Abstract：
:Cataract is a multifactorial disease, and a large variety of stressors induce cataracts. Many cataractogenic stressors and endoplasmic reticulum (ER) stressors induce the unfolded protein response (UPR) in various cell types. The UPR is known to produce reactive oxygen species (ROS) prior to the inducement of apoptosis. We investigated whether ER stressors induce the UPR in lens epithelial cells (LECs) or whole rat lenses. Our results showed that higher levels of ER stressors activated Bip/GRP78, ATF4, and caspase-12. In addition, ROS were produced, free glutathione was decreased, and apoptosis was induced. LECs in the mitotic zone were the most susceptible to the UPR while the central LECs were the most resistant. The UPR induced the production of ROS in the ER and probably in the mitochondria. The detectable ROS production in cultured lenses is limited to the epithelial cells. These findings indicate that ER stressors induce the UPR in LECs with and without the induction of apoptosis, and we conclude that the UPR is probably one of the initiating factors of many types of cataracts.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Ikesugi K,Yamamoto R,Mulhern ML,Shinohara Tdoi
10.1016/j.exer.2006.01.033subject
Has Abstractpub_date
2006-09-01 00:00:00pages
508-16issue
3eissn
0014-4835issn
1096-0007pii
S0014-4835(06)00168-0journal_volume
83pub_type
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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更新日期：1986-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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更新日期：2008-03-01 00:00:00
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journal_title：Experimental eye research
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更新日期：2014-08-01 00:00:00
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journal_title：Experimental eye research
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更新日期：2004-09-01 00:00:00
