CytA enables CryIV endotoxins of Bacillus thuringiensis to overcome high levels of CryIV resistance in the mosquito, Culex quinquefasciatus.

abstract：:Brief visual experience causes rapid physiological changes in the visual cortex during early postnatal development. A possible mediator of these effects is the immediate early genes whose protein products are involved in the rapid response of neurons to transsynaptic stimulation. Here we report evidence that the level...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosen KM,McCormack MA,Villa-Komaroff L,Mower GD

更新日期：1992-06-15 00:00:00

abstract：:To improve the efficacy of plasminogen activators, we produced a monoclonal antibody (RWR) that inhibits human alpha 2-antiplasmin (alpha 2AP). In addition to inhibiting alpha 2AP in plasma, RWR binds to and inhibits fibrin cross-linked alpha 2AP and reproduces the "spontaneous" clot lysis that is the hallmark of huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed GL 3rd,Matsueda GR,Haber E

更新日期：1990-02-01 00:00:00

abstract：:On the basis of earlier energy computations, the various single peptide units in proteins were designated as helix-making or helix-breaking.(1) With the use of these designations, empirical rules for distinguishing between alpha-helical and non-alpha-helical regions of proteins have been formulated. These rules includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kotelchuck D,Scheraga HA

更新日期：1969-01-01 00:00:00

abstract：:Beyond state-of-the-art lithium-ion battery (LIB) technology with metallic lithium anodes to replace conventional ion intercalation anode materials is highly desirable because of lithium's highest specific capacity (3,860 mA/g) and lowest negative electrochemical potential (∼3.040 V vs. the standard hydrogen electrode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu KK,Gong Y,Dai J,Gong A,Han X,Yao Y,Wang C,Wang Y,Chen Y,Yan C,Li Y,Wachsman ED,Hu L

更新日期：2016-06-28 00:00:00

abstract：:Antimicrobial peptides constitute an important component of the mammalian innate immune response. Several types of antimicrobial peptides, including the beta-defensins, are produced at epithelial surfaces in response to infectious threats. Here we show that a class of small molecules, including l-isoleucine and severa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fehlbaum P,Rao M,Zasloff M,Anderson GM

更新日期：2000-11-07 00:00:00

abstract：:Investigation of retinal neurochemistry in a well-defined chick model of form-deprivation myopia indicated that dopamine and its metabolite 3,4-dihydroxyphenylacetic acid are reduced in myopic as compared to control eyes. The reduction in retinal dopamine is evident only during light adaptation and is accompanied by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stone RA,Lin T,Laties AM,Iuvone PM

更新日期：1989-01-01 00:00:00

abstract：:alpha-Isopropylmalate synthase [3-hydroxy-4-methyl-3-carboxyvalerate 2-oxo-3-methylbutyrate-lyase (CoA-acetylating); EC 4.1.3.12], the enzyme catalyzing the first committed step in leucine biosynthesis, and homocitrate synthase [3-hydroxy-3-carboxyadipate 2-oxoglutarate-lyase (CoA-acetylating); EC 4.1.3.21], the first...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tracy JW,Kohlhaw GB

更新日期：1975-05-01 00:00:00

abstract：:Legionella pneumophila, the causal agent of Legionnaires' disease, is an intracellular parasite and invades and proliferates within different eukaryotic cells, including human alveolar macrophages. After several 100-fold multiplication within host cells, the pathogens are released for new invasion by induction of apop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belyi Y,Niggeweg R,Opitz B,Vogelsgesang M,Hippenstiel S,Wilm M,Aktories K

更新日期：2006-11-07 00:00:00

abstract：:Fluoride activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] is significantly enhanced (2 to 5 times) by a protein factor isolated from rat brain. The fluoride-dependent adenylate cyclase stimulator (FCS) is nondialyzable, trypsin-labile, and stable at 90 degrees C for 10 min. FCS stimula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasenick MM,Bitensky MW

