Zinc exocytosis is sensitive to myosin light chain kinase inhibition in mouse and human eggs.

abstract：:Pregnancy-associated plasma protein-A and -A2 (PAPP-A and -A2) are proteases that cleave insulin-like growth factor-binding proteins (IGFBPs), resulting in local activation of IGF signaling pathways. Here, we examined PAPP-A and -A2 mRNA and protein levels in placenta and maternal sera from women with pre-eclampsia an...

journal_title：Molecular human reproduction

authors： Nishizawa H,Pryor-Koishi K,Suzuki M,Kato T,Kogo H,Sekiya T,Kurahashi H,Udagawa Y

更新日期：2008-10-01 00:00:00

abstract：:The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its ...

journal_title：Molecular human reproduction

authors： Jing Y,Run-Qian L,Hao-Ran W,Hao-Ran C,Ya-Bin L,Yang G,Fei C

更新日期：2020-06-01 00:00:00

abstract：:Human pregnancy represents a situation of semiallograft to maternal host. Therefore, it has been reported that tolerance to the fetal allograft represents a mechanism for maintaining a pregnancy. CD4(+)CD25(bright) regulatory T cells are known to play an important role in the development and maintenance of tolerance i...

journal_title：Molecular human reproduction

authors： Sasaki Y,Sakai M,Miyazaki S,Higuma S,Shiozaki A,Saito S

更新日期：2004-05-01 00:00:00

abstract：:The use of interphase fluorescent in situ hybridization (FISH) has shown that a large number of human embryos exhibit chromosomal abnormalities in vitro. The most common abnormality is mosaicism which is seen in up to 50% of preimplantation embryos at all stages of development. In this study, comparative genomic hybri...

journal_title：Molecular human reproduction

authors： Daphnis DD,Fragouli E,Economou K,Jerkovic S,Craft IL,Delhanty JD,Harper JC

更新日期：2008-02-01 00:00:00

abstract：STUDY HYPOTHESIS:What factors in mouse oocytes are involved in the ageing-related decline in oocyte quality? STUDY FINDING:The maternal effect gene Mater is involved in ageing-related oocyte quality decline in mice. WHAT IS KNOWN ALREADY:Premature loss of centromere cohesion is a hallmark of ageing-related oocyte qua...

journal_title：Molecular human reproduction

authors： Lu YQ,He XC,Zheng P

更新日期：2016-04-01 00:00:00

abstract：:No phenotypic effect is observed in most inversion heterozygotes. However, reproductive risks may occur in the form of infertility, spontaneous abortions or chromosomally unbalanced children as a consequence of meiotic recombination between inverted and non-inverted chromosomes. An odd number of crossovers within the ...

journal_title：Molecular human reproduction

authors： Chantot-Bastaraud S,Ravel C,Berthaut I,McElreavey K,Bouchard P,Mandelbaum J,Siffroi JP

更新日期：2007-01-01 00:00:00

abstract：:Human endometrial stromal cells (ESC) can produce a variety of chemokines, especially after inflammatory stimulation. Interferon-gamma-inducible protein-10 (IP-10) is a potent chemoattractant for lymphocytes, and belongs to the family of non-ELR CXC chemokines. The expression of IP-10 in ESC after stimulation with int...

journal_title：Molecular human reproduction

authors： Kai K,Nasu K,Nakamura S,Fukuda J,Nishida M,Miyakawa I

更新日期：2002-02-01 00:00:00

abstract：:The requisite endpoint of mammalian oocyte maturation, whether in vivo or in vitro, is a metaphase II oocyte which is able to be fertilized and which can eventually support normal embryonic development. Oocytes which have been matured in vivo basically fulfill these criteria. On the other hand, a completely different ...

journal_title：Molecular human reproduction

authors： Fulka J Jr,First NL,Moor RM

更新日期：1998-01-01 00:00:00

abstract：:In addition to prostaglandins, inflammatory cytokines induce uterine contraction via oxytocin (OT). Placental leucine aminopeptidase (P-LAP), an oxytocinase that is identical to cystine aminopeptidase, destroys OT activity. Patients with spontaneous preterm delivery have higher concentrations of inflammatory cytokines...

journal_title：Molecular human reproduction

authors： Ikoma Y,Nomura S,Ito T,Katsumata Y,Nakata M,Iwanaga K,Okada M,Kikkawa F,Tamakoshi K,Nagasaka T,Tsujimoto M,Mizutani S

更新日期：2003-02-01 00:00:00

abstract：:The epithelium lining the epididymis in the male reproductive tract maintains a luminal environment that promotes sperm cell maturation. This process is dependent on the coordinated expression of many genes that encode proteins with a role in epithelial transport. We previously generated genome-wide maps of open chrom...

