Abstract:
:The effect of kainic acid (KA) on rat retinal morphology was investigated with emphasis on the ganglion cell layer. Two hours after intraocular injection of KA, 70% of the neurones in the ganglion cell layer display morphological alterations. These alterations at the ultrastructural level include the absence of identifiable Golgi complexes and the presence of abundant round empty vacuoles among other nuclear and cytoplasmic modifications. These alterations of the Golgi complex are discussed in relation to axoplasmic transport inhibition by kainic acid. Seven days after KA treatment the retina showed a decreased number of cells in the inner nuclear layer and ganglion cell layer and the inner plexiform layer had virtually disappeared. Despite the disappearance of cells from the ganglion cell layer a week after KA injection, abundant ganglion cells could be retrogradely labelled with horseradish peroxidase. Thus although retinal ganglion cells seem to be sensitive to KA most of them survive KA treatment.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Gómez-Ramos P,Pérez-Rico Cdoi
10.1016/0014-4835(83)90014-3subject
Has Abstractpub_date
1983-02-01 00:00:00pages
299-304issue
2eissn
0014-4835issn
1096-0007pii
0014-4835(83)90014-3journal_volume
36pub_type
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更新日期:2004-10-01 00:00:00
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更新日期:2001-07-01 00:00:00
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更新日期:1983-08-01 00:00:00
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更新日期:2008-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
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更新日期:2007-01-01 00:00:00
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1006/exer.2001.1085
更新日期:2001-12-01 00:00:00
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更新日期:2006-09-01 00:00:00