Abstract：
:With the combined purpose of facilitating useful vision over a lifetime, a number of ocular cells have evolved specialized features not found elsewhere in the body. The trabecular meshwork (TM) cell at the irido-corneal angle, which is a key regulator of intraocular pressure, is no exception. Examination of cells in culture isolated from the human TM has shown that they are unique in many ways, displaying characteristic features of several different cell types. Thus, these neural crest derived cells display expression patterns and behaviors typical of endothelia, fibroblasts, smooth muscle and macrophages, owing to the multiple roles and two distinct environments where they operate to maintain intraocular pressure homeostasis. In most individuals, TM cells function normally over a lifetime in the face of persistent stressors, including phagocytic, oxidative, mechanical and metabolic stress. Study of TM cells isolated from ocular hypertensive eyes has shown a compromised ability to perform their daily duties. This review highlights the many responsibilities of the TM cell and its challenges, progress in our understanding of TM biology over the past 30 years, as well as discusses unanswered questions about TM dysfunction that results in IOP dysregulation and glaucoma.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Stamer WD,Clark AFdoi
10.1016/j.exer.2016.07.009subject
Has Abstractpub_date
2017-05-01 00:00:00pages
112-123eissn
0014-4835issn
1096-0007pii
S0014-4835(16)30190-7journal_volume
158pub_type
杂志文章,评审abstract：:The objective of this study was to determine the cellular localization of P2Y(2) receptor gene expression in rabbit and primate ocular tissues using the technique of non-isotopic in situ hybridization. Fresh frozen whole eye from a New Zealand White rabbit and whole eye and eyelid from a rhesus macaque were cut into 5...
journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 杂志文章,评审
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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更新日期：2018-07-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：1993-10-01 00:00:00
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更新日期：2019-06-01 00:00:00
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journal_title：Experimental eye research
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更新日期：2004-07-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2006.08.009
更新日期：2007-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2016.07.003
更新日期：2016-10-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/0014-4835(83)90116-1
更新日期：1983-03-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2008.11.034
更新日期：2009-05-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：1984-07-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：1992-09-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：1998-05-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：1993-06-01 00:00:00
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更新日期：2021-01-23 00:00:00
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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更新日期：2014-09-01 00:00:00
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更新日期：2007-12-01 00:00:00
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更新日期：2016-03-01 00:00:00
abstract：:The aim of this study was to investigate the developmental potential of embryonic stem (ES) cell-derived eye-like structures as a replacement cell therapy model for retinas with N-methyl-d-aspartate (NMDA)-induced damage. For this purpose mouse ES cells were induced to differentiate into eye-like structures in vitro f...
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更新日期：2007-05-01 00:00:00
abstract：:Beta-crystallins are major protein constituents of the mammalian lens, where their stability and association into higher order complexes are critical for lens clarity and refraction. Dimerization is an initial step in formation of beta-crystallin complexes. Beta-crystallin association into dimers is energetically high...
journal_title：Experimental eye research
pub_type： 杂志文章,评审
doi：10.1016/j.exer.2004.06.011
更新日期：2004-09-01 00:00:00
