Effect of betaxolol, timolol and nimodipine on human and pig retinal arterioles.

abstract：:Prolyl oligopeptidase (EC 3.4.21.26) has been purified 26,000-fold from bovine lens tissue by anion-exchange chromatography, gel filtration and isoelectric focussing, with an overall yield of 11%. The purified enzyme exhibited an isoelectric point of 4.8, a pH optimum of 7.5 and a molecular mass of 72 kDa under both n...

journal_title：Experimental eye research

authors： Sharma KK,Ortwerth BJ

更新日期：1994-07-01 00:00:00

abstract：:Structure and function of the retina mainly rely on its fatty acid (FA) composition. Evidence from epidemiological studies and from animal experiments indicates that FA composition of the retina is influenced by the diet. Mice under chronic high-fat diet (HFD) develop metabolic syndrome, a risk factor for diabetes tha...

journal_title：Experimental eye research

authors： Albouery M,Buteau B,Grégoire S,Martine L,Gambert S,Bron AM,Acar N,Chassaing B,Bringer MA

更新日期：2020-07-01 00:00:00

abstract：:Anthocyanins (ACs) are phenolic compounds that are distributed widely in fruits and vegetables. Although consumption of these compounds has been shown to improve visual function, the distribution of ACs in ocular tissue has not been examined in detail. The aim of this study was therefore to evaluate the ocular distrib...

journal_title：Experimental eye research

authors： Matsumoto H,Nakamura Y,Iida H,Ito K,Ohguro H

更新日期：2006-08-01 00:00:00

abstract：:Pericytes exert an important influence on the control of retinal blood flow; however, little is known regarding the molecular basis of retinal pericyte excitability. The purpose of this study was to elucidate the signaling pathway of how prostacyclin (PGI2), an important endogenous regulator of retinal blood flow, sti...

journal_title：Experimental eye research

authors： Burnette JO,White RE

更新日期：2006-12-01 00:00:00

abstract：:Patients with inflammatory bowel disease suffer not only from gut inflammation, but also from extraintestinal manifestations of the disease, including ocular pathology. The mechanisms causing ocular inflammation in these patients are unknown. The purpose of the current study was to investigate the possible vascular ch...

journal_title：Experimental eye research

authors： Watts MN,Eshaq RS,Carter PR,Harris NR

更新日期：2013-10-01 00:00:00

abstract：:The purpose of this study was to investigate the roles of endothelium-derived factors in the retinal arteriolar responses to acute severe elevation in systemic blood pressure (BP) in cats. Acute elevation of mean arterial BP by 60% for 5 min was achieved by inflating a balloon-tipped catheter in the descending aorta. ...

journal_title：Experimental eye research

authors： Nakabayashi S,Nagaoka T,Tani T,Sogawa K,Hein TW,Kuo L,Yoshida A

更新日期：2012-10-01 00:00:00

abstract：:Calf lens alpha-crystallin was isolated and the lysine residues were extensively modified with a variety of chemical agents. The effect of these modifications on elastase inhibitor activity, apparent molecular size, antibody reactivity and solubility were determined. The addition of either a methyl group or a threose ...

journal_title：Experimental eye research

authors： Ortwerth BJ,Olesen PR,Sharma KK,Prabhakaram M

更新日期：1993-01-01 00:00:00

abstract：:Corneal autofluorescence, as measured with a commercial scanning fluorophotometer (lambda(exc): 415-491 nm; lambda(em): 515-630 nm), is increased in patients with diabetes mellitus. However, such fluorophotometers register an average fluorescence signal over all corneal layers as a consequence of their limited axial r...

journal_title：Experimental eye research

authors： Van Schaik HJ,Coppens J,Van den Berg TJ,Van Best JA

更新日期：1999-11-01 00:00:00

abstract：:To trace the path taken by the putative postganglionic secretomotor fibres to the lacrimal gland the contents of the orbital and pterygopalatine fossa were removed whole, cut coronally into slabs and embedded in resin. Thin sections were cut at varying intervals to reconstruct the pathway taken. One group of rami orbi...

journal_title：Experimental eye research

authors： Ruskell GL

更新日期：2004-03-01 00:00:00

abstract：:As wounds in stratified epithelia close, the numbers of cells at the leading edge of migration decreases. It is not known whether cells at the leading edge are continually replaced or whether some retain their position at the leading edge over time. Replication-deficient adenovirus carrying the green fluorescent prote...

