Angiogenin promotes invasiveness of cultured endothelial cells by stimulation of cell-associated proteolytic activities.

abstract：:The maytansinoid drug DM1 is 100- to 1000-fold more cytotoxic than anticancer drugs that are currently in clinical use. The immunoconjugate C242-DM1 was prepared by conjugating DM1 to the monoclonal antibody C242, which recognizes a mucin-type glycoprotein expressed to various extents by human colorectal cancers. C242...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Tadayoni BM,Bourret LA,Mattocks KM,Derr SM,Widdison WC,Kedersha NL,Ariniello PD,Goldmacher VS,Lambert JM,Blättler WA,Chari RV

更新日期：1996-08-06 00:00:00

abstract：:A major challenge of the 21st century is to produce more food for a growing population without increasing humanity's agricultural footprint. Urban food production may help to solve this challenge; however, little research has examined the productivity of urban farming systems. We investigated inputs and produce yields...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McDougall R,Kristiansen P,Rader R

更新日期：2019-01-02 00:00:00

abstract：:An inwardly rectifying, ATP-regulated K+ channel with a distinctive molecular architecture, ROMK1, was recently cloned from rat kidney. Using patch clamp techniques, we have investigated the regulation of ROMK1 with particular emphasis on phosphorylation/dephosphorylation processes. Spontaneous channel rundown occurre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNicholas CM,Wang W,Ho K,Hebert SC,Giebisch G

更新日期：1994-08-16 00:00:00

abstract：:The autophagic ubiquitin-like protein (ublp) autophagy-related (ATG)12 is a component of the ATG12∼ATG5-ATG16L1 E3 complex that promotes lipid conjugation of members of the LC3 ublp family. A role of ATG12 in the E3 complex is to recruit the E2 enzyme ATG3. Here we report the identification of the ATG12 binding sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metlagel Z,Otomo C,Takaesu G,Otomo T

更新日期：2013-11-19 00:00:00

abstract：:Transforming growth factor betas (TGF-betas) regulate key aspects of embryonic development and major human diseases. Although Smad2, Smad3, and extracellular signal-regulated kinase (ERK) mitogen-activated protein kinases (MAPKs) have been proposed as key mediators in TGF-beta signaling, their functional specificities...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang YC,Piek E,Zavadil J,Liang D,Xie D,Heyer J,Pavlidis P,Kucherlapati R,Roberts AB,Böttinger EP

更新日期：2003-09-02 00:00:00

abstract：:Whereas 234(92)U142 and other actinon nuclei have ground-state bands that indicate that each nucleus consists of a sphere and a single revolving cluster with constant composition and with only a steady increase in the moment of inertia with increase in J, the angular-momentum quantum number, many of the lanthanon grou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1991-02-01 00:00:00

abstract：:Genetic analysis for group selection is developed for the case of a biallelic locus (A, a) undergoing group selection of founder populations only. By contrast to R. Levins"E = E(x) models, extinction now depends on genetics at the propagule stage but acts uniformly on larger populations. Biological evidence supports t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boorman SA

更新日期：1978-04-01 00:00:00

abstract：:Among 21 human mammary tumors analyzed for transforming genes by transfection of NIH/3T3 cells, only DNA of a carcinosarcoma cell line, HS578T, registered as positive. A Harvey (H)-ras oncogene identified in this line was cloned in biologically active form and the activating lesion was identified as a single nucleotid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus MH,Yuasa Y,Aaronson SA

更新日期：1984-09-01 00:00:00

abstract：:DNA from one biopsy sample of invasive cancer of the cervix contained sequences hybridizing with human papillomavirus (HPV) type 11 DNA only under nonstringent conditions. This DNA was molecularly cloned in lambda phage. Under stringent conditions of hybridization it cross-hybridized to a minor extent (less than 0.1%)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dürst M,Gissmann L,Ikenberg H,zur Hausen H

更新日期：1983-06-01 00:00:00

abstract：:A high molecular weight protein (HMWP) with properties similar to those of both actin-binding protein (ABP) and filamin has been isolated from cultured baby hamster kidney (BHK-21) cells. The protein was present in an actomyosin-depleted sucrose extract of the cells and was eluted, upon gel chromatography on Sepharose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schloss JA,Goldman RD

更新日期：1979-09-01 00:00:00

abstract：:Heat shock (HS) initiates rapid, extensive, and evolutionarily conserved changes in transcription that are accompanied by chromatin decondensation and nucleosome loss at HS loci. Here we have employed in situ Hi-C to determine how heat stress affects long-range chromatin conformation in human and Drosophila cells. We ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray J,Munn PR,Vihervaara A,Lewis JJ,Ozer A,Danko CG,Lis JT

