Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A.

abstract：:Three lines of evidence indicate that RNA-dependent RNA synthesis occurs in mouse erythroleukemia cells. The first involves labeling studies with [3H]uridine and shows a greater initial labeling rate of globin RNA in the cytoplasm than in the nucleus. Labeled globin RNA found in the cytoplasm after a very short pulse ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volloch V

更新日期：1986-03-01 00:00:00

abstract：:Members of the order Nidovirales express their structural protein ORFs from a nested set of 3' subgenomic mRNAs (sg mRNAs), and for most of these ORFs, a single genomic transcription regulatory sequence (TRS) was identified. Nine TRSs were previously reported for the arterivirus Simian hemorrhagic fever virus (SHFV). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di H,Madden JC Jr,Morantz EK,Tang HY,Graham RL,Baric RS,Brinton MA

更新日期：2017-10-17 00:00:00

abstract：:Identifying the drivers and processes that determine globally the geographic range size of species is crucial to understanding the geographic distribution of biodiversity and further predicting the response of species to current global changes. However, these drivers and processes are still poorly understood, and no e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvajal-Quintero J,Villalobos F,Oberdorff T,Grenouillet G,Brosse S,Hugueny B,Jézéquel C,Tedesco PA

更新日期：2019-07-02 00:00:00

abstract：:A yeast gene has been identified by screening for DNA replication mutants using a permeabilized cell replication assay. The mutant is temperature sensitive for growth and shows a cell cycle phenotype typical of DNA replication mutants. RNA synthesis is normal in the mutant but DNA synthesis ceases upon shift to the no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Budd ME,Campbell JL

更新日期：1995-08-15 00:00:00

abstract：:Crop species experienced strong selective pressure directed at genes controlling traits of agronomic importance during their domestication and subsequent episodes of selective breeding. Consequently, these genes are expected to exhibit the signature of selection. We screened 501 maize genes for the signature of select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vigouroux Y,McMullen M,Hittinger CT,Houchins K,Schulz L,Kresovich S,Matsuoka Y,Doebley J

更新日期：2002-07-23 00:00:00

abstract：:Two subjects, of 11,000 healthy individuals screened, were found to be missing three and four immunoglobulin isotypes, respectively (IgA1, IgG2, and IgG4; IgA1, IgG2, IgG4, and IgE), and have been analyzed at the DNA level by means of Southern blotting and Ig heavy-chain-specific probes. A broad deletion within the he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Migone N,Oliviero S,de Lange G,Delacroix DL,Boschis D,Altruda F,Silengo L,DeMarchi M,Carbonara AO

更新日期：1984-09-01 00:00:00

abstract：:Angiogenin, a potent inducer of neovascularization in the chicken chorioallantoic membrane and rabbit cornea, promotes endothelial cell invasion of Matrigel basement membrane. A transformed bovine aortic endothelial cell line, GM 7373, is 5 times more invasive when cultured in the presence of 1 microgram of bovine ang...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu G,Riordan JF,Vallee BL

更新日期：1994-12-06 00:00:00

abstract：:This article presents an agent-based computational model of civil violence. Two variants of the civil violence model are presented. In the first a central authority seeks to suppress decentralized rebellion. In the second a central authority seeks to suppress communal violence between two warring ethnic groups. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Epstein JM

更新日期：2002-05-14 00:00:00

abstract：:Neuroblastoma-glioma hybrid cells (NG108-15) in suspension accumulate the permeant lipophilic cation [(3)H]tetraphenylphosphonium (TPP(+)) against a concentration gradient. The steady-state level of TPP(+) accumulation is about twice as great in physiological media of low K(+) concentration (i.e., 5 mM K(+)/135 mM Na(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lichtshtein D,Kaback HR,Blume AJ

更新日期：1979-02-01 00:00:00

abstract：:Cancer is a genetic disease caused by genomic instability. In many cancers, this instability is manifested by chromosomal reconfigurations and karyotypic complexity. These features are particular hallmarks of the epithelial cancers that are some of the malignancies most resistant to long term control by current chemot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roschke AV,Lababidi S,Tonon G,Gehlhaus KS,Bussey K,Weinstein JN,Kirsch IR

