Retinal remodeling during retinal degeneration.

abstract：:The pink-eyed dilution (p) locus is known to control the quantity of melanin pigment made within melanocytes and retinal pigment epithelium (RPE) in the eye. We have examined the effects of several mutant allele combinations at the murine p locus on the number and morphology of melanosomes in choroidal melanocytes and...

journal_title：Experimental eye research

authors： Orlow SJ,Brilliant MH

更新日期：1999-02-01 00:00:00

abstract：:The purpose of this study was to quantify how the elastic modulus of the ex vivo iris changes following stimulation by pilocarpine (PILO), phenylephrine (PE), and tropicamide (TROP). Irides (n = 20) were dissected from porcine eyes within 4 h post-mortem and tested uniaxially. Either the entire iris or sector thereof ...

journal_title：Experimental eye research

authors： Whitcomb JE,Barnett VA,Olsen TW,Barocas VH

更新日期：2009-10-01 00:00:00

abstract：:The purpose of this study was to determine the aqueous levels and pharmacokinetics of topical fluconazole 0.2% upon single and multiple drop applications. Forty-nine patients undergoing cataract surgery were given topical fluconazole 0.2%. They either received single drop or a loading dose of 1 drop per 5 min for 20 m...

journal_title：Experimental eye research

authors： Abbasoğlu OE,Hoşal BM,Sener B,Erdemoğlu N,Gürsel E

更新日期：2001-02-01 00:00:00

abstract：:The wound-healing response is critical to the outcome of refractive surgery and studying wound healing contributes to an understanding of the pathophysiology of other corneal injuries. Animal models allow research to be conducted with sufficient samples and under controlled parameters. We studied the hen to determine ...

journal_title：Experimental eye research

authors： Martínez-García MC,Merayo-Llovés J,Blanco-Mezquita T,Mar-Sardaña S

更新日期：2006-10-01 00:00:00

abstract：:The calcium-binding regulatory protein, calmodulin, was immunohistologically examined in feline rod outer segments. The peroxidase antiperoxidase technique was used for the immunohistological analysis and protein A-gold, to localize calmodulin electron-microscopically. Calmodulin was found to be located in the distal ...

journal_title：Experimental eye research

authors： Wakakura M,Yamamoto N

更新日期：1987-03-01 00:00:00

abstract：:Over the past 40 years, several groups have shown that epithelial debridement results in the death of keratocytes subjacent to the wound area. More recently this cell death has been shown to involve apoptosis. The purpose of this project was to examine the proliferative response of the normally quiescent keratocytes t...

journal_title：Experimental eye research

authors： Zieske JD,Guimarães SR,Hutcheon AE

更新日期：2001-01-01 00:00:00

abstract：:The Purkinje cell degeneration (pcd) mutant mouse rapidly loses cerebellar Purkinje cells and about 50% of its retinal photoreceptor cells at between 3 and 5 weeks of age, and thereafter slowly loses the remaining photoreceptor cells during the first year of life. An ultrastructural study of the developing photorecept...

journal_title：Experimental eye research

authors： Blanks JC,Spee C

更新日期：1992-05-01 00:00:00

abstract：:A serum-free culture of chicken retinal pigmented epithelial cells has been established in order to analyse how cell-substrate interactions or environmental factors affect the process of transdifferentiation into lens cells from pigmented epithelial cells. The serum-free culture medium for chicken pigmented epithelial...

journal_title：Experimental eye research

authors： Kosaka J,Watanabe K,Eguchi G

更新日期：1992-08-01 00:00:00

abstract：:This study tests the hypothesis that choroidal myogenic autoregulation participates in the intraocular pressure (IOP) response to mean arterial pressure (MAP) by minimizing arterial-pressure-dependent changes in choroidal blood volume. To test this hypothesis, the IOP response to MAP was quantified before and after im...

journal_title：Experimental eye research

authors： Kiel JW

更新日期：1994-05-01 00:00:00

abstract：:Anatomic and physiological barriers limit drug delivery to the posterior segment of the eye via topical or systemic administration. Intravitreal administration has proven to be a safe and effective means of treating various posterior segment diseases. Elimination of a compound from the vitreous chamber may depend on l...

