Latanoprost does not affect immune privilege of corneal allografts.

abstract：:We describe a model of acute intraocular pressure (IOP) elevation in the mouse eye that induces reversible loss of inner retinal function associated with oxidative stress, glial cell activation and minimal loss of retinal ganglion cell (RGC) number. Young healthy mouse eyes recover inner retinal function within 7-days...

journal_title：Experimental eye research

authors： Crowston JG,Kong YX,Trounce IA,Dang TM,Fahy ET,Bui BV,Morrison JC,Chrysostomou V

更新日期：2015-12-01 00:00:00

abstract：:The autonomic innervation in the anterior chamber (AC) structures might play an efferent role in neural intraocular pressure (IOP) regulation, the center of which is thought to be located in the hypothalamus. In this study, we identified the efferent pathway from the hypothalamus to the autonomic innervation in the AC...

journal_title：Experimental eye research

authors： Yang F,Zhu X,Liu X,Ma L,Zhang Z,Pei L,Wang H,Xu F,Liu H

更新日期：2021-01-01 00:00:00

abstract：:Although the presence of 'cartilage-specific' collagens in the eye has been documented earlier, very little is known about their synthesis rates during ocular development, growth and aging. The purpose of the present study was to follow changes in the mRNA levels and distribution of key components of the extracellular...

journal_title：Experimental eye research

authors： Ihanamäki T,Salminen H,Säämänen AM,Pelliniemi LJ,Hartmann DJ,Sandberg-Lall M,Vuorio E

更新日期：2001-04-01 00:00:00

abstract：:The objective of this study were to establish a cell line derived from porcine hyalocytes and to investigate the regulation of hyaluronan (HA) synthesis in response to cytokines. After 50 passages of the cells derived from porcine vitreous tissue, a cell line was generated. The immortalized cells showed fibroblastic m...

journal_title：Experimental eye research

authors： Nishitsuka K,Kashiwagi Y,Tojo N,Kanno C,Takahashi Y,Yamamoto T,Heldin P,Yamashita H

更新日期：2007-10-01 00:00:00

abstract：:Macular corneal dystrophy (MCD) is an autosomal recessive disease characterized by abnormal deposition of glycosaminoglycans in corneal stroma, keratocytes, Descemet's membrane and corneal endothelium. According to the presence and distribution of sulfated keratan sulfate (KS)-epitopes in serum and cornea (using mAb 5...

journal_title：Experimental eye research

authors： Cursiefen C,Hofmann-Rummelt C,Schlötzer-Schrehardt U,Fischer DC,Haubeck HD,Küchle M,Naumann GO

更新日期：2001-11-01 00:00:00

abstract：:Transforming growth factor β (TGFβ) signaling is one of the most important signaling pathways regulating cell behavior in ocular tissues. Its functions are mainly linked to tissue fibrosis and inflammatory responses in ophthalmology. In epithelial cells, however, the growth inhibitory activity of TGFβ was reported in ...

journal_title：Experimental eye research

authors： Hu L,Pu Q,Zhang Y,Ma Q,Li G,Li X

更新日期：2019-05-01 00:00:00

abstract：:The development of a synthetic material allowing increased cellular adhesion and ingrowth would improve keratoprosthetic devices and requires an understanding of cell colonization processes. Interlamellar implantation of hydrophobic synthetic material may lead to poor corneal nutrition with subsequent necrosis. The pr...

journal_title：Experimental eye research

authors： Legeais JM,Renard G,Parel JM,Serdarevic O,Mei-Mui M,Pouliquen Y

更新日期：1994-01-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is the major cause of blindness for people over 60. In the "wet" form of AMD compounds targeting growth factor signaling pathways such as VEGF have been a major focus for therapeutic interventions. In a previously developed rat model of CNV, we utilized two receptor tyrosine kina...

journal_title：Experimental eye research

authors： Wang FE,Shi G,Niesman MR,Rewolinski DA,Miller SS

更新日期：2007-05-01 00:00:00

abstract：:Congenic hereditary cataract mice, BALB/c-nct/nct, were established by introducing the nct gene from Nakano into BALB/c mice. These mice developed a milder cortical form of cataract which developed sporadically and later in life than in Nakano mice. Combined use of BALB/c and BALB/c-nct/nct mice enables biochemical co...

journal_title：Experimental eye research

authors： Wada E,Koyama-Ito H,Matsuzawa A

更新日期：1991-05-01 00:00:00

abstract：:Peroxisomes were localized in the head of wild-type and mutant strains of Drosophila melanogaster by use of a cytochemical method for the demonstration of D-amino acid oxidase activity. With similar techniques we had found previously that vertebrate photoreceptors have few, if any, bodies with cytochemically demonstra...

