Hexose transport in microvascular endothelial cells cultured from bovine retina.

abstract：BACKGROUND:Absence of collagen VII causes blistering of the skin, eyes and many other tissues. This disease is termed dystrophic epidermolysis bullosa (DEB). Corneal fibrosis occurs in up to 41% and vision loss in up to 64% of patients. Standard treatments are supportive and there is no cure. The hypomorphic mouse mode...

journal_title：Experimental eye research

authors： Chen VM,Shelke R,Nyström A,Laver N,Sampson JF,Zhiyi C,Bhat N,Panjwani N

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:This microscopic study was undertaken to compare the melanocytes of peripheral iridectomy specimens from two eyes that had latanoprost-induced iris darkening (LIID) with iridectomies taken from the fellow untreated eyes. METHODS:The two patients in this study were the ones who underwent LIID in the latanoprost...

journal_title：Experimental eye research

authors： Cracknell KP,Grierson I,Hogg P,Appleton P,Pfeiffer N

更新日期：2003-12-01 00:00:00

abstract：:The purpose of this study was to evaluate the inhibitory activity of the heparan sulfate suleparoide on vascular cell growth in vitro and angiogenesis in vivo. Human HUV-EC-C endothelial cell proliferation and microvessel sprouting from cultured rat aortic rings were assayed by the bioreduction of 3-[4,5-dimethylthiaz...

journal_title：Experimental eye research

authors： Benelli U,Bocci G,Danesi R,Lepri A,Bernardini N,Bianchi F,Lupetti M,Dolfi A,Campagni A,Agen C,Nardi M,Del Tacca M

更新日期：1998-08-01 00:00:00

abstract：:This lecture summarizes studies on the effects of some of the neuropeptides which seem to be present in somatosensory and autonomic nerves in the uvea. Release of these peptides is likely to explain nerve induced effects in the eye which are not due to classical transmitters. Trigeminal nerve fibres in the eye seem to...

journal_title：Experimental eye research

authors： Anders B

更新日期：1991-07-01 00:00:00

abstract：:We have studied the growth of neurites from single retinal ganglion cells isolated from adult goldfish and maintained under various primary cell culture conditions. In 10% Leibovitz's L-15 medium at 23 degrees C, these ganglion cells remained viable for up to 10 days and generated extensive fields of neurites. We foun...

journal_title：Experimental eye research

authors： Ishida AT,Cheng MH

更新日期：1991-02-01 00:00:00

abstract：:Hypoxia-inducible factor (HIF) signaling cascade plays a critical role in angiogenesis by activating the transcription of genes encoding angiogenic growth factors. This study evaluated the effects of YC-1, a HIF-1 inhibitor, on the morphological, biochemical and molecular changes in human retinal microvascular endothe...

journal_title：Experimental eye research

authors： DeNiro M,Alsmadi O,Al-Mohanna F

更新日期：2009-11-01 00:00:00

abstract：:Transforming growth factor β (TGFβ) signaling is one of the most important signaling pathways regulating cell behavior in ocular tissues. Its functions are mainly linked to tissue fibrosis and inflammatory responses in ophthalmology. In epithelial cells, however, the growth inhibitory activity of TGFβ was reported in ...

journal_title：Experimental eye research

authors： Hu L,Pu Q,Zhang Y,Ma Q,Li G,Li X

更新日期：2019-05-01 00:00:00

abstract：:Arf encodes an important tumor suppressor, p19(Arf), which also plays a critical role to control hyperplasia in the primary vitreous during mouse eye development. In the absence of Arf, mice are born blind and display a phenotype closely mimicking severe forms of the human eye disease, persistent hyperplastic primary ...

journal_title：Experimental eye research

authors： Iqbal NS,Devitt CC,Sung CY,Skapek SX

更新日期：2016-04-01 00:00:00

abstract：:The response of the poikilothermal lens to various incubation temperatures in vitro was compared with that of the homothermal lens. The rainbow trout lens was used as the poikilothermal lens and the rat lens as the homothermal lens. In contrast to rat lenses, cataract developed at 37 degrees C in rainbow trout lenses,...

journal_title：Experimental eye research

authors： Iwata S,Hikida M

更新日期：1985-08-01 00:00:00

abstract：:Corneal endothelium appears to be an important target tissue for retinoids and epidermal growth factor (EGF). We report here that retinoic acid, or its synthetic analogue CBS-211 A (10(-8)-10(-7) M) dose-dependently enhances the mitogenic effect of EGF on cultured bovine corneal endothelial cells (BCEC). Furthermore, ...