journal_title：Experimental eye research

authors： Danjo Y,Gipson IK

更新日期：2002-02-01 00:00:00

abstract：:Glaucoma is defined as a progressive optic neuropathy and is characterized by an irreversible loss of retinal ganglion cells. The main risk factor to develop glaucoma is an increased intraocular pressure (IOP). During the course of glaucoma structural changes in the optic nerve head (ONH) take place which lead to the ...

journal_title：Experimental eye research

authors： Schneider M,Fuchshofer R

更新日期：2016-01-01 00:00:00

abstract：:The cornea receives the densest sensory innervation of the body, which is exclusively from small-fiber nociceptive (pain-sensing) neurons. These are similar to those in the skin of the legs, the standard location for neurodiagnostic skin biopsies used to diagnose small-fiber peripheral polyneuropathies. Many cancer ch...

journal_title：Experimental eye research

authors： Ferrari G,Nallasamy N,Downs H,Dana R,Oaklander AL

更新日期：2013-08-01 00:00:00

abstract：:An extraneous exon-skipping mRNA encodes an altered form of a light-absorbing opsin in human retina and pigment epithelium (RPE). The predicted protein variant differs from full-length RPE-retinal G protein-coupled receptor (RGR) by having an in-frame deletion of exon 6, which contains the entire sixth transmembrane d...

journal_title：Experimental eye research

authors： Fong HK,Lin MY,Pandey S

更新日期：2006-07-01 00:00:00

abstract：:Lens lipid composition and lipid hydrocarbon chain structure change with age, region and cataract. Since the lens Ca(2+)-ATPase pump is important to the maintenance of calcium homeostasis and lens clarity, muscle sarcoplasmic reticulum Ca(2+)-ATPase was reconstituted with bovine lens lipids and dihydrosphingomyelin, t...

journal_title：Experimental eye research

authors： Zeng J,Zhang Z,Paterson CA,Ferguson-Yankey S,Yappert MC,Borchman D

更新日期：1999-09-01 00:00:00

abstract：:The state of water and water fractions in normal and senile cataractous eye lenses was studied by the NMR method. Combining NMR with vacuum dehydration provided additional information on multifractional samples. A new mathematical procedure is presented which separates the characteristic parameters of the different fr...

journal_title：Experimental eye research

authors： Rácz P,Tompa K,Pócsik I,Bánki P

更新日期：1983-05-01 00:00:00

abstract：:Endocannabinoid system involves in neuroprotective effects on the central neural system. The cannabinoid receptor 1 (CB1R) is widely expressed in the mouse retina. However, the role of cannabinoid receptors in the retina remains unclear. In this work, we established a photoreceptor degeneration mouse model via N-methy...

journal_title：Experimental eye research

authors： Chen Y,Luo X,Liu S,Shen Y

更新日期：2018-02-01 00:00:00

abstract：:We sought to characterize the ocular pharmacology, tolerability and intraocular pressure (IOP)-lowering efficacy of FR-190997, a non-peptidic bradykinin (BK) B2-receptor agonist. FR-190997 possessed a relatively high receptor binding affinity (Ki = 27 nM) and a high in vitro potency (EC50 = 18.3 ± 4.4 nM) for inositol...

journal_title：Experimental eye research

authors： Sharif NA,Li L,Katoli P,Xu S,Veltman J,Li B,Scott D,Wax M,Gallar J,Acosta C,Belmonte C

更新日期：2014-11-01 00:00:00

abstract：:Suzuki et al. [Vis. Res. 26, 425-9 (1986); Vis. Res. 28, 1061-70 (1988)] have described a formaldehyde-based (HCHO-based) extraction procedure that efficiently recovers 11-cis retinal initially present as rhodopsin chromophore in photoreceptor membranes. Using the isolated retina of the toad (Bufo marinus), we tested ...

journal_title：Experimental eye research

authors： Okajima TL,Pepperberg DR

更新日期：1997-09-01 00:00:00

abstract：:Glutamate is an excitatory neurotransmitter in the central and peripheral nervous systems of the vertebrate. The previous studies show the presence of mRNAs of AMPA-type glutamate receptors, GluR1 and GluR2, in the optic tectum of the pigeon, suggesting glutamatergic input from the retina. The present study examined l...

journal_title：Experimental eye research

authors： Islam MR,Atoji Y

更新日期：2009-09-01 00:00:00

abstract：:To investigate the nature of the 140 kDa glycoprotein in the trabecular meshwork, polypeptides were extracted with either urea/sodium dodecyl sulfate (SDS)/beta-2-mercaptoethanol (BME) or guanidine hydrochloride followed by pepsin digestion. After electrophoresis and immunoblotting with anti-type-VI-collagen antibodie...