更新日期：2019-09-24 00:00:00

abstract：:Metals in one spatial dimension are described at the lowest energy scales by the Luttinger liquid theory. It is well understood that this free theory, and even interacting integrable models, can support ballistic transport of conserved quantities including energy. In contrast, realistic one-dimensional metals, even wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulchandani VB,Karrasch C,Moore JE

更新日期：2020-06-09 00:00:00

abstract：:Cardiotoxin VII4 from Naja mossambica mossambica crystallizes in space group P61 (a = b = 73.9 A; c = 59.0 A) with two molecules of toxin (molecular mass = 6715 Da) in the asymmetric unit. The structure was solved by using a combination of multiple isomorphous replacement and density modification methods. Model buildi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rees B,Samama JP,Thierry JC,Gilibert M,Fischer J,Schweitz H,Lazdunski M,Moras D

更新日期：1987-05-01 00:00:00

abstract：:By comparing the amino acid sequences of 11 mammalian and 1 avian prion proteins (PrP), structural analyses predicted four alpha-helical regions. Peptides corresponding to these regions of Syrian hamster PrP were synthesized, and, contrary to predictions, three of the four spontaneously formed amyloids as shown by ele...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gasset M,Baldwin MA,Lloyd DH,Gabriel JM,Holtzman DM,Cohen F,Fletterick R,Prusiner SB

更新日期：1992-11-15 00:00:00

abstract：:D gene segments with irregular spacers (DIR) are D gene segments that are specific to higher primates. Their use is controversial because of their G+C-rich long sequences. In the human, it has always been tempting to assume that a complementarity-determining region 3 sequence has been added by terminal deoxynucleotidy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuaillon N,Capra JD

更新日期：1998-02-17 00:00:00

abstract：:Capsaicin (CP), the pungent component of chili pepper, acts on sensory neurons to convey the sensation of pain. The CP receptor, vanilloid receptor 1 (VR1), has been shown to be highly expressed by nociceptive neurons in dorsal root and trigeminal ganglia. We demonstrate here that the dendritic cell (DC), a key cell t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu S,Srivastava P

更新日期：2005-04-05 00:00:00

abstract：:When the visual (striate) cortex (V1) is damaged in human subjects, cortical blindness results in the contralateral visual half field. Nevertheless, under some experimental conditions, subjects demonstrate a capacity to make visual discriminations in the blind hemifield (blindsight), even though they have no phenomena...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiskrantz L,Barbur JL,Sahraie A

更新日期：1995-06-20 00:00:00

abstract：:Cell-free DNA shed by cancer cells has been shown to be a rich source of putative tumor-specific biomarkers. Because cell-free DNA from brain and spinal cord tumors cannot usually be detected in the blood, we studied whether the cerebrospinal fluid (CSF) that bathes the CNS is enriched for tumor DNA, here termed CSF-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Springer S,Zhang M,McMahon KW,Kinde I,Dobbyn L,Ptak J,Brem H,Chaichana K,Gallia GL,Gokaslan ZL,Groves ML,Jallo GI,Lim M,Olivi A,Quinones-Hinojosa A,Rigamonti D,Riggins GJ,Sciubba DM,Weingart JD,Wolinsky JP

更新日期：2015-08-04 00:00:00

abstract：:In eukaryotic photosynthetic organisms, the conversion of solar into chemical energy occurs in thylakoid membranes in the chloroplast. How thylakoid membranes are formed and maintained is poorly understood. However, previous observations of vesicles adjacent to the stromal side of the inner envelope membrane of the ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hertle AP,García-Cerdán JG,Armbruster U,Shih R,Lee JJ,Wong W,Niyogi KK

更新日期：2020-04-21 00:00:00

abstract：:If X(1), X(2),... are independent random variables with zero expectation and finite variances, the cumulative sums S(n) are, on the average, of the order of magnitude S(n), where S(n) (2) = E(S(n) (2)). The occasional maxima of the ratios S(n)/S(n) are surprisingly large and the problem is to estimate the extent of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feller W

更新日期：1969-07-01 00:00:00

abstract：:In the vertebrate embryo, the cephalic neural crest cells (CNCCs) produce cells belonging to two main lineages: the neural [including neurons, glial cells of the peripheral nervous system (PNS), and melanocytes] and the mesenchymal (chondrocytes, osteoblasts, smooth muscle cells, and connective tissue cells), whereas ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calloni GW,Glavieux-Pardanaud C,Le Douarin NM,Dupin E