journal_title：Experimental eye research

authors： Junquéro D,Modat G,Coquelet C,Bonne C

更新日期：1990-07-01 00:00:00

abstract：:The corneal endothelial monolayer helps maintain corneal transparency through its barrier and ionic "pump" functions. This transparency function can become compromised, resulting in a critical loss in endothelial cell density (ECD), corneal edema, bullous keratopathy, and loss of visual acuity. Although penetrating ke...

journal_title：Experimental eye research

authors： Joyce NC

更新日期：2012-02-01 00:00:00

abstract：:In our earlier study we showed that invasive retinoblastoma (RB) had down regulated tetraspanin protein KAI1/CD82, a family of cell surface glycoprotein. KAI1 may link to the cell surface molecules, such as integrins, E-cadherin, and other TM4SF members, and loss of KAI1 function may have a significant role in the pro...

journal_title：Experimental eye research

authors： Mohan A,Nalini V,Mallikarjuna K,Jyotirmay B,Krishnakumar S

更新日期：2007-04-01 00:00:00

abstract：:Fibroblast growth factors play a key role in regulating lens epithelial cell proliferation and differentiation via an anteroposterior gradient that exists between the aqueous and vitreous humours. FGF-2 is the most important for lens epithelial cell proliferation and differentiation. It has been proposed that the pres...

journal_title：Experimental eye research

authors： Wu W,Tholozan FM,Goldberg MW,Bowen L,Wu J,Quinlan RA

更新日期：2014-03-01 00:00:00

abstract：:The supply of L-carnosine, a bioactive dipeptide of β-alanine and l-histidine, to the retina across the blood-retinal barrier (BRB) was studied. The in vivo and in vitro studies revealed low uptake activities for [(3)H]Gly-Sar, a representative dipeptide, suggesting that l-carnosine transport plays only a minor role a...

journal_title：Experimental eye research

authors： Usui T,Kubo Y,Akanuma S,Hosoya K

更新日期：2013-08-01 00:00:00

abstract：:An experimental study was conducted on eight litters of newborn rats to evaluate the effects of supplemental oxygen administration on the retinal vasculature. The animals and their mothers were kept inside a pressure chamber and treated for the first 5 days of life. On the sixth day, they were removed and kept for fiv...

journal_title：Experimental eye research

authors： Ricci B

更新日期：1987-03-01 00:00:00

abstract：:In this study, we examined calcium-mediated degradation of a neurofilament protein (NFP), and autolytic activation of calpain in Lewis rat optic nerve in vitro. After incubation with calcium, homogenized optic nerve samples were analysed by SDS-PAGE in association with ECL immunoblot techniques. 68 kD NFP, calpain, an...

journal_title：Experimental eye research

authors： Shields DC,Leblanc C,Banik NL

更新日期：1997-07-01 00:00:00

abstract：:Primary cultures of chick lens annular pad (CLAP) cells were exposed to beta-adrenergic drugs and lipid soluble cAMP analogues. In dose-dependent manners, these agents inhibited re-entry into the cell cycle when these normally post-mitotic cells were cultured in the presence of serum. The inhibition of cell division w...

journal_title：Experimental eye research

authors： Ireland ME,Tran K,Mrock L

更新日期：1993-09-01 00:00:00

abstract：:Forskolin, a diterpene, a potent and direct stimulator of the catalytic unit of adenylate cyclase, can reduce intraocular pressure when administered topically to rabbit eyes in a 1% suspension. Using an intravitreal plant of fluorescein-dextran, aqueous flow was measured by a modification of the method of Maurice. For...

journal_title：Experimental eye research

authors： Caprioli J,Sears M

更新日期：1984-07-01 00:00:00

abstract：:Hyaluronan (HA) distribution in the posterior eye wall from the vitreous through the sclera, with special consideration to localization in the retina and interphotoreceptor matrix (IPM), was evaluated in human, bovine, guinea pig, dog, rat and mouse tissues using a specific probe for HA (bHABC, biotinylated hyaluronan...

journal_title：Experimental eye research

authors： Hollyfield JG,Rayborn ME,Tammi M,Tammi R

更新日期：1998-02-01 00:00:00

abstract：:We have compared IOP elevations induced by water-loading and by increased cephalic venous pressure in normal and denervated pigmented rabbits. Denervations were performed by sympathetic ganglionectomy and/or blockade of the sensory and autonomic innervation of the eye through retrobulbar anesthesia; retrobulbar anesth...