journal_title：Experimental eye research

authors： Atluri H,Mitra AK

更新日期：2003-03-01 00:00:00

abstract：:Diabetic retinopathy is a sight-threatening complication of diabetes, characterized by loss of retinal pericytes and abnormal angiogenesis. We previously demonstrated that extracellular vesicles (EVs) derived from mesenchymal stem cells cultured in diabetic-like conditions are able to enter the pericytes, causing thei...

journal_title：Experimental eye research

authors： Mazzeo A,Beltramo E,Lopatina T,Gai C,Trento M,Porta M

更新日期：2018-11-01 00:00:00

abstract：:Previous studies have shown that corneal endothelial cells contain mRNA and protein of various growth factors. However, the role of these endogenous growth factors in corneal endothelial wound healing is not fully elucidated. In the present study, we investigated the role of endogenous factors and several growth facto...

journal_title：Experimental eye research

authors： Schilling-Schön A,Pleyer U,Hartmann C,Rieck PW

更新日期：2000-12-01 00:00:00

abstract：:Our previous gene expression analysis suggested that conjunctival epithelial cells of Sjögren's syndrome (SS) are inclined to hyper-proliferation and keratinisation status. The goal of this study is to elucidate whether such pathological situations really exist in the conjunctival epithelium of SS. Also, involvement o...

journal_title：Experimental eye research

authors： Hirai N,Kawasaki S,Tanioka H,Connon CJ,Yamasaki K,Yokoi N,Komuro A,Kinoshita S

更新日期：2006-03-01 00:00:00

abstract：:A proteinase from human lens membrane was purified by a procedure previously developed for a similar proteinase from bovine lenses (Srivastava, 1988a). The purification of the human proteinase was achieved by solubilization of the enzyme from membranes with 2% sodium deoxycholate followed by two consecutive passages t...

journal_title：Experimental eye research

authors： Srivastava OP,Srivastava K

更新日期：1989-02-01 00:00:00

abstract：:We have previously shown that corticotropin-releasing hormone plays an important proinflammatory role in the induction of experimental autoimmune uveoretinitis. In this study, we examined the role of apoptosis in the destruction of the retina during experimental autoimmune uveoretinitis, and the role of corticotropin-...

journal_title：Experimental eye research

authors： Poulaki V,Mitsiades N,Mastorakos G,Caspi RR,Chrousos GP,Bouzas E

更新日期：2001-06-01 00:00:00

abstract：:Retinal pigment epithelial cell dysfunction mediated by reactive oxygen intermediates has been suggested as a possible cause of age-related macular degeneration. To test the hypothesis that retinal pigment cells are susceptible to genetic damage mediated by reactive oxygen intermediates, retinal pigment epithelial cel...

journal_title：Experimental eye research

authors： Ballinger SW,Van Houten B,Jin GF,Conklin CA,Godley BF

更新日期：1999-06-01 00:00:00

abstract：:Hypoxic preconditioning protects photoreceptors against light-induced degeneration preserving retinal morphology and function. Although hypoxia inducible transcription factors 1 and 2 (HIF1, HIF2) are the main regulators of the hypoxic response, photoreceptor protection does not depend on HIF1 in rods. Here we used ro...

journal_title：Experimental eye research

authors： Kast B,Schori C,Grimm C

更新日期：2016-05-01 00:00:00

abstract：:Primary cultures of chick lens annular pad (CLAP) cells were exposed to beta-adrenergic drugs and lipid soluble cAMP analogues. In dose-dependent manners, these agents inhibited re-entry into the cell cycle when these normally post-mitotic cells were cultured in the presence of serum. The inhibition of cell division w...

journal_title：Experimental eye research

authors： Ireland ME,Tran K,Mrock L

更新日期：1993-09-01 00:00:00

abstract：:Sex steroids impact regulation of the ocular surface tissues and thus influence dry eye. Most tissues in the human body synthesise and metabolise active sex steroids at levels required by the tissue. This is likely to also be the case for humans in ocular surface tissues. This study investigated the presence and quant...

journal_title：Experimental eye research

authors： Gibson EJ,Bucknall MP,Golebiowski B,Stapleton F

更新日期：2019-02-01 00:00:00

abstract：:Fungal keratitis is a common disease that causes blindness. An effective animal model for fungal keratitis is essential for advancing research on this disease. Our objective is to develop a novel mouse model of Fusarium solani keratitis through the inoculation of fluorescent-labeled fungi into the cornea to facilitate...

