Galardin inhibits collagen degradation by rabbit keratocytes by inhibiting the activation of pro-matrix metalloproteinases.

abstract：:An enzymatic procedure for the estimation of organic hydroperoxides has been adapted to biological tissues and applied to the measurement of hydroperoxides in the rat retina. Hydroperoxides are determined from the coupled activities of glutathione peroxidase and glutathione reductase as measured by the loss of NADPH a...

journal_title：Experimental eye research

authors： Organisciak DT,Favreau P,Wang HM

更新日期：1983-03-01 00:00:00

abstract：:This study describes the phosphatic metabolite contribution of the porcine corneal stroma [by phosphorus-31 nuclear magnetic resonance (P-31 NMR)] and the corneal epithelium (by difference calculation) to the total phosphatic metabolic profile of the intact (i.e. whole, undissected) cornea. In order to provide such a ...

journal_title：Experimental eye research

authors： Greiner JV,Braude LS,Glonek T

更新日期：1985-03-01 00:00:00

abstract：:Crystallin-bound non-tryptophan fluorescence and protein cross-linking were studied in chronic galactosemia. Fluorescence (excitation/emission--370/440 nm) was significantly higher in galactosemic rats compared to controls (P less than 0.001). Accumulation of fluorescence was significantly reduced both in water solubl...

journal_title：Experimental eye research

authors： Nagaraj RH,Monnier VM

更新日期：1990-10-01 00:00:00

abstract：:The extracellular matrix (ECM) plays a significant role in cellular and retinal health. The study of retinal tyrosine-sulfated proteins is an important first step toward understanding the role of ECM in retinal health and diseases. These secreted proteins are members of the retinal ECM. Tyrosine sulfation was shown to...

journal_title：Experimental eye research

authors： Kanan Y,Al-Ubaidi MR

更新日期：2015-04-01 00:00:00

abstract：:Purified retinal pigment epithelial cells of bovine eyes have been fractionated by a series of buffer and detergent extractions. The electropherogram of the buffer-insoluble, Triton X-100-soluble fraction (RPE-TS) exhibits a major polypeptide band of M(r) 65 kDa and a variety of minor components. Electrophoretically p...

journal_title：Experimental eye research

authors： Broekhuyse RM,Kuhlmann ED,Winkens HJ

更新日期：1992-12-01 00:00:00

abstract：:Previous studies have shown that the inhibition of Rho kinase is involved in the regulation of outflow facility in the live rabbit eye and the enucleated porcine eye. However, it is unknown whether the Rho kinase inhibition will do the same in non-human primates. To determine if the Rho kinase inhibitor Y-27632 will r...

journal_title：Experimental eye research

authors： Tian B,Kaufman PL

更新日期：2005-02-01 00:00:00

abstract：:Eosinophil infiltration is one of the aspects of the inflammatory response to an allergen. The aim of this study was to establish T-helper type-2 (Th2)-induced conjunctival eosinophilia in mice to evaluate the effect of anti-allergic drugs. Th2 clone, D10.G4.1. (D10) with its specific antigen, conalbumin was co-inject...

journal_title：Experimental eye research

authors： Hamada M,Sawa K,Nakata K

更新日期：1999-07-01 00:00:00

abstract：:Increasing evidence points to inflammation as a key factor in the pathogenesis of diabetic retinopathy (DR). Choroidal inflammatory changes in diabetes have been reported and in vivo choroidal thickness (CT) has been searched as a marker of retinopathy with contradictory results. We aimed to investigate the early stag...

journal_title：Experimental eye research

authors： Campos A,Campos EJ,Martins J,Rodrigues FSC,Silva R,Ambrósio AF

更新日期：2020-10-01 00:00:00

abstract：:The Publisher regrets that this article is an accidental duplication of an article that has already been published, doi:10.1016/j.exer.2010.03.008. The duplicate article has therefore been withdrawn. ...

journal_title：Experimental eye research

authors： Osborne NN

更新日期：2011-07-29 00:00:00

abstract：:Maintenance of cellular calcium levels is critical to cell function. Loss of calcium homeostasis might be a contributing factor to the development of cataract in the lens. In lens epithelium, calcium is involved in cell signaling and its precise regulation is vital. In this study, we investigated the regulation of sar...

journal_title：Experimental eye research

authors： Liu L,Paterson CA,Borchman D

更新日期：2002-11-01 00:00:00

abstract：:Selective pericyte loss, the histological hallmark of early diabetic retinopathy (DR), enhances the breakdown of the blood-retinal barrier (BRB) in diabetes. However, the role of pericytes on BRB alteration in diabetes and the signaling pathways involved in their effects are currently unknown. To understand the role o...