journal_title：Molecular human reproduction

authors： Browne JA,Yang R,Song L,Crawford GE,Leir SH,Harris A

更新日期：2014-12-01 00:00:00

abstract：:The objectives of this study were to determine if human ejaculated sperm exhibit active caspases and if caspase-dependent apoptosis markers are identifiable. Sperm from fertile donors and infertile patients were examined after gradient separation into leukocyte-free fractions of high and low motility. Sperm were evalu...

journal_title：Molecular human reproduction

authors： Weng SL,Taylor SL,Morshedi M,Schuffner A,Duran EH,Beebe S,Oehninger S

更新日期：2002-11-01 00:00:00

abstract：:Prader-Willi syndrome (PWS) is a genomic disorder mostly caused by deletions of 15q11-q13 region (70%). It has been suggested that the particular genomic architecture of 15q11-q13 region, characterized to be flanked by low copy repeats, could predispose it to Non-Allelic Homologous Recombination (NAHR). However, no st...

journal_title：Molecular human reproduction

authors： Molina O,Blanco J,Vidal F

更新日期：2010-05-01 00:00:00

abstract：:Glutathione S-transferase M1 (GSTM1), one member of the GST family, is responsible for metabolism of xenobiotics and carcinogens. Myeloperoxidase (MPO) plays an important role in the oxidation and activation of carcinogens and nitric oxide. Allelic variants of GSTM1 and MPO gene polymorphisms might impair detoxificati...

journal_title：Molecular human reproduction

authors： Hsieh YY,Chang CC,Tsai FJ,Lin CC,Chen JM,Tsai CH

更新日期：2004-10-01 00:00:00

abstract：:Surfactant protein D (SP-D) plays a role in innate immunity against various pathogens and in vivo studies have demonstrated that SP-D also has anti-inflammatory properties. SP-D was originally demonstrated in alveolar type II cells, but recent studies have shown extrapulmonary expression of SP-D indicating a systemic ...

journal_title：Molecular human reproduction

authors： Leth-Larsen R,Floridon C,Nielsen O,Holmskov U

更新日期：2004-03-01 00:00:00

abstract：:We report an improvement in the PGD test for fragile X syndrome (FXS). Recently, multiple displacement amplification (MDA) has been reported to yield large amounts of DNA from single cells. Taking into account this technique, we developed a new PGD test for FXS, enabling combined analysis of linked polymorphic markers...

journal_title：Molecular human reproduction

authors： Burlet P,Frydman N,Gigarel N,Kerbrat V,Tachdjian G,Feyereisen E,Bonnefont JP,Frydman R,Munnich A,Steffann J

更新日期：2006-10-01 00:00:00

abstract：:Imprinted genes are characterized by expression of only one of the two alleles according to its inheritance from the mother or the father. This mono-allelic expression must arise from primary differential epigenetic modification of the parental alleles of the imprinted gene in the spermatozoon and the oocyte. Most of ...

journal_title：Molecular human reproduction

authors： Salpekar A,Huntriss J,Bolton V,Monk M

更新日期：2001-09-01 00:00:00

abstract：:Persistent organohalogen pollutants (POPs) have been suggested to be involved in changing the proportion of ejaculated Y-bearing sperm. The androgen receptor (AR), aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor repressor (AHRR) may modulate the effect of POPs with regard to previously observed sperm Y:X...

journal_title：Molecular human reproduction

authors： Tiido T,Rignell-Hydbom A,Jönsson BA,Rylander L,Giwercman A,Giwercman YL

更新日期：2007-04-01 00:00:00

abstract：:In humans, male and female partners contribute more or less equally to the infertility problem. In approximately 20% of infertile couples, the concurrence of male and female factors is suggested to be responsible for infertility. Neither of these factors are known nor is there a model system to prove this assumption. ...

journal_title：Molecular human reproduction

authors： Nayernia K,Adham IM,Shamsadin R,Müller C,Sancken U,Engel W

更新日期：2002-05-01 00:00:00

abstract：:Prostaglandins (PG) E2 and F2 alpha are produced by the human corpus luteum in significant amounts and they are known to exert local luteotrophic and luteolytic effects respectively. The present study determined how PGE2 and PGF2 alpha are involved in the regulation of inhibin A, a granulosa cell-derived glycoprotein ...

journal_title：Molecular human reproduction

authors： Erämaa M,Ritvos O

更新日期：1996-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared with luteinized granulosa cells from women with a normal...