更新日期：2005-02-22 00:00:00

abstract：:The environments we humans encounter daily are sources of exposure to diverse microbial communities, some of potential concern to human health. In this study, we used culture-independent technology to investigate the microbial composition of biofilms inside showerheads as ecological assemblages in the human indoor env...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feazel LM,Baumgartner LK,Peterson KL,Frank DN,Harris JK,Pace NR

更新日期：2009-09-22 00:00:00

abstract：:A 600-base-pair region essential for ColE1 and pMBl plasmid replication contains two promoters responsible for the synthesis of two RNA molecules central to copy number control. One promoter directs synthesis of the primer RNA precursor. The second promoter directs the synthesis of a small RNA molecule, RNAl, which ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cesareni G,Muesing MA,Polisky B

更新日期：1982-10-01 00:00:00

abstract：:The ATP-binding cassette (ABC) transporter of mitochondria (Atm1) mediates iron homeostasis in eukaryotes, while the prokaryotic homolog from Novosphingobium aromaticivorans (NaAtm1) can export glutathione derivatives and confer protection against heavy-metal toxicity. To establish the structural framework underlying ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan C,Kaiser JT,Rees DC

更新日期：2020-08-11 00:00:00

abstract：:A fraction of mouse RNA containing messenger RNA coding for mouse interferon was translated with high efficiency in a wheat germ system into a fully active product. This product fulfills the criteria for mouse interferon, namely: (1) it was active against vesicular stomatitis virus and herpes simplex virus in mouse ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thang MN,Thang DC,De Maeyer E,Montagnier L

更新日期：1975-10-01 00:00:00

abstract：:The S region of the murine major histocompatibility complex contains two structurally related genes (21-OHase A and 21-OHase B) that encode 21-hydroxylase (21-OHase), an enzyme essential for the synthesis of adrenal steroids. Expression of these two genes has been analyzed by using oligonucleotide probes specific for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parker KL,Chaplin DD,Wong M,Seidman JG,Smith JA,Schimmer BP

更新日期：1985-12-01 00:00:00

abstract：:The ATM (ataxia telangiectasia mutated) protein plays a central role in sensing and responding to DNA double-strand breaks. Lymphoid cells are unique in undergoing physiologic double-strand breaks in the processes of Ig class switch recombination and T or B cell receptor V(D)J recombination, and a role for ATM in thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vacchio MS,Olaru A,Livak F,Hodes RJ

更新日期：2007-04-10 00:00:00

abstract：:There is increasing, but largely indirect, evidence pointing to an effect of commensal gut microbiota on the central nervous system (CNS). However, it is unknown whether lactic acid bacteria such as Lactobacillus rhamnosus could have a direct effect on neurotransmitter receptors in the CNS in normal, healthy animals. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bravo JA,Forsythe P,Chew MV,Escaravage E,Savignac HM,Dinan TG,Bienenstock J,Cryan JF

更新日期：2011-09-20 00:00:00

abstract：:Lipoprotein oxidation is thought to play a pivotal role in atherogenesis, yet the underlying reaction mechanisms remain poorly understood. We have explored the possibility that high density lipoprotein (HDL) might be oxidized by peroxidase-generated tyrosyl radical. Exposure of HDL to L-tyrosine, H2O2, and horseradish...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Francis GA,Mendez AJ,Bierman EL,Heinecke JW

更新日期：1993-07-15 00:00:00

abstract：:Repetitive brain stimulation protocols induce plasticity in the stimulated site in brain slice models. Recent evidence from network models has indicated that additional plasticity-related changes occur in nonstimulated remote regions. Despite increasing use of brain stimulation protocols in experimental and clinical s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abe M,Fukuyama H,Mima T

更新日期：2014-03-25 00:00:00

abstract：:It is unknown whether cross-regulatory interactions between homeotic genes, which have been shown to play an important role in the maintenance of their expression domains during Drosophila development, are also important during mammalian development. We have analyzed here the expression of Hox genes in Hoxa-1 (Hox-1.6...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dollé P,Lufkin T,Krumlauf R,Mark M,Duboule D,Chambon P

