Fas/Fas ligand-associated apoptosis in experimental autoimmune uveoretinitis in rodents: role of proinflammatory corticotropin-releasing hormone.

abstract：:The DBA/2 mouse has been used as a model for spontaneous secondary glaucoma. We attempted to determine the in vivo time course and spatial distribution of retinal ganglion cells (RGCs) undergoing apoptotic death in DBA/2 mice. Female DBA/2 mice, 3, 9-10, 12, 15, and 18 months of age, received intravitreal injections o...

journal_title：Experimental eye research

authors： Reichstein D,Ren L,Filippopoulos T,Mittag T,Danias J

更新日期：2007-01-01 00:00:00

abstract：:The ocular lens is surrounded by the lens capsule, which is an elastic and unusually thick basal membrane. Anionic sites are thought to be responsible for charge-selective permeability barriers in basal membranes. We have used cationic colloidal gold as a tracer for anionic binding sites to investigate the distributio...

journal_title：Experimental eye research

authors： Winkler J,Wirbelauer C,Frank V,Laqua H

更新日期：2001-03-01 00:00:00

abstract：:Retinal arrestin is known to participate in the quenching of phototransduction through binding to light-activated and phosphorylated rhodopsin. Recently, a splice variant of retinal arrestin was identified in bovine photoreceptors which could bind unphosphorylated photoactive rhodopsin. In this report, a splice varian...

journal_title：Experimental eye research

authors： Smith WC

更新日期：1996-06-01 00:00:00

abstract：:The objective of this study was to determine the cellular localization of P2Y(2) receptor gene expression in rabbit and primate ocular tissues using the technique of non-isotopic in situ hybridization. Fresh frozen whole eye from a New Zealand White rabbit and whole eye and eyelid from a rhesus macaque were cut into 5...

journal_title：Experimental eye research

authors： Cowlen MS,Zhang VZ,Warnock L,Moyer CF,Peterson WM,Yerxa BR

更新日期：2003-07-01 00:00:00

abstract：:Rhegmatogenous retinal detachment is by far the most common indication for retinal surgery and a major cause of severe vision loss. Increased levels of glutamate found in the vitreous of human patients and persistent remodeling, even after reattachment, suggest substantial neurochemical, functional and anatomical chan...

journal_title：Experimental eye research

authors： de Souza CF,Kalloniatis M,Polkinghorne PJ,McGhee CN,Acosta ML

更新日期：2012-04-01 00:00:00

abstract：:The purpose of this study was to describe the distribution of Muller cell within the peripapillary retinal nerve fiber layer (RNFL) in human eyes. Eleven unpaired normal postmortem eyes were recruited into this study. Each eye was sectioned using the "umbrella technique" to obtain a concentric peripapillary ring cente...

journal_title：Experimental eye research

authors： Frenkel S,Goshen G,Leach L,Pe'er J,Mimouni M,Blumenthal EZ

更新日期：2018-01-01 00:00:00

abstract：:Previous studies have suggested that abnormal corneal wound healing in patients after photorefractive keratectomy (PRK) is associated with the appearance of myofibroblasts in the stroma between two and four weeks after surgery. The purpose of this study was to examine potential myofibroblast progenitor cells that migh...

journal_title：Experimental eye research

authors： Chaurasia SS,Kaur H,de Medeiros FW,Smith SD,Wilson SE

更新日期：2009-08-01 00:00:00

abstract：:Evidence is presented that alpha-crystallin isolated at 37 degrees C exists as a species, alpha m, which has a minimum molecular weight of about 320000 and a sedimentation coefficient of about 12 S. The amino acid composition, subunit distribution, near- and far-UV CD spectra and immunochemical properties were identic...

journal_title：Experimental eye research

authors： Thomson JA,Augusteyn RC

更新日期：1983-10-01 00:00:00

abstract：:There are few previous estimates of the size of the human lens epithelium. In this study the lens epithelium is measured by specular reflex photography with a macro camera. The results are corrected for cornea magnification. One hundred subjects were studied ranging in age from 11 to 75 and including 20 diabetics and ...

journal_title：Experimental eye research

authors： Brown NA,Bron AJ

更新日期：1987-06-01 00:00:00

abstract：:Many ocular surface tests have been developed for the clinical diagnosis of keratoconjunctivitis sicca, and several have been used to 'validate' animal models of Sjogren's and non-Sjogren's dry eye. However, many of these tests themselves have not been systematically studied or standardized, and yet their use in anima...

