Intraocular pressure effects of water loading and venous compression tests in normal and denervated pigmented rabbits.

abstract：:Glaucoma challenges the survival of retinal ganglion cell axons in the optic nerve through processes dependent on both aging and ocular pressure. Relevant stressors likely include complex interplay between axons and astrocytes, both in the retina and optic nerve. In the DBA/2J mouse model of pigmentary glaucoma, early...

journal_title：Experimental eye research

authors： Cooper ML,Crish SD,Inman DM,Horner PJ,Calkins DJ

更新日期：2016-09-01 00:00:00

abstract：:Autophagy is a lysosomal degradative process that is essential for cellular homeostasis and metabolic stress adaptation. Defective autophagy is involved in the pathogenesis of many diseases including granular corneal dystrophy type 2 (GCD2). GCD2 is an autosomal dominant disorder caused by substitution of histidine fo...

journal_title：Experimental eye research

authors： Choi SI,Kim EK

更新日期：2016-03-01 00:00:00

abstract：:In the ophthalmological clinic, intravitreally applied antibodies or Fc-containing fusion proteins are frequently used, but the biology and pharmacokinetics of these therapeutics in the retina are not well understood. We have previously shown intracellular uptake of Fc-containing molecules in RPE cells. In this study,...

journal_title：Experimental eye research

authors： Dithmer M,Hattermann K,Pomarius P,Aboul Naga SH,Meyer T,Mentlein R,Roider J,Klettner A

更新日期：2016-04-01 00:00:00

abstract：:The effects of the instillation of a PGE2-analogue (11-deoxy-13,14-didehydro-16 (S)-methyl PGE2 methylester: FCE 20700) in the conjunctival sac of the rabbit were studied by means of two methods. The former is a clinical study (Dohlman test), the latter is a morphological investigation (semithin sections) on specimens...

journal_title：Experimental eye research

authors： Aragona P,Candela V,Caputi AP,Micali A,Puzzolo D,Quintieri M

更新日期：1987-11-01 00:00:00

abstract：:Specific [3H]-dexamethasone binding sites were demonstrated in bovine corneal cytosol using titration analyses. Specific glucocorticoid binding to corneal cytosol exhibited a single class of sites with apparent dissociation constants of 4-6 nM and 68-72 fmol binding sites mg-1 cytosolic protein. Association of steroid...

journal_title：Experimental eye research

authors： Lin MT,Eiferman RA,Wittliff JL

更新日期：1984-04-01 00:00:00

abstract：:Between 5 and 70% of genetic disease is caused by in-frame nonsense mutations, which introduce a premature termination codon (PTC) within the disease-causing gene. Consequently, during translation, non-functional or gain-of-function truncated proteins of pathological significance, are formed. Approximately 50% of all ...

journal_title：Experimental eye research

authors： Richardson R,Smart M,Tracey-White D,Webster AR,Moosajee M

更新日期：2017-02-01 00:00:00

abstract：:Müller cells can completely repair retinal injury by acting as endogenous stem/progenitor cells in lower-order vertebrates. However, a safe and effective approach to activate progenitor potential of retinal Müller cells in higher-order vertebrates, which rarely re-enter the cell cycle, is a bottleneck problem. In the ...

journal_title：Experimental eye research

authors： Jian Q,Li Y,Yin ZQ

更新日期：2015-03-01 00:00:00

abstract：:The effects of temperature on rod outer segment (ROS) length and membrane shedding were studied in a cyprinodont fish, Fundulus zebrinus. After 30 days in 14L/10D cyclic light and 17 degrees C, ROS length averaged 41.2 microns. Fish were then exposed to 7, 17 or 27 degrees C for 10 and 25 days before being sampled 5 h...

journal_title：Experimental eye research

authors： Allen DM

更新日期：1995-08-01 00:00:00

abstract：:The distribution of chondroitin sulfate proteoglycans in the mouse interphotoreceptor matrix (IPM) proximal to the retinal pigment epithelium (RPE) was evaluated with EM histochemical techniques using Cupromeronic Blue (CmB) before and after retinal separation. Densely packed, sheet-like processes surrounding vesicle-...

journal_title：Experimental eye research

authors： Iwasaki M,Rayborn ME,Tawara A,Hollyfield JG

更新日期：1992-03-01 00:00:00

abstract：:Patients with inflammatory bowel disease suffer not only from gut inflammation, but also from extraintestinal manifestations of the disease, including ocular pathology. The mechanisms causing ocular inflammation in these patients are unknown. The purpose of the current study was to investigate the possible vascular ch...

