Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma (POAG).


:Thirty-one trabeculectomy specimens of patients suffering from primary open-angle glaucoma (POAG) who had received no, or only minor, medication prior to surgery were ultrastructurally and quantitatively analysed. Most of the specimens revealed thickened trabeculae, increased amounts of plaque-material deposited within the cribriform layer and an abundance of long spacing (lattice) collagen. The uveal meshwork was partly deprived of cells whereas the cribriform layer often contained numerous enlarged, light cells with many small mitochondria and lysosomes but no prominent endoplasmic reticulum or Golgi complexes. The quantitation of sheath-deprived plaque material (SD plaques) in a defined area of inner and outer wall of Schlemm's canal showed no significant difference between the untreated cases studied here and the treated ones studied previously. However, both groups had significantly higher amounts of SD plaque material in the inner wall than normal controls of a similar age range.


Exp Eye Res


Rohen JW,Lütjen-Drecoll E,Flügel C,Meyer M,Grierson I




Has Abstract


1993-06-01 00:00:00














  • Inflammatory cells proliferate in the choroid and retina without choroidal thickness change in early Type 1 diabetes.

    abstract::Increasing evidence points to inflammation as a key factor in the pathogenesis of diabetic retinopathy (DR). Choroidal inflammatory changes in diabetes have been reported and in vivo choroidal thickness (CT) has been searched as a marker of retinopathy with contradictory results. We aimed to investigate the early stag...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Campos A,Campos EJ,Martins J,Rodrigues FSC,Silva R,Ambrósio AF

    更新日期:2020-10-01 00:00:00

  • Optical treatment strategies to slow myopia progression: effects of the visual extent of the optical treatment zone.

    abstract::In order to develop effective optical treatment strategies for myopia, it is important to understand how visual experience influences refractive development. Beginning with the discovery of the phenomenon of form deprivation myopia, research involving many animal species has demonstrated that refractive development is...

    journal_title:Experimental eye research

    pub_type: 杂志文章,评审


    authors: Smith EL 3rd

    更新日期:2013-09-01 00:00:00

  • Bicarbonate activates glycolysis and lactate production in corneal endothelial cells by increased pHi.

    abstract::Recent studies have shown that lactate coupled water flux is the underlying mechanism of the corneal endothelial pump, which is highly dependent on the presence of bicarbonate. In this study we test the hypothesis that the increased intracellular pH (pHi) caused by bicarbonate stimulates glycolytic activity and the pr...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Li S,Shyam R,Ogando DG,Bonanno JA

    更新日期:2020-10-01 00:00:00

  • Autofluorescence distribution along the corneal axis in diabetic and healthy humans.

    abstract::Corneal autofluorescence, as measured with a commercial scanning fluorophotometer (lambda(exc): 415-491 nm; lambda(em): 515-630 nm), is increased in patients with diabetes mellitus. However, such fluorophotometers register an average fluorescence signal over all corneal layers as a consequence of their limited axial r...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Van Schaik HJ,Coppens J,Van den Berg TJ,Van Best JA

    更新日期:1999-11-01 00:00:00

  • Collagen VII deficient mice show morphologic and histologic corneal changes that phenotypically mimic human dystrophic epidermolysis bullosa of the eye.

    abstract:BACKGROUND:Absence of collagen VII causes blistering of the skin, eyes and many other tissues. This disease is termed dystrophic epidermolysis bullosa (DEB). Corneal fibrosis occurs in up to 41% and vision loss in up to 64% of patients. Standard treatments are supportive and there is no cure. The hypomorphic mouse mode...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Chen VM,Shelke R,Nyström A,Laver N,Sampson JF,Zhiyi C,Bhat N,Panjwani N

    更新日期:2018-10-01 00:00:00

  • The contribution of GSH peroxidase-1, catalase and GSH to the degradation of H2O2 by the mouse lens.

    abstract::Utilizing cultured lenses from normal and homozygous glutathione peroxidase (GSHPx-1) knockout mice and inhibitors for GSSG Reductase (GSSG Red), 1,3-bis(2-chlorethyl)-1-nitrosourea (BCNU) and catalase (Cat), 3-aminotriazole (3-AT), the ability to degrade H2O2 was examined at two H2O2 concentrations, 300 microM and 80...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Spector A,Ma W,Wang RR,Yang Y,Ho YS

    更新日期:1997-03-01 00:00:00

  • Endotoxin-induced uveitis in the rat: observations on altered vascular permeability, clinical findings, and histology.

