Molecular cloning and characterization of the human orthologue of male germ cell-specific actin capping protein alpha3 (cpalpha3).

abstract：:A molecule isolated from the peritoneal fluids of women undergoing laparoscopy for in-vitro fertilization techniques has been chemically characterized and identified as 1-palmitic-3-phosphorylcholine (lysophosphatidylcholine, LPC). This lipid is able, at physiological concentrations, to completely inhibit sperm motili...

journal_title：Molecular human reproduction

authors： Keller F,Togni G,Soldati G,Balmelli T,Medici G,Rose K,Balerna M

更新日期：1997-03-01 00:00:00

abstract：:Mammalian sperm undergo a series of maturation steps before acquiring fertilization competence. Our previous work demonstrated the importance of binder of sperm (BSP) proteins in bovine sperm capacitation. Recent studies identified a BSP-homologous DNA sequence in the human genome (BSPH1) and mRNA expression in the ep...

journal_title：Molecular human reproduction

authors： Lefebvre J,Boileau G,Manjunath P

更新日期：2009-02-01 00:00:00

abstract：:Fetal membranes overlying the cervix in patients prior to and during labour, and within the rupture tear after spontaneous delivery at term, exhibit altered morphology. In this study we report that in comparison to mid-zone fetal membranes biopsies, these regions are characterized by increased expression of the matric...

journal_title：Molecular human reproduction

authors： McParland PC,Bell SC,Pringle JH,Taylor DJ

更新日期：2001-05-01 00:00:00

abstract：:Folate deficiency has been linked to a wide range of pregnancy disorders. Most research about folate-deficiency has focused on the embryo itself, little attention has been paid to possible effects on the placenta. According to our results, the morphology of the placenta, endocrine function, and the expression of genes...

journal_title：Molecular human reproduction

authors： Yin X,Gao R,Geng Y,Chen X,Liu X,Mu X,Ding Y,Wang Y,He J

更新日期：2019-06-06 00:00:00

abstract：:We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases of globozoospermia were associated with DNA alterations, suggesting that DPY19L2-dependent globozoospermia may be associated with poor DNA quality. However the origins of such defects have no...

journal_title：Molecular human reproduction

authors： Yassine S,Escoffier J,Martinez G,Coutton C,Karaouzène T,Zouari R,Ravanat JL,Metzler-Guillemain C,Lee HC,Fissore R,Hennebicq S,Ray PF,Arnoult C

更新日期：2015-02-01 00:00:00

abstract：:This study assesses the role of progesterone receptor membrane component 1 (PGRMC1) in actions of progesterone (P4) on human myometrium during pregnancy and labour. Myometrial tissues were obtained from non-pregnant patients during hysterectomy or pregnant women undergoing C-section at term and preterm, before and dur...

journal_title：Molecular human reproduction

authors： Wu W,Shi SQ,Huang HJ,Balducci J,Garfield RE

更新日期：2011-04-01 00:00:00

abstract：:E-cadherin (uvomorulin)-mediated cell interactions are essential for preimplantation development in mammals. We observed that E-cadherin is expressed at contact sites between blastomeres of 2-cell mouse embryos of non-blocking genotype (CBA x C57BL F1) explanted at 32 h post human chorionic gonadotrophin (HCG) and cul...

journal_title：Molecular human reproduction

authors： Neganova IE,Sekirina GG,Eichenlaub-Ritter U

更新日期：2000-05-01 00:00:00

abstract：STUDY HYPOTHESIS:In women with preterm premature rupture of the membranes (PPROM), increased oxidative stress may accelerate premature cellular senescence, senescence-associated inflammation and proteolysis, which may predispose them to rupture. STUDY FINDING:We demonstrate mechanistic differences between preterm birt...

journal_title：Molecular human reproduction

authors： Dutta EH,Behnia F,Boldogh I,Saade GR,Taylor BD,Kacerovský M,Menon R

更新日期：2016-02-01 00:00:00

abstract：:The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its ...

journal_title：Molecular human reproduction

authors： Jing Y,Run-Qian L,Hao-Ran W,Hao-Ran C,Ya-Bin L,Yang G,Fei C

更新日期：2020-06-01 00:00:00

abstract：:Oocyte quality is one of the most important aspects of in vitro embryo development. Extensive epigenetic programming must occur during oocyte growth and maturation. A specific DNA methylation pattern of the imprinted genes must be established on differentially methylated regions (DMR). The insulin-like growth factor 2...

journal_title：Molecular human reproduction

authors： Fagundes NS,Michalczechen-Lacerda VA,Caixeta ES,Machado GM,Rodrigues FC,Melo EO,Dode MA,Franco MM

