Analysis of the evolution of chromosome abnormalities in human embryos from Day 3 to 5 using CGH and FISH.

abstract：:Granzyme B (graB) plays a pivotal role in cytotoxic lymphocyte granule-mediated apoptosis through cleavage of intracellular proteins in target cells. Proteinase inhibitor-9 (PI-9) is a potent inhibitor of graB and is highly expressed in cytotoxic lymphocytes. Here, we show by immunohistochemistry that PI-9 is also abu...

journal_title：Molecular human reproduction

authors： Hirst CE,Buzza MS,Sutton VR,Trapani JA,Loveland KL,Bird PI

更新日期：2001-12-01 00:00:00

abstract：:Olfactory receptors are G protein-coupled transmembrane receptors. Genes encoding olfactory receptors constitute a large gene family of approximately 1000 total member genes. In mammals, a subset of member genes is specifically expressed in the testis (and not in the olfactory mucosa) and olfactory receptor proteins h...

journal_title：Molecular human reproduction

authors： Goto T,Salpekar A,Monk M

更新日期：2001-06-01 00:00:00

abstract：:The objectives of this study were to determine if human ejaculated sperm exhibit active caspases and if caspase-dependent apoptosis markers are identifiable. Sperm from fertile donors and infertile patients were examined after gradient separation into leukocyte-free fractions of high and low motility. Sperm were evalu...

journal_title：Molecular human reproduction

authors： Weng SL,Taylor SL,Morshedi M,Schuffner A,Duran EH,Beebe S,Oehninger S

更新日期：2002-11-01 00:00:00

abstract：:Follicular development and ovulation are major processes in the reproductive system. Understanding their complexity is important to female fertility treatments and the control of reproductive processes. Wnt signaling pathway components were shown to be involved in reproduction in animal models. The secreted frizzled-r...

journal_title：Molecular human reproduction

authors： Maman E,Yung Y,Cohen B,Konopnicki S,Dal Canto M,Fadini R,Kanety H,Kedem A,Dor J,Hourvitz A

更新日期：2011-07-01 00:00:00

abstract：:Binder of SPerm (BSP) proteins are a family of proteins expressed exclusively in the male reproductive tract (seminal vesicles or epididymis) of several mammalian species. They are known to promote capacitation, a sperm maturation step essential for fertilization. Our recent studies have shown that in human, the Binde...

journal_title：Molecular human reproduction

authors： Plante G,Thérien I,Lachance C,Leclerc P,Fan J,Manjunath P

更新日期：2014-05-01 00:00:00

abstract：STUDY QUESTION:What is the association between placental formyl peptide receptor 2 (FPR2) and trophoblast and endothelial functions in pregnancies affected by foetal growth restriction (FGR)? SUMMARY ANSWER:Reduced FPR2 placental expression in idiopathic FGR results in significantly altered trophoblast differentiation...

journal_title：Molecular human reproduction

authors： Lappas M,McCracken S,McKelvey K,Lim R,James J,Roberts CT,Fournier T,Alfaidy N,Powell KL,Borg AJ,Morris JM,Leaw B,Singh H,Ebeling PR,Wallace EM,Parry LJ,Dimitriadis E,Murthi P

更新日期：2018-02-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) plays a key role in the maintenance of human pregnancy and labour onset. PGE2 can elicit diverse actions within the uterus depending on the PGE2 receptors (EP1, EP2, EP3 and EP4) expressed. By signalling through different intracellular pathways the EP receptors may inhibit or promote smooth mus...

journal_title：Molecular human reproduction

authors： Astle S,Thornton S,Slater DM

更新日期：2005-04-01 00:00:00

abstract：:Recombinant human ZP3 (rhuZP3) generated by Chinese hamster ovary cells transfected with a plasmid containing human ZP3 cDNA was used to study the acrosome reaction (AR) and intracellular calcium fluxes in capacitated human spermatozoa. Conditioned medium containing rhuZP3 significantly induced the AR (P < or = 0.005)...

journal_title：Molecular human reproduction

authors： Brewis IA,Clayton R,Barratt CL,Hornby DP,Moore HD

更新日期：1996-08-01 00:00:00

abstract：:E-cadherin (uvomorulin)-mediated cell interactions are essential for preimplantation development in mammals. We observed that E-cadherin is expressed at contact sites between blastomeres of 2-cell mouse embryos of non-blocking genotype (CBA x C57BL F1) explanted at 32 h post human chorionic gonadotrophin (HCG) and cul...

journal_title：Molecular human reproduction

authors： Neganova IE,Sekirina GG,Eichenlaub-Ritter U

更新日期：2000-05-01 00:00:00

abstract：:Fatty acid amide hydrolase (FAAH) is involved in embryo development and implantation. Sex hormones down-modulate FAAH activity in the mouse uterus. However, the regulation of the FAAH gene in the uterus is unknown. Our results showed that FAAH mRNA is localized to uterine epithelial cells and circular myometrium durin...

