Abstract：
:We have examined the mercapturic acid pathway of the cataractous rabbit lens following induction by naphthalene as an oxidative foreign substance. 1,2-Naphthoquinone, which is formed in the eye from naphthalene diol and other naphthalene derivatives by a combination of enzymic and non-enzymic reactions, readily oxidizes GSH and GSH S-transferase [EC 2.5.1.18] in the lens scavenging system. 1,2-Naphthoquinone appeared in the rabbit aqueous humor after 8 h, and showed a maximum level in the lens 24 h after naphthalene administration, with marked accumulation in the lens nucleus. At the same time, the GSH level and GSH S-transferase activity in the lens decreased after 4 h, and lens opacification appeared 7 days after naphthalene administration. Furthermore, we identified the naphthalene metabolite, N-acetyl-S-(1,2-dihydro-2-hydroxynaphthyl) cysteine, in the lens of rabbit after naphthalene administration and in an in vitro experiment on lens homogenate using gas chromatography-mass spectrometry (GC-MS). This compound is an intermediate of the mercapturic acid pathway, and indicates that naphthalene derivatives are metabolized through the mercapturic acid pathway which acts as a scavenging system in the lens.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Iwata S,Maesato Tdoi
10.1016/0014-4835(88)90058-9subject
Has Abstractpub_date
1988-09-01 00:00:00pages
479-88issue
3eissn
0014-4835issn
1096-0007journal_volume
47pub_type
杂志文章abstract：:N-methyl-D-aspartate (NMDA)-induced excitotoxicity is an acute form of experimental retinal injury as a result of overactivation of glutamate receptors. NLRP3 (nucleotide-binding domain, leucine-rich-repeat containing family, pyrin domain containing-3) inflammasome, one of the most studied sensors of innate immunity, ...
journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2009.09.017
更新日期：2010-01-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1006/exer.1998.0650
更新日期：1999-06-01 00:00:00
abstract：:Neovascular age-related macular degeneration (AMD) is a leading cause of vision loss worldwide. Although intravitreal injection of anti-VEGF antibodies and VEGF Trap have significant clinical benefits, the complications of intravitreal injection, drug resistance and patient compliance still need to be concerned. In th...
journal_title：Experimental eye research
pub_type： 杂志文章
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更新日期：2018-03-01 00:00:00
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1006/exer.1996.0194
更新日期：1997-02-01 00:00:00
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journal_title：Experimental eye research
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journal_title：Experimental eye research
pub_type： 杂志文章
doi：10.1016/j.exer.2005.01.015
更新日期：2005-07-01 00:00:00
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journal_title：Experimental eye research
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doi：10.1016/j.exer.2006.05.005
更新日期：2006-10-01 00:00:00