更新日期：2011-02-01 00:00:00

abstract：:Psoriasin is a small calcium-binding protein first found in psoriatic lesions and also up-regulated in other inflammatory skin diseases and cancer tissues. Psoriasin is also present in the fetal epithelial cells. Its biological function is unclear, but there is both in vitro and in vivo evidence for its chemokine-like...

journal_title：Molecular human reproduction

authors： Porre S,Heinonen S,Mäntyjärvi R,Rytkönen-Nissinen M,Perola O,Rautiainen J,Virtanen T

更新日期：2005-02-01 00:00:00

abstract：:Endometriosis, the presence of ectopic endometrial tissue outside the uterine cavity, is a common disease affecting women during their reproductive years. The aim of this study was to identify the molecular mechanism of transcriptional regulation of inflammatory cyclooxygenase-2 (COX-2) gene during endometriosis by hy...

journal_title：Molecular human reproduction

authors： Kim KH,Kim HY,Kim HH,Lee KS,Cheong J

更新日期：2011-11-01 00:00:00

abstract：:Polar body emission is a specialized cell division throughout the animal kingdom, serving to reduce chromosome ploidy while preserving the egg cytoplasm. Critical to polar body emission are the asymmetric positioning of the meiotic spindle prior to anaphase, with one pole attached to the oocyte cortex, and the simulta...

journal_title：Molecular human reproduction

authors： Leblanc J,Zhang X,McKee D,Wang ZB,Li R,Ma C,Sun QY,Liu XJ

更新日期：2011-05-01 00:00:00

abstract：:Estrogen and selective estrogen receptor modulators (SERMs) differentially impact endometrial cell function, however, the biological basis of these differences is not established. Deregulated cell adhesion to the extracellular matrix, cell movement and invasion are related to endometrial disorders, such as endometrios...

journal_title：Molecular human reproduction

authors： Flamini MI,Sanchez AM,Goglia L,Tosi V,Genazzani AR,Simoncini T

更新日期：2009-10-01 00:00:00

abstract：:The endocrine disrupting chemical o, p'-dichlorodiphenyltrichloroethane (DDT) can affect reproductive organs, tissues and cells in several species. Treatment of human endometrial endothelial cells (HEECs) with 50 microM o,p'-DDT decreased their proliferation compared with the control. Microarray analyses revealed that...

journal_title：Molecular human reproduction

authors： Bredhult C,Sahlin L,Olovsson M

更新日期：2008-02-01 00:00:00

abstract：:We describe a rapid and specific differential amplification system which can detect five of the most common cystic fibrosis mutations from a single cell. In the first round of the polymerase chain reaction (PCR), regions of exons 4, 10 and 11 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene conta...

journal_title：Molecular human reproduction

authors： Scobie G,Woodroffe B,Fishel S,Kalsheker N

更新日期：1996-03-01 00:00:00

abstract：STUDY QUESTION:Does dynamin regulate human sperm acrosomal exocytosis? SUMMARY ANSWER:Our studies of dynamin localization and function have implicated this family of mechanoenzymes in the regulation of progesterone-induced acrosomal exocytosis in human spermatozoa. WHAT IS KNOWN ALREADY:Completion of an acrosome reac...

journal_title：Molecular human reproduction

authors： Zhou W,Anderson AL,Turner AP,De Iuliis GN,McCluskey A,McLaughlin EA,Nixon B

更新日期：2017-10-01 00:00:00

abstract：:Granzyme B (graB) plays a pivotal role in cytotoxic lymphocyte granule-mediated apoptosis through cleavage of intracellular proteins in target cells. Proteinase inhibitor-9 (PI-9) is a potent inhibitor of graB and is highly expressed in cytotoxic lymphocytes. Here, we show by immunohistochemistry that PI-9 is also abu...

journal_title：Molecular human reproduction

authors： Hirst CE,Buzza MS,Sutton VR,Trapani JA,Loveland KL,Bird PI

更新日期：2001-12-01 00:00:00

abstract：:The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony-stimulating factor (MCSF) and transforming growth factor beta (TGFbeta) on the secretion of matrix metalloproteinases (MMP), human chorionic gonadotrophin (HCG) and fetal fibrone...

journal_title：Molecular human reproduction

authors： Meisser A,Chardonnens D,Campana A,Bischof P

更新日期：1999-03-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase-1 (IDO1) is an intracellular enzyme that catalyses essential amino acid tryptophan along the kynurenine pathway. The aim of this study was to determine the impact of IDO1 expression on the biological characteristic of the endometrial stromal cells (ESCs). IDO1, cyclooxygenase-2 (COX-2) and ...

journal_title：Molecular human reproduction

authors： Mei J,Jin LP,Ding D,Li MQ,Li DJ,Zhu XY

更新日期：2012-10-01 00:00:00

abstract：:In women with premature ovarian failure, fertility may be preserved by ovarian tissue culture in vitro. However, techniques for tissue culture and follicle maturation have remained suboptimal. Our aim was to characterize ovarian tissue degeneration in cultures and to establish a model for cell death research in cultur...

