期：2010-10-01 00:00:00

abstract：:Tenascin-C is an extracellular matrix glycoprotein whose monomers include eight consecutive fibronectin type III-like repeats, encoded by exons 10-16, and which are subject to alternative splicing. Transcripts containing these exons are expressed during tissue wounding and active tissue remodelling. Human fetal membra...

journal_title：Molecular human reproduction

authors： Bell SC,Pringle JH,Taylor DJ,Malak TM

更新日期：1999-11-01 00:00:00

abstract：:FSH is a pituitary gonadotropin that along with LH plays a key role in the regulation of gonadal function. The gonadotropic hormones are composed of two subunits, the common alpha subunit and the hormone-specific beta subunit, which determines the binding to specific receptors and induction of biological response. Unl...

journal_title：Molecular human reproduction

authors： Lamminen T,Jokinen P,Jiang M,Pakarinen P,Simonsen H,Huhtaniemi I

更新日期：2005-08-01 00:00:00

abstract：:A novel gene, TSG23/Tsg23, was identified by comparing the expression profiles of human adult and fetal testis using Affymetrix Genechips. RT-PCR analysis from multiple human and mouse tissues indicated TSG23/Tsg23 mRNA was mainly expressed in the testis. In situ hybridization revealed that TSG23/Tsg23 mRNA was locate...

journal_title：Molecular human reproduction

authors： Zhou Y,Qin D,Tang A,Zhou D,Qin J,Yan B,Diao R,Jiang Z,Cai Z,Gui Y

更新日期：2009-04-01 00:00:00

abstract：:Oxidative damage by reactive oxygen species (ROS) is a major cause of sperm dysfunction. Excessive ROS generation reduces fertilization and enhances DNA damage of spermatozoa. Interaction between spermatozoa and oviductal epithelial cells improves the fertilizing ability of and reduces chromatin damage in spermatozoa....

journal_title：Molecular human reproduction

authors： Huang VW,Lee CL,Lee YL,Lam KK,Ko JK,Yeung WS,Ho PC,Chiu PC

更新日期：2015-06-01 00:00:00

abstract：:Etoposide is widely used in the treatment of patients with testicular cancer. The mechanism underlying apoptosis induction in cancer cells has been studied in different cell types, but it is not known whether the same factors participate in viable germ cells undergoing programmed cell death. Since testicular cancer pr...

journal_title：Molecular human reproduction

authors： Ortiz RJ,Lizama C,Codelia VA,Moreno RD

更新日期：2009-06-01 00:00:00

abstract：:Uterine contractions are tightly regulated by the electrical activity of myometrial smooth muscle cells (MSMCs). These cells require a depolarizing current to initiate Ca(2+) influx and induce contraction. Cationic leak channels, which permit a steady flow of cations into a cell, are known to cause membrane depolariza...

journal_title：Molecular human reproduction

authors： Reinl EL,Cabeza R,Gregory IA,Cahill AG,England SK

更新日期：2015-10-01 00:00:00

abstract：:The signals initiating the growth of primordial follicles are unknown. Growth factors such as neurotrophin 4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) may play a role in this process. To investigate the expression of NT-4/5 and BDNF and their receptor tyrosine kinase B (TrkB) in the early developing foll...

journal_title：Molecular human reproduction

authors： Harel S,Jin S,Fisch B,Feldberg D,Krissi H,Felz C,Freimann S,Tan SL,Ao A,Abir R

更新日期：2006-06-01 00:00:00

abstract：STUDY HYPOTHESIS:In women with preterm premature rupture of the membranes (PPROM), increased oxidative stress may accelerate premature cellular senescence, senescence-associated inflammation and proteolysis, which may predispose them to rupture. STUDY FINDING:We demonstrate mechanistic differences between preterm birt...

journal_title：Molecular human reproduction

authors： Dutta EH,Behnia F,Boldogh I,Saade GR,Taylor BD,Kacerovský M,Menon R

更新日期：2016-02-01 00:00:00

abstract：:Early embryonic development is characterized by drastic changes in chromatin structure that affects the accessibility of the chromatin. In human, the chromosome reorganization and its involvement in the first linage segregation are poorly characterized due to the difficulties in obtaining human embryonic material and ...

journal_title：Molecular human reproduction

authors： Yang M,Tao X,Titus S,Zhao T,Scott RT,Seli E

更新日期：2020-09-01 00:00:00