The natural center of chromaticity space is not always achromatic: a new look at color induction.

abstract：:The molecular mechanism of desensitization of soluble guanylyl cyclase (sGC), the NO receptor, has long remained unresolved. Posttranslational modification and redox state have been postulated to affect sGC sensitivity to NO but evidence has been lacking. We now show that sGC can be S-nitrosylated in primary aortic sm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sayed N,Baskaran P,Ma X,van den Akker F,Beuve A

更新日期：2007-07-24 00:00:00

abstract：:Junctional Adhesion Molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. Here we report that JAM-A is required for the correct infiltration of polymorphonuclear leukocytes (PMN) into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. The def...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corada M,Chimenti S,Cera MR,Vinci M,Salio M,Fiordaliso F,De Angelis N,Villa A,Bossi M,Staszewsky LI,Vecchi A,Parazzoli D,Motoike T,Latini R,Dejana E

更新日期：2005-07-26 00:00:00

abstract：:Ellagic acid, a naturally occurring plant phenol, inhibits the activity of the direct-acting mutagen N-methyl-N-nitrosourea (MeNU) in Salmonella typhimurium TA100. Ellagic acid at 0.10, 0.25, 0.50, and 1.00 mM inhibited the mutagenicity of MeNU (0.40 mM) by 3%, 13%, 45%, and 60%, respectively. Ellagic acid (3 mM) also...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dixit R,Gold B

更新日期：1986-11-01 00:00:00

abstract：:Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and amphiregulin are structurally and functionally related growth regulatory proteins. These secreted polypeptides all bind to the 170-kDa cell-surface EGF receptor, activating its intrinsic kinase activity. However, amphiregulin exhibits dif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Plowman GD,Whitney GS,Neubauer MG,Green JM,McDonald VL,Todaro GJ,Shoyab M

更新日期：1990-07-01 00:00:00

abstract：:Liddle syndrome is a mendelian form of hypertension characterized by constitutively elevated renal Na reabsorption that can result from activating mutations in the beta or gamma subunit of the epithelial Na channel. All reported mutations have deleted the last 45-76 normal amino acids from the cytoplasmic C terminus o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansson JH,Schild L,Lu Y,Wilson TA,Gautschi I,Shimkets R,Nelson-Williams C,Rossier BC,Lifton RP

更新日期：1995-12-05 00:00:00

abstract：:Indoor residual spraying (IRS) is used to control visceral leishmaniasis (VL) in India, but it is poorly quality assured. Quality assurance was performed in eight VL endemic districts in Bihar State, India, in 2014. Residual dichlorodiphenyltrichloroethane (DDT) was sampled from walls using Bostik tape discs, and DDT ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coleman M,Foster GM,Deb R,Pratap Singh R,Ismail HM,Shivam P,Ghosh AK,Dunkley S,Kumar V,Coleman M,Hemingway J,Paine MJ,Das P

更新日期：2015-07-14 00:00:00

abstract：:Trypanosomatid RNA editing is a unique process and essential for these organisms. It therefore represents a drug target for a group of protozoa that includes the causative agents for African sleeping sickness and other devastating tropical and subtropical diseases. Here, we present drug-like inhibitors of a key enzyme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amaro RE,Schnaufer A,Interthal H,Hol W,Stuart KD,McCammon JA

更新日期：2008-11-11 00:00:00

abstract：:Five DNA fragments have been cloned from yeast, chicken, and mouse DNA that titrate lac repressor in an Escherichia coli lac+ I+Z+ wild-type strain when on a multi-copy plasmid. The five repressor-binding sequences have been identified by DNA sequence determinations and DNase cleavage-inhibition patterns. They share t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons A,Tils D,von Wilcken-Bergmann B,Müller-Hill B

更新日期：1984-03-01 00:00:00

abstract：:Targeted disruption of the pp60(src) (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Herein we describe the discovery of a nonpeptide inhibitor (AP22408) of Src that demonstrates in vivo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shakespeare W,Yang M,Bohacek R,Cerasoli F,Stebbins K,Sundaramoorthi R,Azimioara M,Vu C,Pradeepan S,Metcalf C 3rd,Haraldson C,Merry T,Dalgarno D,Narula S,Hatada M,Lu X,van Schravendijk MR,Adams S,Violette S,Smith J,