journal_title：Molecular human reproduction

authors： Xiao AZ,Zhao YG,Duan EK

更新日期：2002-07-01 00:00:00

abstract：:The DAZL (DAZ-like) gene is suggested to be an ancestral gene of the DAZ (deleted in azoospermia) gene on the Y chromosome, which is a strong candidate for the azoospermic factor. Recently, it has been reported that the T54A (Thr54-->Ala) polymorphism in exon 3 of the DAZL gene is associated with spermatogenic failure...

journal_title：Molecular human reproduction

authors： Yang XJ,Shinka T,Nozawa S,Yan HT,Yoshiike M,Umeno M,Sato Y,Chen G,Iwamoto T,Nakahori Y

更新日期：2005-07-01 00:00:00

abstract：:Successful pregnancy in humans depends on deep invasion of the maternal decidua by extravillous trophoblast cells (EVTs), a process regulated by autocrine and paracrine signals in the decidual-trophoblast microenvironment. Here we examined whether trophoblast invasion is affected by decidual differentiation of endomet...

journal_title：Molecular human reproduction

authors： Gonzalez M,Neufeld J,Reimann K,Wittmann S,Samalecos A,Wolf A,Bamberger AM,Gellersen B

更新日期：2011-07-01 00:00:00

abstract：:Sperm capacitation is a maturation event that takes place in the female reproductive tract and is essential for fertilization. A family of phospholipid-binding proteins present in bovine seminal plasma (BSP proteins) binds the sperm membrane at ejaculation and promotes bovine sperm capacitation. Homologues of these pr...

journal_title：Molecular human reproduction

authors： Lefebvre J,Fan J,Chevalier S,Sullivan R,Carmona E,Manjunath P

更新日期：2007-01-01 00:00:00

abstract：:Fluorescent in situ hybridization (FISH) studies of human preimplantation embryos have demonstrated a high proportion of chromosomal mosaicism. To investigate the different timings and nature of chromosomal mosaicism, we developed single cell multiplex fluorescent (FL)-PCR to distinguish meiotic and mitotic cell divis...

journal_title：Molecular human reproduction

authors： Katz-Jaffe MG,Trounson AO,Cram DS

更新日期：2004-02-01 00:00:00

abstract：:Artificial oocyte activation to overcome failed fertilization after intracytoplasmic sperm injection (ICSI) in human oocytes typically employs Ca(2+) ionophores to produce a single cytosolic Ca(2+) increase. In contrast, recombinant phospholipase Czeta (PLCζ) causes Ca(2+) oscillations indistinguishable from those occ...

journal_title：Molecular human reproduction

authors： Sanusi R,Yu Y,Nomikos M,Lai FA,Swann K

更新日期：2015-10-01 00:00:00

abstract：:Persistent organohalogen pollutants (POPs) have been suggested to be involved in changing the proportion of ejaculated Y-bearing sperm. The androgen receptor (AR), aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor repressor (AHRR) may modulate the effect of POPs with regard to previously observed sperm Y:X...

journal_title：Molecular human reproduction

authors： Tiido T,Rignell-Hydbom A,Jönsson BA,Rylander L,Giwercman A,Giwercman YL

更新日期：2007-04-01 00:00:00

abstract：:Survivin is a novel inhibitor of apoptosis. It has been reported that survivin is expressed during fetal development and in cancer tissues, but its expression has not been reported in adult tissues. We investigated the expression of survivin in the endometria of women with regular menstrual cycles using reverse transc...

journal_title：Molecular human reproduction

authors： Konno R,Yamakawa H,Utsunomiya H,Ito K,Sato S,Yajima A

更新日期：2000-06-01 00:00:00

abstract：:The etiology of preeclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Although many candidate genes for preeclampsia have been suggested and studied, the specific causative genes still remain to be identified. Catechol-O-methyltransferase (COMT...

journal_title：Molecular human reproduction

authors： Roten LT,Fenstad MH,Forsmo S,Johnson MP,Moses EK,Austgulen R,Skorpen F

更新日期：2011-07-01 00:00:00

abstract：:The human endometrium is a cyclically regenerating organ under the influence of ovarian steroid hormones. Disturbances in this highly coordinated regulation of endometrial proliferation and differentiation may result in infertility and diseases such as endometriosis and endometrial cancer. Environmental toxins belongi...

journal_title：Molecular human reproduction

authors： Willing C,Peich M,Danescu A,Kehlen A,Fowler PA,Hombach-Klonisch S

更新日期：2011-02-01 00:00:00

abstract：:The Prader-Willi (PWS) and Angelman (AS) syndromes are two clinically distinct syndromes which result from lack of expression of imprinted genes within chromosome 15q11-q13. These two syndromes result from 15q11-q13 deletions, chromosome 15 uniparental disomy (UPD), imprinting centre mutations and, for AS, probable mu...

