Abstract:
:Myopia is one of the leading ocular disorders causing visual impairment worldwide, with the prevalence increasing rapidly. It's a significant global public health concern in 21st century. Myopia, particularly high myopia, often exhibits apparent familial aggregation, and multiple evidences have shown that genetic factors significantly contribute to its pathogenesis. Recent molecular technologies such as linkage analysis, candidate gene authentication, genome-wide association study (GWAS), and next-generation sequencing (NGS) have identified many myopia-associated loci and genetic mutations or variants. There exist ethnic variations in myopia occurrence as observed in populations of different genetic backgrounds, and different genetic components are found to be associated with the development of myopia-related phenotypes. A better understanding of the genetic basis triggering and controlling myopic changes may further help in myopia prevention. This review is to provide an updated overview of genetic findings in non-syndromic myopia.
journal_name
Exp Eye Resjournal_title
Experimental eye researchauthors
Cai XB,Shen SR,Chen DF,Zhang Q,Jin ZBdoi
10.1016/j.exer.2019.107778subject
Has Abstractpub_date
2019-11-01 00:00:00pages
107778eissn
0014-4835issn
1096-0007pii
S0014-4835(19)30313-6journal_volume
188pub_type
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