journal_title：Experimental eye research

authors： Barabino S,Chen W,Dana MR

更新日期：2004-11-01 00:00:00

abstract：:Prolyl oligopeptidase (EC 3.4.21.26) has been purified 26,000-fold from bovine lens tissue by anion-exchange chromatography, gel filtration and isoelectric focussing, with an overall yield of 11%. The purified enzyme exhibited an isoelectric point of 4.8, a pH optimum of 7.5 and a molecular mass of 72 kDa under both n...

journal_title：Experimental eye research

authors： Sharma KK,Ortwerth BJ

更新日期：1994-07-01 00:00:00

abstract：:The current study investigates the cellular events which trigger activation of proapoptotic Bcl-2-associated × protein (Bax) in retinal cell death induced by all-trans-retinal (atRAL). Cellular events which activate Bax, such as DNA damage by oxidative stress and phosphorylation of p53, were evaluated by immunochemica...

journal_title：Experimental eye research

authors： Sawada O,Perusek L,Kohno H,Howell SJ,Maeda A,Matsuyama S,Maeda T

更新日期：2014-06-01 00:00:00

abstract：:Murine macrophages treated with TGF-beta2 are capable of inducing anterior chamber-associated immune deviation (ACAID), and these macrophages are characterized by impaired IL-12 production and CD40 expression, consequently failing to promote Th1 cell differentiation. In this study, we investigated whether human monocy...

journal_title：Experimental eye research

authors： Takeuchi M,Keino H,Suzuki J,Usui Y,Hattori T,Takeuchi A,Oh-I K,Okunuki Y,Kezuka T,Usui M

更新日期：2006-10-01 00:00:00

abstract：:The mechanisms by which sulfhydryl (SH-) binding reagents modulate the light-sensitive conductance of retinal rods were investigated by current recording from single rods, by patch clamp recording from the plasma membrane of the rod outer segment (ROS), and by biochemical study of their effects on the light-induced hy...

journal_title：Experimental eye research

authors： Donner K,Hemilä S,Kalamkarov G,Koskelainen A,Pogozheva I,Rebrik T

更新日期：1990-07-01 00:00:00

abstract：:Neovascular age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Although intravitreal injection of anti-VEGF antibodies and VEGF Trap have significant clinical benefits, the complications of intravitreal injection, drug resistance and patient compliance still need to be concerned. In th...

journal_title：Experimental eye research

authors： Wei X,Zhang T,Yao Y,Zeng S,Li M,Xiang H,Zhao C,Cao G,Li M,Wan R,Yang P,Yang J

更新日期：2018-03-01 00:00:00

abstract：:Dietary restriction can effectively extend lifespan and retard many age-related debilities. One hypothesis to explain the beneficial effects of dietary restriction is that it prolongs maintenance of cellular homeostasis by limiting endogenous oxidative stress and preserves oxidative defense mechanisms during aging. As...

journal_title：Experimental eye research

authors： Taylor A,Jahngen-Hodge J,Smith DE,Palmer VJ,Dallal GE,Lipman RD,Padhye N,Frei B

更新日期：1995-07-01 00:00:00

abstract：:We showed previously that treatment of cultured rabbit lens epithelial cells (LECs) with hyperbaric oxygen (HBO) produced DNA strand-breaks, caused reversible inhibition of protein synthesis and induced the synthesis of a 32 kD protein. In the present work, we employed immunostaining procedures to identify the 32 kD p...

journal_title：Experimental eye research

authors： Padgaonkar VA,Giblin FJ,Fowler K,Leverenz VR,Reddan JR,Dziedzic DC

更新日期：1997-09-01 00:00:00

abstract：:A key model for examining the activity-dependent development of primary visual cortex (V1) involves the imbalance in activity between the two eyes induced by monocular deprivation (MD). MD early in life causes dramatic changes in the functional and structural organization of mammalian visual cortex. The molecular sign...

journal_title：Experimental eye research

authors： Shan L,Yong H,Song Q,Wei Y,Qin R,Zhang G,Xu M,Zhang S

更新日期：2013-04-01 00:00:00

abstract：:The early events that occur rapidly after injury trigger signal cascades that are essential for proper wound closure of corneal epithelial cells. We hypothesize that injury releases ATP, which stimulates purinergic receptors and elicits the phosphorylation of epidermal growth factor receptor (EGFR) tyrosine residues a...

journal_title：Experimental eye research

authors： Boucher I,Yang L,Mayo C,Klepeis V,Trinkaus-Randall V

更新日期：2007-07-01 00:00:00

abstract：:The development and growth of the vertebrate ocular lens is dependent on the regulated proliferation of an anterior monolayer of epithelial cells, and their subsequent differentiation into elongate fiber cells. The growth factor rich ocular media that bathes the lens mediates these cellular processes, and their respec...

