Alpha 1 antitrypsin activity is decreased in human amnion in premature rupture of the fetal membranes.

abstract：STUDY QUESTION:Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER:We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in ...

journal_title：Molecular human reproduction

authors： Martinez G,Hograindleur JP,Voisin S,Abi Nahed R,Abd El Aziz TM,Escoffier J,Bessonnat J,Fovet CM,De Waard M,Hennebicq S,Aucagne V,Ray PF,Schmitt E,Bulet P,Arnoult C

更新日期：2017-02-10 00:00:00

abstract：:The pool of primordial follicles in humans is laid down during embryonic development and follicles can remain dormant for prolonged intervals, often decades, until individual follicles resume growth. The mechanisms that induce growth and maturation of primordial follicles are poorly understood but follicles once activ...

journal_title：Molecular human reproduction

authors： Markholt S,Grøndahl ML,Ernst EH,Andersen CY,Ernst E,Lykke-Hartmann K

更新日期：2012-02-01 00:00:00

abstract：:Recent data demonstrated that CD4+CD25+ regulatory T (Treg) cells and an enzyme called indoleamine 2,3-dioxygenase (IDO) mediate maternal tolerance to the fetus. Interestingly, Treg cells express the CTLA-4 molecule on their surface, and B7 (CD80/86) ligation by CTLA-4 enhanced IDO activity of dendritic cells (DCs) an...

journal_title：Molecular human reproduction

authors： Miwa N,Hayakawa S,Miyazaki S,Myojo S,Sasaki Y,Sakai M,Takikawa O,Saito S

更新日期：2005-12-01 00:00:00

abstract：:Estrogen and selective estrogen receptor modulators (SERMs) differentially impact endometrial cell function, however, the biological basis of these differences is not established. Deregulated cell adhesion to the extracellular matrix, cell movement and invasion are related to endometrial disorders, such as endometrios...

journal_title：Molecular human reproduction

authors： Flamini MI,Sanchez AM,Goglia L,Tosi V,Genazzani AR,Simoncini T

更新日期：2009-10-01 00:00:00

abstract：:Acrosome status in human spermatozoa from 20 normozoospermic men was evaluated by flow cytometry following the induction of the acrosome reaction with the ionophore A23187. Dual fluorescence staining of methanol fixed spermatozoa incubated with and without (control) the ionophore A23187 was performed with probes which...

journal_title：Molecular human reproduction

authors： Nikolaeva MA,Golubeva EL,Kulakov VI,Sukhikh GT

更新日期：1998-03-01 00:00:00

abstract：:This study was initiated to determine the relationship between the fertilizing potential of spermatozoa and abnormalities in the compact packing of their chromatin which occurs in the final stage of male germ cell differentiation. Chromatin packing involves disulphide bridge covalent cross-linking. The degree of packi...

journal_title：Molecular human reproduction

authors： Filatov MV,Semenova EV,Vorob'eva OA,Leont'eva OA,Drobchenko EA

更新日期：1999-09-01 00:00:00

abstract：:Chemokines are implicated in the implantation process. The aim of this study was to investigate mRNA expression and protein levels of chemokine receptors CXCR1, CXCR4, CCR5 and CCR2B in human endometrium throughout the menstrual cycle, during HRT and in the human blastocyst. The regulation of chemokine receptors in th...

journal_title：Molecular human reproduction

authors： Dominguez F,Galan A,Martin JJ,Remohi J,Pellicer A,Simón C

更新日期：2003-04-01 00:00:00

abstract：:E-cadherin (uvomorulin)-mediated cell interactions are essential for preimplantation development in mammals. We observed that E-cadherin is expressed at contact sites between blastomeres of 2-cell mouse embryos of non-blocking genotype (CBA x C57BL F1) explanted at 32 h post human chorionic gonadotrophin (HCG) and cul...

journal_title：Molecular human reproduction

authors： Neganova IE,Sekirina GG,Eichenlaub-Ritter U

更新日期：2000-05-01 00:00:00

abstract：:An altered inflammatory activity due to functionally relevant polymorphisms of the innate immune system may influence pathways leading to labour and, therefore, impact on the frequency of preterm birth. We examined five polymorphisms of the innate immune system in a large cohort of preterm very-low-birth-weight (VLBW,...

journal_title：Molecular human reproduction

authors： Härtel Ch,Finas D,Ahrens P,Kattner E,Schaible T,Müller D,Segerer H,Albrecht K,Möller J,Diedrich K,Göpel W,Genetic Factors in Neonatology Study Group.