更新日期：1980-08-01 00:00:00

abstract：:Mouse L929 cells were incubated with antibody-targeted liposomes containing oligodeoxyribonucleotides (oligomers). When the oligomer was a 15-mer complementary to the 5'-end region of the mRNA encoding the N protein of vesicular stomatitis virus, the cells became less permissive for multiplication of that virus; great...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonetti JP,Machy P,Degols G,Lebleu B,Leserman L

更新日期：1990-04-01 00:00:00

abstract：:We determined the complete nucleotide sequence of an infectious proviral molecular clone (FIV-14) of the feline immunodeficiency virus (FIV). FIV-14 has a genome organization similar in complexity to other lentiviruses. In addition to three large open reading frames representing the gag, pol, and env genes, at least f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olmsted RA,Hirsch VM,Purcell RH,Johnson PR

更新日期：1989-10-01 00:00:00

abstract：:Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients to multisystem prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray DT,Zhou X,Kato M,Xiang S,Tycko R,McKnight SL

更新日期：2018-10-16 00:00:00

abstract：:By using clones of murine T cells reactive with alloantigens as well as soluble antigens, it has been possible to demonstrate that Ia antigens, Ir gene phenomena (defined as the ability of immune T cells to recognize antigen), and mixed lymphocyte reaction (MLR)-stimulating determinants encoded within the I-A subregio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fathman CG,Kimoto M,Melvold R,David CS

更新日期：1981-03-01 00:00:00

abstract：:A mutation in RPB5 (rpb5-9), an essential RNA polymerase subunit assembled into RNA polymerases I, II, and III, revealed a role for this subunit in transcriptional activation. Activation by GAL4-VP16 was impaired upon in vitro transcription with mutant whole-cell extracts. In vivo experiments using inducible reporter ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyao T,Woychik NA

更新日期：1998-12-22 00:00:00

abstract：:The explosive growth in citizen science combined with a recalcitrance on the part of mainstream science to fully embrace this data collection technique demands a rigorous examination of the factors influencing data quality and project efficacy. Patterns of contributor effort and task performance have been well reviewe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parrish JK,Jones T,Burgess HK,He Y,Fortson L,Cavalier D

更新日期：2019-02-05 00:00:00

abstract：:Most human cancers are of monoclonal origin and display many genetic alterations. In an effort to determine whether clonal expansion itself could account for the large number of genetic alterations, we compared spontaneous transformation in cloned and uncloned populations of NIH 3T3 cells. We have reported that progre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chow M,Rubin H

更新日期：2000-01-04 00:00:00

abstract：:In the presence of the S polypeptide, maize chloroplast DNA-dependent RNA polymerase preferentially transcribes sequences within the 2200-nucleotide-pair-long maize chloroplast chromosome fragment Eco [unk] from a supercoiled chimeric plasmid cloned in Escherichia coli [Jolly, S. O. & Bogorad, L. (1980) Proc. Natl. Ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwarz Z,Jolly SO,Steinmetz AA,Bogorad L

更新日期：1981-06-01 00:00:00

abstract：:Because the insolubility of the scrapie prion protein (PrP(Sc)) has frustrated structural studies by x-ray crystallography or NMR spectroscopy, we used electron crystallography to characterize the structure of two infectious variants of the prion protein. Isomorphous two-dimensional crystals of the N-terminally trunca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wille H,Michelitsch MD,Guenebaut V,Supattapone S,Serban A,Cohen FE,Agard DA,Prusiner SB

更新日期：2002-03-19 00:00:00

abstract：:Pyramidal cells in piriform cortex receive excitatory inputs from two different sources that are segregated onto adjacent segments of their apical dendrites. The present studies show that excitatory postsynaptic potentials (EPSPs) evoked by primary olfactory tract afferents that terminate on distal apical segments dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bower JM,Haberly LB

更新日期：1986-02-01 00:00:00

abstract：:The lateral mobility of individual murine polyoma virus-like particles (VLPs) bound to live cells and artificial lipid bilayers was studied by single fluorescent particle tracking using total internal reflection fluorescence microscopy. The particle trajectories were analyzed in terms of diffusion rates and modes of m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ewers H,Smith AE,Sbalzarini IF,Lilie H,Koumoutsakos P,Helenius A