journal_title：Experimental eye research

authors： Tam OH,Pennisi D,Wilkinson L,Little MH,Wazin F,Wan VL,Lovicu FJ

更新日期：2018-05-01 00:00:00

abstract：:Myofibroblast development and haze generation in the corneal stroma is mediated by cytokines, including transforming growth factor-beta (TGF-beta), and possibly other cytokines. This study examined the effects of stromal PDGF-beta blockade on the development of myofibroblasts in response to -9.0 diopter photorefractiv...

journal_title：Experimental eye research

authors： Kaur H,Chaurasia SS,de Medeiros FW,Agrawal V,Salomao MQ,Singh N,Ambati BK,Wilson SE

更新日期：2009-05-01 00:00:00

abstract：:The ocular lens fiber cell assembles a novel cytoskeletal element, the Beaded Filament, from CP49 and filensin, two proteins expressed only in the differentiated lens fiber cell. We report the primary sequence, secondary structural analysis, gene structure and Yeast Two Hybrid interaction data for human filensin, and ...

journal_title：Experimental eye research

authors： Hess JF,Casselman JT,Kong AP,FitzGerald PG

更新日期：1998-05-01 00:00:00

abstract：:Early stages of glaucoma and optic neuropathies are thought to show inner retina remodeling and functional changes of retinal ganglion cells (RGCs) before they die. To assess RGC functional plasticity, we investigated the contrast-gain control properties of the pattern electroretinogram (PERG), a sensitive measure of ...

journal_title：Experimental eye research

authors： Chou TH,Feuer WJ,Schwartz O,Rojas MJ,Roebber JK,Porciatti V

更新日期：2016-04-01 00:00:00

abstract：:The shapes of two human lenses of different ages (27 and 46 years old) were altered by applying a stretching force to the ciliary muscle. The force was in the outward radial direction and was produced by an electronically driven stretching instrument which is described. The lenses were photographed for different degre...

journal_title：Experimental eye research

authors： Pierscionek BK

更新日期：1993-11-01 00:00:00

abstract：:Preretinal pH was measured in the avascular region of 19 rabbit retinas during alternating cycles of light and dark, using a miniature, needle-type pH electrode. In 14 experiments with the rabbits breathing room air, cyclic changes in pH, decreasing in the dark and increasing in the light, were observed. The transitio...

journal_title：Experimental eye research

authors： Murray DL,Feke GT,Weiter JJ

更新日期：1991-12-01 00:00:00

abstract：:The present study was designed to identify genomic loci modulating the susceptibility of retinal ganglion cells (RGC) to elevated intraocular pressure (IOP) in the BXD recombinant inbred mouse strain set. IOP was elevated by injecting magnetic microspheres into the anterior chamber and blocking the trabecular meshwork...

journal_title：Experimental eye research

authors： Struebing FL,King R,Li Y,Cooke Bailey JN,NEIGHBORHOOD consortium.,Wiggs JL,Geisert EE

更新日期：2018-04-01 00:00:00

abstract：:Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has also been proposed as an iron-transporter protein, th...

journal_title：Experimental eye research

authors： Valença A,Mendes-Jorge L,Bonet A,Catita J,Ramos D,Jose-Cunilleras E,Garcia M,Carretero A,Nacher V,Navarro M,Ruberte J

更新日期：2021-01-01 00:00:00

abstract：:The anterior avian cornea possesses several distinct cellular and extracellular regions including the epithelial basal lamina, Bowman's layer and the interfacial matrix that separates Bowman's layer from the stroma. These unique regions differ biochemically, physically and morphologically but all contain type XII coll...

journal_title：Experimental eye research

authors： Marchant JK,Zhang G,Birk DE

更新日期：2002-12-01 00:00:00

abstract：:The human lens crystallin gene CRYGC T5P is associated with Coppock-like cataract and has a phenotype of a dust-like opacity of the fetal lens nucleus and deep cortical region. Previous in vitro mutation studies indicate that the protein has changed conformation, solubility, and stability, which may make it susceptibl...

journal_title：Experimental eye research

authors： Liu BF,Song S,Hanson M,Liang JJ

更新日期：2008-12-01 00:00:00

abstract：:In normal retina the developing photoreceptor cells first show presence of opsin over the distal ends of the ciliary protrusions. In a fully differentiated cell intense activity is seen over the rod outer-segment discs; some activity is also seen over the Golgi zone and near the distal ends of the inner segments but t...

journal_title：Experimental eye research

authors： Jansen HG,Sanyal S,De Grip WJ,Schalken JJ

更新日期：1987-03-01 00:00:00