journal_title：Molecular human reproduction

authors： Otala M,Erkkilä K,Tuuri T,Sjöberg J,Suomalainen L,Suikkari AM,Pentikäinen V,Dunkel L

更新日期：2002-03-01 00:00:00

abstract：STUDY QUESTION:Do human adult Leydig cells (ALCs) within hyperplastic micronodules display characteristics of foetal LCs (FLCs)? SUMMARY ANSWER:The gene expression profiles of FLCs and all ALC subgroups were clearly different, but there were no significant differences in expressed genes between the normally clustered ...

journal_title：Molecular human reproduction

authors： Lottrup G,Belling K,Leffers H,Nielsen JE,Dalgaard MD,Juul A,Skakkebæk NE,Brunak S,Rajpert-De Meyts E

更新日期：2017-05-01 00:00:00

abstract：:Successful pregnancy in humans depends on deep invasion of the maternal decidua by extravillous trophoblast cells (EVTs), a process regulated by autocrine and paracrine signals in the decidual-trophoblast microenvironment. Here we examined whether trophoblast invasion is affected by decidual differentiation of endomet...

journal_title：Molecular human reproduction

authors： Gonzalez M,Neufeld J,Reimann K,Wittmann S,Samalecos A,Wolf A,Bamberger AM,Gellersen B

更新日期：2011-07-01 00:00:00

abstract：:The expression of insulin-like growth factor-I (IGF-I) was measured at the mRNA and protein level in myometrium and fibroids from women with and without preoperative treatment with a gonadotrophin-releasing hormone (GnRH) agonist for 3 months, from post-menopausal women, from pregnant women and in myometrium from wome...

journal_title：Molecular human reproduction

authors： Englund K,Lindblom B,Carlström K,Gustavsson I,Sjöblom P,Blanck A

更新日期：2000-10-01 00:00:00

abstract：:Follicular prostaglandin concentrations increase following the gonadotrophin surge in domestic animals and rodents approximately 10 h before follicle rupture, suggesting a unifying role for prostaglandins in the timing of ovulation. However, little is known about prostaglandin production by the primate ovulatory folli...

journal_title：Molecular human reproduction

authors： Duffy DM,Stouffer RL

更新日期：2001-08-01 00:00:00

abstract：:In the implantation, trophoblasts penetrate maternal decidua by secreting proteases. It has been reported that cathepsins are highly expressed in the mouse villi, and play an important role in normal embryonal growth and decidualization. In this study, we evaluated cathepsins and their endogenous inhibitors, cystatins...

journal_title：Molecular human reproduction

authors： Nakanishi T,Ozaki Y,Blomgren K,Tateyama H,Sugiura-Ogasawara M,Suzumori K

更新日期：2005-05-01 00:00:00

abstract：:Recent data demonstrated that CD4+CD25+ regulatory T (Treg) cells and an enzyme called indoleamine 2,3-dioxygenase (IDO) mediate maternal tolerance to the fetus. Interestingly, Treg cells express the CTLA-4 molecule on their surface, and B7 (CD80/86) ligation by CTLA-4 enhanced IDO activity of dendritic cells (DCs) an...

journal_title：Molecular human reproduction

authors： Miwa N,Hayakawa S,Miyazaki S,Myojo S,Sasaki Y,Sakai M,Takikawa O,Saito S

更新日期：2005-12-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared with luteinized granulosa cells from women with a normal...

journal_title：Molecular human reproduction

authors： Jiang L,Huang H,Qian Y,Li Y,Chen X,Di N,Yang D

更新日期：2020-08-01 00:00:00

abstract：:Tenascin-C is an extracellular matrix glycoprotein whose monomers include eight consecutive fibronectin type III-like repeats, encoded by exons 10-16, and which are subject to alternative splicing. Transcripts containing these exons are expressed during tissue wounding and active tissue remodelling. Human fetal membra...

journal_title：Molecular human reproduction

authors： Bell SC,Pringle JH,Taylor DJ,Malak TM

更新日期：1999-11-01 00:00:00

abstract：:Artificial oocyte activation to overcome failed fertilization after intracytoplasmic sperm injection (ICSI) in human oocytes typically employs Ca(2+) ionophores to produce a single cytosolic Ca(2+) increase. In contrast, recombinant phospholipase Czeta (PLCζ) causes Ca(2+) oscillations indistinguishable from those occ...

journal_title：Molecular human reproduction

authors： Sanusi R,Yu Y,Nomikos M,Lai FA,Swann K

更新日期：2015-10-01 00:00:00