当前位置： SCI文献检索 > EARLY HUMAN DEVELOPMENT期刊下所有文献 > Neonatal neurological examination as a predictor of neuromotor outcome at 4 months in term low-Apgar-score babies in Zimbabwe.

Neonatal neurological examination as a predictor of neuromotor outcome at 4 months in term low-Apgar-score babies in Zimbabwe.

Abstract：

:The predictive value of the neonatal neurological examination (NNE) adapted from Prechtl, was investigated in 139 term Zimbabwean infants born with an Apgar score of five or less at 5 min. At 4 months, seven infants had died and 13 were lost to follow-up, leaving 119 infants to undergo the Infant Motor Screen (IMS). Eighty-eight infants were diagnosed as normal, six as suspect and 25 as abnormal at screening. The sensitivity, specificity, positive predictive value and negative predictive value of the NNE were 94%, 55%, 42% and 96%, respectively. Seventeen (14%) infants had developed microcephaly at 4 months and 13 (77%) of them scored abnormal on the IMS. Twenty-three of the 48 (48%) infants who had convulsions within 48 h of birth, were diagnosed as abnormal (P < 0.0001). The NNE proved to be very sensitive in detecting neurodevelopmental abnormalities in the neonatal period and the five abnormal syndromes derived from the NNE were able to correctly identify 94% of the abnormal infants. :The incidence of birth asphyxia in term infants in developed countries is 2.9-9.0/1000 live births, and significantly higher in developing countries. Birth asphyxia is responsible for an estimated 3-21% of cases of cerebral palsy in both developed and developing countries. In developed countries, it has been demonstrated that abnormal findings in neonatal neurodevelopmental abnormalities are able to predict developmental disabilities in asphyxiated term infants. Findings are presented from a study conducted in Bulawayo, Zimbabwe, to explore the relationships between the neonatal neurological examination (NNE) adapted from Prechtl and neurological outcome at 4 months in babies with birth asphyxia. The NNE's predictive value was investigated in 139 term Zimbabwean infants born with an Apgar score of 5 or less at 5 minutes. At 4 months, 7 infants had died and 13 were lost to follow-up, leaving 119 infants to undergo the Infant Motor Screen (IMS). 88 infants were diagnosed as normal, 6 as suspect, and 25 as abnormal at screening. The sensitivity, specificity, positive predictive value, and negative predictive value of the NNE were 94%, 55%, 42%, and 96%, respectively. 17 infants had developed microcephaly at 4 months and 13 scored abnormal on the IMS. 23 of the 48 infants who had convulsions within 48 hours of birth were diagnosed as abnormal. The NNE was therefore highly sensitive in detecting neurodevelopmental abnormalities during the neonatal period and the 5 abnormal syndromes derived from the NNE were able to correctly identify 94% of the abnormal infants.

journal_name

Early Hum Dev

journal_title

Early human development

authors

Wolf MJ,Beunen G,Casaer P,Wolf B

doi

10.1016/s0378-3782(97)00120-5

subject

Has Abstract

pub_date

1998-05-29 00:00:00

pages

179-86

issue

eissn

0378-3782

issn

1872-6232

pii

S0378-3782(97)00120-5

journal_volume

pub_type

杂志文章

在线工具

Neonatal neurological examination as a predictor of neuromotor outcome at 4 months in term low-Apgar-score babies in Zimbabwe.