journal_title：Experimental eye research

authors： Rangasamy S,Monickaraj F,Legendre C,Cabrera AP,Llaci L,Bilagody C,McGuire P,Das A

更新日期：2020-06-01 00:00:00

abstract：:Tissue from the outflow system of six surgically enucleated aged eyes was used for an ultrastructural immunocytochemical study of the distribution of laminin and type IV collagen. The immunogold technique provided precise localization of laminin beneath lining endothelial cells of the inner wall of Schlemm's canal. La...

journal_title：Experimental eye research

authors： Marshall GE,Konstas AG,Lee WR

更新日期：1990-12-01 00:00:00

abstract：:Both in vivo and in vitro models were employed in the present study to assess the relative contribution of osmotic stress and increasing calcium levels to the development of sugar cataracts. In galactose cataract obtained from galactosemic weanling rats, the concentration of total calcium increased by nearly 10% at th...

journal_title：Experimental eye research

authors： Hightower KR,Misiak P

更新日期：1998-06-01 00:00:00

abstract：:Adenosine, produced from the decomposition of adenosine triphosphate, is believed to provide protective effects during ischemia. On the other hand, adenosine metabolites may serve as precursors for oxygen free radical formation. The time course of formation of adenosine and its purine metabolites was studied during re...

journal_title：Experimental eye research

authors： Roth S,Rosenbaum PS,Osinski J,Park SS,Toledano AY,Li B,Moshfeghi AA

更新日期：1997-12-01 00:00:00

abstract：:The wound-healing response is critical to the outcome of refractive surgery and studying wound healing contributes to an understanding of the pathophysiology of other corneal injuries. Animal models allow research to be conducted with sufficient samples and under controlled parameters. We studied the hen to determine ...

journal_title：Experimental eye research

authors： Martínez-García MC,Merayo-Llovés J,Blanco-Mezquita T,Mar-Sardaña S

更新日期：2006-10-01 00:00:00

abstract：:Myofibroblast development and haze generation in the corneal stroma is mediated by cytokines, including transforming growth factor-beta (TGF-beta), and possibly other cytokines. This study examined the effects of stromal PDGF-beta blockade on the development of myofibroblasts in response to -9.0 diopter photorefractiv...

journal_title：Experimental eye research

authors： Kaur H,Chaurasia SS,de Medeiros FW,Agrawal V,Salomao MQ,Singh N,Ambati BK,Wilson SE

更新日期：2009-05-01 00:00:00

abstract：:Argon laser energy was applied to the trabecular meshwork of pigmented rabbits in an attempt to develop an animal model of 'glaucoma'. Laser energy was varied to determine the optimal level needed to produce sustained ocular hypertension. An initial response of ocular hypertension followed by hypotension was observed ...

journal_title：Experimental eye research

authors： Gherezghiher T,March WF,Nordquist RE,Koss MC

更新日期：1986-12-01 00:00:00

abstract：:The genetically encoded green fluorescent protein-based calcium sensor, GCaMP, has been used to detect calcium transients and report neuronal activity. We evaluated the specificity of GCaMP3 expression to retinal ganglion cells (RGCs) of the transgenic Thy1-GCaMP3 mouse line in healthy control animals and in those aft...

journal_title：Experimental eye research

authors： Yabana T,Hooper ML,Farrell SR,Chauhan BC

更新日期：2021-01-01 00:00:00

abstract：:In this study, we examined calcium-mediated degradation of a neurofilament protein (NFP), and autolytic activation of calpain in Lewis rat optic nerve in vitro. After incubation with calcium, homogenized optic nerve samples were analysed by SDS-PAGE in association with ECL immunoblot techniques. 68 kD NFP, calpain, an...

journal_title：Experimental eye research

authors： Shields DC,Leblanc C,Banik NL

更新日期：1997-07-01 00:00:00

abstract：:Anti-Vascular Endothelial Growth Factors (Anti-VEGF) agents have received recent interest as potential anti-fibrotic agents for their concurrent use with trabeculectomy. Preliminary cohort studies have revealed improved bleb morphology following trabeculectomy augmented with ranibizumab. The effects of this humanized ...

journal_title：Experimental eye research

authors： Md Noh SM,Sheikh Abdul Kadir SH,Bannur ZM,Froemming GA,Abdul Hamid Hasani N,Mohd Nawawi H,Crowston JG,Vasudevan S

更新日期：2014-10-01 00:00:00

abstract：:Although primary cultures of human lens epithelial (HLE) cells provide important information concerning the role of epithelium in normal lens and cataract formation, the lack of a cell line precludes a broad range of studies on the metabolism and molecular biology of these cells. We have, therefore developed an HLE ce...

