Abstract：
:Beta-crystallins are major protein constituents of the mammalian lens, where their stability and association into higher order complexes are critical for lens clarity and refraction. Dimerization is an initial step in formation of beta-crystallin complexes. Beta-crystallin association into dimers is energetically highly favoured, but rapidly reversible under physiological conditions. Beta-crystallin dimers can exchange monomers, probably through a transient and energetically unfavoured monomer intermediate state. As predicted by molecular modelling, the fraction of beta-crystallin present as dimers increases with increasing temperature, implying that beta-crystallin association is entropically driven.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Hejtmancik JF,Wingfield PT,Sergeev YVdoi
10.1016/j.exer.2004.06.011keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
377-83issue
3eissn
0014-4835issn
1096-0007pii
S0014483504001654journal_volume
79pub_type
杂志文章,评审abstract：:A single intraperitoneal dose of endotoxin (lipopolysaccharide or LPS) induces an acute inflammatory response in the uveal tract of rats. This inflammation is characterized by a breakdown of the blood/aqueous barrier within 3 hr after the LPS and the subsequent development of clinical disease and a cellular infiltrate...
journal_title：Experimental eye research
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journal_title：Experimental eye research
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abstract：:A newly-developed fibre-optic sensor (wavelength of 670 nm) was used to measure the index gradient in 16 human lenses ranging in age from 38 to 78 years. Two of these lenses had nuclear cataract. The refractive index, calculated from the proportion of reflected light at the sensor/sample interface, appeared to increas...
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journal_title：Experimental eye research
pub_type： 杂志文章
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pub_type： 杂志文章,评审
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journal_title：Experimental eye research
pub_type： 杂志文章
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：2009-12-01 00:00:00
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更新日期：2009-06-15 00:00:00
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更新日期：2016-04-01 00:00:00
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1996.0147
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 杂志文章
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