journal_title：Experimental eye research

authors： St Jules R,Setlik W,Kennard J,Holtzman E

更新日期：1990-11-01 00:00:00

abstract：:Identification of novel agents to eradicate the residual lens cell population following cataract surgery provides one mode of preventing PCO formation. The present study investigated the biological mechanism of As(2)O(3) cytotoxicity in a human lens cell line and capsular bag system. FHL 124 cell survival was assessed...

journal_title：Experimental eye research

authors： Zhang H,Duncan G,Wang L,Liu P,Cui H,Reddan JR,Yang BF,Wormstone IM

更新日期：2007-12-01 00:00:00

abstract：:A number of deep-sea fish have bright yellow lenses whose coloration is attributable to a variety of largely unidentified short-wave absorbing pigments. Here the pigment of the deep-sea fish Stylephorus chordatus has been isolated and identified by NMR and mass spectroscopy as kynurenine; a pigment also found in the h...

journal_title：Experimental eye research

authors： Thorpe A,Truscott RJ,Douglas RH

更新日期：1992-07-01 00:00:00

abstract：:Oxyradicals probably play a major role in a number of specific pathological conditions of intraocular tissues, such as cataract formation and retinal degeneration. This paper reviews some of the mechanistic concepts relating to tissue damage by highly reactive oxidants derived from endogenous precursors, hydrogen pero...

journal_title：Experimental eye research

authors： Mittag T

更新日期：1984-12-01 00:00:00

abstract：:Protein myristoylation occurs when the 14 carbon fatty acid, myristic acid, is covalently attached by amide linkage to a protein's N -terminal glycine by an N -terminal myristoyltransferase (NMT). A variation of this called heterogeneous acylation occurs in vivo only in retina when specific proteins are modified by my...

journal_title：Experimental eye research

authors： Rundle DR,Rajala RV,Anderson RE

更新日期：2002-07-01 00:00:00

abstract：:Racemisation of amino acids is one of the most abundant modifications in long-lived proteins. In this study racemisation of Asp 58 in the small heat shock protein, αA crystallin, was investigated. In normal human lenses, levels of l-isoAsp, d-isoAsp and d-Asp increased with age, such that by age 70 they accounted for ...

journal_title：Experimental eye research

authors： Hooi MY,Raftery MJ,Truscott RJ

更新日期：2013-01-01 00:00:00

abstract：:Innervated myotendinous cylinders (IMCs) in rabbit extraocular muscles (EOMs) were identified for the first time. The nature of IMC nerve terminals was demonstrated by means of electron microscopy and double fluorescent staining. The distal EOM portions of four rabbits of different age and sex were prepared for transm...

journal_title：Experimental eye research

authors： Blumer R,Wasicky R,Hötzenecker W,Lukas JR

更新日期：2001-12-01 00:00:00

abstract：:The purpose of this study was to evaluate specific keratocyte phenotypes (keratocyte, fibroblast, myofibroblast) for cell contractility and ability to contract extracellular matrix. Rabbit keratocyte phenotype was modulated by exposure to optimal proliferative doses of IGF-I, IL-1alpha, FGF2, PDGF-AB, and TGFbeta(1). ...

journal_title：Experimental eye research

authors： Jester JV,Ho-Chang J

更新日期：2003-11-01 00:00:00

abstract：:The purpose of this study was to describe the distribution of Muller cell within the peripapillary retinal nerve fiber layer (RNFL) in human eyes. Eleven unpaired normal postmortem eyes were recruited into this study. Each eye was sectioned using the "umbrella technique" to obtain a concentric peripapillary ring cente...

journal_title：Experimental eye research

authors： Frenkel S,Goshen G,Leach L,Pe'er J,Mimouni M,Blumenthal EZ

更新日期：2018-01-01 00:00:00

abstract：:The purpose of this study was to investigate the effects of abnormal-cannabidiol (abn-cbd), a non-psychoactive cannabinoid agonist, on aqueous humor outflow via the trabecular meshwork (TM) of porcine eye, and to examine the involvement of a non-CB1/CB2 cannabinoid receptor and the p42/44 mitogen-activated protein kin...

journal_title：Experimental eye research

authors： Qiao Z,Kumar A,Kumar P,Song ZH

更新日期：2012-07-01 00:00:00

abstract：:Anthocyanins (ACs) are phenolic compounds that are distributed widely in fruits and vegetables. Although consumption of these compounds has been shown to improve visual function, the distribution of ACs in ocular tissue has not been examined in detail. The aim of this study was therefore to evaluate the ocular distrib...