journal_title：Experimental eye research

authors： Ibaraki N,Chen SC,Lin LR,Okamoto H,Pipas JM,Reddy VN

更新日期：1998-11-01 00:00:00

abstract：:To trace the path taken by the putative postganglionic secretomotor fibres to the lacrimal gland the contents of the orbital and pterygopalatine fossa were removed whole, cut coronally into slabs and embedded in resin. Thin sections were cut at varying intervals to reconstruct the pathway taken. One group of rami orbi...

journal_title：Experimental eye research

authors： Ruskell GL

更新日期：2004-03-01 00:00:00

abstract：:Elevated permeability of retinal endothelial cells (REC), as observed in diabetic retinopathy (DR), is induced by extended exposure to ≥25 ng/ml vascular endothelial growth factor A165 (VEGF165) for up to 3 d and this effect is more pronounced when equimolar amounts of basic fibroblast growth factor (bFGF) and insulin...

journal_title：Experimental eye research

authors： Deissler HL,Deissler H,Lang GK,Lang GE

更新日期：2013-10-01 00:00:00

abstract：:Small heat shock proteins and alpha-crystallins are related proteins with several common structural and functional properties including homologous amino acid sequences and similar chaperone-like activity. Furthermore, small heat shock proteins and alpha-crystallins are phosphorylated in vivo at serine residues within ...

journal_title：Experimental eye research

authors： Chiesa R,Noguera I,Sredy J

更新日期：1997-08-01 00:00:00

abstract：:Traumatic optic neuropathy (TON) can occur following blunt trauma to the orbit and can lead to permanent vision loss. In this study, we investigated the effectiveness of elamipretide (MTP-131), a small mitochondrially-targeted tetrapeptide, in conjunction with etanercept, a tumor necrosis factor (TNF) inhibitor, as ne...

journal_title：Experimental eye research

authors： Tse BC,Dvoriantchikova G,Tao W,Gallo RA,Lee JY,Ivanov D,Tse DT,Pelaez D

更新日期：2020-10-01 00:00:00

abstract：:The carbohydrate epitope Gal alpha 1-3Gal-R (alpha-galactosyl epitope), which is detectable by its binding with Bandeiraea simplicifolia-IB4 lectin, was found in glycosphingolipids (GSLs), both neutral and acidic (gangliosides), from lens tissues of non-primate mammals, but not in those of human senile cataracts and O...

journal_title：Experimental eye research

authors： Ogiso M,Okinaga T,Komoto M,Nishiyama I,Hoshi M

更新日期：1994-12-01 00:00:00

abstract：:We previously demonstrated that there are two waves of increased collagen synthesis following corneal laceration in rabbits. In the present study, we have examined whether increases in collagen synthesis and degradation result from increased amounts of mRNAs for collagen and collagenase, respectively. Rabbits were ane...

journal_title：Experimental eye research

authors： Sakai J,Hung J,Zhu G,Katakami C,Boyce S,Kao WW

更新日期：1991-03-01 00:00:00

abstract：:It has been suggested that ambient lighting at night influences eye growth and might play a causal role in human myopia. To test this hypothesis, we reared newly hatched chicks under 12 hr light-dark or light-dim cycles with a light phase intensity of 1500 microW/cm(2) and variable dim phase intensities between 0.01 a...

journal_title：Experimental eye research

authors： Liu J,Pendrak K,Capehart C,Sugimoto R,Schmid GF,Stone RA

更新日期：2004-11-01 00:00:00

abstract：:Myofibroblasts expressing α-smooth muscle actin (α-SMA) are the key cellular mediator of fibrosis. Fibrovascular epiretinal membranes from patients with proliferative diabetic retinopathy (PDR) are characterized by the accumulation of a large number of myofibroblasts. We explored the hypothesis that proliferating endo...

journal_title：Experimental eye research

authors： Abu El-Asrar AM,De Hertogh G,van den Eynde K,Alam K,Van Raemdonck K,Opdenakker G,Van Damme J,Geboes K,Struyf S

更新日期：2015-03-01 00:00:00

abstract：:Exposure of the rabbit lens, in vitro, to 10(-3) M-hydrogen peroxide resulted in an increase of the lens sodium, calcium and water content together with a decrease of the lens potassium content. No such changes were observed in the presence of 10(-4) or 10(-5) M-hydrogen peroxide. 10(-3) M-hydrogen peroxide was observ...

journal_title：Experimental eye research

authors： Delamere NA,Paterson CA,Cotton TR

更新日期：1983-07-01 00:00:00