journal_title：Experimental eye research

authors： Watts MN,Eshaq RS,Carter PR,Harris NR

更新日期：2013-10-01 00:00:00

abstract：:Two previous studies have shown that N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of neuronal nitric oxide synthase, protects retinas of albino rats and mice from damaging levels of light. The aims of the present study were two-fold: (1) to confirm the protective effect of L-NAME on wild type albino rats ...

journal_title：Experimental eye research

authors： Káldi I,Dittmar M,Pierce P,Anderson RE

更新日期：2003-04-01 00:00:00

abstract：:Lens epithelium-derived growth factor (LEDGF) has been shown to enhance survival of lens epithelial cells (LECs) against stress. The objectives of these studies are to determine how LEDGF controls PKC gamma activity in normal LECs: how this control of PKC gamma regulates the phosphorylation of Connexin 43, the inhibit...

journal_title：Experimental eye research

authors： Nguyen TA,Boyle DL,Wagner LM,Shinohara T,Takemoto DJ

更新日期：2003-05-01 00:00:00

abstract：:The proliferation, migration and transdifferentiation of the remaining lens epithelial cells (LECs) after cataract surgery are a major cause of posterior capsular opacification (PCO). It has previously been reported that salmosin, a novel disintegrin, significantly inhibits solid tumor growth in mice by perturbation o...

journal_title：Experimental eye research

authors： Kim JT,Lee DH,Chung KH,Kang IC,Kim DS,Joo CK

更新日期：2002-05-01 00:00:00

abstract：:Giant papillae, characteristic lesions of vernal keratoconjunctivitis, are formed as a result of the proliferation of conjunctival fibroblasts, the deposition of extracellular matrix, and the infiltration of inflammatory cells. The concentration of interleukin (IL)-4 is also increased in the tear fluid of individuals ...

journal_title：Experimental eye research

authors： Fujitsu Y,Fukuda K,Kumagai N,Nishida T

更新日期：2003-01-01 00:00:00

abstract：:Previous studies have suggested that a mannose receptor mediates the phagocytic uptake of effete rod outer segments by retinal pigment epithelial cells. In the present study, the effect of adding a soluble ligand for the mannose receptor, horseradish peroxidase, was examined. Cultured retinal pigment epithelial cells ...

journal_title：Experimental eye research

authors： Lutz DA,Guo Y,McLaughlin BJ

更新日期：1995-10-01 00:00:00

abstract：:Although primary cultures of human lens epithelial (HLE) cells provide important information concerning the role of epithelium in normal lens and cataract formation, the lack of a cell line precludes a broad range of studies on the metabolism and molecular biology of these cells. We have, therefore developed an HLE ce...

journal_title：Experimental eye research

authors： Ibaraki N,Chen SC,Lin LR,Okamoto H,Pipas JM,Reddy VN

更新日期：1998-11-01 00:00:00

abstract：:The purpose of this study was to investigate the influence of molecular shape, conformability, net surface charge and tissue interaction on transscleral diffusion. Unfixed, porcine sclera was clamped in an Ussing chamber. Fluorophore-labelled neutral albumin, neutral dextran, or neutral ficoll were placed in one hemi-...

journal_title：Experimental eye research

authors： Srikantha N,Mourad F,Suhling K,Elsaid N,Levitt J,Chung PH,Somavarapu S,Jackson TL

更新日期：2012-09-01 00:00:00

abstract：:SPACRCAN is a novel proteoglycan present in the interphotoreceptor matrix (IPM) of the rat and human retina that resists aqueous extraction through its binding to hyaluronan. The purpose of this study was: to clone mouse Spacrcan; to characterize the promoter elements; to define the deduced amino acid sequence; to est...

journal_title：Experimental eye research

authors： Chen Q,Lee JW,Nishiyama K,Shadrach KG,Rayborn ME,Hollyfield JG

更新日期：2003-01-01 00:00:00

abstract：:Aceclidine can dissociate accommodative and outflow facility responses in monkeys and humans. We sought to determine if different muscarinic receptor subtypes control outflow facility, accommodative and pupillary responses to aceclidine in the living rhesus monkey eye, as a possible basis for this separation. Each eye...

journal_title：Experimental eye research

authors： Gabelt BT,Kaufman PL

更新日期：1994-05-01 00:00:00

abstract：:The aquaporins (AQPs) are a family of more than 10 homologous water transporting proteins expressed in many mammalian epithelia and endothelia. At least five AQPs are expressed in the eye: AQP0 (MIP) in lens fiber, AQP1 in cornea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP...

