Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.

abstract：:Replication of the single-stranded DNA genome of geminiviruses occurs via a double-stranded intermediate that is subsequently used as a template for rolling-circle replication of the viral strand. Only one of the proteins encoded by the virus, here referred to as replication initiator protein (Rep protein), is indispe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laufs J,Traut W,Heyraud F,Matzeit V,Rogers SG,Schell J,Gronenborn B

更新日期：1995-04-25 00:00:00

abstract：:The photosynthetic apparatus converts light into chemical energy by a series of reactions that give rise to a coupled flow of electrons and protons that generate reducing power and ATP, respectively. A key intermediate in these reactions is plastoquinone (PQ), the most abundant electron and proton (hydrogen) carrier i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCauley SW,Melis A,Tang GM,Arnon DI

更新日期：1987-12-01 00:00:00

abstract：:During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao X,Castro-Gomez S,Grendel J,Graf S,Süsens U,Binkle L,Mensching D,Isbrandt D,Kuhl D,Ohana O

更新日期：2018-12-04 00:00:00

abstract：:The cytochrome P-450 superfamily of enzymes catalyzes the oxidative metabolism of innumerable lipophilic compounds (e.g., drugs, carcinogens, steroids). Although the three-dimensional structure of a soluble bacterial P-450 (P-450cam) has been solved, little is known about the structures of the membrane-bound mammalian...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronbach T,Larabee TM,Johnson EF

更新日期：1989-11-01 00:00:00

abstract：:A new class of Escherichia coli mutants, referred to as grn, has been isolated by localized mutagenesis. These mutations affect the sigma subunit of DNA-dependent RNA polymerase (ribonucleoside 5'-triphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) by abolishing the expression of the lambda N gene, and they are close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,Kurihara T,Saito H,Uchida H

更新日期：1979-09-01 00:00:00

abstract：:Plasma samples exhibiting alloalbuminemia on electrophoresis at pH 8.6 were requested from clinical laboratories throughout Sweden. Nine variants, each representing a different single point mutation, were found in 100 apparently unrelated Swedes. The overall prevalence of alloalbuminemia was estimated at 1:1700. Mutat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carlson J,Sakamoto Y,Laurell CB,Madison J,Watkins S,Putnam FW

更新日期：1992-09-01 00:00:00

abstract：:Murine mastocytoma cells treated with calcium ionophore A23187 produced a slow-reacting substance (SRS) that caused guinea pig ileum to contract. The response was reversed by the SRS antagonist FPL 55712. On the basis of isotope incorporation experiments, spectroscopy, and chemical degradations, the SRS was identified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy RC,Hammarström S,Samuelsson B

更新日期：1979-09-01 00:00:00

abstract：:The effect of Zn2+ on a voltage-dependent, transient potassium current (IA) in acutely dissociated neurons from the suprachiasmatic nucleus was studied with the whole-cell patch-clamp technique. At micromolar concentrations, Zn2+ markedly potentiated IA activated from a holding potential of -60 mV, which is the restin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang RC,Peng YW,Yau KW

更新日期：1993-12-15 00:00:00

abstract：:Spectrin is an important structural component of the plasma membrane skeleton. Heretofore-unidentified isoforms of spectrin also associate with Golgi and other organelles. We have discovered another member of the beta-spectrin gene family by homology searches of the GenBank databases and by 5' rapid amplification of c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stankewich MC,Tse WT,Peters LL,Ch'ng Y,John KM,Stabach PR,Devarajan P,Morrow JS,Lux SE

更新日期：1998-11-24 00:00:00

abstract：:Operant conditioning techniques were used to assess how gender and song familiarity affect song discrimination in adult zebra finches (Taeniopygia guttata). Twenty-five males and females, divided into five cohorts, were trained to discriminate between conspecific songs at different times of year. Males discriminating ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cynx J,Nottebohm F

更新日期：1992-02-15 00:00:00

abstract：:Adipose tissue dysfunction is causally implicated in the impaired metabolic homeostasis associated with obesity; however, detailed mechanisms underlying dysregulated adipocyte functions in obesity remain to be elucidated. Here we searched for genes that provide a previously unknown mechanism in adipocyte metabolic fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wardhana DA,Ikeda K,Barinda AJ,Nugroho DB,Qurania KR,Yagi K,Miyata K,Oike Y,Hirata KI,Emoto N