    abstract::A single intraperitoneal dose of endotoxin (lipopolysaccharide or LPS) induces an acute inflammatory response in the uveal tract of rats. This inflammation is characterized by a breakdown of the blood/aqueous barrier within 3 hr after the LPS and the subsequent development of clinical disease and a cellular infiltrate...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Cousins SW,Guss RB,Howes EL Jr,Rosenbaum JT

    更新日期:1984-11-01 00:00:00

  • Tissue transglutaminase catalyzes the deamidation of glutamines in lens betaB(2)- and betaB(3)-crystallins.

    abstract::Tissue transglutaminase (tTG) is a Ca(2+)-dependent enzyme catalyzing the formation of covalent crosslinks between peptide-bound glutamine and lysine residues. Lens crystallins, including alphaB-crystallin and several beta-crystallins, are in vitro substrates for tTG. In both human and bovine fetal lens extracts treat...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Boros S,Wilmarth PA,Kamps B,de Jong WW,Bloemendal H,Lampi K,Boelens WC

    更新日期:2008-02-01 00:00:00

  • TIMP-1 affects the spatial distribution of dendritic processes of second-order neurons in a rat model of Retinitis Pigmentosa.

    abstract::Retinitis Pigmentosa (RP) is an inherited disorder that may lead to blindness. In the rhodopsin S334ter-line-3 rat model of RP, the death of rods induces spatial rearrangement of cones into regular ring mosaics. Using this model, we discovered that the ring mosaics are restored to a homogeneous distribution upon appli...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Shin JA,Eom YS,Yu WQ,Grzywacz NM,Craft CM,Lee EJ

    更新日期:2015-11-01 00:00:00

  • Characterization of adenylate cyclase in human retinal pigment epithelial cells in vitro.

    abstract::Human retinal pigment epithelial cells in culture demonstrate adenylate cyclase activity. It is membrane-bound and modulated by GTP regulatory proteins. It is effectively activated only by beta-adrenergic agonists (L-isoproterenol greater than or equal to L-epinephrine greater than L-norepinephrine) and some prostagla...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Friedman Z,Hackett SF,Campochiaro PA

    更新日期:1987-04-01 00:00:00

  • Retinal ganglion cell numbers and delayed retinal ganglion cell death in the P23H rat retina.

    abstract::The P23H-1 rat strain carries a rhodopsin mutation frequently found in retinitis pigmentosa patients. We investigated the progressive degeneration of the inner retina in this strain, focussing on retinal ganglion cells (RGCs) fate. Our data show that photoreceptor death commences in the ventral retina, spreading to th...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: García-Ayuso D,Salinas-Navarro M,Agudo M,Cuenca N,Pinilla I,Vidal-Sanz M,Villegas-Pérez MP

    更新日期:2010-12-01 00:00:00

  • An intravital and confocal microscopic study of the distribution of intracameral antigen in the aqueous outflow pathways and limbus of the rat eye.

    abstract::In a previous investigation into the fate of fluorescently labelled antigen (Ag) injected into the anterior chamber (AC) of the rat eye, a large number of Ag+ cells were noted in the conventional and non-conventional aqueous humour outflow pathways together with the external limbus. The aim of this study was to invest...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Camelo S,Shanley AC,Voon AS,McMenamin PG

    更新日期:2004-10-01 00:00:00

  • On the reactivity of corneal collagen and subcomponent C1q of the complement system with human platelets and IgG-coated latex particles.

    abstract::Collagen was isolated from bovine cornea and tested for reactivity towards platelets and IgG-coated polystyrene latex particles. The corneal collagen caused a dose- and temperature-dependent platelet aggregation in all human platelet-rich plasmas studied. As little as 0 . 31 micrograms of purified corneal collagen cou...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Csako G,Suba EA,Herp A

    更新日期:1983-03-01 00:00:00

  • The effects of age on mitochondria, axonal transport, and axonal degeneration after chronic IOP elevation using a murine ocular explant model.

    abstract::The purpose of this study was to compare younger and older mice after chronic intraocular pressure (IOP) elevation lasting up to 4 days with respect to mitochondrial density, structure, and movement, as well as axonal integrity, in an ex vivo explant model. We studied 2 transgenic mouse strains, both on a C57BL/6J bac...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Kimball EC,Jefferys JL,Pease ME,Oglesby EN,Nguyen C,Schaub J,Pitha I,Quigley HA