更新日期：2005-10-18 00:00:00

abstract：:Reactive oxygen species (ROS) mediate apoptosis in many different cell types. We have previously shown that the antioxidant Mn(III) tetrakis(5,10,15,20-benzoic acid)porphyrin (MnTBAP) decreased intracellular ROS and prevented the apoptosis of activated T cells in vitro. To determine the mechanism(s) by which MnTBAP af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hildeman DA,Mitchell T,Aronow B,Wojciechowski S,Kappler J,Marrack P

更新日期：2003-12-09 00:00:00

abstract：:A central question in protein-DNA recognition is the origin of the specificity that permits binding to the correct site in the presence of excess, nonspecific DNA. In the P22 Arc repressor, the Phe-10 side chain is part of the hydrophobic core of the free protein but rotates out to pack against the sugar-phosphate bac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schildbach JF,Karzai AW,Raumann BE,Sauer RT

更新日期：1999-02-02 00:00:00

abstract：:The apparent detection of an exoplanet orbiting Fomalhaut was announced in 2008. However, subsequent observations of Fomalhaut b raised questions about its status: Unlike other exoplanets, it is bright in the optical and nondetected in the infrared, and its orbit appears to cross the debris ring around the star withou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gáspár A,Rieke GH

更新日期：2020-05-05 00:00:00

abstract：:Although current theories of color vision differ in many respects, they all assume the existence of a uniquely defined neutral point in chromaticity space. It generally is assumed that this point satisfies several criteria simultaneously. One of these criteria is that it is perceived as achromatic. A further criterion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ekroll V,Faul F,Niederée R,Richter E

更新日期：2002-10-01 00:00:00

abstract：:The nuclear exosome-targeting (NEXT) complex functions as an RNA exosome cofactor and is involved in surveillance and turnover of aberrant transcripts and noncoding RNAs. NEXT is a ternary complex composed of the RNA-binding protein RBM7, the scaffold zinc-knuckle protein ZCCHC8, and the helicase MTR4. While RNA inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Puno MR,Lima CD

更新日期：2018-06-12 00:00:00

abstract：:We studied the coupled binding and folding of alpha-synuclein, an intrinsically disordered protein linked with Parkinson's disease. Using single-molecule fluorescence resonance energy transfer and correlation methods, we directly probed protein membrane association, structural distributions, and dynamics. Results reve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferreon AC,Gambin Y,Lemke EA,Deniz AA

更新日期：2009-04-07 00:00:00

abstract：:We have determined the localization and orientation of two genetic probes within the human major histocompatibility complex by chromosomal in situ hybridization. Our data indicate that a cloned genomic probe cross-hybridizing to HLA-A, -B, and -C heavy chain loci is homologous to sequences located on chromosome 6 at b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton CC,Kirsch IR,Nance WE,Evans GA,Korman AJ,Strominger JL

更新日期：1984-05-01 00:00:00

abstract：:Homopyrimidine oligonucleotides bind to the major groove of a complementary homopyrimidine.homopurine stretch by triple helix formation. The bla gene from transposon Tn3 contains a homopyrimidine.homopurine sequence of 13 base pairs located just downstream of the RNA polymerase binding site. A 13-mer homopyrimidine ol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duval-Valentin G,Thuong NT,Hélène C

更新日期：1992-01-15 00:00:00

abstract：:Perception and cognition in infants have been traditionally investigated using habituation paradigms, assuming that babies' memories in laboratory contexts are best constructed after numerous repetitions of the very same stimulus in the absence of interference. A crucial, yet open, question regards how babies deal wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benavides-Varela S,Siugzdaite R,Gómez DM,Macagno F,Cattarossi L,Mehler J

更新日期：2017-07-18 00:00:00

abstract：:Lymphocyte homeostasis is the result of a critical balance between cell proliferation and death. Disruption of this subtle equilibrium can lead to the onset of leukemia, an increase in the number of lymphocytes being potentially due to both of these parameters. The relative importance of cell proliferation vs. apoptos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debacq C,Asquith B,Kerkhofs P,Portetelle D,Burny A,Kettmann R,Willems L

更新日期：2002-07-23 00:00:00