Abstract:
:The damaging effects incurred during a light-insult on the albino rat retina are studied separately from the resultant loss of visual cells which occurs. Groups of rats, 5-20 weeks of age, are exposed to 48 hr of 80 lux illumination, maintained in the dark for various lengths of time, and then killed. Beginning at light-off and continuing throughout 3 days of darkness, assays are made of (i) outer nuclear layer thickness; (ii) whole retina rhodopsin levels; and (iii) activities of lysosomal proteases known to be important in the degradation of retinal and ocular tissue. It is found that (a) having been given the light-insult, most of the visual cells that will die and disappear do so during the dark, postexposure period; (b) the retinas of all the animals show a limited capability for regenerating rhodopsin after the light-insult but younger animals are somewhat more successful at sustaining this than are older ones; (c) proteolytic enzyme activity is greatest in older animals which are also the ones that lose the most cells.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Penn JS,Baker BN,Howard AG,Williams TPdoi
10.1016/s0014-4835(85)80017-8subject
Has Abstractpub_date
1985-09-01 00:00:00pages
275-84issue
3eissn
0014-4835issn
1096-0007journal_volume
41pub_type
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