    更新日期:2018-07-01 00:00:00

  • Protein-protein interactions involving congenital cataract T5P gammaC-crystallin mutant: a confocal fluorescence microscopy study.

    abstract::The human lens crystallin gene CRYGC T5P is associated with Coppock-like cataract and has a phenotype of a dust-like opacity of the fetal lens nucleus and deep cortical region. Previous in vitro mutation studies indicate that the protein has changed conformation, solubility, and stability, which may make it susceptibl...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Liu BF,Song S,Hanson M,Liang JJ

    更新日期:2008-12-01 00:00:00

  • Proteoglycans in the mouse interphotoreceptor matrix. V. Distribution at the apical surface of the pigment epithelium before and after retinal separation.

    abstract::The distribution of chondroitin sulfate proteoglycans in the mouse interphotoreceptor matrix (IPM) proximal to the retinal pigment epithelium (RPE) was evaluated with EM histochemical techniques using Cupromeronic Blue (CmB) before and after retinal separation. Densely packed, sheet-like processes surrounding vesicle-...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Iwasaki M,Rayborn ME,Tawara A,Hollyfield JG

    更新日期:1992-03-01 00:00:00

  • Lens deviations in rabbit offspring after short-term prenatal exposure to dexamethasone: a light-microscopic study.

    abstract::Female New Zealand White rabbits were treated subcutaneously with 0.0375 or 0.15 mg kg-1 dexamethasone or physiological saline solution from the 8th through to the 11th day of gestation. Short-term administration of 0.15 mg kg-1 dexamethasone induced two types of morphological lens deviations in the offspring (lenses ...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Koksma JM,Hoyng PF,Willekens BW

    更新日期:1984-08-01 00:00:00

  • Differential effects of the EGF family of growth factors on protein secretion, MAPK activation, and intracellular calcium concentration in rat lacrimal gland.

    abstract::The purpose of this study was to investigate the expression of the EGF family of growth factors and EGF receptor subtypes (ErbB1-4) present in lacrimal gland and determine the effects of these growth factors on different functions of rat lacrimal gland. RT-PCR was used to detect mRNA expression in the lacrimal gland o...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Chen LL,Johansson JK,Hodges RR,Zoukhri D,Ghinelli E,Rios JD,Dartt DA

    更新日期:2005-03-01 00:00:00

  • Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera.

    abstract::There has been generally little attention paid to the utilization of biomaterials as an anti-myopia treatment. The purpose of this study was to investigate whether polymeric hydrogels, either implanted or injected adjacent to the outer scleral surface, slow ocular elongation. White Leghorn (Gallus gallus domesticus) c...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Su J,Iomdina E,Tarutta E,Ward B,Song J,Wildsoet CF

    更新日期:2009-03-01 00:00:00

  • Comparative study of glycosphingolipid composition in mammalian lenses.

    abstract::The carbohydrate epitope Gal alpha 1-3Gal-R (alpha-galactosyl epitope), which is detectable by its binding with Bandeiraea simplicifolia-IB4 lectin, was found in glycosphingolipids (GSLs), both neutral and acidic (gangliosides), from lens tissues of non-primate mammals, but not in those of human senile cataracts and O...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Ogiso M,Okinaga T,Komoto M,Nishiyama I,Hoshi M

    更新日期:1994-12-01 00:00:00

  • Retinal ganglion cell survival in development: mechanisms of retinal growth hormone action.

    abstract::Several variants of growth hormone (GH) are found in the retina and vitreous of the chick embryo, where they appear to act as cell survival factors, having neuroprotective effects on retinal ganglion cells (RGCs). Here, we investigate the molecular mechanisms of the anti-apoptotic effect of GH in cultured RGCs. GH tre...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Sanders EJ,Parker E,Harvey S

    更新日期:2006-11-01 00:00:00

  • Mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3 kinase (PI3K) pathways differently regulate retinal pigment epithelial cell-mediated collagen gel contraction.

    abstract::Retinal pigment epithelial (RPE) cell-mediated extracellular matrix contraction is believed to contribute to developing proliferative vitreoretinopathy. It has been shown that platelet-derived growth factor (PDGF) and its intracellular signaling pathway, including mitogen-activated protein kinase (MAPK) and phosphatid...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Bando H,Ikuno Y,Hori Y,Sayanagi K,Tano Y

    更新日期:2006-03-01 00:00:00

  • Association of type XII collagen with regions of increased stability and keratocyte density in the cornea.

