Abstract:
:As wounds in stratified epithelia close, the numbers of cells at the leading edge of migration decreases. It is not known whether cells at the leading edge are continually replaced or whether some retain their position at the leading edge over time. Replication-deficient adenovirus carrying the green fluorescent protein gene was applied to corneal epithelial wounds in mice and it was found that they primarily infect the leading edge cells of healing epithelium. Eighteen hr after viral transduction, green fluorescent protein expressing cells were located in the apical layer at varying distances behind the leading edge. These data indicate that leading edge cells are replaced during healing of stratified epithelia.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Danjo Y,Gipson IKdoi
10.1006/exer.2001.1115keywords:
subject
Has Abstractpub_date
2002-02-01 00:00:00pages
199-204issue
2eissn
0014-4835issn
1096-0007pii
S0014483501911157journal_volume
74pub_type
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