Abstract:
:Angiotensin II and aldosterone are the main effectors of the renin-angiotensin aldosterone system (RAAS) and have a central role in hypertension as well as cardiovascular and renal disease. The localization of RAAS components within the retina has led to studies investigating the roles of angiotensin II, aldosterone and the counter regulatory arm of the pathway in vision-threatening retinopathies. This review will provide a brief overview of RAAS components as well as the vascular pathology that develops in the retinal diseases, retinopathy of prematurity, diabetic retinopathy and neovascular age-related macular degeneration. The review will discuss pre-clinical and clinical evidence that modulation of the RAAS alters the development of vasculopathy and inflammation in the aforementioned retinopathies, as well as the emerging role of aldosterone and the mineralocorticoid receptor in central serous chorioretinopathy.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Wilkinson-Berka JL,Suphapimol V,Jerome JR,Deliyanti D,Allingham MJdoi
10.1016/j.exer.2019.107766subject
Has Abstractpub_date
2019-10-01 00:00:00pages
107766eissn
0014-4835issn
1096-0007pii
S0014-4835(19)30431-2journal_volume
187pub_type
杂志文章,评审abstract::The lacrimal functional unit (LFU) is defined by the 2007 International Dry Eye WorkShop as 'an integrated system comprising the lacrimal glands, ocular surface (cornea, conjunctiva and meibomian glands) and lids, and the sensory and motor nerves that connect them'. The LFU maintains a healthy ocular surface primarily...
journal_title:Experimental eye research
pub_type: 杂志文章,评审
doi:10.1016/j.exer.2008.09.002
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abstract::Lack of an optimal in vitro model of human corneal epithelial (HCE) cells is a major limitation in studying normal functions and gene regulations in HCE. Moreover, availability of a multi-layered HCE culture can reduce the usage of animals in the toxicity testing of consumer products. We have developed tetracycline-re...
journal_title:Experimental eye research
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doi:10.1016/s0014-4835(03)00175-1
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pub_type: 杂志文章
doi:10.1016/j.exer.2016.10.012
更新日期:2016-12-01 00:00:00
abstract::An experimental study was conducted on eight litters of newborn rats to evaluate the effects of supplemental oxygen administration on the retinal vasculature. The animals and their mothers were kept inside a pressure chamber and treated for the first 5 days of life. On the sixth day, they were removed and kept for fiv...
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doi:10.1016/s0014-4835(87)80179-3
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2005.05.007
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journal_title:Experimental eye research
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doi:10.1016/j.exer.2009.07.019
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abstract::Müller cells can completely repair retinal injury by acting as endogenous stem/progenitor cells in lower-order vertebrates. However, a safe and effective approach to activate progenitor potential of retinal Müller cells in higher-order vertebrates, which rarely re-enter the cell cycle, is a bottleneck problem. In the ...
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pub_type: 杂志文章
doi:10.1016/j.exer.2015.01.008
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2006.10.007
更新日期:2007-02-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章,评审
doi:10.1016/j.exer.2016.07.009
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journal_title:Experimental eye research
pub_type: 杂志文章,评审
doi:10.1016/j.exer.2012.11.019
更新日期:2013-09-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2013.03.016
更新日期:2013-06-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/0014-4835(84)90065-4
更新日期:1984-11-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2003.08.009
更新日期:2003-12-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2013.06.002
更新日期:2013-08-01 00:00:00
abstract::Rifampicin, an antibacterial drug widely used in the treatment of tuberculosis and leprosy, has recently been reported to have anti-oxidative and anti-apoptotic effects. However, its anti-angiogenic effect has not been investigated. We examined its anti-angiogenic effect on tube formation and proliferation by human um...
journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2007.10.003
更新日期:2008-01-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/s0014-4835(03)00056-3
更新日期:2003-06-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2015.08.006
更新日期:2015-11-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章,评审
doi:10.1016/j.exer.2004.06.011
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journal_title:Experimental eye research
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journal_title:Experimental eye research
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2006.06.004
更新日期:2006-11-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1994.1057
更新日期:1994-05-01 00:00:00
abstract::It has long been assumed that unstimulated tears are more thoroughly equilibrated with epithelial secretions than stimulated tears, since they are in contact with tarsal, bulbar and corneal surfaces for longer. It was also believed from results with model solutions that soluble mucin is responsible for the observed su...
journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1998.0600
更新日期:1999-02-01 00:00:00
abstract::The integrity of the retinal pigment epithelium, especially that of the macula is essential for the preservation of vision into old age. The chronic exposure to sunlight and peroxidized lipids from phagocytized photoreceptor outer segments imposes a high level of oxidative stress on the retinal tissues, which increase...
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doi:10.1006/exer.2001.1146
更新日期:2002-06-01 00:00:00
abstract::The aim of the study was to determine anatomical and growth factor profiles in patients with clinically significant macular oedema (CSMO) undergoing pars plana vitrectomy (PPV). Twenty patients with moderate nonproliferative diabetic retinopathy (NPDR) with persistent CSMO underwent PPV. Patients had baseline and post...
journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2005.10.002
更新日期:2006-05-01 00:00:00
abstract::Form-deprivation of chicks during early postnatal development results in ocular enlargement and great myopic refractive error (form-deprivation myopia). Previous studies have indicated that the retina, RPE and choroid play important roles in ocular enlargement in form-deprivation myopia. We aimed to isolate genes up-r...
journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1006/exer.1999.0765
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abstract::Human tear fluid was collected with blunted glass capillaries before and after performing the Schirmer test (ST). The test caused an increase in the tear fluid (TF) plasmin concentration (from 0.40 +/- 0.29 microgram ml-1 (mean +/- S.E.M.) to 1.14 +/- 0.26 microgram ml-1; Mann-Whitney test P less than 0.001) and a dec...
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pub_type: 杂志文章
doi:10.1016/0014-4835(90)90223-h
更新日期:1990-02-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2014.11.002
更新日期:2014-12-01 00:00:00
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journal_title:Experimental eye research
pub_type: 杂志文章
doi:10.1016/j.exer.2018.08.013
更新日期:2019-06-01 00:00:00