更新日期：2018-02-13 00:00:00

abstract：:Some of the most important impacts of global climate change will be felt among the populations, predominantly in developing countries, referred to as "subsistence" or "smallholder" farmers. Their vulnerability to climate change comes both from being predominantly located in the tropics, and from various socioeconomic,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton JF

更新日期：2007-12-11 00:00:00

abstract：:In the past 15 years, the adoption of subnational immigration policies in the United States, such as those established by individual states, has gone from nearly zero to over 300 per year. These include welcoming policies aimed at attracting and incorporating immigrants, as well as unwelcoming policies directed at den...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huo YJ,Dovidio JF,Jiménez TR,Schildkraut DJ

更新日期：2018-01-30 00:00:00

abstract：:Mutational inactivation of the retinoblastoma (RB) gene has been implicated in the genesis of retinoblastoma, osteosarcoma, and other human tumors. Our strategy has been to characterize naturally occurring mutants from tumor cells to pinpoint potential domains of RB protein crucial for tumor suppression. We show here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shew JY,Lin BT,Chen PL,Tseng BY,Yang-Feng TL,Lee WH

更新日期：1990-01-01 00:00:00

abstract：:Deregulation of microRNA (miRNA) expression can lead to cancer initiation and progression. However, limited information exists on the function of miRNAs in cancer maintenance. We examined these issues in the case of myeloproliferative diseases and neoplasms (MPN), a collection of hematopoietic neoplasms regarded as pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J

更新日期：2012-10-09 00:00:00

abstract：:Arabinose-binding protein, maltose-binding protein, and lambda receptor are synthesized in vitro on membrane-bound polysomes from Escherichia coli. All three proteins are exported from the cytoplasm of E. coli and all three are made in vitro in a form a few thousand daltons larger than the authentic protein. The large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randall LL,Hardy SJ,Josefsson LG

更新日期：1978-03-01 00:00:00

abstract：:Human beings differ in their ability to master the sounds of their second language (L2). Phonetic training studies have proposed that differences in phonetic learning stem from differences in psychoacoustic abilities rather than speech-specific capabilities. We aimed at finding the origin of individual differences in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Díaz B,Baus C,Escera C,Costa A,Sebastián-Gallés N

更新日期：2008-10-21 00:00:00

abstract：:During the periimplantation period of pregnancy, pig blastocysts undergo morphological changes and differentiation requiring secretion and transport of nutrients (histotroph) into the uterine lumen. Of these nutrients, glucose is converted to fructose, an isomer of glucose, by conceptus trophectoderm. Although glucose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim J,Song G,Wu G,Bazer FW

更新日期：2012-06-19 00:00:00

abstract：:The phosphorylation of diacylglycerol (DG), a reaction catalyzed by DG kinase, may be critical in the termination of effector-induced signals mediated by protein kinase C. Synapsin I is a principal target of intracellular protein kinases and is thought to be involved in the release of neurotransmitter from axon termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn DW,Besterman JM

更新日期：1991-07-15 00:00:00

abstract：:Beyond state-of-the-art lithium-ion battery (LIB) technology with metallic lithium anodes to replace conventional ion intercalation anode materials is highly desirable because of lithium's highest specific capacity (3,860 mA/g) and lowest negative electrochemical potential (∼3.040 V vs. the standard hydrogen electrode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu KK,Gong Y,Dai J,Gong A,Han X,Yao Y,Wang C,Wang Y,Chen Y,Yan C,Li Y,Wachsman ED,Hu L

更新日期：2016-06-28 00:00:00

abstract：:We have previously shown that nuclear transcripts of the multifunctional enzyme, carbamoyl-phosphate synthetase, aspartate transcarbamylase, dihydroorotase RNA can be released from nuclei of Syrian hamster cells as compact ribonucleoprotein (RNP) particles that sediment at the 200S region in a sucrose gradient. The 20...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spann P,Feinerman M,Sperling J,Sperling R