    abstract::The anterior avian cornea possesses several distinct cellular and extracellular regions including the epithelial basal lamina, Bowman's layer and the interfacial matrix that separates Bowman's layer from the stroma. These unique regions differ biochemically, physically and morphologically but all contain type XII coll...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Marchant JK,Zhang G,Birk DE

    更新日期:2002-12-01 00:00:00

  • The interactive effects of genetic polymorphisms within LFA-1/ICAM-1/GSK-3β pathway and environmental hazards on the development of Graves' opthalmopathy.

    abstract::The purpose of this investigation was to explore the combined effects of single nucleotide polymorphisms (SNPs) within LFA-1/ICAM-1/GSK-3β pathway and environmental hazards on susceptibility to Graves' opthalmopathy (GO) among a Chinese Han population. Altogether 305 GO patients and 283 Graves' disease (GD) subjects w...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Yang G,Fu Y,Lu X,Wang M,Dong H,Li Q

    更新日期:2018-09-01 00:00:00

  • Transplantation of corneas reconstructed with cultured adult human corneal endothelial cells in nude rats.

    abstract:PURPOSE:The feasibility of corneal reconstruction with cultured adult human corneal endothelial cells (HCEC) was examined in a nude rat model. METHODS:Endothelial cells were removed from the corneas of Lewis rats using a sterile cotton swab. Cultured adult HCEC labelled with a fluorescent marker chloromethyl-benzamido...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Mimura T,Amano S,Usui T,Araie M,Ono K,Akihiro H,Yokoo S,Yamagami S

    更新日期:2004-08-01 00:00:00

  • Effects of basic fibroblast growth factor on the retinal degeneration of the mi(vit)/mi(vit) (vitiligo) mouse: a morphologic and electrophysiologic study.

    abstract::Basic fibroblast growth factor (bFGF) has been shown to rescue dying photoreceptor cells in the RCS rat, a model with a genetic defect of the RPE that impairs outer segment phagocytosis. The purpose of the present study was to determine whether intravitreal injection of bFGF would have a similar effect on photorecepto...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Smith SB,Titelman R,Hamasaki DI

    更新日期:1996-11-01 00:00:00

  • Retinal differentiation in an altricial bird species, Taeniopygia guttata: An immunohistochemical study.

    abstract::The bird retina offers an excellent model to investigate the mechanisms that coordinate the morphogenesis, histogenesis, and differentiation of neuron and glial cells. Although these developmental features have been intensively studied in the chicken (Gallus gallus, Linnaeus 1758), a precocial bird species, little is ...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Álvarez-Hernán G,Hernández-Núñez I,Rico-Leo EM,Marzal A,de Mera-Rodríguez JA,Rodríguez-León J,Martín-Partido G,Francisco-Morcillo J

    更新日期:2020-01-01 00:00:00

  • Effects of topical erythropoietin on healing experimentally-induced avascular scleral damage in a rabbit model.

    abstract::The present study was designed to investigate the effect of topical erythropoietin on the healing process of induced necrotizing scleritis and to evaluate the ocular side effects of this treatment modality in a rabbit model. Necrotizing scleritis was induced in 8 New Zealand albino rabbits. The animals were then rando...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Feizi S,Kanavi MR,Safari S,Ebrahimi H,Javadi MA

    更新日期:2020-01-01 00:00:00

  • All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.

    abstract::The current study investigates the cellular events which trigger activation of proapoptotic Bcl-2-associated × protein (Bax) in retinal cell death induced by all-trans-retinal (atRAL). Cellular events which activate Bax, such as DNA damage by oxidative stress and phosphorylation of p53, were evaluated by immunochemica...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Sawada O,Perusek L,Kohno H,Howell SJ,Maeda A,Matsuyama S,Maeda T

    更新日期:2014-06-01 00:00:00

  • Development of genetically engineered tet HPV16-E6/E7 transduced human corneal epithelial clones having tight regulation of proliferation and normal differentiation.

    abstract::Lack of an optimal in vitro model of human corneal epithelial (HCE) cells is a major limitation in studying normal functions and gene regulations in HCE. Moreover, availability of a multi-layered HCE culture can reduce the usage of animals in the toxicity testing of consumer products. We have developed tetracycline-re...

    journal_title:Experimental eye research

    pub_type: 杂志文章


    authors: Mohan RR,Possin DE,Mohan RR,Sinha S,Wilson SE

    更新日期:2003-10-01 00:00:00