更新日期：2004-12-01 00:00:00

abstract：:Endometriosis, the presence of ectopic endometrial tissue outside the uterine cavity, is a common disease affecting women during their reproductive years. The aim of this study was to identify the molecular mechanism of transcriptional regulation of inflammatory cyclooxygenase-2 (COX-2) gene during endometriosis by hy...

journal_title：Molecular human reproduction

authors： Kim KH,Kim HY,Kim HH,Lee KS,Cheong J

更新日期：2011-11-01 00:00:00

abstract：:Patients with rare overgrowth disorders, such as Beck-Wiedemann syndrome and Simpson-Golabi-Behmel syndrome, are predisposed to embryonal tumours, including Wilms' tumour of the kidney. Therefore, these disorders offer a link between hyperplastic growth and cancer. Genetic lesions at chromosome 11p15 have been associa...

journal_title：Molecular human reproduction

authors： Ward A

更新日期：1997-02-01 00:00:00

abstract：:Sperm capacitation is a maturation event that takes place in the female reproductive tract and is essential for fertilization. A family of phospholipid-binding proteins present in bovine seminal plasma (BSP proteins) binds the sperm membrane at ejaculation and promotes bovine sperm capacitation. Homologues of these pr...

journal_title：Molecular human reproduction

authors： Lefebvre J,Fan J,Chevalier S,Sullivan R,Carmona E,Manjunath P

更新日期：2007-01-01 00:00:00

abstract：STUDY QUESTION:Do human adult Leydig cells (ALCs) within hyperplastic micronodules display characteristics of foetal LCs (FLCs)? SUMMARY ANSWER:The gene expression profiles of FLCs and all ALC subgroups were clearly different, but there were no significant differences in expressed genes between the normally clustered ...

journal_title：Molecular human reproduction

authors： Lottrup G,Belling K,Leffers H,Nielsen JE,Dalgaard MD,Juul A,Skakkebæk NE,Brunak S,Rajpert-De Meyts E

更新日期：2017-05-01 00:00:00

abstract：:In humans, the most common chromosomal abnormality is aneuploidy. Because the majority of aneuploid conceptuses die during the early stages of embryonic development, an accurate estimate of the frequency of aneuploidy at conception can only be assessed by directly studying the gametes. The vast majority of aneuploidie...

journal_title：Molecular human reproduction

authors： Templado C,Uroz L,Estop A

更新日期：2013-10-01 00:00:00

abstract：:The major regulators of endometrial function are oestrogen and progesterone, which act through binding their nuclear receptors and by activating transcription of their target genes. Interactions between steroid receptors and transcription proteins, e.g. c-JUN/AP-1, can modulate steroid action at the transcriptional le...

journal_title：Molecular human reproduction

authors： Salmi A,Pakarinen P,Peltola AM,Rutanen EM

更新日期：1998-12-01 00:00:00

abstract：:Ascorbic acid serves a vital role as a pre-eminent antioxidant. In animals, it has been shown to be concentrated in granulosa and theca cells of the follicle, in luteal cells of the corpus luteum, and in the peripheral cytoplasm of the oocyte. We have previously identified hormonally-regulated ascorbic acid transporte...

journal_title：Molecular human reproduction

authors： Zreik TG,Kodaman PH,Jones EE,Olive DL,Behrman H

更新日期：1999-04-01 00:00:00

abstract：:The expression of insulin-like growth factor-I (IGF-I) was measured at the mRNA and protein level in myometrium and fibroids from women with and without preoperative treatment with a gonadotrophin-releasing hormone (GnRH) agonist for 3 months, from post-menopausal women, from pregnant women and in myometrium from wome...

journal_title：Molecular human reproduction

authors： Englund K,Lindblom B,Carlström K,Gustavsson I,Sjöblom P,Blanck A

更新日期：2000-10-01 00:00:00

abstract：:Oxidative damage by reactive oxygen species (ROS) is a major cause of sperm dysfunction. Excessive ROS generation reduces fertilization and enhances DNA damage of spermatozoa. Interaction between spermatozoa and oviductal epithelial cells improves the fertilizing ability of and reduces chromatin damage in spermatozoa....

journal_title：Molecular human reproduction

authors： Huang VW,Lee CL,Lee YL,Lam KK,Ko JK,Yeung WS,Ho PC,Chiu PC

更新日期：2015-06-01 00:00:00

abstract：:Maturation (M-phase) promoting factor (MPF) plays a pivotal role in oocytes during their maturation. This review concentrates on its function at three important time-points. First, its activation during meiotic progression from prophase I arrest at germinal vesicle breakdown. Second, its role during the transition fro...

journal_title：Molecular human reproduction

authors： Jones KT

更新日期：2004-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression post-transcriptionally. We explored whether connexin 43 (Cx43) was differently expressed in luteinized granulosa cells from women with polycystic ovary syndrome (PCOS) compared with luteinized granulosa cells from women with a normal...

journal_title：Molecular human reproduction

authors： Jiang L,Huang H,Qian Y,Li Y,Chen X,Di N,Yang D

更新日期：2020-08-01 00:00:00

abstract：:The identification of polymorphisms in genes encoding proinflammatory cytokines that affect transcription or the secretion rate has opened new ways to understand the variation in responses to infection during pregnancy. In this study, human amniochorion carrying hyper-responsive alleles of tumour necrosis factor-alpha...