更新日期：1989-01-01 00:00:00

abstract：:Our laboratory has previously developed cell lines derived from mouse NIH 3T3 fibroblasts and C127 mammary tumor cells that stably express mouse mammary tumor virus (MMTV) long terminal repeat fusion genes in bovine papillomavirus-based episomes. Glucocorticoid hormone strongly activates transcription from episomes an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bresnick EH,John S,Berard DS,LeFebvre P,Hager GL

更新日期：1990-05-01 00:00:00

abstract：:Horizontal drilling and hydraulic fracturing have enhanced energy production but raised concerns about drinking-water contamination and other environmental impacts. Identifying the sources and mechanisms of contamination can help improve the environmental and economic sustainability of shale-gas extraction. We analyze...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Darrah TH,Vengosh A,Jackson RB,Warner NR,Poreda RJ

更新日期：2014-09-30 00:00:00

abstract：:The endbrain (telencephalon) is at the rostral end of the central nervous system and is primarily responsible for supporting cognition and affect. Structurally, it consists of right and left cerebral hemispheres, each parceled into multiple cortical and nuclear gray matter regions. The global network organization of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson LW,Hahn JD,Jeub LGS,Fortunato S,Sporns O

更新日期：2018-07-17 00:00:00

abstract：:Priming of the organ-specific premetastatic sites is thought to be an important yet incompletely understood step during metastasis. In this study, we show that the metastatic tumors we examined overexpress granulocyte-colony stimulating factor (G-CSF), which expands and mobilizes Ly6G+Ly6C+ granulocytes and facilitate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kowanetz M,Wu X,Lee J,Tan M,Hagenbeek T,Qu X,Yu L,Ross J,Korsisaari N,Cao T,Bou-Reslan H,Kallop D,Weimer R,Ludlam MJ,Kaminker JS,Modrusan Z,van Bruggen N,Peale FV,Carano R,Meng YG,Ferrara N

更新日期：2010-12-14 00:00:00

abstract：:Widespread belief in misinformation circulating online is a critical challenge for modern societies. While research to date has focused on psychological and political antecedents to this phenomenon, few studies have explored the role of digital media literacy shortfalls. Using data from preregistered survey experiment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guess AM,Lerner M,Lyons B,Montgomery JM,Nyhan B,Reifler J,Sircar N

更新日期：2020-07-07 00:00:00

abstract：:All science has uncertainty. Unless that uncertainty is communicated effectively, decision makers may put too much or too little faith in it. The information that needs to be communicated depends on the decisions that people face. Are they (i) looking for a signal (e.g., whether to evacuate before a hurricane), (ii) c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischhoff B,Davis AL

更新日期：2014-09-16 00:00:00

abstract：:Photosystem II (PSII), the light-driven water/plastoquinone photooxidoreductase, is of central importance in the planetary energy cycle. The product of the reaction, plastohydroquinone (PQH2), is released into the membrane from the QB site, where it is formed. A plastoquinone (PQ) from the membrane pool then binds int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Causmaecker S,Douglass JS,Fantuzzi A,Nitschke W,Rutherford AW

更新日期：2019-09-24 00:00:00

abstract：:The polyhedral borane ion [n-B20H18]2- reacts with liquid ammonia in the presence of a suitable base to produce an apical-equatorial (ae) isomer of the [B20H17NH3]3- ion, [1-(2'-B10H9)-2-NH3B10H8]3-. The structure of this product has been confirmed by 11B NMR spectroscopy and x-ray crystallography. This species underg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feakes DA,Shelly K,Knobler CB,Hawthorne MF

更新日期：1994-04-12 00:00:00

abstract：:Multiple studies have established that microRNAs (miRNAs) are involved in the initiation and progression of cancer. Notably, miR-155 is one of the most overexpressed miRNAs in several solid and hematological malignancies. Ectopic miR-155 expression in mice B cells (Eμ-miR-155 transgenic mice) has been shown to induce ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sandhu SK,Volinia S,Costinean S,Galasso M,Neinast R,Santhanam R,Parthun MR,Perrotti D,Marcucci G,Garzon R,Croce CM

更新日期：2012-12-04 00:00:00