journal_title：Experimental eye research

authors： Matsumoto H,Nakamura Y,Iida H,Ito K,Ohguro H

更新日期：2006-08-01 00:00:00

abstract：:A small percentage of retinal ganglion cells (RGCs) express melanopsin and are intrinsically photosensitive (ipRGCs). Whether light can affect the development of ipRGCs is not clear. In the rat retina, we found constant light exposure during the first postnatal week significantly increased the number of melanopsin imm...

journal_title：Experimental eye research

authors： Hong J,Zeng Q,Wang H,Kuo DS,Baldridge WH,Wang N

更新日期：2013-06-01 00:00:00

abstract：:The effect of acute exposure to various intensities of white light on visual behavior and retinal structure was evaluated in the T4R RHO dog, a naturally-occurring model of autosomal dominant retinitis pigmentosa due to a mutation in the Rhodopsin gene. A total of 14 dogs (ages: 4-5.5 months) were used in this study: ...

journal_title：Experimental eye research

authors： Iwabe S,Ying GS,Aguirre GD,Beltran WA

更新日期：2016-05-01 00:00:00

abstract：:When 15-day-old developing chick embryos were administered hydrocortisone hemisuccinate sodium (HC:0.25 mumol per egg) the concentration of glucose in both the aqueous humor and the vitreous body began to increase significantly after 3 hr and reached 24.4 +/- 0.3 mM and 22.3 +/- 0.9 mM, respectively, at 48 hr. Thereaf...

journal_title：Experimental eye research

authors： Nishigori H,Lee JW,Yamauchi Y,Iwatsuru M

更新日期：1989-10-01 00:00:00

abstract：:The function of acetylcholinesterase (AChE) is to terminate the action of acetylcholine at the cholinergic synapse. Recent evidence suggests additional roles for acetylcholinesterase as a peptidase and/or a protease which is expressed by growing neurites as part of their invasion of developing neural structures. We re...

journal_title：Experimental eye research

authors： Hutchins JB,Bernanke JM,Jefferson VE

更新日期：1995-02-01 00:00:00

abstract：:Interphotoreceptor retinoid-binding protein (IRBP) is a vitamin A carrier present only in the extracellular material lying between the neural retina and the retinal pigment epithelium of vertebrate eyes. The amount of retinol bound endogenously by IRBP in this interphotoreceptor space is known to increase upon illumin...

journal_title：Experimental eye research

authors： Adler AJ,Spencer SA

更新日期：1991-09-01 00:00:00

abstract：:Age-related Macular Degeneration (AMD) is the leading cause of visual impairment and blindness in the elderly in developed countries. Neovascular/exudative (wet) AMD is the aggressive form of AMD and can involve choroidal neovascularization and vascular leakage. Anti-vascular endothelial growth factor (anti-VEGF) medi...

journal_title：Experimental eye research

authors： Giddabasappa A,Lalwani K,Norberg R,Gukasyan HJ,Paterson D,Schachar RA,Rittenhouse K,Klamerus K,Mosyak L,Eswaraka J

更新日期：2016-04-01 00:00:00

abstract：:The objective of this study was to determine the cellular localization of P2Y(2) receptor gene expression in rabbit and primate ocular tissues using the technique of non-isotopic in situ hybridization. Fresh frozen whole eye from a New Zealand White rabbit and whole eye and eyelid from a rhesus macaque were cut into 5...

journal_title：Experimental eye research

authors： Cowlen MS,Zhang VZ,Warnock L,Moyer CF,Peterson WM,Yerxa BR

更新日期：2003-07-01 00:00:00

abstract：:Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has also been proposed as an iron-transporter protein, th...

journal_title：Experimental eye research

authors： Valença A,Mendes-Jorge L,Bonet A,Catita J,Ramos D,Jose-Cunilleras E,Garcia M,Carretero A,Nacher V,Navarro M,Ruberte J

更新日期：2021-01-01 00:00:00

abstract：:Jin H. Kinoshita has had a major role in fostering investigations on the molecular biology of the eye during his tenure as Scientific Director of the National Eye Institute (N.E.I.). His appreciation and support of molecular biology have been the basis for many advances in this area in the N.E.I. and have led to a fer...

journal_title：Experimental eye research

authors： Piatigorsky J

更新日期：1990-06-01 00:00:00

abstract：:A technology has recently been developed that allows for the rapid transduction of full-length functionally active proteins into intact tissue through intravenous injection and into cultured cells. This technology involves the fusion of an 11 amino acid sequence of the HIV TAT protein to the protein of interest. In th...

journal_title：Experimental eye research

authors： Guo X,Hutcheon AE,Zieske JD

更新日期：2004-05-01 00:00:00