更新日期：1993-08-15 00:00:00

abstract：:The bacterial RsgA, a circularly permutated GTPase, whose GTPase activity is dependent on the 30S ribosomal subunit, is a late-stage ribosome biogenesis factor involved in the 30S subunit maturation. The role of RsgA is to release another 30S biogenesis factor, RbfA, from the mature 30S subunit in a GTP-dependent mann...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo Q,Yuan Y,Xu Y,Feng B,Liu L,Chen K,Sun M,Yang Z,Lei J,Gao N

更新日期：2011-08-09 00:00:00

abstract：:Peripheral inhibitory nerves are physiological regulators of the contractile behavior of visceral smooth muscles. One of the transmitters responsible for inhibitory neurotransmission has been reputed to be a purine, possibly ATP. However, the exact identity of this substance has never been verified. Here we show that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mutafova-Yambolieva VN,Hwang SJ,Hao X,Chen H,Zhu MX,Wood JD,Ward SM,Sanders KM

更新日期：2007-10-09 00:00:00

abstract：:The phytohormone cytokinin influences many aspects of plant growth and development, several of which also involve the cellular process of autophagy, including leaf senescence, nutrient remobilization, and developmental transitions. The Arabidopsis type-A response regulators (type-A ARR) are negative regulators of cyto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acheampong AK,Shanks C,Cheng CY,Schaller GE,Dagdas Y,Kieber JJ

更新日期：2020-10-27 00:00:00

abstract：:We have previously identified and purified a cell surface glycoprotein from retina and brain, called neural cell adhesion molecule or N-CAM, that appears to be involved in neural cell--cell adhesion, the fasciculation of neurites, and the formation of normal tissue patterns in the retina. The present studies reveal th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rutishauser U,Hoffman S,Edelman GM

更新日期：1982-01-01 00:00:00

abstract：:During clathrin-mediated endocytosis, adaptor proteins recognize specific internalization signals on cargo receptors, either recruiting cargos into clathrin-coated pits (CCPs) or initiating clathrin-coat assembly around the cargo molecules. Here, we identify epsin 1, a clathrin-, ubiquitin-, and phospholipid-interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen C,Zhuang X

更新日期：2008-08-19 00:00:00

abstract：:Although it is now more than two decades since it was first reported that the imidazobenzodiazepine Ro15-4513 reverses behavioral alcohol effects, the molecular target(s) of Ro15-4513 and the mechanism of alcohol antagonism remain elusive. Here, we show that Ro15-4513 blocks the alcohol enhancement on recombinant "ext...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wallner M,Hanchar HJ,Olsen RW

更新日期：2006-05-30 00:00:00

abstract：:Mouse tumor C1300 has been established in tissue culture. The cells have a round cell morphology in both the subcutaneous tumor and in suspension culture. However, when given a surface on which to attach, they send out processes up to 3 mm in length and assume the morphology of mature neurons. The attached cells are s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schubert D,Humphreys S,Baroni C,Cohn M

更新日期：1969-09-01 00:00:00

abstract：:LTRs of endogenous retroviruses are known to affect expression of several human genes, typically as a relatively minor alternative promoter. Here, we report that an endogenous retrovirus LTR acts as one of at least two alternative promoters for the human beta1,3-galactosyltransferase 5 gene, involved in type 1 Lewis a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn CA,Medstrand P,Mager DL

更新日期：2003-10-28 00:00:00

abstract：:In everyday listening, sound reaches our ears directly from a source as well as indirectly via reflections known as reverberation. Reverberation profoundly distorts the sound from a source, yet humans can both identify sound sources and distinguish environments from the resulting sound, via mechanisms that remain uncl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Traer J,McDermott JH

更新日期：2016-11-29 00:00:00

abstract：:Iron/sulfur cluster (ISC)-containing proteins are essential components of cells. In most eukaryotes, Fe/S clusters are synthesized by the mitochondrial ISC machinery, the cytosolic iron/sulfur assembly system, and, in photosynthetic species, a plastid sulfur-mobilization (SUF) system. Here we show that the anaerobic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsaousis AD,Ollagnier de Choudens S,Gentekaki E,Long S,Gaston D,Stechmann A,Vinella D,Py B,Fontecave M,Barras F,Lukeš J,Roger AJ

更新日期：2012-06-26 00:00:00