更新日期：2000-08-15 00:00:00

abstract：:By using a simplified model of small open liquid-like clusters with surface effects, in the gas phase, it is shown how the statistical thermodynamics of small systems can be extended to include metastable supersaturated gaseous states not too far from the gas-liquid equilibrium transition point. To accomplish this, on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL,Chamberlin RV

更新日期：1998-10-27 00:00:00

abstract：:The Caulobacter crescentus flagellum is formed at a specific time in the cell cycle and its assembly requires the ordered expression of a large number of genes. These genes are controlled in a positive trans-acting hierarchy that reflects the order of assembly of the flagellum. Using plasmids carrying transcriptional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu H,Dingwall A,Shapiro L

更新日期：1989-09-01 00:00:00

abstract：:Protein interactions with the collagen triple helix play a critical role in collagen fibril formation, cell adhesion, and signaling. However, structural insight into sequence-specific collagen recognition is limited to an integrin-peptide complex. A GVMGFO motif in fibrillar collagens (O denotes 4-hydroxyproline) bind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohenester E,Sasaki T,Giudici C,Farndale RW,Bächinger HP

更新日期：2008-11-25 00:00:00

abstract：:Although geophysical observations of mantle regions that suggest the presence of partial melt have often been interpreted in light of the properties of basaltic liquids erupted at the surface, the seismic and rheological consequences of partial melting in the upper mantle depend instead on the properties of interstiti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SK,Mosenfelder JL,Park SY,Lee AC,Asimow PD

更新日期：2020-09-08 00:00:00

abstract：:We describe here the successful establishment of a reverse genetics system for rotavirus (RV), a member of the Reoviridae family whose genome consists of 10-12 segmented dsRNA. The system is based on the recombinant vaccinia virus T7 RNA polymerase-driven procedure for supplying artificial viral mRNA in the cytoplasm....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Komoto S,Sasaki J,Taniguchi K

更新日期：2006-03-21 00:00:00

abstract：:Under various conditions, specific genetic areas of the phage T4 DNA molecule are preferentially and repeatedly replicated, resulting in the amplification of these areas. These areas are found to lie in the vicinity of the known origins of DNA replication. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozinski AW,Ling SK,Hutchinson N,Halpern ME,Mattson T

更新日期：1980-09-01 00:00:00

abstract：:Prions are infectious proteins that encipher biological information within their conformations; variations in these conformations dictate different prion strains. Toward elucidating the molecular language of prion protein (PrP) conformations, we produced an array of recombinant PrP amyloids with varying conformational...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colby DW,Giles K,Legname G,Wille H,Baskakov IV,DeArmond SJ,Prusiner SB

更新日期：2009-12-01 00:00:00

abstract：:Thyrotoxicosis increases endogenous glucose production (EGP) and induces hepatic insulin resistance. We have recently shown that these alterations can be modulated by selective hepatic sympathetic and parasympathetic denervation, pointing to neurally mediated effects of thyroid hormone on glucose metabolism. Here, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klieverik LP,Janssen SF,van Riel A,Foppen E,Bisschop PH,Serlie MJ,Boelen A,Ackermans MT,Sauerwein HP,Fliers E,Kalsbeek A

更新日期：2009-04-07 00:00:00

abstract：:Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phenotype (SASP). We fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Tchkonia T,Ding H,Ogrodnik M,Lubbers ER,Pirtskhalava T,White TA,Johnson KO,Stout MB,Mezera V,Giorgadze N,Jensen MD,LeBrasseur NK,Kirkland JL

更新日期：2015-11-17 00:00:00

abstract：:Several domains of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein have been identified that are involved in HIV-1-mediated membrane fusion. One domain that is involved in membrane fusion is the hydrophobic amino terminus of the HIV-1 transmembrane glycoprotein gp41. Here we show that a polar sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freed EO,Delwart EL,Buchschacher GL Jr,Panganiban AT

更新日期：1992-01-01 00:00:00

abstract：:Previous experiments have demonstrated that the human beta-globin gene is correctly regulated in transgenic mice. The beta-globin gene is not expressed in yolk sac-derived erythroid cells in early embryonic development but is expressed concomitantly with the adult mouse beta-globin genes in 14- to 16-day fetal liver a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Behringer RR,Hammer RE,Brinster RL,Palmiter RD,Townes TM