journal_title：Experimental eye research

authors： Gual A,Mintenig GM,Belmonte C

更新日期：1989-03-01 00:00:00

abstract：:This study demonstrates post-translational arginylation of bovine serum albumin and endogenous lens proteins by bovine lens arginyl-tRNA:protein transferase. This reaction has been proposed to be the first step in marking specific proteins for degradation by the non-lysosomal, ATP-dependent, ubiquitin-mediated proteol...

journal_title：Experimental eye research

authors： Wagner BJ,Margolis JW

更新日期：1991-11-01 00:00:00

abstract：:The transmembrane glycoprotein CD44 is a cell adhesion molecule which has recently been localized in a variety of cell types. It mediates cell attachment to extracellular matrix components and also binds to the actin cytoskeleton within the cell. In this study, the presence and distribution of CD44 in the mouse retina...

journal_title：Experimental eye research

authors： Chaitin MH,Wortham HS,Brun-Zinkernagel AM

更新日期：1994-03-01 00:00:00

abstract：:The aim of this study was to develop consistently focal elevated choroidal masses of human choroidal melanoma in immunosuppressed rabbits and to correlate the visualization of prognostically significant microcirculation patterns from confocal indocyanine green angiography with histologic microcirculation patterns. A h...

journal_title：Experimental eye research

authors： Mueller AJ,Folberg R,Freeman WR,Bartsch DU,Bergeron-Lynn G,Mehaffey MG,Kan-Mitchell J,Huang X,Jian G,Avila C,Taskintuna I,Cheng L,Wang J

更新日期：1999-06-01 00:00:00

abstract：:There is increasing evidence that the macular pigment carotenoids, lutein and zeaxanthin, may play an important role in the prevention of age-related macular degeneration, cataract, and other blinding disorders. Although it is well known that the retina and lens are enriched in these carotenoids, relatively little is ...

journal_title：Experimental eye research

authors： Bernstein PS,Khachik F,Carvalho LS,Muir GJ,Zhao DY,Katz NB

更新日期：2001-03-01 00:00:00

abstract：:The reversible phosphorylation of proteins plays essential roles in regulating various cellular events, and is regulated by the opposing actions of protein kinases and protein phosphatases. Protein kinases in the lens system have been well studied, but very little is known about lens protein phosphatases. Protein phos...

journal_title：Experimental eye research

authors： Umeda IO,Nakata H,Nishigori H

更新日期：2004-12-01 00:00:00

abstract：:Intraocular pressure (IOP) is an important risk factor for glaucoma, and the response of the ONH and surrounding tissues to elevated IOP are often investigated to better understand pathophysiology. In vivo structure including that of the optic nerve head (ONH) and surrounding tissue of the eye are often assessed using...

journal_title：Experimental eye research

authors： Patel N,McAllister F,Pardon L,Harwerth R

更新日期：2018-04-01 00:00:00

abstract：:The overall importance of the peak or the mean serum concentrations as predictors of ocular drug penetration is unknown. To address this fundamental question with an agent which shows promise as adjunctive therapy in the treatment of endophthalmitis, we studied the penetration of ciprofloxacin into the aqueous and vit...

journal_title：Experimental eye research

authors： Madu AA,Mayers M,Perkins R,Liu W,Drusano GL,Aswani R,Madu CN,Miller MH

更新日期：1996-08-01 00:00:00

abstract：:The central retinal artery (CRA) is the main vessel for inner retinal oxygen and nutrition supply. While the intraocular branches lack autonomic innervation, the innervation pattern of the extra-ocular part of this vessel along its course within the optic nerve is poorly investigated. This part however is essential fo...

journal_title：Experimental eye research

authors： Bergua A,Kapsreiter M,Neuhuber WL,Reitsamer HA,Schrödl F

更新日期：2013-05-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are involved in tumour invasion, metastasis and angiogenesis, and have been implicated as progression markers in uveal melanoma, although their topographical expression has not been fully described. In this study we compared the distribution and sp...

journal_title：Experimental eye research

authors： Lai K,Conway RM,Crouch R,Jager MJ,Madigan MC

更新日期：2008-06-01 00:00:00

abstract：:The effects of temperature on rod outer segment (ROS) length and membrane shedding were studied in a cyprinodont fish, Fundulus zebrinus. After 30 days in 14L/10D cyclic light and 17 degrees C, ROS length averaged 41.2 microns. Fish were then exposed to 7, 17 or 27 degrees C for 10 and 25 days before being sampled 5 h...

journal_title：Experimental eye research

authors： Allen DM

更新日期：1995-08-01 00:00:00