journal_title：Experimental eye research

authors： Zhang H,Wang L,Li Z,Liu S,Xie Y,He S,Deng X,Yang B,Liu H,Chen G,Zhao H,Zhang J

更新日期：2013-05-01 00:00:00

abstract：:In order to develop effective optical treatment strategies for myopia, it is important to understand how visual experience influences refractive development. Beginning with the discovery of the phenomenon of form deprivation myopia, research involving many animal species has demonstrated that refractive development is...

journal_title：Experimental eye research

authors： Smith EL 3rd

更新日期：2013-09-01 00:00:00

abstract：:The zebrafish retina regenerates in response to acute retinal lesions, replacing damaged neurons with new neurons. In this study we test the hypothesis that chronic stress to inner retinal neurons also triggers a retinal regeneration response in the bugeye zebrafish. Mutations in the lrp2 gene in zebrafish are associa...

journal_title：Experimental eye research

authors： Sherpa T,Hunter SS,Frey RA,Robison BD,Stenkamp DL

更新日期：2011-10-01 00:00:00

abstract：:We have compared IOP elevations induced by water-loading and by increased cephalic venous pressure in normal and denervated pigmented rabbits. Denervations were performed by sympathetic ganglionectomy and/or blockade of the sensory and autonomic innervation of the eye through retrobulbar anesthesia; retrobulbar anesth...

journal_title：Experimental eye research

authors： Gual A,Mintenig GM,Belmonte C

更新日期：1989-03-01 00:00:00

abstract：:In response to injury, the adult mammalian retina shows signs of structural remodeling, possibly in an attempt to preserve or regain some of its functional neural connections. In order to study the mechanisms involved in injury-induced plasticity, we have studied changes in growth associated protein 43 (GAP-43) after ...

journal_title：Experimental eye research

authors： Dijk F,Bergen AA,Kamphuis W

更新日期：2007-05-01 00:00:00

abstract：:Immunofluorescent imaging is an indispensable technique to study morphology and molecular aspects in tissues. Classical approaches make it necessary to cut physical sections of tissue samples to overcome the limited penetration depth of light, restricting the available information to two dimensions. Recent advances in...

journal_title：Experimental eye research

authors： Henning Y,Osadnik C,Malkemper EP

更新日期：2019-03-01 00:00:00

abstract：:The effect of kainic acid (KA) on rat retinal morphology was investigated with emphasis on the ganglion cell layer. Two hours after intraocular injection of KA, 70% of the neurones in the ganglion cell layer display morphological alterations. These alterations at the ultrastructural level include the absence of identi...

journal_title：Experimental eye research

authors： Gómez-Ramos P,Pérez-Rico C

更新日期：1983-02-01 00:00:00

abstract：:The heparan sulfate (HS) is a component of proteoglycans in the extracellular matrix and on cell surfaces, modulating developmental processes. The aim of this study is to investigate whether the defect of HS in the periocular mesenchyme impairs ocular morphogenesis. First, using Protein 0-Cre transgenic mice, we ablat...

journal_title：Experimental eye research

authors： Iwao K,Inatani M,Ogata-Iwao M,Yamaguchi Y,Okinami S,Tanihara H

更新日期：2010-01-01 00:00:00

abstract：:Liquid protein diets have been widely used in the United States to control weight gain. Pregnant rats were fed a standard casein diet in which liquid protein was substituted for the protein portion; all other necessary nutrients were supplied. The average incidence of cataracts in the offspring from mothers fed liquid...

journal_title：Experimental eye research

authors： Wagner N,Kanai A,Harrington JS,Kaufman HE,Nakamoto T

更新日期：1983-08-01 00:00:00

abstract：:The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microa...

journal_title：Experimental eye research

authors： Stowell C,Burgoyne CF,Tamm ER,Ethier CR,Lasker\/IRRF Initiative on Astrocytes and Glaucomatous Neurodegeneration Participants.

更新日期：2017-04-01 00:00:00

abstract：:Specific [3H]-dexamethasone binding sites were demonstrated in bovine corneal cytosol using titration analyses. Specific glucocorticoid binding to corneal cytosol exhibited a single class of sites with apparent dissociation constants of 4-6 nM and 68-72 fmol binding sites mg-1 cytosolic protein. Association of steroid...

journal_title：Experimental eye research

authors： Lin MT,Eiferman RA,Wittliff JL

更新日期：1984-04-01 00:00:00