journal_title：Experimental eye research

authors： Verkman AS

更新日期：2003-02-01 00:00:00

abstract：:Glaucoma is defined as a progressive optic neuropathy and is characterized by an irreversible loss of retinal ganglion cells. The main risk factor to develop glaucoma is an increased intraocular pressure (IOP). During the course of glaucoma structural changes in the optic nerve head (ONH) take place which lead to the ...

journal_title：Experimental eye research

authors： Schneider M,Fuchshofer R

更新日期：2016-01-01 00:00:00

abstract：:To determine the effect of roscovitine, a potent antiviral in tissue culture administered intramuscularly to rabbits or by eye drops to mice for the treatment of herpetic keratitis this study was commenced.New Zealand white rabbits infected with McKrae strain herpesvirus (HSV-1) were treated twice a day with 10mg Rosc...

journal_title：Experimental eye research

authors： Avunduk AM,Varnell ED,Kaufman HE

更新日期：2003-06-01 00:00:00

abstract：:The elimination of spermine, the end product of cellular polyamine, from the retina to the blood across the blood-retinal barrier (BRB) was investigated. The in vivo microdialysis study revealed that the elimination of [(3)H]spermine from vitreous humor after vitreous bolus injection was in a biexponential manner. The...

journal_title：Experimental eye research

authors： Kubo Y,Tomise A,Tsuchiyama A,Akanuma S,Hosoya K

更新日期：2014-07-01 00:00:00

abstract：:Corneal autofluorescence, as measured with a commercial scanning fluorophotometer (lambda(exc): 415-491 nm; lambda(em): 515-630 nm), is increased in patients with diabetes mellitus. However, such fluorophotometers register an average fluorescence signal over all corneal layers as a consequence of their limited axial r...

journal_title：Experimental eye research

authors： Van Schaik HJ,Coppens J,Van den Berg TJ,Van Best JA

更新日期：1999-11-01 00:00:00

abstract：:(O-acyl) ω-hydroxy fatty acids (OAHFAs) are a recently found group of polar lipids in meibum. Since these lipids can potentially serve as a surfactant in the tear film lipid layer, the surface properties of a molecule of this lipid class was investigated and compared with a structurally related wax ester and a fatty a...

journal_title：Experimental eye research

authors： Schuett BS,Millar TJ

更新日期：2013-10-01 00:00:00

abstract：:cDNA clones encoding S-antigen (arrestin) were isolated from the expression library constructed from porcine retina and sequenced. The 1490 base pair fragment contained a 1215 base pair open reading frame. From the nucleotide sequence, an amino acid sequence consisting of 405 residues was deduced and a molecular mass ...

journal_title：Experimental eye research

authors： Singh AK,Kumar G,Shinohara T,Shichi H

更新日期：1996-03-01 00:00:00

abstract：:Mice carrying the rd mutation are affected with an autosomal recessive disease characterized by the total degeneration of retinal photoreceptor cells, which begins at postnatal day 8 and reaches completion by 3 wk of life. Biochemical studies have led to the proposal that a lesion in cGMP metabolism may be the cause o...

journal_title：Experimental eye research

authors： Danciger M,Tuteja N,Kozak CA,Farber DB

更新日期：1989-02-01 00:00:00

abstract：:In ocular surface inflammatory diseases, such as dry eye disease, long-term symptom relief requires targeting the inflammation itself rather than treating only the surface-associated dryness with artificial tears. Therefore, we included an anti-inflammatory agent in an unpreserved liposome-based (LP) formulation used ...

journal_title：Experimental eye research

authors： Soriano-Romaní L,Vicario-de-la-Torre M,Crespo-Moral M,López-García A,Herrero-Vanrell R,Molina-Martínez IT,Diebold Y

更新日期：2017-01-01 00:00:00

abstract：:Glucosyltransferase, an enzyme involved in the synthesis of the carbohydrate portion of basement membranes and collagens, and collagen content were determined in the retina of normal and streptozotocin diabetic rats. No significant difference in glucosyltransferase activity was found at 4 weeks of diabetes. However, t...

journal_title：Experimental eye research

authors： Reddi AS

更新日期：1985-09-01 00:00:00

abstract：:Fibroblast growth factors play a key role in regulating lens epithelial cell proliferation and differentiation via an anteroposterior gradient that exists between the aqueous and vitreous humours. FGF-2 is the most important for lens epithelial cell proliferation and differentiation. It has been proposed that the pres...

journal_title：Experimental eye research

authors： Wu W,Tholozan FM,Goldberg MW,Bowen L,Wu J,Quinlan RA

更新日期：2014-03-01 00:00:00