Abstract：
:Female New Zealand White rabbits were treated subcutaneously with 0.0375 or 0.15 mg kg-1 dexamethasone or physiological saline solution from the 8th through to the 11th day of gestation. Short-term administration of 0.15 mg kg-1 dexamethasone induced two types of morphological lens deviations in the offspring (lenses were studied by means of sagittal serial sections). In the first type of deviation a progressive series of changes in the lens bow region was observed. Early changes consisted of an enlargement of some lens bow nuclei, an increase in the number of lens bow nuclei and a disturbance in the shape of the lens bow. Later changes consisted of the degeneration and vacuolization of a peripheral zone of cortex fibre cells. The overall picture showed that the size of up to 8% of the nuclei in the deviating lens bows was enlarged and that the average number of lens bow nuclei in the deviating lenses was 28% higher (P less than 0.01) than in the lens bows without deviations. The second type of lens deviation consisted of isolated bundles of disintegrated cortex fibre cells, which extend downwards (anterior-posterior) from subepithelial vesicles. In these bundles all nuclei were smaller and more basophilic than normally. Both types of lens deviations occurred independently in the superficial cortex. Control offspring treated with physiological saline solution showed neither the first nor the second type of lens deviation. Of the offspring exposed to 0.0375 mg kg-1 dexamethasone one animal (8%) showed lens changes of the first type only, whereas 59% of the offspring exposed to 0.15 mg kg-1 dexamethasone displayed either one or both types of lens deviations.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Koksma JM,Hoyng PF,Willekens BWdoi
10.1016/0014-4835(84)90008-3subject
Has Abstractpub_date
1984-08-01 00:00:00pages
195-206issue
2eissn
0014-4835issn
1096-0007pii
0014-4835(84)90008-3journal_volume
39pub_type
杂志文章abstract：:The cornea is a self-renewing tissue located at the front of the eye. Its transparency is essential for allowing light to focus onto the retina for visual perception. The continuous renewal of corneal epithelium is supported by limbal stem cells (LSCs) which are located in the border region between conjunctiva and cor...
journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2016.09.008
更新日期：2016-11-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1016/s0014-4835(86)80030-6
更新日期：1986-10-01 00:00:00
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journal_title：Experimental eye research
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更新日期：2018-12-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1016/j.exer.2018.12.003
更新日期：2019-03-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
doi：10.1016/j.exer.2004.07.002
更新日期：2004-11-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1016/0014-4835(91)90064-l
更新日期：1991-05-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2007.03.009
更新日期：2007-07-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
doi：10.1016/j.exer.2016.01.002
更新日期：2016-09-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1996.0004
更新日期：1996-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：1989-02-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2005.01.004
更新日期：2005-07-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2005.03.015
更新日期：2005-11-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2015.02.008
更新日期：2016-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/0014-4835(91)90106-o
更新日期：1991-12-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2013.05.016
更新日期：2013-08-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/0014-4835(89)90074-2
更新日期：1989-07-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1997.0391
更新日期：1997-12-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1996.0133
更新日期：1996-10-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
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更新日期：2018-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.2001.1077
更新日期：2001-11-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1993.1119
更新日期：1993-08-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：1983-09-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/0014-4835(85)90004-1
更新日期：1985-02-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.2001.0992
更新日期：2001-06-01 00:00:00
abstract：:The phagocytosis of photoreceptor outer segments (OS) by the retinal pigment epithelium (RPE) is a receptor mediated process. A key component of this process is the receptor tyrosine kinase, Mer. RPE cells from the RCS rat, which lacks a functional mer gene, and do not express Mer protein, are able to bind OS, but are...
journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/s0014-4835(03)00158-1
更新日期：2003-09-01 00:00:00
abstract：:The purpose of this study was to investigate the influence of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region and determine a potential autoregulative capacity of the choroid under these conditions. In a randomized cross-over study 100% O2 and a mixture of 5% CO2 with air was inhale...
journal_title：Experimental eye research
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1995-12-01 00:00:00
abstract：:We have determined the pattern of RNA labeling (uridine incorporation) in the normal retina of the domestic cat. One eye in each of eight cats was labeled by injecting [3H]uridine into the vitreous cavity. Two of the labeled eyes had the lens and vitreous removed 10 days before labeling. Three additional animals recei...
journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/0014-4835(90)90066-4
更新日期：1990-08-01 00:00:00
abstract：:The trabecular meshwork is considered a smooth muscle like tissue contributing to aqueous outflow regulation and thus to regulation of intraocular pressure. An elevation in intraocular pressure is one of the greatest risk factors for most forms of glaucoma. We assume that contraction of trabecular meshwork reduces aqu...
journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2004.12.013
更新日期：2005-06-01 00:00:00
abstract：:Antibiotics such as fluoroquinolones (FQLs) are commonly used to treat ocular infections but are also known to cause dermal melanocyte toxicity. The release of dispersed pigments from the iris into the aqueous humor has been considered a possible ocular side effect of the systemic administration of FQLs such as Moxifl...
journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2017.07.006
更新日期：2017-09-01 00:00:00