journal_title：Molecular human reproduction

authors： Jiang L,Huang H,Qian Y,Li Y,Chen X,Di N,Yang D

更新日期：2020-08-01 00:00:00

abstract：:Patients with rare overgrowth disorders, such as Beck-Wiedemann syndrome and Simpson-Golabi-Behmel syndrome, are predisposed to embryonal tumours, including Wilms' tumour of the kidney. Therefore, these disorders offer a link between hyperplastic growth and cancer. Genetic lesions at chromosome 11p15 have been associa...

journal_title：Molecular human reproduction

authors： Ward A

更新日期：1997-02-01 00:00:00

abstract：:Ovaries surgically removed for fertility preservation from a total of 24 women served as a source of human small antral follicles, including the follicular fluid (FF) and the corresponding granulosa cells (GC). The FF was used to evaluate the intrafollicular concentrations of anti-Müllerian hormone (AMH), inhibin-B, e...

journal_title：Molecular human reproduction

authors： Eilsø Nielsen M,Rasmussen IA,Fukuda M,Westergaard LG,Yding Andersen C

更新日期：2010-09-01 00:00:00

abstract：:An understanding of the relationship between nuclear morphology and DNA function is important in cytology and preimplantation diagnosis. In this study, direct polymerase chain reaction (PCR) amplification was used to diagnose the common delta F508 mutation of cystic fibrosis in 62 biopsied human embryo cells. The nucl...

journal_title：Molecular human reproduction

authors： Cui KH,Matthews CD

更新日期：1996-01-01 00:00:00

abstract：STUDY QUESTION:Can enzymatically dispersed testicular cells from adult men reassemble into seminiferous cord-like structures in vitro? SUMMARY ANSWER:Adult human testicular somatic cells reassembled into testicular cord-like structures via dynamic interactions of Sertoli and peritubular cells. WHAT IS KNOWN ALREADY:I...

journal_title：Molecular human reproduction

authors： Mincheva M,Sandhowe-Klaverkamp R,Wistuba J,Redmann K,Stukenborg JB,Kliesch S,Schlatt S

更新日期：2018-02-01 00:00:00

abstract：:The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony-stimulating factor (MCSF) and transforming growth factor beta (TGFbeta) on the secretion of matrix metalloproteinases (MMP), human chorionic gonadotrophin (HCG) and fetal fibrone...

journal_title：Molecular human reproduction

authors： Meisser A,Chardonnens D,Campana A,Bischof P

更新日期：1999-03-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is a heterogeneous condition with unknown etiology and is considered to be the most common endocrine disorder in women of reproductive age. Two meta-analyses are presented here concerning the association of Plasminogen Activator Inhibitor 1 (PAI-1) 4G/5G polymorphism and the methylene-...

journal_title：Molecular human reproduction

authors： Bagos PG

更新日期：2009-01-01 00:00:00

abstract：STUDY HYPOTHESIS:Does a preferential X chromosome inactivation (XCI) pattern exist in female human pluripotent stem cells (hPSCs) and does the pattern change during long-term culture or upon differentiation? STUDY FINDING:We identified two independent phenomena that lead to aberrant XCI patterns in female hPSC: a rapi...

journal_title：Molecular human reproduction

authors： Geens M,Seriola A,Barbé L,Santalo J,Veiga A,Dée K,Van Haute L,Sermon K,Spits C

更新日期：2016-04-01 00:00:00

abstract：:Successful intracytoplasmic sperm injection (ICSI) is dependent upon the competence of the oocyte to respond to the injection of a spermatozoon in the presence of calcium. This study determined if oocytes that failed to become fertilized (absence of any pronuclei) failed to undergo cytoplasmic activation, as ascertain...

journal_title：Molecular human reproduction

authors： Gross V,Dubey A,Penzias AS,Layman L,Reindollar R,Ducibella T

更新日期：1996-12-01 00:00:00

abstract：:The aim of the present study was to investigate the potential role of Toll-like receptor 4 (TLR4) in lipopolysaccharide (LPS)-induced preterm delivery. Intraperitoneal injection of LPS in the presence or absence of previous TLR4 blockade was performed to establish a murine model of preterm delivery. The incidences of ...

journal_title：Molecular human reproduction

authors： Li L,Kang J,Lei W

更新日期：2010-04-01 00:00:00

abstract：:In early gestation, the human placental renin-angiotensin system (RAS) is upregulated and plays a role in placental development. Among other functions, signalling through the angiotensin II type 1 receptor (AT1R) initiates proliferation. Many microRNAs (miRNAs) targeting placental RAS mRNAs are downregulated at this t...

journal_title：Molecular human reproduction

authors： Arthurs AL,Lumbers ER,Pringle KG

更新日期：2019-04-01 00:00:00