更新日期：1987-10-01 00:00:00

abstract：:Mammalian class A macrophage-specific scavenger receptors (SR-A) exhibit unusually broad binding specificity for a wide variety of polyanionic ligands. The properties of these receptors suggest that they may be involved in atherosclerosis and host defense. We have previously observed a similar receptor activity in Dro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pearson A,Lux A,Krieger M

更新日期：1995-04-25 00:00:00

abstract：:Nitric oxide synthesized by inducible nitric oxide synthase (iNOS) has been implicated as a mediator of inflammation in rheumatic and autoimmune diseases. We report that exposure of lipopolysaccharide-stimulated murine macrophages to therapeutic concentrations of aspirin (IC50 = 3 mM) and hydrocortisone (IC50 = 5 micr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amin AR,Vyas P,Attur M,Leszczynska-Piziak J,Patel IR,Weissmann G,Abramson SB

更新日期：1995-08-15 00:00:00

abstract：:A method is proposed for rapidly, quantitatively comparing protein structures of arbitrary sizes, based on the differential geometric representation. The method is applied to a group of 22 protein x-ray structures, and the resulting network of closest relationships is delineated. Several well-known fold types are auto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rackovsky S,Goldstein DA

更新日期：1988-02-01 00:00:00

abstract：:Human activities increasingly take place in online environments, providing novel opportunities for relating individual behaviors to population-level outcomes. In this paper, we introduce a simple generative model for the collective behavior of millions of social networking site users who are deciding between different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gleeson JP,Cellai D,Onnela JP,Porter MA,Reed-Tsochas F

更新日期：2014-07-22 00:00:00

abstract：:A typing method for bacteria was developed and applied to several species, including Escherichia coli and Actinobacillus actinomycetemcomitans. Total genomic DNA was digested with a restriction endonuclease, and fragments were enabled with [alpha-32P]dATP by using the Klenow fragment of DNA polymerase and separated by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Steenbergen TJ,Colloms SD,Hermans PW,de Graaff J,Plasterk RH

更新日期：1995-06-06 00:00:00

abstract：:One of the main differences between bacteria and archaea concerns their membrane composition. Whereas bacterial membranes are made up of glycerol-3-phosphate ester lipids, archaeal membranes are composed of glycerol-1-phosphate ether lipids. Here, we report the construction of a stable hybrid heterochiral membrane thr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caforio A,Siliakus MF,Exterkate M,Jain S,Jumde VR,Andringa RLH,Kengen SWM,Minnaard AJ,Driessen AJM,van der Oost J

更新日期：2018-04-03 00:00:00

abstract：:Using a proteomics screen, we have identified the methyltransferase G9a as an interacting partner of the hematopoietic activator NF-E2. We show that G9a is recruited to the beta-globin locus in a NF-E2-dependent manner and spreads over the entire locus. While G9a is often regarded as a corepressor, knocking down this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaturvedi CP,Hosey AM,Palii C,Perez-Iratxeta C,Nakatani Y,Ranish JA,Dilworth FJ,Brand M

更新日期：2009-10-27 00:00:00

abstract：:Mutations are introduced into rearranged Ig variable genes at a frequency of 10(-2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair. Therefore, hyperm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winter DB,Phung QH,Umar A,Baker SM,Tarone RE,Tanaka K,Liskay RM,Kunkel TA,Bohr VA,Gearhart PJ

更新日期：1998-06-09 00:00:00

abstract：:The S1-nuclease analysis was used to investigate the pattern of inhibin expression in the rat. In a first series of experiments, expression of the alpha, beta A, and beta B subunits of inhibin were monitored in various tissues from male and female rats. Two observations emerge from these studies. First, expression of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meunier H,Rivier C,Evans RM,Vale W

更新日期：1988-01-01 00:00:00

abstract：:Human gene MAGE-1 encodes tumor-specific antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. This gene is expressed in a significant proportion of tumors of various histological types, but not in normal tissues except male germ-line cells. We reported previously that reporter genes dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Smet C,De Backer O,Faraoni I,Lurquin C,Brasseur F,Boon T

更新日期：1996-07-09 00:00:00