journal_title：Molecular human reproduction

authors： Hernandez-Guerrero C,Monzon-Bordonaba F,Jimenez-Zamudio L,Ahued-Ahued R,Arechavaleta-Velasco F,Strauss JF 3rd,Vadillo-Ortega F

更新日期：2003-10-01 00:00:00

abstract：:In the uterus, epithelial cell proliferation changes during the estrous cycle and pregnancy. Uncontrolled epithelial cell proliferation results in implantation failure and/or cancer development. Transforming growth factor-β (TGF-β) signaling is a fundamental regulator of diverse biological processes and is indispensab...

journal_title：Molecular human reproduction

authors： Gao Y,Li S,Li Q

更新日期：2014-08-01 00:00:00

abstract：:The 2019 novel coronavirus (2019-nCoV) appeared in December 2019 and then spread throughout the world rapidly. The virus invades the target cell by binding to angiotensin-converting enzyme (ACE) 2 and modulates the expression of ACE2 in host cells. ACE2, a pivotal component of the renin-angiotensin system, exerts its ...

journal_title：Molecular human reproduction

authors： Jing Y,Run-Qian L,Hao-Ran W,Hao-Ran C,Ya-Bin L,Yang G,Fei C

更新日期：2020-06-01 00:00:00

abstract：:A rapid fluorescence in-situ hybridization (FISH) technique was used for direct chromosomal analysis on germ cells from an infertile male with large-headed spermatozoa. The interphase chromosomes were fluorescently-labelled using an extremely bright cyanine dye during a 5-15 min FISH procedure. Germ cells were analyse...

journal_title：Molecular human reproduction

authors： Yurov YB,Saias MJ,Vorsanova SG,Erny R,Soloviev IV,Sharonin VO,Guichaoua MR,Luciani JM

更新日期：1996-09-01 00:00:00

abstract：:Matrix metalloproteinases (MMP), tissue inhibitors of metalloproteinases (TIMP), and MMP-TIMP interactions may contribute to the highly programmed process of embryo implantation. The loss of the delicate MMP-TIMP balance may lead to abnormal implantation. The role of TIMP-4 in mouse implantation has not been reported....

journal_title：Molecular human reproduction

authors： Zhang J,Zhao YG,Cao YJ,Sang QX,Duan EK

更新日期：2003-03-01 00:00:00

abstract：:The spindle assembly checkpoint modulates the timing of anaphase initiation in response to the improper alignment of chromosomes at the metaphase plate. If defects are detected, a signal is transduced to halt further progression of the cell cycle until correct bipolar attachment to the spindle is achieved. The mitotic...

journal_title：Molecular human reproduction

authors： Steuerwald N,Cohen J,Herrera RJ,Sandalinas M,Brenner CA

更新日期：2001-01-01 00:00:00

abstract：:Success rate in human pregnancies is believed to be very low and sex-specific mechanisms may operate in prenatal loss. Assuming a sex-differential in prenatal loss exists, we examined genetic markers in biologically plausible targets in the HLA complex, other immune system-related and iron-regulatory genes in 388 heal...

journal_title：Molecular human reproduction

authors： Ucisik-Akkaya E,Davis CF,Do TN,Morrison BA,Stemmer SM,Amadio WJ,Dorak MT

更新日期：2010-10-01 00:00:00

abstract：:Oocyte vitrification has been introduced into clinical settings without extensive pre-clinical safety testing. In this study, we analysed major safety aspects of human oocyte vitrification in a high security closed system: (i) chromosomal meiotic segregation, (ii) embryonic developmental kinetics and (iii) DNA (hydrox...

journal_title：Molecular human reproduction

authors： De Munck N,Petrussa L,Verheyen G,Staessen C,Vandeskelde Y,Sterckx J,Bocken G,Jacobs K,Stoop D,De Rycke M,Van de Velde H

更新日期：2015-06-01 00:00:00

abstract：:To mimic post-ovulatory ageing, we have extended the in vitro maturation (IVM) phase to 48 h and examined effects on (i) developmental potential, (ii) expression of a panel of developmentally important genes and (iii) gene-specific epigenetic marks. Results were compared with the 24 h IVM protocol (control) usually em...

journal_title：Molecular human reproduction

authors： Heinzmann J,Mattern F,Aldag P,Bernal-Ulloa SM,Schneider T,Haaf T,Niemann H

更新日期：2015-10-01 00:00:00

abstract：:The androgen receptor (AR) gene is located on the X chromosome and contains a polymorphic CAG tract. CAG repeat expansions in the AR have been associated with male infertility and the neuromuscular disease, spinal bulbar muscular atrophy (SBMA). Based on Mendelian inheritance patterns, moderate CAG expansions in infer...

journal_title：Molecular human reproduction

authors： Cram DS,Song B,McLachlan RI,Trounson AO

更新日期：2000-09-01 00:00:00