Abstract:
:The mechanical, histological and pharmacological properties of the isolated cat ophthalmociliary artery are reported and compared for passively stretched ring segments from three locations on the artery. Ring segments were mounted in a modified myograph system after the method of Hogestatt, Andersson and Edvinsson (1983, Acta Physiol Scand. 117, 49-61) and comparative length tension curves were measured. The most distal segment (DOA), nearest the eye, developed by far the smallest maximal tension compared to the middle segment (MOA) and the most proximal segment (POA), despite the fact that lumen diameters were similar. All segments displayed a phasic and tonic component in response to passive stretching and during activation with K(+)-Krebs. Cumulative contractile dose-response curves were measured for nine agonists: histamine (HIS), 5-hydroxytryptamine (5-HT), dopamine (DOPA), adrenaline (A), noradrenaline (NA), tyramine (TYR), phenylephrine (PHE), isoproterenol (ISOP) and xylazine (XYL) and the maximum active tension developed at a concentration of 10(-3) M was compared with that for 0.124 M K(+)-Krebs. The order of contraction magnitude in the three segments was: POA, HIS much greater than Kmax much greater than NA greater than A greater than DOPA greater than PH = TYR greater than 5-HT = ISOP greater than XYL; MOA, Kmax much greater than NA much greater than A = HIS much greater than DOPA greater than ISOP = PHE greater than TYR = 5-HT greater than XYL; DOA, Kmax much greater than NA greater than A greater than HIS = DOPA greater than ISOP greater than PHE = 5-HT greater than XYL = TYR. Pre-activation did not produce relaxation in response to histamine and isoproterenol. Testing with specific alpha 1 and beta antagonists supported the presence of alpha 1 receptors but not beta receptors. It is concluded that functional HIS, alpha 1 and 5-HT receptors are present and that the ophthalmociliary artery is heterogeneous in its response to HIS, with the POA segment producing the largest responses. The magnitude of the contractile responses to A and NA grew with increasing passive tension, whereas the response to histamine was independent of passive tension.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Yu DY,Su EN,Alder VA,Cringle SJ,Mele EMdoi
10.1016/0014-4835(92)90047-vkeywords:
subject
Has Abstractpub_date
1992-03-01 00:00:00pages
347-59issue
3eissn
0014-4835issn
1096-0007journal_volume
54pub_type
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