journal_title：Experimental eye research

authors： Tripathi BJ,Hansen M,Li J,Tripathi RC

更新日期：1994-02-01 00:00:00

abstract：:It has been reported that chymase activity was increased in allergic conjunctivitis patients and this activity was correlated with the severity of the disease. However, the precise roles of chymase in allergic conjunctivitis are unclear, and whether chymase inhibitors are effective for allergic conjunctivitis has not ...

journal_title：Experimental eye research

authors： Nabe T,Kijitani Y,Kitagawa Y,Sakano E,Ueno T,Fujii M,Nakao S,Sakai M,Takai S

更新日期：2013-08-01 00:00:00

abstract：:The integrity of the retinal pigment epithelium, especially that of the macula is essential for the preservation of vision into old age. The chronic exposure to sunlight and peroxidized lipids from phagocytized photoreceptor outer segments imposes a high level of oxidative stress on the retinal tissues, which increase...

journal_title：Experimental eye research

authors： Godley BF,Jin GF,Guo YS,Hurst JS

更新日期：2002-06-01 00:00:00

abstract：:Studies using conventional electron microscopy describe the cytoplasm of lens fiber cells as having essentially an amorphous structure. We hypothesized that significant structural detail might have been lost as a result of projecting the entire thickness of the section (50-100 nm) onto a single plane (the "projection ...

journal_title：Experimental eye research

authors： Schietroma C,Fain N,Zampighi LM,Lanzavecchia S,Zampighi GA

更新日期：2009-03-01 00:00:00

abstract：:Rifampicin, an antibacterial drug widely used in the treatment of tuberculosis and leprosy, has recently been reported to have anti-oxidative and anti-apoptotic effects. However, its anti-angiogenic effect has not been investigated. We examined its anti-angiogenic effect on tube formation and proliferation by human um...

journal_title：Experimental eye research

authors： Chikaraishi Y,Matsunaga N,Shimazawa M,Hara H

更新日期：2008-01-01 00:00:00

abstract：:It has been suggested that ambient lighting at night influences eye growth and might play a causal role in human myopia. To test this hypothesis, we reared newly hatched chicks under 12 hr light-dark or light-dim cycles with a light phase intensity of 1500 microW/cm(2) and variable dim phase intensities between 0.01 a...

journal_title：Experimental eye research

authors： Liu J,Pendrak K,Capehart C,Sugimoto R,Schmid GF,Stone RA

更新日期：2004-11-01 00:00:00

abstract：:This review describes our recent attempts to develop new therapeutic modalities for corneal endothelial disease using animal models including non-human primate model in which the proliferative ability of corneal endothelial cells is severely limited, as is the case in humans. First, we describe our attempt to develop ...

journal_title：Experimental eye research

authors： Koizumi N,Okumura N,Kinoshita S

更新日期：2012-02-01 00:00:00

abstract：:The part of the light spectrum which is responsible for an increase of lenticular green autofluorescence upon white light exposure was determined for the rabbit. The increase of autofluorescence as a function of the light energy was measured, to assess a possible threshold energy for lens alterations. Thirteen rabbits...

journal_title：Experimental eye research

authors： Van Vreeswijk H,Boets EP,Van Best JA

更新日期：1993-03-01 00:00:00

abstract：:The carbohydrate epitope Gal alpha 1-3Gal-R (alpha-galactosyl epitope), which is detectable by its binding with Bandeiraea simplicifolia-IB4 lectin, was found in glycosphingolipids (GSLs), both neutral and acidic (gangliosides), from lens tissues of non-primate mammals, but not in those of human senile cataracts and O...

journal_title：Experimental eye research

authors： Ogiso M,Okinaga T,Komoto M,Nishiyama I,Hoshi M

更新日期：1994-12-01 00:00:00

abstract：:Transport of circulating sulfur amino acids (SAA) into the lens epithelium and de novo glutathione (GSH) synthesis were studied in the perfused guinea-pig eye. Plasma-to-aqueous transfer of SAA was in their intact form (> or = 98%) and comparable with sucrose (an extracellular marker) within 30 min. The unidirectional...

journal_title：Experimental eye research

authors： Mackic JB,Kannan R,Kaplowitz N,Zlokovic BV

更新日期：1997-04-01 00:00:00

abstract：:The redox homeostasis is controlled by several enzyme systems. Sulfhydryl groups in lens proteins are very sensitive to oxidative stress and can easily conjugate with nonprotein thiols (S-thiolation) to form protein-thiol mixed disulfides. We have observed an elevation of protein S-S-glutathione (PSSG) and protein-S-S...

journal_title：Experimental eye research

authors： Wang GM,Wu F,Raghavachari N,Reddan JR

更新日期：1998-04-01 00:00:00