更新日期：2007-12-11 00:00:00

abstract：:Optogenetic methods have been highly effective for suppressing neural activity and modulating behavior in rodents, but effects have been much smaller in primates, which have much larger brains. Here, we present a suite of technologies to use optogenetics effectively in primates and apply these tools to a classic quest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acker L,Pino EN,Boyden ES,Desimone R

更新日期：2016-11-15 00:00:00

abstract：:The protease encoded by the human immunodeficiency virus (HIV) processes the viral gag and gag-pol protein precursor by posttranslational cleavage. In this study we have demonstrated by site-specific mutagenesis (Asp----Thr) and by pepstatin A inhibition that the recombinant HIV protease is an aspartic-type protease. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seelmeier S,Schmidt H,Turk V,von der Helm K

更新日期：1988-09-01 00:00:00

abstract：:Soil bacteria and fungi play key roles in the functioning of terrestrial ecosystems, yet our understanding of their responses to climate change lags significantly behind that of other organisms. This gap in our understanding is particularly true for drylands, which occupy ∼41% of Earth´s surface, because no global, sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maestre FT,Delgado-Baquerizo M,Jeffries TC,Eldridge DJ,Ochoa V,Gozalo B,Quero JL,García-Gómez M,Gallardo A,Ulrich W,Bowker MA,Arredondo T,Barraza-Zepeda C,Bran D,Florentino A,Gaitán J,Gutiérrez JR,Huber-Sannwald E,Jan

更新日期：2015-12-22 00:00:00

abstract：:A human beta-globin gene derived from an established human lymphoblast cell line was introduced into murine erythroleukemia (MEL) cells by cell fusion. The globin genes in MEL cells are inducible by dimethyl sulfoxide (Me2SO); induction leads to the accumulation of mouse globin mRNA and hemoglobin. Globin mRNA was not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyati J,Kucherlapati RS,Skoultchi AI

更新日期：1980-06-01 00:00:00

abstract：:Several lines of evidence suggest that the serotonin (5-hydroxytryptamine, 5-HT) regulates cardiovascular functions during embryogenesis and adulthood. 5-HT binds to numerous cognate receptors to initiate its biological effects. However, none of the 5-HT receptor disruptions in mice have yet resulted in embryonic defe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nebigil CG,Choi DS,Dierich A,Hickel P,Le Meur M,Messaddeq N,Launay JM,Maroteaux L

更新日期：2000-08-15 00:00:00

abstract：:Cholera and enterotoxigenic Escherichia coli (ETEC) are among the most common causes of acute infantile gastroenteritis globally. We previously developed a rice-based vaccine that expressed cholera toxin B subunit (MucoRice-CTB) and had the advantages of being cold chain-free and providing protection against cholera t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhara D,Yuki Y,Nochi T,Kodama T,Mejima M,Kurokawa S,Takahashi Y,Nanno M,Nakanishi U,Takaiwa F,Honda T,Kiyono H

更新日期：2010-05-11 00:00:00

abstract：:The high-pressure behavior of amorphous selenium has been investigated with time-resolved diamond anvil cell synchrotron x-ray diffraction and computed microtomography techniques. A two-step dynamic crystallization process is observed in which the monoclinic phase crystallized from the amorphous selenium and gradually...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Wang L,Xiao X,De Carlo F,Feng J,Mao HK,Hemley RJ

更新日期：2008-09-09 00:00:00

abstract：:Hemolytic uremic syndrome (HUS) is an important cause of acute renal failure in children. Mutations in one or more genes encoding complement-regulatory proteins have been reported in approximately one-third of nondiarrheal, atypical HUS (aHUS) patients, suggesting a defect in the protection of cell surfaces against co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goicoechea de Jorge E,Harris CL,Esparza-Gordillo J,Carreras L,Arranz EA,Garrido CA,López-Trascasa M,Sánchez-Corral P,Morgan BP,Rodríguez de Córdoba S

更新日期：2007-01-02 00:00:00

abstract：:Comparative vertebrate genome sequencing offers a powerful method for detecting conserved regulatory sequences. We propose that the compact genome of the teleost Fugu rubripes is well suited for this purpose. The evolutionary distance of teleosts from other vertebrates offers the maximum stringency for such evolutiona...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aparicio S,Morrison A,Gould A,Gilthorpe J,Chaudhuri C,Rigby P,Krumlauf R,Brenner S

更新日期：1995-02-28 00:00:00