journal_title：Molecular human reproduction

authors： Glenn CC,Driscoll DJ,Yang TP,Nicholls RD

更新日期：1997-04-01 00:00:00

abstract：:Tyrosine nitration is a widely used marker of peroxynitrite (ONOO-) produced from the reaction of nitric oxide (NO.) with superoxide (O2(.-)). Since human spermatozoa are able to produce both NO. and O2(.-) during capacitation in vitro, we investigated whether spontaneous tyrosine nitration of proteins occurs in human...

journal_title：Molecular human reproduction

authors： Herrero MB,de Lamirande E,Gagnon C

更新日期：2001-10-01 00:00:00

abstract：:In humans, male and female partners contribute more or less equally to the infertility problem. In approximately 20% of infertile couples, the concurrence of male and female factors is suggested to be responsible for infertility. Neither of these factors are known nor is there a model system to prove this assumption. ...

journal_title：Molecular human reproduction

authors： Nayernia K,Adham IM,Shamsadin R,Müller C,Sancken U,Engel W

更新日期：2002-05-01 00:00:00

abstract：:Several lines of evidence indicate that mammalian fertilization is initiated via a binding process that is dependent upon the recognition of oligosaccharide sequences associated with zona pellucida (ZP) glycoproteins. Here, specific chemical and enzymatic methods were employed to modify human ZP and to test their effe...

journal_title：Molecular human reproduction

authors： Ozgur K,Patankar MS,Oehninger S,Clark GF

更新日期：1998-04-01 00:00:00

abstract：:We have previously shown that the estrogen responsiveness of the human lactoferrin gene in a transient transfection system is mediated through an imperfect estrogen response element (ERE) and a steroidogenic factor 1 binding element (SFRE) 26 bp upstream from ERE. Reporter constructs containing SFRE and ERE respond to...

journal_title：Molecular human reproduction

authors： Teng CT,Gladwell W,Beard C,Walmer D,Teng CS,Brenner R

更新日期：2002-01-01 00:00:00

abstract：:Within the context of an oocyte in vitro maturation (IVM) program for reproductive treatment, oocyte cumulus complexes (COCs) derived from follicles <6 mm in patients with PCOS were matured in vitro. Key transcripts related to meiotic maturation (FSHR, LHCGR, EGFR, PGR) and oocyte competence (AREG, ADAMTS, HAS2, PTGS2...

journal_title：Molecular human reproduction

authors： Guzman L,Adriaenssens T,Ortega-Hrepich C,Albuz FK,Mateizel I,Devroey P,De Vos M,Smitz J

更新日期：2013-01-01 00:00:00

abstract：:A novel gene, TSG23/Tsg23, was identified by comparing the expression profiles of human adult and fetal testis using Affymetrix Genechips. RT-PCR analysis from multiple human and mouse tissues indicated TSG23/Tsg23 mRNA was mainly expressed in the testis. In situ hybridization revealed that TSG23/Tsg23 mRNA was locate...

journal_title：Molecular human reproduction

authors： Zhou Y,Qin D,Tang A,Zhou D,Qin J,Yan B,Diao R,Jiang Z,Cai Z,Gui Y

更新日期：2009-04-01 00:00:00

abstract：:Microarray studies generating lists of genes with altered expression in placentas from pregnancies complicated with pre-eclampsia (PE) have so far been published in several different studies. Working under the assumption that altered gene expression in PE may be the result of altered expression of regulatory transcrip...

journal_title：Molecular human reproduction

authors： Vásárhelyi B,Cseh A,Kocsis I,Treszl A,Györffy B,Rigó J Jr

更新日期：2006-01-01 00:00:00

abstract：:Preterm premature rupture of the membranes (PPROM) has been considered to be closely associated with chorioamnionitis. However, the detailed mechanism is not well understood. Alpha 1 antitrypsin (AAT) was reported to decrease in concentration in amniotic fluid obtained from patients with PPROM. However, the origin of ...

journal_title：Molecular human reproduction

authors： Izumi-Yoneda N,Toda A,Okabe M,Koike C,Takashima S,Yoshida T,Konishi I,Saito S,Nikaido T

更新日期：2009-01-01 00:00:00

abstract：:The transcription factor OCT-4 is regarded as a critical factor in controlling mammalian early embryonic development because of its role in toti-/pluripotency. In human preimplantation embryos, OCT-4 studies are limited to RNA analysis of abnormally developing embryos. This study thoroughly investigated the expression...

journal_title：Molecular human reproduction

authors： Cauffman G,Van de Velde H,Liebaers I,Van Steirteghem A

更新日期：2005-03-01 00:00:00

abstract：:The process of sperm chromatin decondensation occurs when a spermatozoon enters an ovum. Protamine disulphide bonds are reduced to SH and the polycationic protamines combine with the polyanionic egg protein, nucleoplasmin, thus being stripped from DNA which then combines with histones. Defective chromatin decondensati...

journal_title：Molecular human reproduction

authors： Samocha-Bone D,Lewin LM,Weissenberg R,Madgar Y,Soffer Y,Shochat L,Golan R

更新日期：1998-02-01 00:00:00